Analytical Chemistry Department Research Laboratory

About

Research Infrastructure

• LC-MS/MS (Shimadzu 8030)
• GC-MS (Shimadzu 2010ultra)
• HPLC (Shimadzu)
• Potentiostat/Galvanostat (Gamry Ref. 600)
• Voltammetric Analyzer (Bass 100 B/W)
• UV-GB Spectrophotometer (Agilent 8453)

Researchers

•    Prof. Dr. Nursabah Elif BAŞCI AKDUMAN
•    Prof. Dr. Sedef KIR
•    Prof. Dr. Nuran ÖZALTIN
•    Prof. Dr. İncilay SÜSLÜ
•    Prof. Dr. Emirhan NEMUTLU
•    Doç. Dr. Mustafa ÇELEBİER
•    Dr. Öğr. Üyesi Ayşegül DOĞAN
•    Dr. Tuba REÇBER
•    Araş. Gör. Sevilay ERDOĞAN
•    Araş. Gör. Ozan KAPLAN
•    Uzm. Kim. Cemil Can EYLEM
•    Ecz. Elif Damla GÖK
•    Uzm. Kim. Mohammed RAZZAHAGİ
•    Uzm. Kim Ece ÖZKAN
•    Uzm. Ecz. Emre ÖZDEMİRHAN
•    Uzm. Kim. Özge Cansın ZEKİ
•    Ecz. Ayşe KUŞ
•    Ecz. Murat ÜLGEN
•    Kim. Müh. Ege ŞEN
•    Kim. Çağrı TALAY
•    Uzm. Kim. Duygu KONUKLU
•    Kim. Pelin GENCER
•    Kim. Merve GÖKŞEN

Ongoing Projects

• Thd-2018-17427; Investigation of the Effects of Environmentally Friendly Mobile Phase Systems Containing Ethanol or Ethyl Lactate on Drug Analysis with HPLC and Developing a Validated Method; Nursabah Elif Başcı Akduman; Aysegul Dogan; Cemil Can Action; 29851.40tl; 2018-2020.
• Thd-2019-18389; Omic Approaches and Electroanalytical Studies for Early Diagnosis of Acute Renal Failure After Cardiopulmonary Bypass; Nuran Özaltın; Sinan Sabit Kocabeyoglu; Abdulkadir Yilmaz; Emirhan Nemutlu; Hope Caravan; Sevilay Erdogan Kablan; 29971.21 TL; 2019-2021.
• Ttu-2019-18400; Effects of Cyp4f2, 4f3, 4a11, 2j2, 2c9, 2c19, Soluble Epoxide Hydrolase Enzymes and Drug Transporter Mdr1 Genetic Polymorphisms in Preeclampsia and Gestational Hypertension; Melih Onder Babaoglu; Nursabah Elif Başcı Akduman; Mustafa Celebier; Ozan Kaplan; Nazan Tonyali; Dilek Şahin Uygur; Mert Can Ongun; Aykan Yucel; 29880.21 Tl; 2019-2022.
• Thd-2020-18956; Chemometric Optimization and Pharmaceutical Analysis of H2 Receptor Antagonists in Green HPLC; Nursabah Elif Başcı Akduman; Ayşegül Doğan, Cemil Can Eylem, Egeşen Halıcı; 29938.96 TL; 2020-2021.
• Tsa-2020-18566; Development and Application of Analytical Methods for Integrated Omix Analysis to be Used in the Determination of Phenotypes of Glioblastoma Multiforme, Meningioma (Primary) and Metastasis (Secondary) Brain Tumors; Nursabah Elif Başcı Akduman; Emirhan Nemutlu; Aysegul Dogan; Cemil Can Action; Ali İhsan Ökten; Yurdal Gezercan; İdil Yet; Suleyman Altintas; Vedat On; 192626.65 TL; 2020-2022.
• Thd-2020-18586; Development of Gcms Method for Targeted Metabolomic Studies for Early Diagnosis of Preeclampsia; Sedef Kir; Emirhan Nemutlu; 30000 TL; 2020-
• Ttu-2019-18473; Radiotherapy Induced Changes in Vitreous Humor; Favorite Printer; Emirhan Nemutlu; 29972 TL; 2019-.
• Tsa-2019-17810; Oxidative Stress, Inflammatory Markers and Metabolomics Responses to Exercise in Chronic Obstructive Pulmonary Patients; Deniz İnal İnce; Emirhan Nemutlu; 129000 TL; 2019-.
• Thd-2019-18393; Effect of Ankaferd Hemostat on Mcf-7 Breast Cancer Cell; İncilay Süslü; Merve Nanni; 8829.94 TL; 2019-2020.
• Thd-2020-18692; Investigation of the Effect and Mechanism of Action of Allogeneic Mesenchymal Stem Cells Obtained from Synovium and Adipose Tissue on Normal and Osteoarthritis Chondrocyte Cell Lines in Invitro Environment; Mustafa Celebier; 2020-2021.
• Ttu-2019-18400; Effects of Cyp4f2, 4f3, 4a11, 2j2, 2c9, 2c19, Soluble Epoxide Hydrolase Enzymes and Drug Transporter Mdr1 Genetic Polymorphisms in Preeclampsia and Gestational Hypertension; Mustafa Celebier; 2019-2022.
• Fhd-2019-18103; Development and Validation of Analytical Methods for Paraben Derivatives and Phenoxyethanol in Cosmetics; Mustafa Celebier; 2019-2021.
• Tsa-2019-17525; Investigation of the Effects of Microbiota, Proteomic and Metabolomic Analysis Results on Disease Pathogenesis and Course in Rheumatic Diseases. Part 2: Proteomics Study in Henoch Schönlein Purpura/Iga Vasculitis; Mustafa Celebier; 2019-2021.
• Fay-2019-18133; Advanced Technologies Application and Research Center Hünitek Ts En Isoıec 17025 Accreditation Application; Mustafa Celebier; 2019-2020.
• 118s578; Investigation of New Biomarkers that Can Be Used in the Diagnosis and Follow-up of Cystinosis, a Rare Disease: Clinical and In Vitro Based Multiomic (Genomic, Proteomic, Metabolomic and Fluxomic) Studies; Rezan Topalloglu; Sedef Kir; Emirhan Nemutlu (Consultant); 360000 TL; 2018-.
• 319s005; Intranasal Metformin Treatment in Mice with Alzheimer's Disease by Intracerebroventricular Administration of Streptozotocin; Pearl Kazkaya; Emirhan Nemutlu; 45000 TL; 2020-.
• 119s182; Development of Bone Marrow Targeted Endocannabinoid Loaded Nanoparticle Carrier System and In Vitro Analysis; Sevil Kose; Emirhan Nemutlu (Consultant); 180000 TL; 2019-.
• 219s661; Gbainvitro: Modeling of the Intestine-Brain Axis (Gba) with 3-Dimensional (3b) Cell Culture Technology and Investigation of Molecular Mechanisms with Sophisticated Omix Platforms; Burak Derkus; Emirhan Nemutlu (Consultant); 700000 TL; 2020-.
• 120s229; Optimization of Solubility and Dissolution Properties of Formulations Containing Celecoxib Using Artificial Neural Network Design; Levent Öner; Emirhan Nemutlu; 2020-.
• 220s225; Effects of Inulin Supplementation on Endocannabinoid Levels, Fatty Liver and Insulin Resistance in Wistar Rats fed a High Fat Diet; Funda Pinar Cakiroglu; Emirhan Nemutlu; 45000 TL; 2020-.
• 220s012; Investigation of Inhibition of Endocannabinoid Metabolism as a New Treatment Strategy in Allergic Respiratory Inflammation; Emrah Bozkurt; Emirhan Nemutlu; 45000 TL; 2020-.
• Project No: Thd-2020-18692, Project Name: Investigation of the Effect and Mechanism of Action of Allogeneic Mesenchymal Stem Cells Obtained from Synovium and Adipose Tissue on Normal and Osteoarthritic Chondrocyte Cell Lines in Invitro, Researcher: Mustafa Çelebier, 28.09.2020 - 28.09. 2021
• Project No: Ttu-2019-18400, Project Name: The Effects of Cyp4f2, 4f3, 4a11, 2j2, 2c9, 2c19, Soluble Epoxide Hydrolase Enzymes and Drug Transporter Mdr1 Genetic Polymorphisms in Preeclampsia and Gestational Hypertension, Position: Researcher: Mustafa Çelebier, 18.11. 2019 - 18.01.2022
• Project No: Fhd-2019-18103, Project Name: Analytical Method Development and Validation for Paraben Derivatives and Phenoxyethanol in Cosmetics, Task: Researcher: Mustafa Çelebier, 02.07.2019- 02.01.2021
• Project No: Tsa-2019-17525, Project Name: Investigation of the Effects of Microbiota, Proteomic and Metabolomic Analysis Results on the Pathogenesis and Course of the Disease in Rheumatic Diseases. Part 2: Proteomics Analysis in Henoch Schönlein Purpura/Iga Vasculitis, Position: Researcher: Mustafa Çelebier, 31.01.2019- 31.01.2021

