“Biosmart” research group was established in 2016. The group intensively work in the fields of (bio) -Sensor / -Materials / -Analytics which the name research team interested in. As a research subject, the group members continue their activities in life sciences with nanomaterials, molecularly imprinted polymers, biointerfaces, biosensors and chromatographic techniques.
• High performance liquid chromatography (HPLC) (Shimadzu)
• Portable QCM
• Water bath
• Sonicator
• Centrifuge
• Rotator
• PH meter
• Precision Balance
• Prof. Dr. Lokman Uzun
• Assoc. Prof. Dr. Mehmet Emin Çorman (Sinop University Faculty Member, Visiting Researcher)
• Lecturer See. Dr. Erdogan Ozgur
• Res. Assist. Dr. Canan Armutcu
• Res. Assist. Doğan Tunalı (PhD Student, Kırkkale University, Bioengineering Department)
• Res. Assist. Eda Avar (PhD Student, Gazi University, Department of Chemistry)
• Mesut Kaplan (PhD Student)
• Rümeysa Güçlü (PhD Student)
• Serdar Uysal (PhD Student)
• Deniz Ağlamaz (PhD Student)
• Seçkin Opinionist (PhD Student)
• Tunca Karasu (PhD Student)
• Emrecan Yıldız (Graduate Student)
• Sezgin Gündüz (Graduate Student)
• Ahmet Burak Berk (Graduate Student)
• Sena Pişkin (Graduate Student-Candidate)
• Miraç Tüysüz (Undergraduate Student)
• Preparation of anti-CTGF conjugated gemcitabine loaded chitosan nanobubbles and investigation of their in vivo effects on pancreatic cancer, Executive, TÜBİTAK 1001, 119S622, 2019-Ongoing.
• Production of molecularly imprinted conductive polymer nanotubes for the detection of multiple biomarkers and development of nanotube integrated sensors, Researcher, TÜBİTAK 1001, 119Z342, 2020-Ongoing.
• Design of Portable Immunosensors and Application of Trinitrotoluene (TNT) Detection for On-Site and Simultaneous Explosive Detection, Researcher, TÜBİTAK 1002, 120M308, (01/11 / 2020-01 / 11/2021).
• Biocompatible artificial carbonic anhydrase for the biological conversion of carbon dioxide (CO2), Researcher, HU-BAB, FHD-2019-18084, 2019-Ongoing.
• Investigation of the effects of cysteine and histidine-based new conductive monomer-containing polymers on fibroblast and osteoblast differentiation, Executive, HU-BAB, FHD-2019-18038, 2019-Ongoing.
• Purification of capsaicin from Samandağ (Hatay) pepper by affinity chromatography, Executive, HU-BAB, FYL-2019-17742, 2019-Ongoing.
• Paper-based biosensor design for the detection of cell death pathways, Executive, HU-BAB, FDK-2019-17733, 2019-Ongoing.
• Production and application of molecular imprinted capacitive sensors, HU-BAB, FBA-2017-14492, 2017-Ongoing.
• The use of high energy conversion fluorescent particles for telomerase activity as a biosensor, Executive, HU-BAB, FDK-2020-18777, 2020-Ongoing.
• Preparation of Monolithic Affinity Columns for Ochratoxin A Determination and Investigation of Online Analysis in Two-Dimensional HPLC System ”. Advisor, TÜBİTAK, 114 Z 708, 2015.
• Design of Selective Monolithic Affinity Columns for Preconcentration of Polycyclic Aromatic Hydrocarbons and Determination in One Step by Two-Dimensional HPLC System ”. Advisor, TÜBİTAK, 214 Z 236, 2015-2016.
• Development of Biomatrics for Directing Induced Pluripotent Stem Cells to Cardiomyocyte Differentiation (International-IntenC Project with Germany). Researcher, TÜBİTAK, 113 T 026, 2014-2017.
• Preparation and Applications of Molecular Imprinted Quartz Crystal Microbalance (QCM) Chips for Melamine Identification ”. Researcher, TÜBİTAK, 112T561, 2015.
• Investigation of Nanofiber Synthesis, Characterization and Its Use in Protein Affinity Removal by Electrospinning Method, Executive, BAP, 02 / 2014-11 / 2016.
