Within the scope of our laboratory, the development of biodegradable ceramic and polymeric biomaterials, cell culture and tissue engineering studies, transdermal drug release systems, 3D bioprinting technologies and medical device research is carried out. Stimulus-response and conductive polymers, innovative decellularization protocols, scaffolds for musculoskeletal regeneration, cornea, nerve, cartilage, aorta, muscle, etc. Activities such as the development of smart elastomers for the repair of soft tissues, such as the development of innovative microneedle technologies, and the development of bioinks are carried out. University-Industry cooperation activities are carried out for the development of Class-III Medical Devices for the medical device industry.
Our laboratory is in close contact with the Medical Device Industry and supports the production of innovative products in joint projects in the development of many biomaterials and diagnostic kits that our country needs. Our researchers took part in the development of many products such as bone grafts, cartilage repair materials, soft tissue augmentation materials, biodegradable composite tendon repair materials and composite pins and screws, which are the first examples in our country.
Olympus Ix 72 Inverted Phase Optical Microscope
Biochrom Ez Read 2000 Elisa Reader
Memmert Vo200 Vacuum Oven and Pump
Memmert Co2 Incubator
UVP Cl-1000 Uv Crosslinking Unit
Carbolite Elf 11/68 Muffle Furnace
Protherm Ptf12105900 Pyrolysis Unit
IKA T18 Homogenizer
IKA V4b Vortex
IKA Rw20 Mechanical Mixer
IKA Rt-10p Multi Magnetic Stirrer
Nuve 0t 40l Autoclave
Nuaire Nu-9483e – 80c Refrigerator
Thermoshaker Gerhardt Heated Shaker
Memmert Wnb 14 Water Bath
Nuaire Nu-425 400s Class II Biosafety Cabinet
Hettich Eba21 Centrifuge
Apple S80-H Sonicator
Spe Company Zook Supercritical Carbon Dioxide Extraction System
Labconco Freezone Plus 6 Lyophilizer
Hedlab Fume Hood
Movel Yj-2005b Microscope
IKA Cmag-Hs7 Magnetic Stirrer with Heating
Leica Microsystems Rm2125rt Rotary Microtome
Leica Microsystems Dm Il Led Inverted Light Microscope
Denvert Instrument Sı-234 Precision Balance
Cryste Puriven Vacuum Drying Oven
Beckman Coulter Allegra 64r Centrifuge
New Era Ne-300 Syringe Pump Electrospinning System
Ebers Tc-3 Load Bioreactor Perfusion Reactor
International Cryogenics Ic 20rx Nitrogen Tank
Biotek Instruments Epoch Microplate Reader
Biologix 81-8204 Sterile Cryotube
Prof. Dr. Halil Murat AYDIN
Assist. Prof. Dr. Soner ÇAKMAK
Assist. Prof. Dr. Damla ÇETİN ALTINDAL
PhD Candidate Selcen GÜLER
MSc Candidate Orhan Gökalp BÜYÜKUYSAL
MSc Candidate Tuğçe ÇALIŞKAN
MSc Candidate Zeynep ÇAĞLAR
MSc Candidate Serkan SÖKMEN
MSc Candidate Meryem GÜZEL
MSc Candidate Buğra Kaan ÜNAL
1. TÜBİTAK 1005 New Ideas and Products Program, 121M086. Development of Cohesive Biphasic Hyaluronic Acid Gels for Soft Tissue Augmentation. Executive: Dr. H.M. Aydın.
2. TÜBİTAK 1005 New Ideas and Products Program, 219S324. 3D Modeling of Airway Cell Culture Systems and Development of Tissue Grafts Targeted for Clinical Use. Researcher: Dr. H.M. Aydın.
3. Hacettepe University Scientific Research Projects Coordination Unit, Career Project, FKB-2022-19592, 2022-2023. Development of Macroporous and Antibacterial Three-Dimensional Nanofibrous Wound Dressing Materials Containing Curcumin. Executive: Dr. S. Çakmak.