Completed Projects

• Establishment of Pharmaceuticals and Cosmetics Research, Development and Quality Control Laboratory, (Ministry of Development, Ankara Development Agency (AKA), Bab6050 Participated Project, 2015, Project Coordinator: Prof. Dr. Bülent Gümüşel)
• Investigation of the Presence and Level of Endocannabinoids and Their Receptors in Human Hematopoietic Stem Cells and Mesenchymal Stem Cells from Bone Marrow, Tubitak 1001, 2016, Project No: 113s819, (Project Director: Prof. Dr. Petek Korkusuz)
• Human Bone Marrow Hematopoietic Niche Characterization by Metabolome Analysis H.Ü. Scientific Research Unit Support Project, 2015, Project No:013 D09 103 001-307, (Project Coordinator: Assoc. Dr. Rıza KöKsal ÖZgüL)
• Hematopoietic Niche Characterization in Human Bone Marrow by Metabolome and Transcriptome Profiling, Tubitak 1001, 2016, Project No: 213s006, (Project Coordinator: Assoc. Dr. Rıza KöKsal ÖZgüL)
• Accreditation Project of Hacettepe University Faculty of Pharmacy Pharmaceuticals and Cosmetics R&D and Quality Control Laboratory (Hünikal) within the scope of Ts En Iso/Iec 17025 Standard (Bab Project Coordinator: Prof. Dr. Reyhan Neslihan Gürsoy, Infrastructure, 2016, Project No: Tay -2015-6923)
• Metabolomic Approaches for High Selectivity Diagnosis of Down Syndrome, H.Ü. Scientific Research Unit, Comprehensive Project, 2016, Project No: 1588, (Project Coordinator: Prof. Dr. Sedef Kır)
• Development and Application of Combined Chromatographic (Lc-Tof-Ms and Lc-Ms/Ms) Methods for Early Diagnosis of Breast Cancer, Tubitak 1001, 2017, Project No: 113z390, (Project Leader: Prof. Dr. Sedef Kır)
• Domestic Vaccine Research and Development Studies, Santez, 2018, Project No: 0687.Stz.2016, (Project Coordinator: Prof. Dr. Sevda Şenel)
• Toxicity of Antipsychotics and the Effect of Individual Sensitivity on Toxicity Tubitak 1001, 2015, Project No: 115s229), (Project Coordinator: Prof. Dr. Bensu Karahalil)
• Development of High Performance Liquid Chromatography Mass Spectrometry Method for Quantification of Metabolites in the Early Diagnosis of Trisomy 21 Disease, (Bab Project Coordinator: Prof. Dr. Sedef Kır), Rapid Support, 2015, Project No: Thd-2015-8016)
• Colistin Blood Level Monitoring and Evaluation in Intensive Care Units, (Bab Project Coordinator: Prof. Dr. Kutay Demirkan), Rapid Support, 2017, Project No: Thd-2017-13239)
• Metabolomics Studies in Children with Central and Peripheral Precocious Puberty, (Bab Project Coordinator: Associate Professor Ülfet Pınar Erkekoğlu), Rapid Support, 2017, Project No: Thd-2017-14278)
• Effects of Fatty Acid Amide Hydrolase (Faah) and Monoacyl Glycerol Lipase (Magl) Inhibitors on Experimental Airway Inflammation in Mice, (Bab Project Coordinator: Associate Prof. Turgut Emrah Bozkurt, Rapid Support, 2017, Project No: Thd-2017-16101 )
• Development of Nano-Formulations Containing Neuroprotective Agents and Evaluation of Their Efficacy in the Peripheral Nerve Damage Model Tubitak 1001, 2015, Project No: 115s202, (Project Coordinator: Assoc. Dr. Hakan Eroğlu)
• Investigation of the Effects of Various Antimicrobial Agents, Single and Combined, on Monomicrobial and Polymicrobial Biofilm Models Caused by Some Pathogens that Cause Nosocomial Infection, and Interspecies Interactions in Polymicrobial Biofilms by Transcriptomic and Metabolomic Methods Tubitak 1001, 2015, Project No: 115s550, (Project Leader: Prof. Dr. Meral Sağıroğlu)
• Development of Analytical Methods for Pathway Analysis Based on Oxygen18 Marking and Its Application to Clarify the Mechanism of Resistance to Chematherapeutics in Caco-2 Human Colon Adenocarcinoma Cells Tubitak 1001, Project No: 116z292 - (Project Coordinator Assoc. Dr. Emirhan Nemutlu)
• In Vitro Based Metabolomics and Analysis in Mesenchymal Stem Cell Production, (Bab Project Coordinator: Prof. Dr. Fahriye Duygu Çetinkaya, Rapid Support, 2018, Project No: Thd-2018-17187)
• The Effects of Zanthan Gum Used in Dysphagia Diet and Modified Corn Starch on In Vivo Drug Release, (Bab Project Coordinator: Associate Prof. Dr. Hülya Gökmen Özel, Rapid Support, 2018, Project No: Thd-2018-16115)
• Investigation of the Cb1 Receptor Mediated Antiproliferative and Apoptotic Effects of the Controlled Acpa Release System in Endometrial Cancer, (Bab Project Coordinator: Prof. Dr. Petek Korkusuz, Comprehensive Research, 2018, Project No: Tsa-2018-17032)
• Investigation of the Role of Asymmetric Dimethyl Arginine (Adma) and the Effects of In Vivo Hydrogen Sulfide Treatment in Lipopolysaccharide-Induced Respiratory Tract Inflammation in Mice, (Bab Project Coordinator: Prof.Dr. İnci Erdemli, Comprehensive Research, 2018, Tsa-2017-14475)
• Investigation of Voltammetric Behaviors of Cefuroxime Axetil and Analysis of Pharmaceutical Preparations by Electroanalytical Methods (Support Project – Tyl-2015-6419) – Director: Nuran Özaltın, (2015).
• Investigation of Voltammetric Behaviors of Pramipexole and Analysis from Pharmaceutical Preparations by Electroanalytical Methods. (Scientific Success Support Project- Tbb-2016-10906) Coordinator: Nuran Özaltın (2016).
• Greening in Pharmaceutical Analysis with High Performance Liquid Chromatography (Hplc) Hacettepe University Graduate Research Project (Project No. 014d08301005, Completed.), Director: Nursabah Elif Başcı Akduman
• Green Chromatographic Analysis of Voriconazole And Tadalafil From Plasma, PhD Thesis Project (Project No: Tdk-2015-8149, Completed. 01.10.2015-26.04.2016), Director: Nursabah Elif Başcı Akduman
• Determination of Acidic Dissociation Constant of Tadalafil Drug Active Substance by Spectrophotometric, Potentiometric and Chromatographic Methods, Rapid Support Project (Project No: Thd-2016-9108 Ongoing Project 27.05.2016-), Director: Nursabah Elif Başcı Akduman
• Thd-2018-17427, Investigation of the Effects of Environmentally Friendly Mobile Phase Systems Containing Ethanol or Ethyl Lactate on Drug Analysis with HPLC and Development of a Validated Method, Executive: Nursabah Elif Başcı Akduman, Researchers: Ayşegül Doğan, Cemil Can Eylem, 29851,40tl, 2020
• Project No: Fay-2019-18133, Project Name: Advanced Technologies Application and Research Center Hünitek Ts En Isoıec 17025 Accreditation Application, Position: Researcher: Mustafa Çelebier, 08.07.2019 - 29.09.2020
• Project No: 014 D04 301 002-518, Metabolomic Studies with Gc-Ms in Biological Materials and Products of Plant Origin, Position: Director: Mustafa Çelebier, 15.04.2014- 02.04.2018
• Project No: Fay-2019-18133, Project Name: Research Center Hünitek Ts En Isoıec 17025 Accreditation Application, Researcher: Mustafa Çelebier, 08.07.2019-29.09.2020
• Project No: Thd-2018-16933, Project Name: Investigation of the Effects of Microbiata and Proteomic and Metabolomic Analysis Results in Rheumatic Diseases on Disease Pathogenesis and Course: Part 1 Metabolomic Analysis in Henoch Schönlein Purpura/ Iga Vasculitis, Researcher: Mustafa Çelebier, 14.05.2018 – 19.072019
• Project No: Ay-2015-6923, Project Name: Accreditation Project of Hacettepe University Faculty of Pharmacy, Pharmaceuticals and Cosmetics R&D and Quality Control Laboratory (Hünikal), Researcher: Mustafa Çelebier, 29.07.2015 – 24.10.2016
• Molecular Investigation of the Healing Effect of Bloodstopper on Colon Cancer, 1001- Research, Researcher/Specialist, Concluded, Ardeb, Sbag - Health Sciences Research Support Group, Project Join/Leave Dates: 01.12.2014 - 01.12.2017, Project Start/ End Dates: 01.12.2014 - 01.12.2017.
• Investigation of the Effect on Different Cancer Cells, 1001- Research, Executive, Concluded, Ardeb, Sbag- Health Sciences Research Support Group, Joining/Leaving the Project Dates: 01.10.2015 - 01.10.2018, Project Start/End Dates: 01.10.2015 - 01.10.2018.
• Ardeb, Sbag- Health Sciences Research Support Group, Project Join/Leave Dates: 01.10.2015 - 01.10.2018, Project Start/End Dates: 01.10.2015 - 01.10.2018.
• Gas Chromatography-Mass Spectrometry (Gc-Ms) Analyzes of In Vivo Obtained Tissues in the Investigation of the Antiproliferative Activity of Natural Compounds Against Colon Cancer”, Bab International Research Cooperation Project, Project No: TBI-2015-5339, 17.02.2015- 03.06.2016, Project Manager: Prof. Dr. İncilay Süslü
• Proteomic Investigation of In-Vitro Antineoplastic Effect of Ankaferd Hemostat with 2d Gel Electrophoresis and Maldi-Tof/Tof-Ms on Hepg2, Caco-2 and Ht-29 Cancer Cells”, Bab Graduate Thesis Project, Project No: Tdk-2018- 17656, 06.12.2018-06.09.2019, Project Coordinator: Prof. Dr. İncilay Süslü.
• The Effect of Ankaferd Hemostat on Mcf-7 Breast Cancer Cell”, Bab Rapid Support Project, Project No: Thd-2019-18393, 24.10.2019 - 30.11.2020, Project Coordinator: Prof. Dr. İncilay Süslü.

