Following the advances in tissue engineering in the last thirty years, all existing approaches have been adopted and applied in our laboratories. Our group conducts research activities at international level in four different laboratories: '' Biomaterials Manufacturing / Characterization Laboratory '', '' PCR Analysis Laboratory '', ''Electrospinning Process Laboratory '' and '' Cell and Tissue Culture Laboratory ''.
• Fume Hood
• Microwave oven
• Vacuum Oven
• Centrifuge (3 pcs)
• Magnetic Stirrers
• Precision Balance
• Fluorescence Spectrophotometer
• High Performance Liquid Chromatography (HPLC)
• UV Spectrophotometer (Nanodrop)
• Water Contact Angle Measurement Device
• Shaking Mixer (2 Pieces)
• Homogenizer
• Sonicator
• Ph Meter
• Vortex (2 Pieces)
• Water bath
• Refrigerated Incubator
• Shaking Incubator (2 Pieces)
• Three Dimensional Bioprinter
• Electrospinning Device
• Freeze Dryer (Lyophilizer - 2 pcs)
• Tissue Embedding Device
• Cold Table
• Semi-Automatic Microtome
• Water bath
• Hot Table
• Texture Painting Station
• Mechanical Test Device
• Real Time Polymerase Chain Reaction (PCR) Device
• Mini Centrifuge
• Laminar Flow Cabinet
• Carbon Dioxide Incubator (2 pcs),
• Refrigerated Centrifuge
• UV Oven
• UV Light Source
• Autoclave (2 pcs)
• Water Bath (2 pcs)
• Ultra Pure Water Device
• Invert Microscope
• UV Microplate Reader
• Precision Balance
• Centrifuge
• Mini Centrifuge
• Liquid Nitrogen Tank (2 pcs)
• -80 ° C Freezer
• Prof. Dr. Menemse Gumusderelioğlu
• Dr. Lecturer Soner Çakmak (Bioengineering USA)
• Dr. Lecturer Damla Çetin Altındal (Bioengineering USA)
• Lecturer Assist. Dr. Anıl Sera Lighter
A. Doctoral Students:
• Fatma Yülek
• Özge Ekin Akdere
• Res. See. Burcu Sarıkaya (Bioengineering USA)
• Ayfer Koyuncu
• Res. Gör. Gökçe Mülazımoğlu (Bioengineering USA)
• Res. Assist.Elvan Konuk
• Sema Coşkun
• Tugce Gultan
• Zeynep Altınışık
• Miray İzgen Canver
• My Site Şahin
• Res. See Demet Cakir
• Res. See Sena Koç
• Res. See Tülay Selin Ertekin
• Serdar Onat Akbulut
Graduate students:
• Hatice Demir
• Şeyma Poyraz
• Hazal Şatır
• Begum Sargon
• Achilles Tendon Regeneration with Tissue Engineering Approaches, Hacettepe University Scientific Research Unit Project, Project No: FBA-2018-17043.
• Development of Bioactive Polyetheretherketone PEEK Dental Implants: Coating with Boron Doped Nanohydroxyapatite and Cell Layers, Hacettepe University Scientific Research Unit Project, Project No: TSA-2018-17055 (under the direction of the Faculty of Dentistry).
• Biological Conduit Model in Peripheral Nerve Defect Repair: Evaluation of the Effect of Nerve Conduit Model Containing De-epithelialized Human Amniotic Membrane and Adipose Originated Mesenchymal Stem Cell Layer on Nerve Healing, TÜBİTAK 1001, Project No: 119S133.
• Development of Gradient Bioinks Formulations for Interface Tissue Engineering, Determination of In-Vitro and In-Vivo Activities, TÜBİTAK 1003, Project No: 218E003.
• Synthesis of Peptide Coated and Chemotherapeutic Drug-Loaded Superparamagnetic Demiroxide Nanoparticles (SPDON) and Development of Hyperthermia Exposure System for Use in Glioblastoma Cell Lines, TÜBİTAK 3501, Project No: 118S027 (under the leadership of Gazi University).
• Investigation of Osteogenic Differentiation of Cells Modified with CRISPR / Cas9 System in Controlled BMP-2 Releasing Tissue Scaffolds, TÜBİTAK 1002, Project No: 119S904 (Coordinator: Dr. Anıl Sera Çakmak).
