In our laboratory, biocompatible, biodegradable micro-nanoparticles are synthesized by various synthesis methods. Applications of these micro-nanoparticles in fields such as nanotechnologically based drugs, drug loading and controlled released from nanoparticles, nanocomposite design from biopolymeric and ceramic materials, antibiotic removal with nanoparticles, adsorption, biosorption, desorption, water / soil bioremediation are investigated.
• Ultrasonicator
• Lyophilizer
• HPLC
• UV-VIS Spectrophotometer
• Mechanical Mixer
• Digital Heated Magnetic Stirrer
• Shaker
• Ultrasonic Homogenizer
• Autoclave
• Centrifuge
• Benchtop Refrigerated Centrifuge
• Centrifugal Grinder
• Peristaltic Pump
• Peristaltic Pump
• Measuring Device (pH / ORP / Temperature / Conc. / TDS / Salt / DO / O2)
• Precision Balance
• Ultra Pure Water System
• Prof. Dr. Yesim Right Açıkel
• Ezgi Türkeş (PhD Thesis Student)
• Merve Öztekin (PhD Thesis Student)
• Görkem Polat (PhD Thesis Student)
• Ayşe Ekin Uzunhasanoğlu (PhD Thesis Student)
• Ayşe Burcu Nazlı (PhD Thesis Student)
• Damla Gürel (Master Thesis Student)
• PhD Thesis Project titled "Development of Dual Drug-Loaded Albumin-Based Nanoparticles as Targetable Drug Delivery System for Breast Cancer" (Supported by Hacettepe University Scientific Research Projects Coordination Unit (BAP))
Completed Projects (Last 5 Years)
• “Antibiotic removal from aqueous media by adsorption using chitosan and halloysite based nanoparticles”, Hacettepe University, Scientific Research Unit, Comprehensive Research Project, Project No: 1363, 03.04.2014 -22.09.2017.
• “Characterization, physicochemical and thermal properties of halloysite-alginate nanogels and halloysite-chitosan nanoparticles”, Hacettepe University, Scientific Research Unit, Rapid Support Project, Project No: FHD-2015-6641, 13.07.2015-24.11.2017.
Articles
• Turkes, E., Acikel, Y. S. (2020). Synthesis and characterization of magnetic halloysite-chitosan nanocomposites: use in the removal of methylene blue in wastewaters. International Journal of Environmental Science and Technology, 17 (3), 1281-1294.
• Oztekin, M., Acikel, Y. S. (2020). Investigation of adsorption of metronidazole on Chitosan - Halloysite nanocomposites and controlled release. Indian Journal of Chemical Technology, 27 (2), 101-115.
• Nazli, A. B., Acikel, Y. S. (2019). Loading of cancer drug resveratrol to pH-Sensitive, smart, alginate-chitosan hydrogels and investigation of controlled release kinetics. Journal of Drug Delivery Science and Technology, 53, 16.
• Polat, G., Acikel, Y. S. (2019). Synthesis and Characterization of Magnetic Halloysite-Alginate Beads for the Removal of Lead (II) Ions from Aqueous Solutions. Journal of Polymers and the Environment, 27 (9), 1971-1987.
• Acikel, Y. S., Goze, B. (2017). Removal of Methyl Red, a cationic dye, Acid Blue 113, an anionic dye, from wastewaters using chitin and chitosan: influence of copper ions. Desalination and Water Treatment, 73,289-300.
• Raeiatbin, P., Acikel, Y. S. (2017). Removal of tetracycline by magnetic chitosan nanoparticles from medical wastewaters. Desalination and Water Treatment, 73, 380-388.
• Turkes, E., Acikel, Y.S. (2017). Chromium (VI) removal by a novel magnetic halloysite-chitosan nanocomposite from aqueous solutions. International Journal of Food and Biosystems Engineering, 5 (1), 7-14.
• Polat, G., Acikel, Y.S. (2017). Synthesis of magnetic halloysite nanotube-alginate hybrid beads: Use in the removal of methylene blue from aqueous media. International Journal of Food and Biosystems Engineering, 5 (1), 15-22.
• Goze, B., Evirgen, O. A., Acikel, Y. S. (2016). Investigation of antagonistic and synergistic interactions on simultaneous adsorption of crystal violet and Cu (II) using chitin and chitosan. Desalination and Water Treatment, 57 (9), 4059-4072.
Chapter in an International Book:
• M. Öztekin, Y.S. Açıkel, "Investigation of Metranidazole Adsorption Equilibrium and Kinetics on Chitosan Nanoparticles", in Current Academic Studies in Engineering Sciences, Edited by: Prof. Dr. Serdar Salman, Prof. Dr. Rıdvan Karapınar, Assoc. Kılıçer, Vol: II, (2018), p.913-930, IVPE, Cetinje, Montenegro.
C. Papers Presented at International Congresses:
• G. Topal Canbaz, Ü. Açıkel, Y. Sağ Açıkel, “Phenol Removal from Aqueous Environment with ZnO Nanoparticles Produced from Onion Peel Wastes by Green Synthesis”, 5th Eurasia Waste Management Symposium, İstanbul, October, 26-27, 2020, Proceedings Book, Full Paper, p. 95-98, ISBN: 978-625-409-001-1.