4. Hacettepe University Scientific Research Projects Coordination Unit, Participatory Research Project, FUK-2022-20075, 2022-2023. Development of a Drug-Adjustable Transdermal Microneedle System for the Treatment of COVID-19. Executive: Dr. S. Çakmak.
1. COST-European Union Project, Development of Growth Factor Releasing Biodegradable Elastomer/Ceramic Based Composite Materials for Bone Tissue Engineering and Investigation of Use Potential as ATMP (Advanced Therapeutic Medical Device), Project No213M184. Executive: Dr. H.M. Aydın.
2. Hacettepe University Scientific Research Unit, No: 1860. Preparation of Decellularized Matrices with Supercritical Carbon Dioxide for Corneal Tissue Engineering. Executive: Dr. H.M. Aydın.
3. Hacettepe University Scientific Research Unit, No: 6021. Production of Oriented Cell Layers with Patterned Surfaces. Director: Dr. H.M. Aydın.
4. Ministry of Science, Industry and Technology TechnoInvestment Program, 0153.TYD.2014.01.SupraChon (BMT Calsis Health Technologies Inc.). Advisor: Dr. H.M. Aydın.
5. Hacettepe University Scientific Research Unit, No: THD-2015-8859, Production of PGS-Acellular Aorta Composite Vascular Grafts. Executive: Dr. H.M. Aydın.
6. Hacettepe University Scientific Research Unit, No: FHD-2016-11817 Preparation of Waste Paper Derived Carbon Airgel-Elastomer Matrices. Executive: Dr. H.M. Aydın.
7. COST-European Union Project, No: 215M071. Preparation of Innovative Synthetic and Decellularized Matrices for Corneal Tissue Engineering. Executive: Dr. H.M. Aydın.
8. TÜBİTAK 1003 (103.SAB.KLNK.2015.2 Call) Priority Areas Research Technology Development and Innovation Project, No: 216S389. Three Dimensional Production of Laser Assisted Bioglass-HAP Biomaterials and Coating on Metal Implant Surfaces (Project Leader: Prof. Dr. M. Erdem Ereyen). Advisor: Dr. H.M. Aydın.
9. TÜBİTAK 1003 (103.SAB.KLNK.2015.2 Call) Priority Areas Research Technology Development and Innovation Project, No: 315S358. Use of Silver Ion Added Calcium Phosphate Based Orthopedic Implants with Special Coating in the Prevention of Implant-Associated Infections (Project Coordinator: Prof. Dr. Nusret Köse). Advisor: Dr. H.M. Aydın.
10. TÜBİTAK 1005 New Ideas and Products Program, No: 215S835. Development of Urethane Ceramic-Based Composite Orbital Implants. Executive: Dr. H.M. Aydın.
11. TÜBİTAK 1511 Priority Areas Research, Technology Development and Innovation Project, No: 1150275. Layered Biomaterial Production for Guided Tissue Regeneration. Advisor: Dr. H.M. Aydın.
12. TUBITAK 1001, No: 118M356. Preparation of Decellularized Myocardial-Elastomer Hybrid Cardiac Patches and Investigation of In vitro Performance with Stem Cells in a Mechanically Stimulated Bioreactor. Executive: Dr. H.M. Aydın.
13. TÜBİTAK 1511 Priority Areas Research, Technology Development and Innovation Project, No: 1180073. Development of a Product Platform Consisting of Cross-linked Hyaluronic Acid-Non-Braided Polymeric Mesh for Articular Cartilage Regeneration and/or Viscosupplementation. Advisor: Dr. H.M. Aydın.
14. Hacettepe University Scientific Research Projects Coordination Unit, FHD-2018-16900. The Effect of Fabrication and Stabilization Processes on Morphological, Mechanical and Biological Properties of Chitosan Scaffolds. Executive: Dr. D. Çetin Altındal.
15. Hacettepe University Scientific Research Projects Coordination Unit, Comprehensive Research Project, FBA-2017-14509. Skeletal Muscle Tissue Engineering with Binary Blends of P3HB and PBA Polymers: Investigation of Myogenic Differentiation. Executive: Dr. D. Çetin Altındal.