• Eye Muscle Regeneration with Decellularized Bovine Eye Muscle and PCL-Muscle Matrix Composite Tissue Scaffolds, TÜBİTAK 1002, Project No: 119S915.
• Evaluation of Osteoinductive and Anticarcinogenic Effects of Melatonin in terms of Bone Tissue Engineering: In Vitro Studies, Hacettepe University Scientific Research Unit Project, Project No: FBA-2015-5315.
• Development of Tissue Scaffold Supported Perfusion Bioreactor for Bone Patches: Determination of Operating Parameters and CFD Modeling Studies, TÜBİTAK 1001, Project No: 214M100.
• Development of Cell-Layer Supported Heart Patch with Cells-Free Myocardial Tissue: In-Vitro Studies, Hacettepe University Scientific Research Unit Project, Project No: FBA-2017-16248.
• 3D Printing of Kappa Carrageenan Hydrogels Methacrylated with Microwave Support for Cartilage Tissue Regeneration, TÜBİTAK 1002, 118M734.
• Çakmak, S., Çakmak, A. S., Kaplan, D. L., Gümüşderelioğlu, M. (2016). A Silk Fibroin and Peptide Amphiphile ‐ Based Co ‐ Culture Model for Osteochondral Tissue Engineering. Macromolecular Bioscience, 16 (8), 1212-1226.
• Tığlı Aydın, R. S., Kaynak, G., Gümüşderelioğlu, M. (2016). Salinomycin encapsulated nanoparticles as a targeting vehicle for glioblastoma cells. Journal of Biomedical Materials Research Part A, 104 (2), 455-464.
• Altındal, D. Ç., Gümüşderelioğlu, M. (2016). Melatonin releasing PLGA micro / nanoparticles and their effect on osteosarcoma cells. Journal of microencapsulation, 33 (1), 53-63.
• Çakmak, A. S., Çakmak, S., White, J. D., Raja, W. K., Kim, K., Yiğit, S., Kaplan D.L., Gümüşderelioğlu, M. (2016). Synergistic effect of exogeneous and endogeneous electrostimulation on osteogenic differentiation of human mesenchymal stem cells seeded on silk scaffolds. Journal of Orthopedic Research, 34 (4), 581-590.
• Gürbüz, S., Demirtaş, T. T., Yüksel, E., Karakeçili, A., Doğan, A., Gümüşderelioğlu, M. (2016). Multi-layered functional membranes for periodontal regeneration: Preparation and characterization. Materials Letters, 178,256-259.
• Çakmak, A. S., Cakmak, S., White, J. D., Raja, W. K., Kaplan, D. L., Gümüşderelioğlu, M. (2016). Osteogenic differentiation of electrostimulated human mesenchymal stem cells seeded on silk-fibroin films. Turkish Journal of Biology, 40 (2).
• Yüksel, E., Karakeçili, A., Demirtaş, T., Gümüşderelioğlu, M. (2016). Preparation of bioactive and antimicrobial PLGA membranes by magainin II / EGF functionalization. International journal of biological macromolecules, 86,162-168.
• Demirtaş, T. T., Göz, E., Karakeçili, A., Gümüşderelioğlu, M. (2016). Combined delivery of PDGF-BB and BMP-6 for enhanced osteoblastic differentiation. Journal of Materials Science: Materials in Medicine, 27 (1), 12.
• Arslan, A., Çakmak, S., Cengiz, A., Gümüşderelioğlu, M. (2016). Poly (butylene adipate-co-terephthalate) scaffolds: processing, structural characteristics and cellular responses. Journal of Biomaterials Science, Polymer Edition, 27 (18), 1841-1859.
• Ülker, N., Çakmak, A. S., Kiremitçi, A. S., Gümüşderelioğlu, M. (2016). Polychromatic light-induced osteogenic activity in 2D and 3D cultures. Lasers in medical science, 31 (8), 1665-1674.
• Şimşek, M., Çakmak, S., Gümüşderelioğlu, M. (2016). Insoluble poly (ethylene oxide) nanofibrous coating materials: effects of crosslinking conditions on the matrix stability. Journal of Polymer Research, 23 (11), 236.
• Tunçay, E. Ö., Demirtaş, T. T., Gümüşderelioğlu, M. (2017). Microwave-induced production of boron-doped HAp (B-HAp) and B-HAp coated composite scaffolds. Journal of Trace Elements in Medicine and Biology, 40, 72-81
• Bayrak, G. K., Demirtaş, T. T., Gümüşderelioğlu, M. (2017). Microwave-induced biomimetic approach for hydroxyapatite coatings of chitosan scaffolds. Carbohydrate polymers, 157,803-813.