• G. Topal Canbaz, Ü. Açıkel, Y. Sağ Açıkel, “Green Synthesis of ZnO Nanoparticles from Onion Peel Wastes”, 5th Eurasia Waste Management Symposium, İstanbul, October, 26-27, 2020, Proceedings Book, Full Paper, p. 117-121, ISBN: 978-625-409-001-1.
• Ü. Açıkel, Z.S. Keskin, G. Topal Canbaz, Y. Sağ Açıkel, "Synthesis of Copper Nanoparticles from Waste Onion Peels", (oral presentation), The 5th International Symposium on Pharmaceutical and Biomedical Sciences, Cappadocia, Nevşehir, April 26-28, 2019, ISPBS -5 Proceedings Book, Abstracts & Full Papers, p. 107-112.
• Ü. Açıkel, G. Topal Canbaz, Y. Sağ Açıkel, “Green Synthesis of Silver Nanoparticles Using pomegranate Waste ”, (oral presentation), The 5th International Symposium on Pharmaceutical and Biomedical Sciences, Cappadocia, Nevşehir, April 26-28, 2019, ISPBS-5 Proceedings Book, Abstracts & Full Papers, p. 113-118.
• Y. Sağ Açıkel, Ö.C. Aşkar, “Controlled Delivery of Ciprofloxacin from Halloysite Nanotubes”, (oral presentation), The 5th International Symposium on Pharmaceutical and Biomedical Sciences, Cappadocia, Nevşehir, April 26-28, 2019, ISPBS-5 Proceedings Book, Abstracts & Full Papers, p . 119-123.
• Y. Sağ Açıkel, M. Öztekin, P. Raeiatbin, “Sustained and Controlled Antibiotic Release from Chitosan and Magnetic Chitosan Nanoparticles”, (oral presentation), The 5th International Symposium on Pharmaceutical and Biomedical Sciences, Cappadocia, Nevşehir, April 26- 28, 2019, ISPBS-5 Proceedings Book, Abstracts & Full Papers, p.124-128.
• M. Öztekin, Y. Sağ Açıkel, "Investigation of Metranidazole Adsorption Equilibrium and Kinetics on Chitosan Nanoparticles", (oral presentation), 5th. International Multidisciplinary Studies Symposium (ISMS), Crowne Plaza Hotel-Ankara, 16-17 November 2018.
• SAĞ ACIKEL Yeşim (Prof. Dr.), Parinaz Raeiatbin (Senior Engineer), “Tetracycline Loading to Magnetic Chitosan-Iron Oxide Nanocomposites and Controlled Release”, oral presentation, International Eurasian Conference on Biological and Chemical Sciences (EurasianBioChem 2018) , Crowne Plaza Hotel, Ankara, Turkey, 26-27 April, 2018, Abstract Book, p 217.
• TOPAL CANBAZ Gamze (Senior Engineer), Ünsal Açıkel (Prof. Dr.), Yeşim Sağ Açıkel (Prof. Dr.), “Biosynthesis of Silver Nanoparticles by Persea Americana”, oral presentation, International Eurasian Conference on Biological and Chemical Sciences (EurasianBioChem 2018), Crowne Plaza Hotel, Ankara, Turkey, 26-27 April, 2018, Abstract Book, p.512.
• SAĞ ACIKEL Yeşim (Prof. Dr.), Parinaz Raeiatbin (Senior Engineer), “Tetracycline Removal by Magnetic Halloysite Nanotubes from Medical Wastewaters”, poster presentation, International Eurasian Conference on Biological and Chemical Sciences (EurasianBioChem 2018), Crowne Plaza Hotel, Ankara, Turkey, 26-27 April, 2018, Abstract Book, p 906.
• POLAT, Görkem (Eng. Eng.), Yeşim Sağ Açıkel (Prof. Dr.), “Investigation of Adsorption Kinetics and Equilibrium of Methylene Blue on Magnetic Halloysite Nanotubes-Alginate Hydrogel Beads”, poster presentation, International Eurasian Conference on Biological and Chemical Sciences (EurasianBioChem 2018), Crowne Plaza Hotel, Ankara, Turkey, 26-27 April, 2018, Abstract Book, p 1382.
• TÜRKEŞ, Ezgi (Senior Engineer), Yeşim Sağ Açıkel (Prof. Dr.), “Investigation of Adsorption Kinetics and Equilibrium of Cr (VI) Ions on Magnetic Halloysite-Chitosan Nanocomposites”, poster presentation, International Eurasian Conference on Biological and Chemical Sciences (EurasianBioChem 2018), Crowne Plaza Hotel, Ankara, Turkey, 26-27 April, 2018, Abstract Book, p 1388.
• ÖZTEKİN, Merve (Eng. Eng.), Yeşim Sağ Açıkel (Prof. Dr.), “Investigation of Metronidazole Loading and Release on / from Chitosan Nanoparticles”, poster presentation, International Eurasian Conference on Biological and Chemical Sciences (EurasianBioChem 2018) , Crowne Plaza Hotel, Ankara, Turkey, 26-27 April, 2018, Abstract Book, p 1389.