Publications

• Akgeyik E, Kaynak Ms, Çelebier M, Altınöz S, Şahin S. Evaluation Of Pharmaceutical Quality Of Conventional Dosage Forms Containing Paracetamol And Caffeine Available In Turkish Drug Market. Dissolution Technologies. 2016;May 2016:36 - 41.
• Armutcu, Ç. Tartan, E. Özgür, E. Nemutlu, L. Uzun, Phosphate Anion Imprinted Cryogel Cartridges For Selective Preconcentration Of Phosphorylated Amino Acids From Protein Lysate: An Alternative Sorbent For Proteome Analyzes, Chemistryselect, 5 (38) 11730-11736, 2020
• Atmaca, M., Süslü İ., “Determination Of Roflumilast In Pharmaceutical Formulations By Derivative Spectrophotometric Method”, Hacettepe University Faculty of Pharmacy Journal, 36 (1), 2016, 27-49.
• Boynueğri S, Süslü İ, Çelebier M, Altınöz S. A Rapid And Simple High - Performance Liquid Chromatographic Method For The Analysis Of Ceftriaxone In Perilymph Fluid. Latin American Journal of Pharmacy. 2016;35(5):1001-5
• C.C. Action, M. Yilmaz, B. Derkus, E. Nemutlu, C.B. Camci, E. Yilmaz, MA Turkoglu, B. Aytac, N. Ozyurt, E. Emregul, “Untargeted Multi-Omics Analysis Of Colorectal Cancer Specific Exosomes Reveals The Joint Pathways Of Colorectal Cancer In Clinical Samples And Cell Culture” Cancer Letters, 469 , 186-194, 2020 Q1
• Celebier M, Recber T, Kocak E, Altınöz S, Kır S. Determination Of Rivaroxaban In Human Plasma By Solid-Phase Extraction-High Performance Liquid Chromatography. Journal of Chromatographic Science. 2015;54(2):216-20.
• Cevher Ha, Schaller D, Gandini Ma, Kaplan O, Gambeta E, Zhang Fx, Et al. Discovery Of Michael Acceptor Containing 1, 4-Dihydropyridines As First Covalent Inhibitors Of L-/T-Type Calcium Channels. Bioorganic Chemistry. 2019;91:103187.
• Çelebier M, Haznedaroğlu İc. Could Targeting Hmgb1 Be Useful For The Clinical Management Of Covid-19 Infection? Combinatorial Chemistry & High Throughput Screening. 2020.
• Çelebier M, Ibáñez C, Simó C, Cifuentes A. A Foodomics Approach: Ce-Ms For Comparative Metabolomics Of Colon Cancer Cells Treated With Dietary Polyphenols. Electrophoretic Separation Of Proteins: Springer; 2019. P. 303-13.
• Çelebier M, Kaplan O, Özel S, Engin-Üstün Y. Polycystic Ovary Syndrome In Adolescents: Q-Tof Lc/Ms Analysis Of Human Plasma Metabolome. Journal of Pharmaceutical and Biomedical Analysis. 2020;191:113543.
• Çelebier M, Koçak E, Altınöz S. Evaluation Of A Capillary Electrophoresis Method For Routine Determination Of Varenicline Tartrate In Quality Control Laboratories. Macedonian Journal Of Chemical And Engineering Data. 2015;34(2):267-75.
• Çelebier M, Nenn M, Altınöz S. Ultrafiltration-Based Extraction And Hplc Analysis Of Naproxen Sodium In Human Plasma Samples: An Innovative Approach On Pharmaceutical Analysis. Pharmaceutical Chemistry Journal. 2016;50(4):221 - 5.
• Çelebier M, Nenni M, Kaplan O, Akgeyik E, Kaynak Ms, Sahin S. Determination Of The Physicochemical Properties Of Piroxicam. Turkish Journal of Pharmaceutical Sciences. 2019.
• Çelebier M, Reçber T, Nemutlu E, Kır S. Ultrafiltration-Based Extraction And Lc-Ms/Ms Quantification Of Phenylalanine In Human Blood Sample For Metabolite Target Analysis. Current Pharmaceutical Analysis. 2019.
• Çelebier Mç, Simó C, Altınöz S, Cifuentes A. Comparative Proteomics To Investigate The In Vitro Antiproliferative Effect Of Dietary Polyphenols Against K562 Leukemia Cells Turkish Journal of Biochemistry. 2015;40(2):95-104.
• Çelebier Mustafa, Nenni Merve, Doğan Ayşegül, Süslü Incilay, Altınöz Sacide, Effect Of Internal Standard On Hplc Analysis Of Tablet Dosage Forms:An Experimental Study With Statistical Comparison, Der Pharma Chemica, 2015, 7(6):168-174
• D. Kart, S. Yavaşoğlu-Çiftçi, E. Nemutlu, “Altered Metabolomic Profile Of Dual-Species Biofilm: Interactions Between Proteus Mirabilis And Candida Albicans” Microbiological Research, 230,126346, 2020 Q2
• Demir S, Kaplan O, Celebier M, Sag E, Bilginer Y, Lay I, Et Al. Predictive Biomarkers Of Iga Vasculitis With Nephritis By Metabolomic Analysis. Seminars In Arthritis And Rheumatism. 2020;50(6):1238-44.
• Dogan, A ; Action, Cc; Akduman, Neb,Application Of Green Methodology To Pharmaceutical Analysis Using Eco-Friendly Ethanol-Water Mobile Phases, Microchemical Journal Volume: ‏ 157 Article Number: 104895 Published: ‏ Sep 2020
• Dogan, A ; Plotka-Wasylka, J; Kempinska-Kupczyk, D; Namiesnik, J; Kot-Wasik, A, Detection, Identification And Determination Of Chiral Pharmaceutical Residues In Wastewater: Problems And Challengestrac-Trends In Analytical Chemistry, Volume: ‏ 122, Article Number: 115710 Published: ‏ Jan 2020
• Dogan, A., Bascı, N. E., Green Bioanalytical And Pharmaceutical Analysis Of Voriconazole And Tadalafil By Hplc, Current Pharmaceutical Analysis, 2017, 13, 495-504
• Dogan, A., Kempińska-Kupczyk, D., Kubica, P., & Kot-Wasik, A Analysis Of Chiral Pharmaceutical Residues Influent And Effluent Samples At Racemic And Enantiomeric Level Using Liquid Chromatography-Tandem Mass Spectrometry. (2020), Microchemical Journal, 159, 105517.
• Dogan, Aysegul; Tobiszewski, Marek, Optimization Of Liquid Chromatographic Separation Of Pharmaceuticals Within Green Analytical Chemistry Framework, Microchemical Journal Volume: ‏ 152 Article Number: 104323 Published: ‏ Jan 2020
• Dönmez, F. Yalcin, Ö. Boyacioglu, P. Korkusuz, E. Kupeli Akkol, E. Nemutlu, Y. Balaban, U. Koca “From Nutrition To Medicine: Assessing Hemorrhoid Healing Activity Of Solanum Melongena L. Via In Vivo Experimental Models And Its Major Chemicals” Journal Of Ethnopharmacology , 261 (2020) 113143
• E. D. Gök, S. Kır, E. Nemutlu, Analysis Of Quinolones In Biological Materials By Liquid Chromatographic Methods, Current Analytical Chemistry
• E. Demirtürk, E. Nemutlu, S. Sahin, L. Oner “Development And Validation Of An Hplc Method For Determination Of Rofecoxib In Bovine Serum Albumin Microspheres” Tukish Journal Of Chemistry, 44 (3), 647-655, 2020
• E. Koçak, C. Ozkul, G. Taşkor Önel, E. Nemutlu, S. Kır, M. Sağıroğlu, Screening The Antimicrobial Effect Of Ferrocene-Boronic Acid On Pseudomonas Aeruginosa Using Proteomics And Metabolomics Approach, Journal Of Research In Pharmacy, 24(6), 812-820, 2020
• E. Nemutlu, G. Orgul, T. Reçber, E. Özkan, E. Aydın, M. Turgal, M. AlikaşİfoğLu, S. Kır, M.S. Beksaç, Metabolic Infrastructure Of Pregnant Women With Trisomy 21 Fetuses; Metabolomic Analysis, Zeitschrift Für Geburtshilfe Und Neonatologie, 223 (05), 297-303, 2019
• E. Nemutlu, İ. Eroğlu, H. Eroğlu, S. Kır, Analytical And Technological Perspectives On In Vitro Release Test Of Nano-Drug Delivery Systems, Current Analytical Chemistry, 15(4), (2019), 373-409
• E. Özkan, E. Nemutlu, S. Beksaç, S. Kır, Gc-Ms Analysis Of Seven Metabolites For Screening Of Pregnant Women With Down Syndrome Fetuses- Journal Of Pharmaceutical And Biomedical Analysis, 188, 113427, 2020
• E.M. Gonulalan, E. Nemutlu, L.O. Demirezer, A New Perspective On Evaluation Of Medicinal Plant Biological Activities: The Correlation Between Phytomics And Matrix Metalloproteinases Activities Of Some Medicinal Plants Saudi Pharmaceutical Journal (2019) 27 (3), 446-452
• E.M. Gonulalan, E. Nemutlu, O. Bayazeid, E. Koçak, F.N. Yalcin, L.O. Demirezer, Metabolomics And Proteomics Profiles Of Some Medicinal Plants And Correlation With Bdnf Activity, Phytomedicine, 74,152920, 2020 Q1
• Ebru Aydogan, Tansel Comoglu, Bilge Pehlivanoglu, Murat Dogan, Selcuk Comoglu, Aysegul Dogan, Nursabah Basci, Process And Formulation Variables Of Pregabalin Microspheres Prepared By W/O/O Double Emulsion Solvent Diffusion Method And Their Clinical Application By Animal Modeling Studies, Drug Development And Industrial Pharmacy, Volume 41, Issue 8, 1 August 2015, Pages 1311-1320.
• Ercan A, Celebier M, Varan G, Öncül S, Nenni M, Kaplan O, Et al. Global Omics Strategies To Investigate The Effect Of Cyclodextrin Nanoparticles On Mcf-7 Breast Cancer Cells. European Journal of Pharmaceutical Sciences. 2018;123:377-86.
• Erdoğan Kablan, S., Özaltın N, “Investigation Of Electrochemical Behavior Of Cefuroxime Axetil Using Hanging Mercury Drop Electrode And Graphene Oxide Modified Glassy Carbon Electrode”, Journal Of Electroanalytical Chemistry, 785, 144–151, (2017).
• Erdoğan Kablan, S., Özaltın N, “Voltammetric Determination Of Cefuroxime Axetil In Pharmaceuticals Using Graphene Oxide Modified Glassy Carbon Electrode And Hanging Mercury Drop Electrode” Russian Journal Of Electrochemistry, 55 (4 ), 305–313,(2019).
• G. Tezel, S.S. Timur, M.K. Haidar, I. Bozkurt, O.F. Turkoglu, I. Eroğlu, E. Nemutlu, L. Öner, H. Eroğlu ""A Snapshot On The Current Status Of Alzheimer's Disease, Treatment Perspectives, In-Vitro And In-Vivo Research Studies And Future Opportunities"" Chemical&Pharmaceutical Bulletin C19, 00511, 2019
• H. Demir, T. Gulsun, M.H. Ozkan, E. Nemutlu, S. Sahin, L. Oner, Assessment Of Dose Proportionality Of Rivaroxaban Nanocrystals, Aaps Pharmscitech 21, 228 (2020)
• H. Eroglu, M.K. Haidar, E. Nemutlu, S. ÖztüRk, C. Bayram, K. Ulubayram, L. Öner, Dual Release Behavior Of Atorvastatin And Alpha-Lipoic Acid From Plga Microspheres For The Combination Therapy In Peripheral Nerve İnjury, Journal Of Drug Delivery Science And Technology 39 (2017) 455e466