• Use of reactive electrospinned nanofibers as functional material on the electrode surface and impedimetric sensor design, Executive, BAP, 02 / 2014-02 / 2017.
• Investigation of Biosensor and Controlled Release Properties of Biosynthesized Biointerfaces, Executive, BAP, 11 / 2016-03 / 2017.
• Development of immunoaffinity sensor for the determination of neurofilament light chain and investigation of its use in the diagnosis of Parkinson's, Researcher, BAP, 02 / 2017-12 / 2017.
• Development of Molecular Imprinted Electrochemical Sensors for Selective Paraben Detection, Executive, BAP, 03 / 2017-04 / 2018.
• Design and Development of Paper-Based Biochips for Cancer Diagnosis, Researcher, BAP, 12 / 2017-12 / 2019.
• Design of Cryogel-Based Bioreactors and Investigation of Protein Degradation Efficiency, Researcher, BAP, 03 / 2018-08 / 2019.
• Seyfi, J., Goodarzi, V., Wurm, F. R., Shojaei, S., Jafari-Nodoushan, M., Najmoddin, N., ... & Uzun, L. (2020). Developing antibacterial superhydrophobic coatings based on polydimethylsiloxane/silver phosphate nanocomposites: Assessment of surface morphology, roughness and chemistry. Progress in Organic Coatings, 149, 105944.
• Öztürk-Öncel, M. Ö., Odabaş, S., Uzun, L., Hür, D., & Garipcan, B. (2020). A facile surface modification of poly (dimethylsiloxane) with amino acid conjugated self-assembled monolayers for enhanced osteoblast cell behavior. Colloids and Surfaces B: Biointerfaces, 196, 111343.
• Baranei, M., Taheri, R. A., Tirgar, M., Saeidi, A., Oroojalian, F., Uzun, L., ... & Goodarzi, V. (2020). Anticancer effect of green tea extract (GTE)-Loaded pH-responsive niosome Coated with PEG against different cell lines. Materials Today Communications, 101751.
• Armutcu, C., Çorman, M. E., Bayram, E., & Uzun, L. (2020). Purification of Fab and Fc using papain immobilized cryogel bioreactor separator system. Journal of Chromatography B, 1158, 122396.
• Köse, K., Mavlan, M., Uzun, L., & Youngblood, J. P. (2020). Cholesterol removal via cyclodextrin-decoration on cellulose nanocrystal (CNC)-grafted poly (HEMA-GMA) nanocomposite adsorbent. Cellulose, 1-17.
• Armutcu, C., Tartan, Ç., Özgür, E., Nemutlu, E., & Uzun, L. (2020). Phosphate Anion Imprinted Cryogel Cartridges for Selective Preconcentration of Phosphorylated Amino Acids from Protein Lysate: An Alternative Sorbent for Proteome Analyses. ChemistrySelect, 5(38), 11730-11736.
• Özgür, E., Patra, H. K., Turner, A. P., Denizli, A., & Uzun, L. (2020). Lanthanide [Terbium (III)]-Doped Molecularly Imprinted Nanoarchitectures for the Fluorimetric Detection of Melatonin. Industrial & Engineering Chemistry Research, 59(36), 16068-16076.
• Özgür, E., Uyanık, H. U., Şenel, S., & Uzun, L. (2020). Immunoaffinity biosensor for neurofilament light chain detection and its use in Parkinson's diagnosis. Materials Science and Engineering: B, 256, 114545.
• Yücebaş, B. B., Yaman, Y. T., Bolat, G., Özgür, E., Uzun, L., & Abaci, S. (2020). Molecular imprinted polymer based electrochemical sensor for selective detection of paraben. Sensors and Actuators B: Chemical, 305, 127368.
• Erol, K., Yıldız, E., Alacabey, İ., Karabörk, M., & Uzun, L. (2019). Magnetic diatomite for pesticide removal from aqueous solution via hydrophobic interactions. Environmental Science and Pollution Research, 26(32), 33631-33641.
• Armutcu, C., Özgür, E., Karasu, T., Bayram, E., Uzun, L., & Çorman, M. E. (2019). Rapid Analysis of Polycyclic Aromatic Hydrocarbons in Water Samples Using an Automated On-line Two-Dimensional Liquid Chromatography. Water, Air, & Soil Pollution, 230(10), 249.