16. Hacettepe University Scientific Research Projects Coordination Unit, FHD-2019-18296. Investigation of In Vivo Efficacy of Platelet-Rich Plasma Supported Compressible Bone Grafts. Executive: Dr. S. Çakmak.
17. Hacettepe University Scientific Research Projects Coordination Unit, FHD-2017-16332. Development of Exosome-Loaded Compressible Bone Grafts. Executive: Dr. S. Çakmak.
18. TUBITAK-3001: Initial R&D Project, 215M179. Compressible and Easily Formable 3-Dimensional Composite Fibrous Materials for the Treatment of Bone Damages- Production, Characterization and In Vitro Cell Culture Studies. Executive: Dr. S. Çakmak.
19. Hacettepe University Scientific Research Projects Coordination Unit, International Bilateral Cooperation Development Project, FBI-2015-7407. Developing Bilateral Cooperation in the Field of Use of Bioreactors in Tissue Engineering. Executive: Dr. S. Çakmak.
20. Hacettepe University Scientific Research Projects Coordination Unit, International Bilateral Cooperation Development Project, 13G602003. Investigation of Performance of Hydroxyapatite/Peptide Amphiphile Based Nanocomposite Tissue Scaffolds in Various Bioreactors. Executive: Dr. S. Çakmak.
1. Sarikaya B & Aydin HM, Collagen/beta-tricalcium Phosphate Based Synthetic Bone Grafts via Dehydrothermal (DHT) Processing, 2015, BioMed Research International - doi:10.1155/2015/576532.
2. Salimi K, Topuzogullari M, Dincer S, Aydin HM, Piskin E, 2016, Microwave Assisted Green Approach for Graft Copolymerization of L-Lactic Acid onto Starch, 2015, Journal of Applied Polymer Science, DOI: 10.1002/app.42937.
3. Namli H et al., Vertical Bone Augmentation Using Bone Marrow Stem Cells: An in vivo Study in the Rabbit Calvaria, 2016, Implant Dentistry, DOI: 10.1097/ID.0000000000000334.
4. Ekin O, et al., Poly(L-Lactide)/Poly(e-Caprolactone) and Collagen/b-Tricalcium Phosphate Scaffolds for the Treatment of Critical-Sized Rat Alveolar Defects: A Microtomographic, Molecular-Biological, and Histological Study, 2016, The Cleft Palate Craniofacial Journal, DOI: 10.1597/14-309.
5. Aydin HM, Kourush S, Yilmaz M, Turk M, Rzayev Z, Piskin E, Synthesis and Characterization of Poly(glycerol-co-sebacate-co-e-caprolactone) Elastomers, Journal of Tissue Engineering and Regenerative Medicine, 2016;10(1): E14-22.
6. Erdogan H, Yilmaz M, Babur E, Duman M, Aydin HM, Demirel G., Fabrication of Plasmonic Nanorod-Embedded Dipeptide Microspheres via the Freeze-Quenching Method for Near-Infrared Laser-Triggered Drug-Delivery Applications, 2016, Biomacromolecules, DOI: 10.1597/14-309.
7. Guler S, Hosseinian P, Aydin HM, Hybrid Aorta Constructs via in-situ Crosslinking of Poly(glycerol-sebacate) within a Decellularized Matrix, 2017, Tissue Engineering Part C, DOI: 10.1089/ten.TEC.2016.0375.
8. Tevlek A, Hosseinian P, Ogutcu C, Turk M, Aydin HM, Bi-layered Constructs of Poly(glycerol-sebacate)-b-tricalcium Phosphate for Bone-Soft Tissue Interface Applications, 2017, Journal of Materials Science and Engineering Part C, DOI: 10.1016/j.msec.2016.082.
9. Sahan S et al., Polyurethane/Tricalcium Phosphate Bone Adhesives and Substitutes for Load Bearing Applications, 2017, Journal of Biomaterials and Tissue Engineering, DOI: 10.1166/jbt.2017.1585.
10. Yucekul A et al., Tri-Layered Composite Plug for the Repair of Osteochondral Defects: in vivo Study in Sheep, 2017, Journal of Tissue Engineering, DOI:10.1177/2041731417697500.