• Haznedaroğlu İc, Çelebier M. Antiinfective And Wound-Healing Pleiotropic Actions Of Ankaferd Hemostat. Turkish Journal of Medical Sciences. 2020;50(5):1434-5.
• Kaplan O, Celebier M. Evaluation Of Recent Data Processing Strategies On Q-Tof Lc/Ms Based Untargeted Metabolomics. Mass Spectrometry Letters. 2020;11(1):1-5.
• Kaplan O, Celebier M. Evaluation Of Recent Data Processing Strategies On Q-Tof Lc/Ms Based Untargeted Metabolomics Mass Spectrometry Letters. 2019;In Press.
• Karabey-Akyürek Y., Nemutlu E., Bilensoy E., Öner L., An Improved And Validated Hplc Method For The Determination Of Methylprednisolone Sodium Sodium Succinate And Its Degradation Products In Nanoparticles, Current Pharmaceutical Analysis, 13, 162-168, 2017
• Watermelon, M; Cylinder-Gunay, M; Kursunel, Ma; Esendagli, G; Dogan, A; Ozer, AY, Design And In Vitro Evaluation Of Folate-Targeted, Co-Drug Encapsulated Theranostic Liposomes For Non-Small Cell Lung Cancer Journal Of Drug Delivery Science And Technology Volume: ‏ 57, Article No 101707 , 2020
• Kaynak Ms, Akgeyik E, Ateş M, Çelebier M, Şahin S. Development Of Hplc Methods For Individual Determination Of 20 Active Pharmaceutical Ingredients For Ussing-Chamber Studies. Current Pharmaceutical Analysis. 2017;13:145-53.
• Kaynak Ms, Celebier M, Akgeyik E, Sahin S, Altınöz S. Application Of Hplc To Investigate The Physicochemical Properties And Intestinal Permeability Of Ketoprofen. Current Pharmaceutical Analysis. 2017;13:72-9.
• Koçak E, Kaplan O, Çelebier M. Liquid-Liquid Extraction And Ultrafiltration Based Sample Preparation Technique For Q-Tof Lc/Ms Analysis Of Non-Polar Metabolites In Human Plasma Samples. Journal of Research in Pharmacy. 2019;23(6):1-6.
• M. Çelebier, T. Reçbera, E. Nemutlu, S. Kır, Ultrafiltration-Based Extraction And Lc-Ms/Ms Quantification Of Phenylalanine In Human Blood Sample For Metabolite Target Analysis, Current Pharmaceutical Analysis Doı : 10.2174/1573412915666190715095300
• M. Yasacan, A. Erikci, C.C. Action, S. Wildoglu Ciftci, E. Nemutlu, K. Ulubayram, I. Eroglu “Polymeric Nanoparticle Versus Liposome Formulations: Comparative Physicochemical And Metabolomic Studies As L-Carnitine Delivery Systems” Aaps Pharmscitech, 21 (8), 1-16, 2020 Q3
• M.K. Haidar, G.M. Demirbolat, S.S. Timur, R.N. Gürsoy, E. Nemutlu, K. Ulubayram, L. ÖNer, H. Eroğlu “Atorvastatin Loaded Nanosprayed Chitosan Nanoparticles For Peripheral Nerve Injury” Bioinspired, Biomimetic And Nanobiomaterials, 9(2) 74-84 2020
• M.K. Haidar, S.S. Timur, A. Kazanci, O.F. Turkoglu, R.N. Gursoy, E. Nemutlu, M.F. Sargon, E. Bodur, M. Gok, K. Ulubayram, L. Oner, H. Eroğlu, Composite Nanofibers Incorporating Alpha Lipoic Acid And Atorvastatin Provides Neuroprotection After Peripheral Nerve Injury In Rats- European Journal Of Pharmaceutics And Biopharmaceutics, 153, 1- 13, 2020
• N. Erdoğar, E. Nemutlu, A. İskit, E. Bilensoy “Improved Oral Bioavailability Of Anticancer Drug Tamoxifen Through Complexation With Water Soluble Cyclodextrins: In Vitro And In Vivo Evaluation” Journal Of Inclusion Phenomena And Macrocyclic Chemistry 96 (1-2 ), 81-91, 2020, Q3
• Nemutlu E., Gupta A., Zhang S., Viqar M., Holmuhamedov E., Terzic A., Jahangir A., ​​Dzeja P. Decline Of Phosphotransfer And Substrate Supply Metabolic Circuits Hinders Atp Cycling In Aging Myocardium Plos One, 10 (9), E0136556, 2015
• Nemutlu E., Zhang S., Xu Y.Z., Terzic A., Zhong L., Dzeja P.D., Cha Y.M. Cardiac Resynchronization Therapy Induces Adaptive Metabolic Transitions In The Metabolomic Profile Of Heart Failure, Journal Of Cardiac Failure, Volume 21(6) 460–469, 2015
• Nenni M, Öncül S, Ercan A, Çelebier M, Süslü İ, Haznedaroğlu İc. Exposure Of Hepatocellular Carcinoma Cells To Ankaferd Blood Stopper® Alters Cell Death Signaling Networks Confirmed By Oncoproteomic And Genomic Profiling Studies. Current Traditional Medicine. 2020;InPress.
• O. Bayazeid, C.C. Action, T. Recber, F.N. Yalçın, S. Kır, E. Nemutlu, An Lc-Esı-Ms/Ms Method For The Simultaneous Determination Of Pronuciferine And Roemerine In Some Papaver Species, Journal Of Chromatography B, 1096 (2018) 223-227
• O. Bayazeid, E. Nemutlu; C.C. Action; F.N. Yalcin “Neuroactivity Of The Naturally Occurring Aporphine Alkaloid Roemerine” Natural Product Research Dollar: 10.1080/14786419.2020.1830395
• O. Bayazeid, E. Nemutlu; C.C. Action; F.N. Yalcin “Structure-Based Virtual Screening Study To Identify The Neuroactivity Of Pronuciferine” Journal Of Biochemical And Molecular Toxicology,E22601, 2020
• O.C. Zeki, C.C. Eylem, T. Reçber, S. Kır, E. Nemutlu “Integration Of Gc–Ms And Lc–Ms For Untargeted Metabolomics Profiling”, Journal Of Pharmaceutical And Biomedical Analysis, 190, 113509, 2020
• An Overview of Proteomics Studies, Merve Nenni, Mustafa ÇElebier, İNcilay Süslü, Hacettepe University Journal Of The Faculty Of Pharmacy Review Article Volume 40 (1): 2020, 48 - 58.
•    R. Abohalaka, E. Nemutlu, S. Celik Onder, I. Sahin-Erdemli, E. Bozkurt “The Effects Of Fatty Acid Amide Hydrolase And Monoacylglycerol Lipase Inhibitor Treatments On Lipopolysaccharide-Induced Airway Inflammation In Mice” Pulmonary Pharmacology & Therapeutics 62, 101920, 2020
•    Rebai, T. Reçber, E. Nemutlu, C. Chbili, S. Kir, S. Kurbanoglu, S. Ben Amor, S. Ben Ammou, S. Özkan, S. Saguem, “Metabolic Profiling Of Parkinson’s Disease With Glutathione S-Transferase M1 And T1 Polymorphism In Tunisian Patients” Combinatorial Chemistry & High Throughput Screening
•    Reçber T, Haznedaroğlu İc, Çelebier M. Review On Characteristics And Analytical Methods Of Rivaroxaban. Critical Reviews İn Analytical Chemistry. 2020:1-13.
•    Renkoğlu P, Çelebier M, Arıca-Yegin B. Hplc Determination Of Olanzapine And Carbamazepine İn Their Nicotinamide Cocrystals And İnvestigation Of The Dissolution Profiles Of Cocrystal Tablet Formulations. Pharmaceutical Development And Technology. 2015;20(3):380-4.
•    S. Köse, F. Aerts-Kaya, Ç.Z. Köprü, E. Nemutlu, B. Kuşkonmaz, B. Karaosmanoğlu, Z.E. Taşkıran, B. Altun, D. Uçkan-Çetinkaya, P. Korkusuz, Human Bone Marrow Mesenchymal Stem Cells Secrete Endocannabinoids That Stimulate İn Vitro Hematopoietic Stem Cell Migration Effectively Comparable To Beta-Adrenergic Stimulation, Experimental Hematology, 57 (2018) 30–41
•    Sapmaz, F., Kalkan, İ.H., Süslü, İ., Demirci, H., Atasoy, P., Güliter S., “Lower Plasma Pantoprazole Level Predicts Helicobacter Pylori Treatment Failure İn Patients With Type 2 Diabetes Mellitus”, Journal Of Digestive Diseases, 2015, 16 (9), 531-536.
•    Sevilay ErdoğAn Kablan  And Nuran ÖZaltın, Simultaneous Determination Of Thiocolchicoside And Diclofenac Diethyl Ammonium İn Topical Gel Formulation By Square Wave Voltammetric Method , Russian Journal Of Electrochemistry, 2020, Vol. 56, No. 7, Pp. 578–586.
•    Soyseven M, Kaynak Ms, Çelebier M, Aboul-Enein Hy, Arli G. Development Of A Rp-Hplc Method For Simultaneous Determination Of Reference Markers Used For İn-Situ Rat İntestinal Permeability Studies. Journal Of Chromatography B. 2020:122150.
•    Süslü İ, Çelebier M, Kablan Se, Altınöz S. Indirect Square-Wave Voltammetric Determination Of Cefepime İn The Presence Of Formaldehyde. Latin American Journal Of Pharmacy. 2016;35(10):2246-53.
•    T. Recber, G. Orgul, E. Aydın, A. Tanacan, E. Nemutlu, S. Kır, M.S. Beksac, Metabolic Infrastructure Of Pregnant Women With Methylenetetrahydrofolate Reductase Polymorphisms: A Metabolomic Analysis"" Biomedical Chromatography, E4842, 2020
•    T. Reçber, E. Nemutlu, K. Beksaç, S. Aksoy, S. Kır “Optimization And Validation Of An Hılıc-Lc-Esı-Ms/Ms Method For The Simultaneous Analysis Of Targeted Metabolites: Cross Validation Of Untargeted Metabolomic Studies For Early Diagnosis Of Breast Cancer” Microchemical Journal, 159, 105559, 2020
•    T. Reçber, E. Özkan, E. Eren Kocak, M. Yılmaz, E. Nemutlu, S. Kır, A Simple Extraction Procedure For Hplc Analysis Of Fluoxetine İn Rat Plasma Samples, Current Pharmaceutical Analysis, 13, 80-84, 2017
•    Taşcı Y, Fındık Rb, Pekcan Mk, Kaplan O, Çelebier M. Uplc-Q-Tof/Ms Based Untargeted Metabolite And Lipid Analysis On Premature Ovarian Insufficiency Plasma Samples. Current Pharmaceutical Analysis. 2019.
•    Tel, G. Telli, S. Celik, E. Nemutlu, E. Bozkurt, Investigation Of The Relationship Between Chronic Montelukast Treatment– Asthma And Depression-Like Behavior In Mice, Experimental And Therapeutic Medicine 21(1):27, 2021
•    Y. Akdag Cayli, S. Sahin, E. Nemutlu, L. Oner “Determination Of N-Acetylcysteine İn The Presence Of Ciprofloxacin Or Levofloxacin İn Microparticulate Dry Powder Inhalers” Tukish Journal Of Chemistry, 43 (3), 846-856, 2019
•    Yüksek H, Koca E, Gürsoy-Kol Ö, Akyıldırım O, Çelebier M. Synthesis, İn Vitro Antioxidant Activity, And Physicochemical Properties Of Novel 4,5-Dihydro-1h-1,2,4-Triazol-5-One Derivatives. Journal Of Molecular Liquids. 2015;206:359-66.
•    Zhang L., Zhang S., Maezawa I., Trushin S., Minhas P., Pinto M., Jin L., Prasain K., Nguyen T.D.T., Yamazaki Y., Kanekiyo T., Bu G., Gateno B., Chang K., Nath K.A., Nemutlu E., Dzeja P., Pang Y.P., Hua D.H., Trushina E. Modulation Of Mitochondrial Complex I Activity Averts Cognitive Decline İn Multiple Animal Models Of Familial Alzheimer's Disease Ebiomedicine 2 (4), 294-305, 2015

