Endocrinology Laboratory

About

Research Infrastructure

•   Hitachi Ultrasonography (for thyroid, parathyroid and lymph node imaging and FNAB)
•   Foot Scan
•   Datex Ohmeda s5 (basal metabolism)
•   Elisa Washer
•   Tanita
•   Ambulatory blood pressure (2 pieces - Tracker and Oscar)
•   Centrifuge NF 800R
•   Centrifuge 800, Revco (-80 degrees)
•   Sanyo (-80 degrees), Frigor (-20 degrees), Bosch (-30 degrees)

Researchers

•    Tomris Erbaş
•    Alper Gürlek
•    Bülent Okan Yıldız
•    Selçuk Dağdelen
•    Uğur Ünlütürk
•    Süleyman Nahit Şendur
•    Seda Oğuz
•    Burçin Gönül İremli
•    Banu Ertürk
•    Damla Eyüpoğlu

Ongoing Projects

• Evaluation of foot pressure parameters with foot scan in patients with primary hyperparathyroidism
•   The relationship of muscle strength with body composition and hormonal changes in women with PCOS (Seren Aksun -TEZ)
•   Cross-sectional investigation of the relationship between Galectin-3 and other marker levels and vitamin D in heart failure with preserved ejection fraction (Mehmet Erdevir - TEZ)
•   Evaluation of non-alcoholic fatty liver disease, sarcopenia and serum angiopoietin-like protein-8 levels in the follow-up of patients with prolactinoma and acromegaly (İmdat Eroğlu - TEZ)
•   Adipokine and mykoin profile of exercise capacity and muscle mass in obese individuals (Selin Tekin - TEZ)
• Clinicopathological effect of immune checkpoint molecule expression in papillary thyroid cancer (Berçemhan Yazırlı - TEZ)

Completed Projects

•   Cardiac steatosis, cardiovascular risk and related biomarkers in patients with acromegaly and prolactinoma (Büşra Fırlatan - 2020 - TEZ)
Angiopoietin-like protein-4 and Follistatin-like 1 protein levels and Angiopoietin-like protein-4 gene polymorphism in patients with diabetic foot (Rıza Gökhan Baykal - 2019 - TEZ)
• The role of HIF-1α, VEGF, TNF-α genes on the development of periodontal diseases in type 2 diabetes mellitus (Selin Küçükyurt Kaya - 2015 - TEZ)
•   Comparison of brain magnetic resonance images of patients with polycystic ovary syndrome and healthy women without polycystic ovary syndrome, and determination of their relationship with body mass index and hormone levels (Basak Özgen Saydam - 2015 - TEZ)
Investigation of the changes in muscle strength, muscle quality and total body fat distribution in obese and non-obese patients diagnosed with PCOS, depending on clinical or biochemical hyperandrogenism, by comparing them with obese and non-obese control groups (Ezgi Çalışkan Güzelce - 2019 - TEZ)
•   Comparison of intestinal microbiota members prevotella melaninogenica, ruminococcus torques and clostridium difficile in healthy women with polycystic ovary syndrome (Gülnar Mammadova - 2017 - TEZ)
•   Evaluation of eating behavior and sense of taste in women with PCOS (Sıla Çetik - 2020 - TEZ)
• The effect of different high-intensity interval training protocols on cardiorespiratory parameters in patients with type 2 diabetes (Cemile Bozdemir - 2020 - PhD Thesis)
•   Biological origins of lifestyle associated with susceptibility to chronic diseases in healthy youth. (Dr. Mert Sold - 2019 -TEZ)
•   Comparison of cardiorespiratory fitness parameters in type 2 diabetes, prediabetic and healthy individuals. (Beyza Nur Karadüz - 2019 - THESIS)
•   The effects of taste sensation on incretin system in healthy young people
•   Taste sensitivity is related to incretin response to oral glucose challenge, dietary habits and body composition: A novel link with energy metabolism
•    Effect of new onset diabetes after renal transplantation on cardiovascular disease and mortality
•   Endocrinological evaluation of adult thalassemia patients
•   Circulating gut microbiota metabolite trimethylamine N-oxide and oral contraceptive use in polycystic ovary syndrome.
•   Microbiota and oral contraceptive use in overweight and obese patients with polycystic ovary syndrome.
•   Effect of subclinical hypothyroidisim on plasma oxysterols by auto-oxidation
•    The effects of period3 gene polymorphism and GH/IGF-1/IGFBP3 system and hypothalamopituitary adrenal axis in autoimmune thyroid diseases
• Evaluation of plasma macrophage apoptosis inhibitor (AIM) and plasma monocyte chemotactic protein-1 (MKP-1) levels in patients with metabolic syndrome