11. Sneddon G et al., Aminated Poly(vinyl chloride) Solid State Adsorbents with Hydrophobic Function for Postcombustion CO2 Capture, 2017, Journal of Materials Chemistry C, DOI: 10.1039/C7TA00389G.
12. Guler S, et al., Supercritical Carbon Dioxide (sc-CO2) Assisted Decellularization of Cornea and Aorta, 2017, Tissue Engineering Part C, – DOI: 10.1089/ten.TEC.2017.0090.
13. Tevlek A ve Aydin HM, Poly(glycerol-sebacate) Elastomer: A Mini Review, 2017, Ortho Surg Open Access, 1(2).OSOA.000507.2017.
14. Aslan B, Guler S, Tevlek A, Aydin HM, Evaluation of Collagen Foam, Poly(L-lactic acid) Nanofiber Mesh, and Decellularized Matrices for Corneal Regeneration, 2018, Journal of Biomedical Materials Research Part B, – DOI: 10.1002/jbm.b.34022.
15. Guler S et al., Improvement of Decellularization Efficiency of Porcine Aorta by Using Dimethyl Sulfoxide as Penetration Enhancer, 2018, Artificial Organs - DOI: 10.1111/aor.12978.
16. Sahan S et al., Polyurethane-Ceramic Matrices as Orbital Implants, 2018, International Journal of Polymeric Materials and Polymeric Biomaterials - DOI: 10.1080/00914037.2017.1354194.
17. Tevlek A et al., Preparation of MC3T3-E1 Cell Sheets Through Short-term Osteogenic Medium Application, 2018, Artificial Cells, Nanomedicine, and Biotechnology, https://doi.org/10.1080/21691401.2018.1481081.
18. Okan M, Aydin HM and Barsbay M, Current Approaches to Waste Polymer Utilization and Minimization: A Review, 2019, Journal of Chemical Technology and Biotechnology, https://doi.org/10.1002/jctb.5778.
19. Garipcan A et al., Critical-Size Alveolar Defect Treatment via TGF-B3 nad BMP-2 Releasing Hybrid Constructs, 2019, Journal of Biomaterials Science Polymer Edition, https://doi.org/10.1080/09205063.2019.1571397.
20. Tevlek A et al., Effects of Severe Plastic Deformation on Pre-osteoblast Cell Behaviour and Proliferation on AISI 304 and Ti-6Al-4V Metallic Substrates, 2019, Surface and Coatings Technology,
https://doi.org/10.1016/j.surfcoat.2019.03.034.
21. Erken M et al., Effects of ceramic particle size on cell attachment and viability in polyurethane based bone adhesive composites, 2019, Journal of Composite Materials, http://doi.org/10.1177/0021998319884729.
22. Tevlek A, Agacik DT, Aydin HM, Stretchable poly(glycerol-sebacate)/β-tricalcium phosphate composites with shape recovery feature by extrusion, 2019, Journal of Applied Polymer Science, https://doi.org/10.1002/app.48689.
23. Uyaniklar M et al., Hybrid Cornea: Cell Laden Hydrogel Incorporated Decellularized Matrix, 2019, ACS Biomaterials Science and Engineering, http://dx.doi.org/10.1021/acsbiomaterials.9b01286.
24. Deniz P et al., Use of Cyclic Strain Bioreactor for the Upregulation of Key Tenocyte Gene Expression on Poly(glycerol-sebacate) Sheets, 2020, Materials Science and Engineering Part: C, https://doi.org/10.1016/j.msec.2019.110293.
25. Evci M, Tevlek A, Aydin HM, Caykara T, Synthesis of temperature and light sensitive mixed polymer brushes via combination of surface-initiated PET–ATRP and interface-mediated RAFT polymerization for cell sheet application, 2020, Applied Surface Science, https://doi.org/10.1016/j.apsusc.2020.145572.
26. Can GD, Tevlek A, Can ME, Öncü E, Aydin HM, Cagil N, Micro and Nanoscale Characterization of Different Natural Biomaterials for Ocular Surface Regeneration, 2020, The European Research Journal, https://doi.org/10.18621/eurj.550522.