• Rezaei, B., Shoushtari, A. M., Rabiee, M., Uzun, L., Turner, A. P., & Cheung Mak, W. (2018). Multifactorial modeling and optimization of solution and electrospinning parameters to generate superfine polystyrene nanofibers. Advances in Polymer Technology, 37(8), 2743-2755.
• Armutcu, C., Uzun, L., & Denizli, A. (2018). Determination of Ochratoxin A traces in foodstuffs: comparison of an automated on-line two-dimensional high-performance liquid chromatography and off-line immunoaffinity-high-performance liquid chromatography system. Journal of Chromatography A, 1569, 139-148.
• Rezaei, B., Shoushtari, A. M., Rabiee, M., Uzun, L., Mak, W. C., & Turner, A. P. (2018). An electrochemical immunosensor for cardiac Troponin I using electrospun carboxylated multi-walled carbon nanotube-whiskered nanofibres. Talanta, 182, 178-186.
• Odabaşı, M., Uzun, L., Baydemir, G., Aksoy, N. H., Acet, Ö., & Erdönmez, D. (2018). Cholesterol imprinted composite membranes for selective cholesterol recognition from intestinal mimicking solution. Colloids and Surfaces B: Biointerfaces, 163, 266-274.
• Rezaei, B., Shoushtari, A. M., Rabiee, M., Uzun, L., Turner, A. P., & Mak, W. C. (2018). Electrochemical performance of nanofibrous highly flexible electrodes enhanced by different structural configurations. Composites Science and Technology, 155, 81-90.
• Ermiş, N., Uzun, L., & Denizli, A. (2017). Preparation of molecularly imprinted electrochemical sensor for L-phenylalanine detection and its application. Journal of Electroanalytical Chemistry, 807, 244-252.
• Özgür, E., Parlak, O., Beni, V., Turner, A. P., & Uzun, L. (2017). Bioinspired design of a polymer-based biohybrid sensor interface. Sensors and Actuators B: Chemical, 251, 674-682.
• Bayram, E., Yılmaz, E., Uzun, L., Say, R., & Denizli, A. (2017). Multiclonal plastic antibodies for selective aflatoxin extraction from food samples. Food chemistry, 221, 829-837.
• Osikoya, A. O., Parlak, O., Murugan, N. A., Dikio, E. D., Moloto, H., Uzun, L., ... & Tiwari, A. (2017). Acetylene-sourced CVD-synthesised catalytically active graphene for electrochemical biosensing. Biosensors and Bioelectronics, 89, 496-504.
• Parlak, O., İncel, A., Uzun, L., Turner, A. P., & Tiwari, A. (2017). Structuring Au nanoparticles on two-dimensional MoS2 nanosheets for electrochemical glucose biosensors. Biosensors and Bioelectronics, 89, 545-550.
• Erol, K., & Uzun, L. (2017). Two-step polymerization approach for synthesis of macroporous surface ion-imprinted cryogels. Journal of Macromolecular Science, Part A, 54(11), 867-875.
• Köse, K., Erol, K., Ali Köse, D., Evcı, E., & Uzun, L. (2017). Affinity purification lipase from wheat germ: comparison of hydrophobic and metal chelation effect. Artificial cells, nanomedicine, and biotechnology, 45(3), 574-583.
• Çorman, M. E., Armutcu, C., Uzun, L., & Denizli, A. (2017). Rapid, efficient and selective preconcentration of benzo [a] pyrene (BaP) by molecularly imprinted composite cartridge and HPLC. Materials Science and Engineering: C, 70, 41-53.
• Köse, K., Erol, K., Özgür, E., Uzun, L., & Denizli, A. (2016). PolyAdenine cryogels for fast and effective RNA purification. Colloids and Surfaces B: Biointerfaces, 146, 678-686.
• Erol, K., Köse, K., Uzun, L., Say, R., & Denizli, A. (2016). Polyethyleneimine assisted-two-step polymerization to develop surface imprinted cryogels for lysozyme purification. Colloids and Surfaces B: Biointerfaces, 146, 567-576.
• Köse, K., & Uzun, L. (2016). PolyGuanine methacrylate cryogels for ribonucleic acid purification. Journal of Separation Science, 39(10), 1998-2005.