Publications

•    Helvaci N, Kabacam S, Dagdelen S, Lay I, Karabulut E, Mut M, Alikasifoglu M, Erbas T. Klotho gene G395A and C1818T polymorphisms in acromegaly: Association with clinical presentation and comorbidities. Clin Endocrinol (Oxf). 2020 Dec 9. doi: 10.1111/cen.14380. Epub ahead of print. PMID: 33296101.
•    Atici K, Alsulami S, Turan-Demirci B, Surendran S, Sendur SN, Lay I, Karabulut E, Ellahi B, Lovegrove JA, Alikasifoglu M, Erbas T, Vimaleswaran KS, Buyuktuncer Z. FTO gene-lifestyle interactions on serum adiponectin concentrations and central obesity in a Turkish population. Int J Food Sci Nutr. 2020 Aug 4:1-11. doi: 10.1080/09637486.2020.1802580. Epub ahead of print. PMID: 32746650.
•   Sendur SN, Koray Ergunay K, Akyon Y, Brinkmann A, Serdar M, Dagdelen D, Erbas T, Nitsche A, E. Yılmaz. Probeable alterations in fecal bacterial microbiota by somatostatin receptor analogs in acromegaly Turkish Journal of Biochemistry, 22 Oct 2020.
•   Sendur SN, Oguz S, Dagdelen S, Erbas T. Assessment of static and dynamic plantar data of patients with acromegaly. pituitary 2019 Aug;22(4):373-380. doi: 10.1007/s11102-019-00964-w. PMID: 31025226.
•    Ozer FF, Dagdelen S, Erbas T. Relation of RANKL and OPG Levels with Bone Resorption in Patients with Acromegaly and Prolactinoma. Horm Metab Res. 2018 Jul;50(7):562-567. doi: 10.1055/a-0630-1529. Epub 2018 Jun 12. PMID: 29895074.
•    Erbas T, Cinar N, Dagdelen S, Gedik A, Yorgun H, Canpolat U, Kabakci G, Alikasifoglu M. Association between ACE and AGT polymorphism and cardiovascular risk in acromegalic patients. pituitary 2017 Oct;20(5):569-577. doi: 10.1007/s11102-017-0819-5. PMID: 28712073.
•   Cinar N, Dagdelen S, Yorgun H, Canpolat U, Kabakçı G, Erbas T. The clinical and cardiometabolic effects of d3-growth hormone receptor polymorphism in acromegaly. pituitary 2015 Feb;18(1):116-25. doi: 10.1007/s11102-014-0564-y. PMID: 24706164.
•    Ozgen Saydam B, Has AC, Bozdag G, Oguz KK, Yildiz BO. Structural imaging of the brain reveals decreased total brain and total gray matter volumes in obese but not in lean women with polycystic ovary syndrome compared to body mass index-matched counterparts. Gynecol Endocrinol. 2017 Jul;33(7):519-523.( Başak Özgen Saydam – THESIS)
•   Caliskan Guzelce E, Eyupoglu D, Torgutalp S, Aktoz F, Portakal O, Demirel H, Yildiz BO. Is muscle mechanical function altered in polycystic ovary syndrome? Arch Gynecol Obstet. 2019 Sep;300(3):771-776. (Ezgi Caliskan Guzelce - THESIS)
•   Mammadova G, Ozkul C, Yilmaz Isikhan S, Acikgoz A, Yildiz BO. Characterization of Gut Microbiota in Polycystic Ovary Syndrome: Findings from a Lean Population. EurJ Clin Invest. 2020 Sep 2:e13417. (Gulnar Mammadova - THESIS)
•    Eyupoglu ND, Caliskan Guzelce E, Acikgoz A, Uyanik E, Bjørndal B, Berge RK, Svardal A, Yildiz BO. Circulating gut microbiota metabolite trimethylamine N-oxide and oral contraceptive use in polycystic ovary syndrome. Clin Endocrinol (Oxf). 2019 Dec;91(6):810-815.
•    Eyupoglu ND, Ergunay K, Acikgoz A, Akyon Y, Yilmaz E, Yildiz BO. Gut Microbiota and Oral Contraceptive Use in Overweight and Obese Patients with Polycystic Ovary Syndrome. J Clin Endocrinol Metab. 2020 Dec 1;105(12):dgaa600.
•    Savas EM, Oğuz SH, Samadi A, Yılmaz Işıkhan S, Ünlütürk U, Lay İ, Gürlek A. Apoptosis Inhibitor of Macrophage, Monocyte Chemotactic Protein-1, and C-Reactive Protein Levels Are Increased in Patients with Metabolic Syndrome: A Pilot study. Metab Syndr Relat Disord. 2020 May;18(4):197-205.
•   Samadi A, Gurlek A, Sendur SN, Karahan S, Akbiyik F, Lay I. Oxysterol species: reliable markers of oxidative stress in diabetes mellitus. J Endocrinol Invest. 2019 Jan;42(1):7-17
•    Helvaci N, Oguz SH, Kabacam S, Karabulut E, Akbiyik F, Alikasifoglu M, Gurlek A. Clock gene PERIOD3 polymorphism is associated with susceptibility to Graves' disease but not to Hashimoto's thyroiditis. Chronobiol Int. 2019 Oct;36(10):1343-1350.
•   Aydin K, Canpolat U, Akın S, Dural M, Karakaya J, Aytemir K, Özer N, Gürlek A. Chemerin is not associated with subclinical atherosclerosis markers in prediabetes and diabetes. Anatol J Cardiol. 2016 Oct;16(10):749-755
•    Kilic MK, Yesilkaya Y, Tezcan K, Cinar N, Akin S, Karakaya J, Akata D, Usman A, Gurlek A. The association between thyroid volume, L-thyroxine therapy and hepatocyte growth factor levels among patients with euthyroid and hypothyroid goitrous and non-goitrous Hashimoto's thyroiditis versus healthy subjects. Endocr Res. 2016 May;41(2):110-5.
•    Gurses KM, Tokgozoglu L, Yalcin MU, Kocyigit D, Evranos B, Yorgun H, Sahiner L, Kaya EB, Kabakci G, Gurlek A, Ozer N, Aytemir K. Epicardial Fat Thickness is Increased in Vitamin D Deficient Premenopausal Women and does not Decrease after Short-term Replacement. J Atheroscler Thromb. 2015;22(6):582-9.