27. Tevlek, A, Atya, AMN, Almemar, M. et al. Synthesis of Conductive Carbon Aerogels Decorated with b-Tricalcium Phosphate Nanocrystallites, 2020, Scientific Reports, https://doi.org/10.1038/s41598-020-62822-1.
28. Gulcin G., Okan M., Gokcen D, Caykara T, Aydin HM. Microwave-Assisted Synthesis of Stretchable and Transparent Poly(Ethyleneglycol-Sebacate) Elastomers with Autonomous Self-Healing and Capacitive Properties, 2020, Soft Robotics, https://doi.org/10.1089/soro.2019.0148.
29. Aylaz G, Okan M, Duman M, Aydin HM. Study on Cost-Efficient Carbon Aerogel to Remove Antibiotics from Water Resources, 2020, ACS Omega, https://dx.doi.org/10.1021/acsomega.0c01479.
30. Odabas S, Tevlek A, Erenay BE, Aydin HM, Suloglu AK, Saglam ASY, Garipcan B. Magnetically Stimulated Cryogels to Enhancee Osteeogenic and Chondrogenic Differentiation of Stem Cells, 2021, bioRxiv, https://doi.org/10.1101/2021.02.15.4311066.
31. Tevlek A and Aydin HM, Multilayered in vitro 3D-bone Model via Combination of Osteogenic Cell Sheets with Electrospun membrane Inteerlayer, 2021, Journal of Biomaterials Applications, https://doi.org/10.1177/08853282211027889.
32. Tsogtbaatar, K., Sousa, D.A., Ferreira, D. Tevlek A., Aydin H.M., Celik E., Rodrigues R., In vitro selection of DNA aptamers against human osteosarcoma, 2021, Investigational New Drugs, https://doi.org/10.1007/s10637-021-01161-y.
33. Atya AMN, Tevlek A, Almemar M, Gokcen D and Aydin HM, Fabrication and characterization of carbon aerogel/poly(glycerol-sebacate) patches for cardiac tissue engineering, 2021, Biomedical Materials, https://doi.org/10.1088/1748-605X/ac2dd3.
34. Topuz B and Aydin HM, Preparation of Decellularized Optic Nerve Grafts, 2021, Artificial Organs, https://doi.org/10/1111/aor.14098.
35. Yuksel S, Asik MD, Aydin HM, Tonuk E, Aydin EY, Bozkurt M, Fabrication of a Multi-Layered Decellularized Amniotic Membranes as Tissue Engineering Constructs, 2021, Tissue and Cell, https://doi.org/10.1016/j.tice.2021.101693.
36. Senturk F., Cakmak S., Kocum I.C., Gumusderelioglu M., Ozturk G.G., Effects of radiofrequency exposure on in vitro blood-brain barrier permeability in the presence of magnetic nanoparticles, Biochemical and Biophysical Research Communications, 2022, 597, 91-97.
37. Senturk, F., Cakmak, S., Gumusderelioglu M., Ozturk, G.G., Hydrolytic instability and low-loading levels of temozolomide to magnetic PLGA nanoparticles remain challenging against glioblastoma therapy, Journal of Drug Delivery Science and Technology, 2022, 68, 103101, 1-10.
38. Cakmak S., Compressible polyglycolic acid-based nanofibrous matrices as a bone filler: fabrication, physicochemical characterisations, and biocompability evaluation, Materials Technology, 2022, 37, 1, 9-20.
39. Senturk F., Cakmak S., Kocum I.C., Gumusderelioglu M., Ozturk G.G., GRGDS-conjugated and curcumin-loaded magnetic polymeric nanoparticles for the hyperthermia treatment of glioblastoma cells, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2021, 622, 126648.
40. Koç A., Çakmak S., Gümüşderelioğlu M., Ertekin T.E., Çalış M., Yılmaz M.M., Akcan G., Çaylı S., Three dimensional nanofibrous and compressible poly(L-lactic acid) bone grafts loaded with platelet-rich plasma, Biomedical Materials, 2021, 16, 045012.