Links

About

Research Infrastructure

• LC-MS/MS (Shimadzu 8030)
• GC-MS (Shimadzu 2010ultra)
• HPLC (Shimadzu)
• Potentiostat/Galvanostat (Gamry Ref. 600)
• Voltammetric Analyzer (Bass 100 B/W)
• UV-GB Spectrophotometer (Agilent 8453)

Researchers

•    Prof. Dr. Nursabah Elif BAŞCI AKDUMAN
•    Prof. Dr. Sedef KIR
•    Prof. Dr. Nuran ÖZALTIN
•    Prof. Dr. İncilay SÜSLÜ
•    Prof. Dr. Emirhan NEMUTLU
•    Doç. Dr. Mustafa ÇELEBİER
•    Dr. Öğr. Üyesi Ayşegül DOĞAN
•    Dr. Tuba REÇBER
•    Araş. Gör. Sevilay ERDOĞAN
•    Araş. Gör. Ozan KAPLAN
•    Uzm. Kim. Cemil Can EYLEM
•    Ecz. Elif Damla GÖK
•    Uzm. Kim. Mohammed RAZZAHAGİ
•    Uzm. Kim Ece ÖZKAN
•    Uzm. Ecz. Emre ÖZDEMİRHAN
•    Uzm. Kim. Özge Cansın ZEKİ
•    Ecz. Ayşe KUŞ
•    Ecz. Murat ÜLGEN
•    Kim. Müh. Ege ŞEN
•    Kim. Çağrı TALAY
•    Uzm. Kim. Duygu KONUKLU
•    Kim. Pelin GENCER
•    Kim. Merve GÖKŞEN

Ongoing Projects

• Thd-2018-17427; Investigation of the Effects of Environmentally Friendly Mobile Phase Systems Containing Ethanol or Ethyl Lactate on Drug Analysis with HPLC and Developing a Validated Method; Nursabah Elif Başcı Akduman; Aysegul Dogan; Cemil Can Action; 29851.40tl; 2018-2020.
• Thd-2019-18389; Omic Approaches and Electroanalytical Studies for Early Diagnosis of Acute Renal Failure After Cardiopulmonary Bypass; Nuran Özaltın; Sinan Sabit Kocabeyoglu; Abdulkadir Yilmaz; Emirhan Nemutlu; Hope Caravan; Sevilay Erdogan Kablan; 29971.21 TL; 2019-2021.
• Ttu-2019-18400; Effects of Cyp4f2, 4f3, 4a11, 2j2, 2c9, 2c19, Soluble Epoxide Hydrolase Enzymes and Drug Transporter Mdr1 Genetic Polymorphisms in Preeclampsia and Gestational Hypertension; Melih Onder Babaoglu; Nursabah Elif Başcı Akduman; Mustafa Celebier; Ozan Kaplan; Nazan Tonyali; Dilek Şahin Uygur; Mert Can Ongun; Aykan Yucel; 29880.21 Tl; 2019-2022.
• Thd-2020-18956; Chemometric Optimization and Pharmaceutical Analysis of H2 Receptor Antagonists in Green HPLC; Nursabah Elif Başcı Akduman; Ayşegül Doğan, Cemil Can Eylem, Egeşen Halıcı; 29938.96 TL; 2020-2021.
• Tsa-2020-18566; Development and Application of Analytical Methods for Integrated Omix Analysis to be Used in the Determination of Phenotypes of Glioblastoma Multiforme, Meningioma (Primary) and Metastasis (Secondary) Brain Tumors; Nursabah Elif Başcı Akduman; Emirhan Nemutlu; Aysegul Dogan; Cemil Can Action; Ali İhsan Ökten; Yurdal Gezercan; İdil Yet; Suleyman Altintas; Vedat On; 192626.65 TL; 2020-2022.
• Thd-2020-18586; Development of Gcms Method for Targeted Metabolomic Studies for Early Diagnosis of Preeclampsia; Sedef Kir; Emirhan Nemutlu; 30000 TL; 2020-
• Ttu-2019-18473; Radiotherapy Induced Changes in Vitreous Humor; Favorite Printer; Emirhan Nemutlu; 29972 TL; 2019-.
• Tsa-2019-17810; Oxidative Stress, Inflammatory Markers and Metabolomics Responses to Exercise in Chronic Obstructive Pulmonary Patients; Deniz İnal İnce; Emirhan Nemutlu; 129000 TL; 2019-.
• Thd-2019-18393; Effect of Ankaferd Hemostat on Mcf-7 Breast Cancer Cell; İncilay Süslü; Merve Nanni; 8829.94 TL; 2019-2020.
• Thd-2020-18692; Investigation of the Effect and Mechanism of Action of Allogeneic Mesenchymal Stem Cells Obtained from Synovium and Adipose Tissue on Normal and Osteoarthritis Chondrocyte Cell Lines in Invitro Environment; Mustafa Celebier; 2020-2021.
• Ttu-2019-18400; Effects of Cyp4f2, 4f3, 4a11, 2j2, 2c9, 2c19, Soluble Epoxide Hydrolase Enzymes and Drug Transporter Mdr1 Genetic Polymorphisms in Preeclampsia and Gestational Hypertension; Mustafa Celebier; 2019-2022.
• Fhd-2019-18103; Development and Validation of Analytical Methods for Paraben Derivatives and Phenoxyethanol in Cosmetics; Mustafa Celebier; 2019-2021.
• Tsa-2019-17525; Investigation of the Effects of Microbiota, Proteomic and Metabolomic Analysis Results on Disease Pathogenesis and Course in Rheumatic Diseases. Part 2: Proteomics Study in Henoch Schönlein Purpura/Iga Vasculitis; Mustafa Celebier; 2019-2021.
• Fay-2019-18133; Advanced Technologies Application and Research Center Hünitek Ts En Isoıec 17025 Accreditation Application; Mustafa Celebier; 2019-2020.
• 118s578; Investigation of New Biomarkers that Can Be Used in the Diagnosis and Follow-up of Cystinosis, a Rare Disease: Clinical and In Vitro Based Multiomic (Genomic, Proteomic, Metabolomic and Fluxomic) Studies; Rezan Topalloglu; Sedef Kir; Emirhan Nemutlu (Consultant); 360000 TL; 2018-.
• 319s005; Intranasal Metformin Treatment in Mice with Alzheimer's Disease by Intracerebroventricular Administration of Streptozotocin; Pearl Kazkaya; Emirhan Nemutlu; 45000 TL; 2020-.
• 119s182; Development of Bone Marrow Targeted Endocannabinoid Loaded Nanoparticle Carrier System and In Vitro Analysis; Sevil Kose; Emirhan Nemutlu (Consultant); 180000 TL; 2019-.
• 219s661; Gbainvitro: Modeling of the Intestine-Brain Axis (Gba) with 3-Dimensional (3b) Cell Culture Technology and Investigation of Molecular Mechanisms with Sophisticated Omix Platforms; Burak Derkus; Emirhan Nemutlu (Consultant); 700000 TL; 2020-.
• 120s229; Optimization of Solubility and Dissolution Properties of Formulations Containing Celecoxib Using Artificial Neural Network Design; Levent Öner; Emirhan Nemutlu; 2020-.
• 220s225; Effects of Inulin Supplementation on Endocannabinoid Levels, Fatty Liver and Insulin Resistance in Wistar Rats fed a High Fat Diet; Funda Pinar Cakiroglu; Emirhan Nemutlu; 45000 TL; 2020-.
• 220s012; Investigation of Inhibition of Endocannabinoid Metabolism as a New Treatment Strategy in Allergic Respiratory Inflammation; Emrah Bozkurt; Emirhan Nemutlu; 45000 TL; 2020-.
• Project No: Thd-2020-18692, Project Name: Investigation of the Effect and Mechanism of Action of Allogeneic Mesenchymal Stem Cells Obtained from Synovium and Adipose Tissue on Normal and Osteoarthritic Chondrocyte Cell Lines in Invitro, Researcher: Mustafa Çelebier, 28.09.2020 - 28.09. 2021
• Project No: Ttu-2019-18400, Project Name: The Effects of Cyp4f2, 4f3, 4a11, 2j2, 2c9, 2c19, Soluble Epoxide Hydrolase Enzymes and Drug Transporter Mdr1 Genetic Polymorphisms in Preeclampsia and Gestational Hypertension, Position: Researcher: Mustafa Çelebier, 18.11. 2019 - 18.01.2022
• Project No: Fhd-2019-18103, Project Name: Analytical Method Development and Validation for Paraben Derivatives and Phenoxyethanol in Cosmetics, Task: Researcher: Mustafa Çelebier, 02.07.2019- 02.01.2021
• Project No: Tsa-2019-17525, Project Name: Investigation of the Effects of Microbiota, Proteomic and Metabolomic Analysis Results on the Pathogenesis and Course of the Disease in Rheumatic Diseases. Part 2: Proteomics Analysis in Henoch Schönlein Purpura/Iga Vasculitis, Position: Researcher: Mustafa Çelebier, 31.01.2019- 31.01.2021