• Beşkardeş, I. G., Hayden, R. S., Glettig, D. L., Kaplan, D. L., Gümüşderelioğlu, M. (2017). Bone tissue engineering with scaffold-supported perfusion co-cultures of human stem cell-derived osteoblasts and cell line-derived osteoclasts. Process Biochemistry, 59,303-311.
• Toz, T., Kiremitçi, A., Sera Çakmak, A., Ünsal Tan, O., Palaska, E., Gümüşderelioğlu, M., Özcan, M. (2017). A comparative study on monomer elution and cytotoxicity of different adhesive restoration materials. Journal of adhesion science and Technology, 31 (4), 414-429.
• Sana, F. A., Yurtsever, M. Ç., Bayrak, G. K., Tunçay, E. Ö., Kiremitci, A. S., Gümüşderelioğlu, M. (2017). Spreading, proliferation and differentiation of human dental pulp stem cells on chitosan scaffolds immobilized with RGD or fibronectin. Cytotechnology, 69 (4), 617-630.
• Calis, M., Demirtas, T. T., Vatansever, A., Irmak, G., Sakarya, A. H., Atilla, P., Ozgur F., Gumusderelioglu, M. (2017). A Biomimetic Alternative to Synthetic Hydroxyapatite: “Boron-Containing Bone-Like Hydroxyapatite” Precipitated From Simulated Body Fluid. Annals of plastic surgery, 79 (3), 304-311.
• Demirtaş, T. T., Irmak, G., Gümüşderelioğlu, M. (2017). A bioprintable form of chitosan hydrogel for bone tissue engineering. Biofabrication, 9 (3), 035003.
• Duruel, T., Çakmak, A. S., Akman, A., Nohutcu, R. M., Gümüşderelioğlu, M. (2017). Sequential IGF-1 and BMP-6 releasing chitosan / alginate / PLGA hybrid scaffolds for periodontal regeneration. International journal of biological macromolecules, 104, 232-241.
• Çakmak, A. S., Çakmak, S., Vatansever, H. S., Gümüşderelioğlu, M. (2018). Photostimulation of osteogenic differentiation on silk scaffolds by plasma arc light source. Lasers in medical science, 33 (4), 785-794.
• Beşkardeş, I. G., Aydın, G., Bektaş, Ş., Cengiz, A., Gümüşderelioğlu, M. (2018). A systematic study for optimal cell seeding and culture conditions in a perfusion mode bone-tissue bioreactor. Biochemical Engineering Journal, 132, 100-111.
• Arslan, A., Çakmak, S., Gümüşderelioğlu, M. (2018). Enhanced osteogenic activity with boron-doped nanohydroxyapatite-loaded poly (butylene adipate-co-terephthalate) fibrous 3D matrix. Artificial cells, nanomedicine, and biotechnology, 46 (sup2), 790-799.
• Can, G. D., Akdere, Ö. E., Can, M. E., Aydın, B., Cagil, N., Gümüşderelioğlu, M. (2018). A completely human-derived biomaterial mimicking limbal niche: platelet-rich fibrin gel. Experimental eye research, 173, 1-12.
• Irmak, G., Demirtaş, T. T., Gümüşderelioǧlu, M. (2018). Highly Methacrylated Gelatin Bioink for Bone Tissue Engineering. ACS Biomaterials Science & Engineering, 5 (2), 831-845.
• Çatıker, E., Konuk, E., Gültan, T., Gümüşderelioğlu, M. (2019). Enhancement of scaffolding properties for poly (3-hydroxybutyrate): blending with poly-β-alanine and wet electrospinning. International Journal of Polymeric Materials and Polymeric Biomaterials, 68 (6), 338-349.
• Akdere, Ö. E., Shikhaliyeva, İ., Gümüşderelioğlu, M. (2019). Boron mediated 2D and 3D cultures of adipose derived mesenchymal stem cells. Cytotechnology, 71 (2), 611-622.
• Çetin Altındal, D., James, E. N., Kaplan, D. L., Gümüşderelioğlu, M. (2019). Melatonin-induced osteogenesis with methanol-annealed silk materials. Journal of Bioactive and Compatible Polymers, 34 (3), 291-305.