41. Arslan A., Çakmak S., Gümüşderelioğlu M., Enhanced osteogenic activity with boron-doped nanohydroxyapatite loaded poly(butylene adipate-co-terephthalate) fibrous 3D matrix, Artificial Cells, Nanomedicine and, Biotechnology, 2018, 46, S2, S790-S799.
42. Çakmak A.S., Çakmak S., Vatansever S., Gümüşderelioğlu M., Photostimulation of osteogenic differentiation on silk scaffolds by plasma arc light source, Lasers in Medical Science, 2018, 33, 4, 785-794.
43. Şimşek M., Çakmak S., Gümüşderelioğlu M., Insoluble poly(ethylene oxide) nanofibrous coating materials: effects of crosslinking conditions on the matrix stability, Journal of Polymer Research, 2016, 23, 236, 1-10.
44. Arslan A., Çakmak S., Cengiz A., Gümüşderelioğlu M., Poly(butyleneadipate-co-terephthalate) scaffolds: processing, structural characteristics and cellular responses, Journal of Biomaterials Science, Polymer Edition, 2016, 27, 18, 1841-1859.
45. Çakmak S., Çakmak A.S., Kaplan D.L., Gümüşderelioğlu M., A silk fibroin and peptide amphiphile based co-culture model for osteochondral tissue engineering, Macromolecular Bioscience, 2016, 16, 8, 1212-1226.
46. Çakmak A.S., Çakmak S., Kim K., Yiğit S., White J.D., Raja W.K., Kaplan D.L., Gümüşderelioğlu M., Synergistic effect of exogenous and endogenous electrical field on osteogenic differentiation of human mesenchymal stem cells, Journal of Orthopaedic Research, 2016, 34, 581-590.
47. Çakmak A.S., Çakmak S., White J.D., Raja W.D., Kaplan D.L., Gümüşderelioğlu M., Osteogenic differentiation of electrostimulated human mesenchymal stem cells seeded on silk-fibroin films, Turkish Journal of Biology, 2016, 40, 462-472.
48. Gümüşderelioğlu M., Çakmak S., Timuçin H.Ö., Çakmak A.S., Thermosensitive pHEMA microcarriers: ATRP synthesis, characterization, and usabilities in cell cultures, Journal of Biomaterials Science, Polymer Edition, 2013, 24, 18, 2110-2125.
49. Çakmak S., Çakmak A.S., Gümüşderelioğlu M, RGD-bearing peptide amphiphile-hydroxyapatite nanocomposite bone scaffold: an in vitro study, Biomedical Materials, 2013, 8, 4, 1-15.
50. Çakmak S., Çakmak A.S., Gümüşderelioğlu M., PNIPAAm-grafted thermoresponsive microcarriers: surface-initiated ATRP synthesis and characterization, Materials Science and Engineering C: Materials for Biological Applications, 2013, 33, 5, 3033-3040.
51. Çapkın M., Çakmak S., Kurt F.Ö., Gümüşderelioğlu M., Şen B.H., Türk B.T., Deliloğlu-Gürhan S.İ., Random/aligned electrospun PCL/PCL-collagen nanofibrous membranes: comparison of neural differentiation of rat AdMSCs and BMSCs, Biomedical Materials, 2012, 7, 4, 1-14.
52. Gümüşderelioğlu M., Dalkıranoğlu S., Aydın R.S.T., Çakmak S., A novel dermal substitute based on biofunctionalized electrospun PCL nanofibrous matrix, Journal of Biomedical Materials Research Part A, 2011, 98A, 3, 461-472.
53. Çakmak S., Gümüşderelioğlu M., Denizli A., Biofunctionalization of magnetic poly(glycidyl methacrylate) microspheres with protein A: Characterization and cellular interactions, Reactive and Functional Polymers, 2009, 69, 8, 586-593.
54. Çetin, D., Kahraman, A.S., Gümüşderelioğlu, M., Novel scaffolds based on poly(2-hydroxyethyl methacrylate) superporous hydrogels for bone tissue engineering, Journal of Biomaterials Science: Polymer Edition, 22, 1157-1178, 2011.