Completed Projects

• Establishment of Pharmaceuticals and Cosmetics Research, Development and Quality Control Laboratory, (Ministry of Development, Ankara Development Agency (AKA), Bab6050 Participated Project, 2015, Project Coordinator: Prof. Dr. Bülent Gümüşel)
• Investigation of the Presence and Level of Endocannabinoids and Their Receptors in Human Hematopoietic Stem Cells and Mesenchymal Stem Cells from Bone Marrow, Tubitak 1001, 2016, Project No: 113s819, (Project Director: Prof. Dr. Petek Korkusuz)
• Human Bone Marrow Hematopoietic Niche Characterization by Metabolome Analysis H.Ü. Scientific Research Unit Support Project, 2015, Project No:013 D09 103 001-307, (Project Coordinator: Assoc. Dr. Rıza KöKsal ÖZgüL)
• Hematopoietic Niche Characterization in Human Bone Marrow by Metabolome and Transcriptome Profiling, Tubitak 1001, 2016, Project No: 213s006, (Project Coordinator: Assoc. Dr. Rıza KöKsal ÖZgüL)
• Accreditation Project of Hacettepe University Faculty of Pharmacy Pharmaceuticals and Cosmetics R&D and Quality Control Laboratory (Hünikal) within the scope of Ts En Iso/Iec 17025 Standard (Bab Project Coordinator: Prof. Dr. Reyhan Neslihan Gürsoy, Infrastructure, 2016, Project No: Tay -2015-6923)
• Metabolomic Approaches for High Selectivity Diagnosis of Down Syndrome, H.Ü. Scientific Research Unit, Comprehensive Project, 2016, Project No: 1588, (Project Coordinator: Prof. Dr. Sedef Kır)
• Development and Application of Combined Chromatographic (Lc-Tof-Ms and Lc-Ms/Ms) Methods for Early Diagnosis of Breast Cancer, Tubitak 1001, 2017, Project No: 113z390, (Project Leader: Prof. Dr. Sedef Kır)
• Domestic Vaccine Research and Development Studies, Santez, 2018, Project No: 0687.Stz.2016, (Project Coordinator: Prof. Dr. Sevda Şenel)
• Toxicity of Antipsychotics and the Effect of Individual Sensitivity on Toxicity Tubitak 1001, 2015, Project No: 115s229), (Project Coordinator: Prof. Dr. Bensu Karahalil)
• Development of High Performance Liquid Chromatography Mass Spectrometry Method for Quantification of Metabolites in the Early Diagnosis of Trisomy 21 Disease, (Bab Project Coordinator: Prof. Dr. Sedef Kır), Rapid Support, 2015, Project No: Thd-2015-8016)
• Colistin Blood Level Monitoring and Evaluation in Intensive Care Units, (Bab Project Coordinator: Prof. Dr. Kutay Demirkan), Rapid Support, 2017, Project No: Thd-2017-13239)
• Metabolomics Studies in Children with Central and Peripheral Precocious Puberty, (Bab Project Coordinator: Associate Professor Ülfet Pınar Erkekoğlu), Rapid Support, 2017, Project No: Thd-2017-14278)
• Effects of Fatty Acid Amide Hydrolase (Faah) and Monoacyl Glycerol Lipase (Magl) Inhibitors on Experimental Airway Inflammation in Mice, (Bab Project Coordinator: Associate Prof. Turgut Emrah Bozkurt, Rapid Support, 2017, Project No: Thd-2017-16101 )
• Development of Nano-Formulations Containing Neuroprotective Agents and Evaluation of Their Efficacy in the Peripheral Nerve Damage Model Tubitak 1001, 2015, Project No: 115s202, (Project Coordinator: Assoc. Dr. Hakan Eroğlu)
• Investigation of the Effects of Various Antimicrobial Agents, Single and Combined, on Monomicrobial and Polymicrobial Biofilm Models Caused by Some Pathogens that Cause Nosocomial Infection, and Interspecies Interactions in Polymicrobial Biofilms by Transcriptomic and Metabolomic Methods Tubitak 1001, 2015, Project No: 115s550, (Project Leader: Prof. Dr. Meral Sağıroğlu)
• Development of Analytical Methods for Pathway Analysis Based on Oxygen18 Marking and Its Application to Clarify the Mechanism of Resistance to Chematherapeutics in Caco-2 Human Colon Adenocarcinoma Cells Tubitak 1001, Project No: 116z292 - (Project Coordinator Assoc. Dr. Emirhan Nemutlu)
• In Vitro Based Metabolomics and Analysis in Mesenchymal Stem Cell Production, (Bab Project Coordinator: Prof. Dr. Fahriye Duygu Çetinkaya, Rapid Support, 2018, Project No: Thd-2018-17187)
• The Effects of Zanthan Gum Used in Dysphagia Diet and Modified Corn Starch on In Vivo Drug Release, (Bab Project Coordinator: Associate Prof. Dr. Hülya Gökmen Özel, Rapid Support, 2018, Project No: Thd-2018-16115)
• Investigation of the Cb1 Receptor Mediated Antiproliferative and Apoptotic Effects of the Controlled Acpa Release System in Endometrial Cancer, (Bab Project Coordinator: Prof. Dr. Petek Korkusuz, Comprehensive Research, 2018, Project No: Tsa-2018-17032)
• Investigation of the Role of Asymmetric Dimethyl Arginine (Adma) and the Effects of In Vivo Hydrogen Sulfide Treatment in Lipopolysaccharide-Induced Respiratory Tract Inflammation in Mice, (Bab Project Coordinator: Prof.Dr. İnci Erdemli, Comprehensive Research, 2018, Tsa-2017-14475)
• Investigation of Voltammetric Behaviors of Cefuroxime Axetil and Analysis of Pharmaceutical Preparations by Electroanalytical Methods (Support Project – Tyl-2015-6419) – Director: Nuran Özaltın, (2015).
• Investigation of Voltammetric Behaviors of Pramipexole and Analysis from Pharmaceutical Preparations by Electroanalytical Methods. (Scientific Success Support Project- Tbb-2016-10906) Coordinator: Nuran Özaltın (2016).
• Greening in Pharmaceutical Analysis with High Performance Liquid Chromatography (Hplc) Hacettepe University Graduate Research Project (Project No. 014d08301005, Completed.), Director: Nursabah Elif Başcı Akduman
• Green Chromatographic Analysis of Voriconazole And Tadalafil From Plasma, PhD Thesis Project (Project No: Tdk-2015-8149, Completed. 01.10.2015-26.04.2016), Director: Nursabah Elif Başcı Akduman
• Determination of Acidic Dissociation Constant of Tadalafil Drug Active Substance by Spectrophotometric, Potentiometric and Chromatographic Methods, Rapid Support Project (Project No: Thd-2016-9108 Ongoing Project 27.05.2016-), Director: Nursabah Elif Başcı Akduman
• Thd-2018-17427, Investigation of the Effects of Environmentally Friendly Mobile Phase Systems Containing Ethanol or Ethyl Lactate on Drug Analysis with HPLC and Development of a Validated Method, Executive: Nursabah Elif Başcı Akduman, Researchers: Ayşegül Doğan, Cemil Can Eylem, 29851,40tl, 2020
• Project No: Fay-2019-18133, Project Name: Advanced Technologies Application and Research Center Hünitek Ts En Isoıec 17025 Accreditation Application, Position: Researcher: Mustafa Çelebier, 08.07.2019 - 29.09.2020
• Project No: 014 D04 301 002-518, Metabolomic Studies with Gc-Ms in Biological Materials and Products of Plant Origin, Position: Director: Mustafa Çelebier, 15.04.2014- 02.04.2018
• Project No: Fay-2019-18133, Project Name: Research Center Hünitek Ts En Isoıec 17025 Accreditation Application, Researcher: Mustafa Çelebier, 08.07.2019-29.09.2020
• Project No: Thd-2018-16933, Project Name: Investigation of the Effects of Microbiata and Proteomic and Metabolomic Analysis Results in Rheumatic Diseases on Disease Pathogenesis and Course: Part 1 Metabolomic Analysis in Henoch Schönlein Purpura/ Iga Vasculitis, Researcher: Mustafa Çelebier, 14.05.2018 – 19.072019
• Project No: Ay-2015-6923, Project Name: Accreditation Project of Hacettepe University Faculty of Pharmacy, Pharmaceuticals and Cosmetics R&D and Quality Control Laboratory (Hünikal), Researcher: Mustafa Çelebier, 29.07.2015 – 24.10.2016
• Molecular Investigation of the Healing Effect of Bloodstopper on Colon Cancer, 1001- Research, Researcher/Specialist, Concluded, Ardeb, Sbag - Health Sciences Research Support Group, Project Join/Leave Dates: 01.12.2014 - 01.12.2017, Project Start/ End Dates: 01.12.2014 - 01.12.2017.
• Investigation of the Effect on Different Cancer Cells, 1001- Research, Executive, Concluded, Ardeb, Sbag- Health Sciences Research Support Group, Joining/Leaving the Project Dates: 01.10.2015 - 01.10.2018, Project Start/End Dates: 01.10.2015 - 01.10.2018.
• Ardeb, Sbag- Health Sciences Research Support Group, Project Join/Leave Dates: 01.10.2015 - 01.10.2018, Project Start/End Dates: 01.10.2015 - 01.10.2018.
• Gas Chromatography-Mass Spectrometry (Gc-Ms) Analyzes of In Vivo Obtained Tissues in the Investigation of the Antiproliferative Activity of Natural Compounds Against Colon Cancer”, Bab International Research Cooperation Project, Project No: TBI-2015-5339, 17.02.2015- 03.06.2016, Project Manager: Prof. Dr. İncilay Süslü
• Proteomic Investigation of In-Vitro Antineoplastic Effect of Ankaferd Hemostat with 2d Gel Electrophoresis and Maldi-Tof/Tof-Ms on Hepg2, Caco-2 and Ht-29 Cancer Cells”, Bab Graduate Thesis Project, Project No: Tdk-2018- 17656, 06.12.2018-06.09.2019, Project Coordinator: Prof. Dr. İncilay Süslü.
• The Effect of Ankaferd Hemostat on Mcf-7 Breast Cancer Cell”, Bab Rapid Support Project, Project No: Thd-2019-18393, 24.10.2019 - 30.11.2020, Project Coordinator: Prof. Dr. İncilay Süslü.