• Tekin, K., Akalin, M. K., Uzun, L., Karagöz, S., Bektaş, S., & Denizli, A. (2016). Adsorption of Pb (II) and Cd (II) Ions Onto Dye‐Attached Sawdust. CLEAN–Soil, Air, Water, 44(4), 339-344.
• Erol, K., Köse, K., Köse, D. A., Sızır, Ü., Tosun Satır, İ., & Uzun, L. (2016). Adsorption of Victoria Blue R (VBR) dye on magnetic microparticles containing Fe (II)–Co (II) double salt. Desalination and Water Treatment, 57(20), 9307-9317.
• Jalilzadeh, M., Uzun, L., Şenel, S., & Denizli, A. (2016). Specific heavy metal ion recovery with ion‐imprinted cryogels. Journal of Applied Polymer Science, 133(10).
• Akkan, C. K., Hür, D., Uzun, L., & Garipcan, B. (2016). Amino acid conjugated self assembling molecules for enhancing surface wettability of fiber laser treated titanium surfaces. Applied Surface Science, 366, 284-291.
• Büyüktiryaki, S., Uzun, L., Denizli, A., Say, R., & Ersöz, A. (2016). Simultaneous depletion of albumin and immunoglobulin G by using twin affinity magnetic nanotraps. Separation Science and Technology, 51(12), 2080-2089.
• Göktürk, I., Üzek, R., Uzun, L., & Denizli, A. (2016). Synthesis of a specific monolithic column with artificial recognition sites for L-glutamic acid via cryo-crosslinking of imprinted nanoparticles. Artificial Cells, Nanomedicine, and Biotechnology, 44(4), 1133-1140.
• Çorman, M. E., Armutcu, C., Uzun, L., Say, R., & Denizli, A. (2016). Reversible and easy post-crosslinking method for developing a surface ion-imprinted hypercrosslinked monolith for specific Cd (II) ion removal from aqueous solutions. RSC advances, 6(91), 88777-88787.
• Köse, K., Erol, K., Emniyet, A. A., Köse, D. A., Avcı, G. A., & Uzun, L. (2015). Fe (II)-Co (II) double salt incorporated magnetic hydrophobic microparticles for invertase adsorption. Applied biochemistry and biotechnology, 177(5), 1025-1039.
• Memmedova, T., Armutcu, C., Uzun, L., & Denizli, A. (2015). Polyglycidyl methacrylate based immunoaffinity cryogels for insulin adsorption. Materials Science and Engineering: C, 52, 178-185.
• Çulha, S., Armutcu, C., Uzun, L., Şenel, S., & Denizli, A. (2015). Synthesis of L-lysine imprinted cryogels for immunoglobulin G adsorption. Materials Science and Engineering: C, 52, 315-324.
• Doğan, T., Bayram, E., Uzun, L., Şenel, S., & Denizli, A. (2015). Trametes versicolor laccase immobilized poly (glycidyl methacrylate) based cryogels for phenol degradation from aqueous media. Journal of Applied Polymer Science, 132(20).
• Özkütük, E. B., Diltemiz, S. E., Özalp, E., Uzun, L., & Ersöz, A. (2015). Ligand exchange and MIP-based paraoxon memories onto QCM sensor. Applied Physics A, 119(1), 351-357.
• Sener, G., Uzun, L., & Denizli, A. (2014). Colorimetric sensor array based on gold nanoparticles and amino acids for identification of toxic metal ions in water. ACS applied materials & interfaces, 6(21), 18395-18400.
• Tabaklı, B., Topçu, A. A., Döker, S., & Uzun, L. (2015). Particle-assisted ion-imprinted cryogels for selective CdII ion removal. Industrial & Engineering Chemistry Research, 54(6), 1816-1823.
• Saylan, Y., Uzun, L., & Denizli, A. (2015). Alanine functionalized magnetic nanoparticles for reversible amyloglucosidase immobilization. Industrial & Engineering Chemistry Research, 54(1), 454-461.
• Çorman, M. E., Armutcu, C., Özkara, S., Uzun, L., & Denizli, A. (2015). Molecularly imprinted cryogel cartridges for the specific filtration and rapid separation of interferon alpha. RSC Advances, 5(56), 45015-45026.