55. Çetin, D., Kahraman, A.S., Gümüşderelioğlu, M., Novel pHEMA-gelatin SPHs as bone scaffolds in dynamic cultures, Journal of Materials Science: Materials in Medicine, 23, 2803-2812, 2012.
56. Irmak, G., Demirtaş, T.T., Çetin Altındal, D., Çalış, M., Gümüşderelioğlu, M., Sustained release of 17β-estradiol stimulates osteogenic differentiation of AdMSCs on chitosan-hydroxyapatite scaffolds, Cells Tissues Organs, 199(1), 37-50, 2014.
57. Gümüşderelioğlu, M., Karakuş, E., Çapkın Yurtsever, M., Çetin Altındal, D., Inosculation potential of angiopoietin-4-immobilized pHEMA-based bone scaffolds, Journal of Bioactive and Compatible Polymers, 30(6), 649-666, 2015.
58. Topal, B., Çetin Altındal, D., Gümüşderelioğlu, M., Melatonin/HPβCD complex: Microwave synthesis, integration with chitosan scaffolds and inhibitory effects on MG-63 cells, International Journal of Pharmaceutics, 496(2), 801-811, 2015.
59. Çetin Altındal, D., Gümüşderelioğlu, M., Melatonin releasing PLGA micro/nanoparticles and their effect on osteosarcoma cells, Journal of Microencapsulation, 33(1), 53-63, 2016.
60. Çetin Altındal, D., James, E.N., Kaplan, D., Gümüşderelioğlu, M., Melatonin-induced osteogenesis with methanol-annealed silk materials, Journal of Bioactive and Compatible Polymers, 34(3), 291-305, 2019.
61. Çetin Altındal, D., Gümüşderelioğlu, M., Dual-functional melatonin releasing device loaded with PLGA microparticles and cyclodextrin inclusion complex for osteosarcoma therapy, Journal of Drug Delivery Science and Technology, 52, 586-596, 2019.
62. Çetin Altındal, D., Türkyılmaz, P., Gümüşderelioğlu, M., P(HEMA)-based SPH vehicles for high molecular weight protein delivery, International Journal of Polymeric Materials and Polymeric Biomaterials, 69(12), 773-785, 2020.
63. Jarrar, H., Çetin Altındal, D., Gümüşderelioğlu, M., The inhibitory effect of melatonin on osteoclastogenesis of RAW 264.7 cells in low concentrations of RANKL and MCSF, Turkish Journal of Biology, 44, 427-436, 2020.
64. Gültan, T., Bektaş Tercan, Ş., Çetin Altındal, D., Gümüşderelioğlu, M., Synergistic effect of fabrication and stabilization methods on physicochemical and biological properties of chitosan scaffolds, International Journal of Polymeric Materials and Polymeric Biomaterials, 70(6), 371-382, 2021.
65. Jarrar, H., Çetin Altındal, D., Gümüşderelioğlu, M., Effect of melatonin/BMP-2 co-delivery scaffolds on the osteoclast activity, Journal of Materials Science: Materials in Medicine, 32(4), 1-32, 2021.
66. Jarrar, H., Çetin Altındal, D., Gümüşderelioğlu, M., Scaffold-based osteogenic dual delivery system with melatonin and BMP-2 releasing PLGA microparticles, International Journal of Pharmaceutics, 600, 120489-120499, 2021.
67. Tatlıdilli, A., Çetin Altındal, D., Gümüşderelioğlu, M., Effects of carbon fiber type and resin ratio on thermal and mechanical lifetime of polyetherimide composites, Polymer Composites, 42, 2920-2932, 2021.
68. Konuk Tokak, E., Çetin Altındal, D., Akdere, Ö.E., Gümüşderelioğlu, M., In-vitro effectiveness of poly-β-alanine reinforced poly(3-hydroxybutyrate) fibrous scaffolds for skeletal muscle regeneration, Materials Science & Engineering C, 131, 112528-112543, 2021.
Prof. Dr. Halil Murat AYDIN
Bioengineering Department Research Laboratory
HÜNİTEK , 06800, Beytepe, ANKARA
E-mail: hmaydin@hacettepe.edu.tr