Publications

• Akgeyik E, Kaynak Ms, Çelebier M, Altınöz S, Şahin S. Evaluation Of Pharmaceutical Quality Of Conventional Dosage Forms Containing Paracetamol And Caffeine Available In Turkish Drug Market. Dissolution Technologies. 2016;May 2016:36 - 41.
• Armutcu, Ç. Tartan, E. Özgür, E. Nemutlu, L. Uzun, Phosphate Anion Imprinted Cryogel Cartridges For Selective Preconcentration Of Phosphorylated Amino Acids From Protein Lysate: An Alternative Sorbent For Proteome Analyzes, Chemistryselect, 5 (38) 11730-11736, 2020
• Atmaca, M., Süslü İ., “Determination Of Roflumilast In Pharmaceutical Formulations By Derivative Spectrophotometric Method”, Hacettepe University Faculty of Pharmacy Journal, 36 (1), 2016, 27-49.
• Boynueğri S, Süslü İ, Çelebier M, Altınöz S. A Rapid And Simple High - Performance Liquid Chromatographic Method For The Analysis Of Ceftriaxone In Perilymph Fluid. Latin American Journal of Pharmacy. 2016;35(5):1001-5
• C.C. Action, M. Yilmaz, B. Derkus, E. Nemutlu, C.B. Camci, E. Yilmaz, MA Turkoglu, B. Aytac, N. Ozyurt, E. Emregul, “Untargeted Multi-Omics Analysis Of Colorectal Cancer Specific Exosomes Reveals The Joint Pathways Of Colorectal Cancer In Clinical Samples And Cell Culture” Cancer Letters, 469 , 186-194, 2020 Q1
• Celebier M, Recber T, Kocak E, Altınöz S, Kır S. Determination Of Rivaroxaban In Human Plasma By Solid-Phase Extraction-High Performance Liquid Chromatography. Journal of Chromatographic Science. 2015;54(2):216-20.
• Cevher Ha, Schaller D, Gandini Ma, Kaplan O, Gambeta E, Zhang Fx, Et al. Discovery Of Michael Acceptor Containing 1, 4-Dihydropyridines As First Covalent Inhibitors Of L-/T-Type Calcium Channels. Bioorganic Chemistry. 2019;91:103187.
• Çelebier M, Haznedaroğlu İc. Could Targeting Hmgb1 Be Useful For The Clinical Management Of Covid-19 Infection? Combinatorial Chemistry & High Throughput Screening. 2020.
• Çelebier M, Ibáñez C, Simó C, Cifuentes A. A Foodomics Approach: Ce-Ms For Comparative Metabolomics Of Colon Cancer Cells Treated With Dietary Polyphenols. Electrophoretic Separation Of Proteins: Springer; 2019. P. 303-13.
• Çelebier M, Kaplan O, Özel S, Engin-Üstün Y. Polycystic Ovary Syndrome In Adolescents: Q-Tof Lc/Ms Analysis Of Human Plasma Metabolome. Journal of Pharmaceutical and Biomedical Analysis. 2020;191:113543.
• Çelebier M, Koçak E, Altınöz S. Evaluation Of A Capillary Electrophoresis Method For Routine Determination Of Varenicline Tartrate In Quality Control Laboratories. Macedonian Journal Of Chemical And Engineering Data. 2015;34(2):267-75.
• Çelebier M, Nenn M, Altınöz S. Ultrafiltration-Based Extraction And Hplc Analysis Of Naproxen Sodium In Human Plasma Samples: An Innovative Approach On Pharmaceutical Analysis. Pharmaceutical Chemistry Journal. 2016;50(4):221 - 5.
• Çelebier M, Nenni M, Kaplan O, Akgeyik E, Kaynak Ms, Sahin S. Determination Of The Physicochemical Properties Of Piroxicam. Turkish Journal of Pharmaceutical Sciences. 2019.
• Çelebier M, Reçber T, Nemutlu E, Kır S. Ultrafiltration-Based Extraction And Lc-Ms/Ms Quantification Of Phenylalanine In Human Blood Sample For Metabolite Target Analysis. Current Pharmaceutical Analysis. 2019.
• Çelebier Mç, Simó C, Altınöz S, Cifuentes A. Comparative Proteomics To Investigate The In Vitro Antiproliferative Effect Of Dietary Polyphenols Against K562 Leukemia Cells Turkish Journal of Biochemistry. 2015;40(2):95-104.
• Çelebier Mustafa, Nenni Merve, Doğan Ayşegül, Süslü Incilay, Altınöz Sacide, Effect Of Internal Standard On Hplc Analysis Of Tablet Dosage Forms:An Experimental Study With Statistical Comparison, Der Pharma Chemica, 2015, 7(6):168-174
• D. Kart, S. Yavaşoğlu-Çiftçi, E. Nemutlu, “Altered Metabolomic Profile Of Dual-Species Biofilm: Interactions Between Proteus Mirabilis And Candida Albicans” Microbiological Research, 230,126346, 2020 Q2
• Demir S, Kaplan O, Celebier M, Sag E, Bilginer Y, Lay I, Et Al. Predictive Biomarkers Of Iga Vasculitis With Nephritis By Metabolomic Analysis. Seminars In Arthritis And Rheumatism. 2020;50(6):1238-44.
• Dogan, A ; Action, Cc; Akduman, Neb,Application Of Green Methodology To Pharmaceutical Analysis Using Eco-Friendly Ethanol-Water Mobile Phases, Microchemical Journal Volume: ‏ 157 Article Number: 104895 Published: ‏ Sep 2020
• Dogan, A ; Plotka-Wasylka, J; Kempinska-Kupczyk, D; Namiesnik, J; Kot-Wasik, A, Detection, Identification And Determination Of Chiral Pharmaceutical Residues In Wastewater: Problems And Challengestrac-Trends In Analytical Chemistry, Volume: ‏ 122, Article Number: 115710 Published: ‏ Jan 2020
• Dogan, A., Bascı, N. E., Green Bioanalytical And Pharmaceutical Analysis Of Voriconazole And Tadalafil By Hplc, Current Pharmaceutical Analysis, 2017, 13, 495-504
• Dogan, A., Kempińska-Kupczyk, D., Kubica, P., & Kot-Wasik, A Analysis Of Chiral Pharmaceutical Residues Influent And Effluent Samples At Racemic And Enantiomeric Level Using Liquid Chromatography-Tandem Mass Spectrometry. (2020), Microchemical Journal, 159, 105517.
• Dogan, Aysegul; Tobiszewski, Marek, Optimization Of Liquid Chromatographic Separation Of Pharmaceuticals Within Green Analytical Chemistry Framework, Microchemical Journal Volume: ‏ 152 Article Number: 104323 Published: ‏ Jan 2020
• Dönmez, F. Yalcin, Ö. Boyacioglu, P. Korkusuz, E. Kupeli Akkol, E. Nemutlu, Y. Balaban, U. Koca “From Nutrition To Medicine: Assessing Hemorrhoid Healing Activity Of Solanum Melongena L. Via In Vivo Experimental Models And Its Major Chemicals” Journal Of Ethnopharmacology , 261 (2020) 113143
• E. D. Gök, S. Kır, E. Nemutlu, Analysis Of Quinolones In Biological Materials By Liquid Chromatographic Methods, Current Analytical Chemistry
• E. Demirtürk, E. Nemutlu, S. Sahin, L. Oner “Development And Validation Of An Hplc Method For Determination Of Rofecoxib In Bovine Serum Albumin Microspheres” Tukish Journal Of Chemistry, 44 (3), 647-655, 2020
• E. Koçak, C. Ozkul, G. Taşkor Önel, E. Nemutlu, S. Kır, M. Sağıroğlu, Screening The Antimicrobial Effect Of Ferrocene-Boronic Acid On Pseudomonas Aeruginosa Using Proteomics And Metabolomics Approach, Journal Of Research In Pharmacy, 24(6), 812-820, 2020
• E. Nemutlu, G. Orgul, T. Reçber, E. Özkan, E. Aydın, M. Turgal, M. AlikaşİfoğLu, S. Kır, M.S. Beksaç, Metabolic Infrastructure Of Pregnant Women With Trisomy 21 Fetuses; Metabolomic Analysis, Zeitschrift Für Geburtshilfe Und Neonatologie, 223 (05), 297-303, 2019
• E. Nemutlu, İ. Eroğlu, H. Eroğlu, S. Kır, Analytical And Technological Perspectives On In Vitro Release Test Of Nano-Drug Delivery Systems, Current Analytical Chemistry, 15(4), (2019), 373-409
• E. Özkan, E. Nemutlu, S. Beksaç, S. Kır, Gc-Ms Analysis Of Seven Metabolites For Screening Of Pregnant Women With Down Syndrome Fetuses- Journal Of Pharmaceutical And Biomedical Analysis, 188, 113427, 2020
• E.M. Gonulalan, E. Nemutlu, L.O. Demirezer, A New Perspective On Evaluation Of Medicinal Plant Biological Activities: The Correlation Between Phytomics And Matrix Metalloproteinases Activities Of Some Medicinal Plants Saudi Pharmaceutical Journal (2019) 27 (3), 446-452
• E.M. Gonulalan, E. Nemutlu, O. Bayazeid, E. Koçak, F.N. Yalcin, L.O. Demirezer, Metabolomics And Proteomics Profiles Of Some Medicinal Plants And Correlation With Bdnf Activity, Phytomedicine, 74,152920, 2020 Q1
• Ebru Aydogan, Tansel Comoglu, Bilge Pehlivanoglu, Murat Dogan, Selcuk Comoglu, Aysegul Dogan, Nursabah Basci, Process And Formulation Variables Of Pregabalin Microspheres Prepared By W/O/O Double Emulsion Solvent Diffusion Method And Their Clinical Application By Animal Modeling Studies, Drug Development And Industrial Pharmacy, Volume 41, Issue 8, 1 August 2015, Pages 1311-1320.
• Ercan A, Celebier M, Varan G, Öncül S, Nenni M, Kaplan O, Et al. Global Omics Strategies To Investigate The Effect Of Cyclodextrin Nanoparticles On Mcf-7 Breast Cancer Cells. European Journal of Pharmaceutical Sciences. 2018;123:377-86.
• Erdoğan Kablan, S., Özaltın N, “Investigation Of Electrochemical Behavior Of Cefuroxime Axetil Using Hanging Mercury Drop Electrode And Graphene Oxide Modified Glassy Carbon Electrode”, Journal Of Electroanalytical Chemistry, 785, 144–151, (2017).
• Erdoğan Kablan, S., Özaltın N, “Voltammetric Determination Of Cefuroxime Axetil In Pharmaceuticals Using Graphene Oxide Modified Glassy Carbon Electrode And Hanging Mercury Drop Electrode” Russian Journal Of Electrochemistry, 55 (4 ), 305–313,(2019).
• G. Tezel, S.S. Timur, M.K. Haidar, I. Bozkurt, O.F. Turkoglu, I. Eroğlu, E. Nemutlu, L. Öner, H. Eroğlu ""A Snapshot On The Current Status Of Alzheimer's Disease, Treatment Perspectives, In-Vitro And In-Vivo Research Studies And Future Opportunities"" Chemical&Pharmaceutical Bulletin C19, 00511, 2019
• H. Demir, T. Gulsun, M.H. Ozkan, E. Nemutlu, S. Sahin, L. Oner, Assessment Of Dose Proportionality Of Rivaroxaban Nanocrystals, Aaps Pharmscitech 21, 228 (2020)
• H. Eroglu, M.K. Haidar, E. Nemutlu, S. ÖztüRk, C. Bayram, K. Ulubayram, L. Öner, Dual Release Behavior Of Atorvastatin And Alpha-Lipoic Acid From Plga Microspheres For The Combination Therapy In Peripheral Nerve İnjury, Journal Of Drug Delivery Science And Technology 39 (2017) 455e466