• TOPAL CANBAZ Gamze (Eng. Eng.), Ünsal Açıkel (Prof. Dr.), Yeşim Sağ Açıkel (Prof. Dr.), “Equilibrium and Thermodynamic Studies for Adsorption of Cu (II) on Activated Sludge”, poster presentation, International Eurasian Conference on Biological and Chemical Sciences (EurasianBioChem 2018), Crowne Plaza Hotel, Ankara, Turkey, 26-27 April, 2018, Abstract Book, p 1390.
• TÜRKEŞ, Ezgi (Senior Engineer), Yeşim Sağ Açıkel (Prof. Dr.), “Chromium (VI) removal by a novel magnetic halloysite-chitosan nanocomposite from aqueous solutions”, 3rd International Conference of Food and Biosystems Engineering, Rhodes Island, Greece, 1-4 June, 2017, Proceedings of 3rd. INNER. FABE 2017, 202-209.
• POLAT, Görkem. (Engineering Engineer), Yeşim Sağ Açıkel (Prof. Dr.), “Synthesis of magnetic halloysite nanotube-alginate hybrid beads: Use in the removal of methylene blue from aqueous media”, 3rd International Conference of Food and Biosystems Engineering, Rhodes Island, Greece, 1-4 June, 2017, Proceedings of 3rd. INNER. FABE 2017, 210-217.
• AçıkEL, Yeşim Sağ (Prof. Dr.), Başak Göze (Senior Engineer), “Removal of methyl red, a cationic dye, acid blue 113, an anionic dye, from wastewaters using chitin and chitosan: influence of copper ions ”, Desalination for the Environment: Clean Water and Energy, Rome, Italy, 22-26 May 2016, Abstracts, European Desalination Society, 2016, 81-82, Ps 2.
• RAEIATBİN, Perinaz (Senior Eng.), AçıkEL, Yeşim Sağ Açıkel (Prof. Dr.), “Removal of tetracycline by magnetic chitosan nanoparticles from medical wastewaters”, Desalination for the Environment: Clean Water and Energy, Rome, Italy, 22-26 May 2016, Abstracts, European Desalination Society, 2016, 82-83, Ps 2.
• GÖZE, Virgo (High. Eng.), Yeşim Sağ Açıkel (Prof. Dr.), “Investigation of Biosorption Kinetics and Equilibrium of Zinc by Chitin and Chitosan”, 16th International Symposium on Environmental Issues and Waste Management in Energy and Mineral Production, Istanbul, 5-7 October , 2016, Proceedings of SWEMP 2016-6, AGRO ARGE Danışmanlık San. Ve Tic. A.S. Istanbul, Turkey, p.7.
D. Notifications Presented at National Congresses:
• A.B. Nazlı, Y. Sağ Açıkel, “Investigation of Controlled Release of Resveratrol from Cross-Loaded Chitosan Nanoparticles” (oral presentation), 13th National Chemical Engineering Congress, Van Yüzüncü Yıl University, September 3-6, 2018, Abstract Book, 5843, S12.
• G. Polat, Y. Sağ, Açıkel, “Synthesis, Characterization of Fe3O4-Halloysite-Alginate Hydrogel Spheres and Their Use in Methylene Blue Removal” (oral presentation), 13th National Chemical Engineering Congress, Van Yüzüncü Yıl University, 3-6 September 2018 , Abstract Book, 5851, S68.
• E. Türkeş, Y. Sağ Açıkel, "Synthesis, Characterization of Halloysite-Fe3O4-Chitosan Nanocomposites and Their Use in Heavy Metal Removal" (oral presentation), 13th National Chemical Engineering Congress, Van Yüzüncü Yıl University, 3-6 September 2018, Abstract Book, 5852, S56.
• M. Öztekin, Y. Sağ Açıkel, “Antibiotic Removal from Aqueous Media by Adsorption Using Chitosan Nanoparticles” (oral presentation), 13th National Chemical Engineering Congress, Van Yüzüncü Yıl University, 3-6 September 2018, Abstract Book, 5842, S96 .
• RAEIATBİN, Perinaz (M.Sc. Eng.), Açıkel, Yeşim Sağ Açıkel (Prof. Dr.), “The use of tetracycline loaded magnetic halloysite nanoparticles as nano drug carriers”, 12th National Chemical Engineering Congress, İzmir, 23-26 August, 2016.
• ÖZTEKİN, Merve (M.Sc. Eng.), Açıkel, Yeşim Sağ Açıkel (Prof. Dr.), “Investigation of metranidazole loading and adsorption on chitosan nanoparticles”, 12th National Chemical Engineering Congress, İzmir, 23-26 August, 2016.
• AŞKAR Özge Can (Eng. Eng.), Açıkel, Yeşim Sağ Açıkel (Prof. Dr.), “Investigation of ciprofloxacin loading, adsorption and characterization into halloysite nanotubes, 12th National Chemical Engineering Congress, İzmir, 23-26 August, 2016.