• Altındal, D. Ç., Gümüşderelioğlu, M. (2019). Dual-functional melatonin releasing device loaded with PLGA microparticles and cyclodextrin inclusion complex for osteosarcoma therapy. Journal of Drug Delivery Science and Technology, 52,586-596.
• Can, G. D., Akdere, Ö. E., Can, M. E., Gümüşderelioğlu, M. (2019). A simple and efficient method for cultivation of limbal explant stem cells with clinically safe potential. Cytotherapy, 21 (1), 83-95.
• Bayrak, G. K., Gümüşderelioğlu, M. (2019). Construction of cardiomyoblast sheets for cardiac tissue repair: comparison of three different approaches. Cytotechnology, 71 (4), 819-833.
• Calis, M., Demirtas, T. T., Sert, G., Irmak, G., Gumusderelioglu, M., Turkkani, A., Çakar A.N., Ozgur, F. (2019). Photobiomodulation with polychromatic light increases zone 4 survival of transverse rectus abdominis musculocutaneous flap. Lasers in surgery and medicine, 51 (6), 538-549.
• Şimşek, M., Aldemir, S. D., Gümüşderelioğlu, M. (2019). Anticellular PEO coatings on titanium surfaces by sequential electrospinning and crosslinking processes. Emergent Materials, 2 (2), 169-179.
• Ayhan, D. K., Temiz, A., Sana, F. A., Gümüşderelioğlu, M. (2019). Surface properties and exopolysaccharide production of surface-associated microorganisms isolated from a dairy plant. Annals of Microbiology, 69 (9), 895-907.
• Gümüşderelioğlu, M., Sunal, E., Demirtaş, T. T., Kiremitçi, A. S. (2020). Chitosan-based double-faced barrier membrane coated with functional nanostructures and loaded with BMP-6. Journal of Materials Science: Materials in Medicine, 31 (1), 4.
• Gültan, T., Bektaş Tercan, Ş., Çetin Altındal, D., Gümüşderelioğlu, M. (2020). Synergistic effect of fabrication and stabilization methods on physicochemical and biological properties of chitosan scaffolds. International Journal of Polymeric Materials and Polymeric Biomaterials, 1-12.
• Yurtsever, M. Ç., Kiremitci, A., Gümüşderelioğlu, M. (2020). Dopaminergic induction of human dental pulp stem cells by photobiomodulation: comparison of 660nm laser light and polychromatic light in the nir. Journal of Photochemistry and Photobiology B: Biology, 204, 111742.
• Irmak, G., Demirtaş, T. T., Gümüşderelioğlu, M. (2020). Sustained release of growth factors from photoactivated platelet rich plasma (PRP). European Journal of Pharmaceutics and Biopharmaceutics, 148, 67-76.
• Gültan, T., Yurtsever, M. Ç., Gümüşderelioğlu, M. (2020). NaOH-etched / boron-doped nanohydroxyapatite-coated PEEK implants enhance the proliferation and differentiation of osteogenic cells. Biomedical Materials, 15 (3), 035019.
• Irmak, G., Öztürk, M. G., Gümüşderelioğlu, M. (2020). Salinomycin Encapsulated Plga Nanoparticles Eliminate Osteosarcoma Cells Via Inducing / Inhibiting Multiple Signaling Pathways: Comparison With Free Salinomycin. Journal of Drug Delivery Science and Technology, 101834.
• Irmak, G., Gümüşderelioğlu, M. (2020). Photo-activated platelet-rich plasma (PRP) -based patient-specific bio-ink for cartilage tissue engineering. Biomedical Materials, 15 (6), 065010.
• Çetin Altındal, D., Türkyılmaz, P., Gümüşderelioğlu, M. (2020). P (HEMA) -based SPH vehicles for high molecular weight protein delivery. International Journal of Polymeric Materials and Polymeric Biomaterials, 69 (12), 773-785.
• İlhan, G. T., Irmak, G., Gümüşderelioğlu, M. (2020). Microwave assisted methacrylation of Kappa carrageenan: A bioink for cartilage tissue engineering. International Journal of Biological Macromolecules, 164,3523-3534.
• Jarrar, H., Altındal, D. Ç., Gümüşderelioğlu, M. (2020). The inhibitory effect of melatonin on osteoclastogenesis of RAW 264.7 cells in low concentrations of RANKL and MCSF. Turkish Journal of Biology, 44 (6), 427-436.
Official Web Page
tissueeng.hacettepe.edu.tr