• Haznedaroğlu İc, Çelebier M. Antiinfective And Wound-Healing Pleiotropic Actions Of Ankaferd Hemostat. Turkish Journal of Medical Sciences. 2020;50(5):1434-5.
• Kaplan O, Celebier M. Evaluation Of Recent Data Processing Strategies On Q-Tof Lc/Ms Based Untargeted Metabolomics. Mass Spectrometry Letters. 2020;11(1):1-5.
• Kaplan O, Celebier M. Evaluation Of Recent Data Processing Strategies On Q-Tof Lc/Ms Based Untargeted Metabolomics Mass Spectrometry Letters. 2019;In Press.
• Karabey-Akyürek Y., Nemutlu E., Bilensoy E., Öner L., An Improved And Validated Hplc Method For The Determination Of Methylprednisolone Sodium Sodium Succinate And Its Degradation Products In Nanoparticles, Current Pharmaceutical Analysis, 13, 162-168, 2017
• Watermelon, M; Cylinder-Gunay, M; Kursunel, Ma; Esendagli, G; Dogan, A; Ozer, AY, Design And In Vitro Evaluation Of Folate-Targeted, Co-Drug Encapsulated Theranostic Liposomes For Non-Small Cell Lung Cancer Journal Of Drug Delivery Science And Technology Volume: ‏ 57, Article No 101707 , 2020
• Kaynak Ms, Akgeyik E, Ateş M, Çelebier M, Şahin S. Development Of Hplc Methods For Individual Determination Of 20 Active Pharmaceutical Ingredients For Ussing-Chamber Studies. Current Pharmaceutical Analysis. 2017;13:145-53.
• Kaynak Ms, Celebier M, Akgeyik E, Sahin S, Altınöz S. Application Of Hplc To Investigate The Physicochemical Properties And Intestinal Permeability Of Ketoprofen. Current Pharmaceutical Analysis. 2017;13:72-9.
• Koçak E, Kaplan O, Çelebier M. Liquid-Liquid Extraction And Ultrafiltration Based Sample Preparation Technique For Q-Tof Lc/Ms Analysis Of Non-Polar Metabolites In Human Plasma Samples. Journal of Research in Pharmacy. 2019;23(6):1-6.
• M. Çelebier, T. Reçbera, E. Nemutlu, S. Kır, Ultrafiltration-Based Extraction And Lc-Ms/Ms Quantification Of Phenylalanine In Human Blood Sample For Metabolite Target Analysis, Current Pharmaceutical Analysis Doı : 10.2174/1573412915666190715095300
• M. Yasacan, A. Erikci, C.C. Action, S. Wildoglu Ciftci, E. Nemutlu, K. Ulubayram, I. Eroglu “Polymeric Nanoparticle Versus Liposome Formulations: Comparative Physicochemical And Metabolomic Studies As L-Carnitine Delivery Systems” Aaps Pharmscitech, 21 (8), 1-16, 2020 Q3
• M.K. Haidar, G.M. Demirbolat, S.S. Timur, R.N. Gürsoy, E. Nemutlu, K. Ulubayram, L. ÖNer, H. Eroğlu “Atorvastatin Loaded Nanosprayed Chitosan Nanoparticles For Peripheral Nerve Injury” Bioinspired, Biomimetic And Nanobiomaterials, 9(2) 74-84 2020
• M.K. Haidar, S.S. Timur, A. Kazanci, O.F. Turkoglu, R.N. Gursoy, E. Nemutlu, M.F. Sargon, E. Bodur, M. Gok, K. Ulubayram, L. Oner, H. Eroğlu, Composite Nanofibers Incorporating Alpha Lipoic Acid And Atorvastatin Provides Neuroprotection After Peripheral Nerve Injury In Rats- European Journal Of Pharmaceutics And Biopharmaceutics, 153, 1- 13, 2020
• N. Erdoğar, E. Nemutlu, A. İskit, E. Bilensoy “Improved Oral Bioavailability Of Anticancer Drug Tamoxifen Through Complexation With Water Soluble Cyclodextrins: In Vitro And In Vivo Evaluation” Journal Of Inclusion Phenomena And Macrocyclic Chemistry 96 (1-2 ), 81-91, 2020, Q3
• Nemutlu E., Gupta A., Zhang S., Viqar M., Holmuhamedov E., Terzic A., Jahangir A., ​​Dzeja P. Decline Of Phosphotransfer And Substrate Supply Metabolic Circuits Hinders Atp Cycling In Aging Myocardium Plos One, 10 (9), E0136556, 2015
• Nemutlu E., Zhang S., Xu Y.Z., Terzic A., Zhong L., Dzeja P.D., Cha Y.M. Cardiac Resynchronization Therapy Induces Adaptive Metabolic Transitions In The Metabolomic Profile Of Heart Failure, Journal Of Cardiac Failure, Volume 21(6) 460–469, 2015
• Nenni M, Öncül S, Ercan A, Çelebier M, Süslü İ, Haznedaroğlu İc. Exposure Of Hepatocellular Carcinoma Cells To Ankaferd Blood Stopper® Alters Cell Death Signaling Networks Confirmed By Oncoproteomic And Genomic Profiling Studies. Current Traditional Medicine. 2020;InPress.
• O. Bayazeid, C.C. Action, T. Recber, F.N. Yalçın, S. Kır, E. Nemutlu, An Lc-Esı-Ms/Ms Method For The Simultaneous Determination Of Pronuciferine And Roemerine In Some Papaver Species, Journal Of Chromatography B, 1096 (2018) 223-227
• O. Bayazeid, E. Nemutlu; C.C. Action; F.N. Yalcin “Neuroactivity Of The Naturally Occurring Aporphine Alkaloid Roemerine” Natural Product Research Dollar: 10.1080/14786419.2020.1830395
• O. Bayazeid, E. Nemutlu; C.C. Action; F.N. Yalcin “Structure-Based Virtual Screening Study To Identify The Neuroactivity Of Pronuciferine” Journal Of Biochemical And Molecular Toxicology,E22601, 2020
• O.C. Zeki, C.C. Eylem, T. Reçber, S. Kır, E. Nemutlu “Integration Of Gc–Ms And Lc–Ms For Untargeted Metabolomics Profiling”, Journal Of Pharmaceutical And Biomedical Analysis, 190, 113509, 2020
• An Overview of Proteomics Studies, Merve Nenni, Mustafa ÇElebier, İNcilay Süslü, Hacettepe University Journal Of The Faculty Of Pharmacy Review Article Volume 40 (1): 2020, 48 - 58.
•    R. Abohalaka, E. Nemutlu, S. Celik Onder, I. Sahin-Erdemli, E. Bozkurt “The Effects Of Fatty Acid Amide Hydrolase And Monoacylglycerol Lipase Inhibitor Treatments On Lipopolysaccharide-Induced Airway Inflammation In Mice” Pulmonary Pharmacology & Therapeutics 62, 101920, 2020
•    Rebai, T. Reçber, E. Nemutlu, C. Chbili, S. Kir, S. Kurbanoglu, S. Ben Amor, S. Ben Ammou, S. Özkan, S. Saguem, “Metabolic Profiling Of Parkinson’s Disease With Glutathione S-Transferase M1 And T1 Polymorphism In Tunisian Patients” Combinatorial Chemistry & High Throughput Screening
•    Reçber T, Haznedaroğlu İc, Çelebier M. Review On Characteristics And Analytical Methods Of Rivaroxaban. Critical Reviews İn Analytical Chemistry. 2020:1-13.
•    Renkoğlu P, Çelebier M, Arıca-Yegin B. Hplc Determination Of Olanzapine And Carbamazepine İn Their Nicotinamide Cocrystals And İnvestigation Of The Dissolution Profiles Of Cocrystal Tablet Formulations. Pharmaceutical Development And Technology. 2015;20(3):380-4.
•    S. Köse, F. Aerts-Kaya, Ç.Z. Köprü, E. Nemutlu, B. Kuşkonmaz, B. Karaosmanoğlu, Z.E. Taşkıran, B. Altun, D. Uçkan-Çetinkaya, P. Korkusuz, Human Bone Marrow Mesenchymal Stem Cells Secrete Endocannabinoids That Stimulate İn Vitro Hematopoietic Stem Cell Migration Effectively Comparable To Beta-Adrenergic Stimulation, Experimental Hematology, 57 (2018) 30–41
•    Sapmaz, F., Kalkan, İ.H., Süslü, İ., Demirci, H., Atasoy, P., Güliter S., “Lower Plasma Pantoprazole Level Predicts Helicobacter Pylori Treatment Failure İn Patients With Type 2 Diabetes Mellitus”, Journal Of Digestive Diseases, 2015, 16 (9), 531-536.
•    Sevilay ErdoğAn Kablan  And Nuran ÖZaltın, Simultaneous Determination Of Thiocolchicoside And Diclofenac Diethyl Ammonium İn Topical Gel Formulation By Square Wave Voltammetric Method , Russian Journal Of Electrochemistry, 2020, Vol. 56, No. 7, Pp. 578–586.
•    Soyseven M, Kaynak Ms, Çelebier M, Aboul-Enein Hy, Arli G. Development Of A Rp-Hplc Method For Simultaneous Determination Of Reference Markers Used For İn-Situ Rat İntestinal Permeability Studies. Journal Of Chromatography B. 2020:122150.
•    Süslü İ, Çelebier M, Kablan Se, Altınöz S. Indirect Square-Wave Voltammetric Determination Of Cefepime İn The Presence Of Formaldehyde. Latin American Journal Of Pharmacy. 2016;35(10):2246-53.
•    T. Recber, G. Orgul, E. Aydın, A. Tanacan, E. Nemutlu, S. Kır, M.S. Beksac, Metabolic Infrastructure Of Pregnant Women With Methylenetetrahydrofolate Reductase Polymorphisms: A Metabolomic Analysis"" Biomedical Chromatography, E4842, 2020
•    T. Reçber, E. Nemutlu, K. Beksaç, S. Aksoy, S. Kır “Optimization And Validation Of An Hılıc-Lc-Esı-Ms/Ms Method For The Simultaneous Analysis Of Targeted Metabolites: Cross Validation Of Untargeted Metabolomic Studies For Early Diagnosis Of Breast Cancer” Microchemical Journal, 159, 105559, 2020
•    T. Reçber, E. Özkan, E. Eren Kocak, M. Yılmaz, E. Nemutlu, S. Kır, A Simple Extraction Procedure For Hplc Analysis Of Fluoxetine İn Rat Plasma Samples, Current Pharmaceutical Analysis, 13, 80-84, 2017
•    Taşcı Y, Fındık Rb, Pekcan Mk, Kaplan O, Çelebier M. Uplc-Q-Tof/Ms Based Untargeted Metabolite And Lipid Analysis On Premature Ovarian Insufficiency Plasma Samples. Current Pharmaceutical Analysis. 2019.
•    Tel, G. Telli, S. Celik, E. Nemutlu, E. Bozkurt, Investigation Of The Relationship Between Chronic Montelukast Treatment– Asthma And Depression-Like Behavior In Mice, Experimental And Therapeutic Medicine 21(1):27, 2021
•    Y. Akdag Cayli, S. Sahin, E. Nemutlu, L. Oner “Determination Of N-Acetylcysteine İn The Presence Of Ciprofloxacin Or Levofloxacin İn Microparticulate Dry Powder Inhalers” Tukish Journal Of Chemistry, 43 (3), 846-856, 2019
•    Yüksek H, Koca E, Gürsoy-Kol Ö, Akyıldırım O, Çelebier M. Synthesis, İn Vitro Antioxidant Activity, And Physicochemical Properties Of Novel 4,5-Dihydro-1h-1,2,4-Triazol-5-One Derivatives. Journal Of Molecular Liquids. 2015;206:359-66.
•    Zhang L., Zhang S., Maezawa I., Trushin S., Minhas P., Pinto M., Jin L., Prasain K., Nguyen T.D.T., Yamazaki Y., Kanekiyo T., Bu G., Gateno B., Chang K., Nath K.A., Nemutlu E., Dzeja P., Pang Y.P., Hua D.H., Trushina E. Modulation Of Mitochondrial Complex I Activity Averts Cognitive Decline İn Multiple Animal Models Of Familial Alzheimer's Disease Ebiomedicine 2 (4), 294-305, 2015

Links