Links

About

Research Infrastructure

•   Hitachi Ultrasonography (for thyroid, parathyroid and lymph node imaging and FNAB)
•   Foot Scan
•   Datex Ohmeda s5 (basal metabolism)
•   Elisa Washer
•   Tanita
•   Ambulatory blood pressure (2 pieces - Tracker and Oscar)
•   Centrifuge NF 800R
•   Centrifuge 800, Revco (-80 degrees)
•   Sanyo (-80 degrees), Frigor (-20 degrees), Bosch (-30 degrees)

Researchers

•    Tomris Erbaş
•    Alper Gürlek
•    Bülent Okan Yıldız
•    Selçuk Dağdelen
•    Uğur Ünlütürk
•    Süleyman Nahit Şendur
•    Seda Oğuz
•    Burçin Gönül İremli
•    Banu Ertürk
•    Damla Eyüpoğlu

Ongoing Projects

• Evaluation of foot pressure parameters with foot scan in patients with primary hyperparathyroidism
•   The relationship of muscle strength with body composition and hormonal changes in women with PCOS (Seren Aksun -TEZ)
•   Cross-sectional investigation of the relationship between Galectin-3 and other marker levels and vitamin D in heart failure with preserved ejection fraction (Mehmet Erdevir - TEZ)
•   Evaluation of non-alcoholic fatty liver disease, sarcopenia and serum angiopoietin-like protein-8 levels in the follow-up of patients with prolactinoma and acromegaly (İmdat Eroğlu - TEZ)
•   Adipokine and mykoin profile of exercise capacity and muscle mass in obese individuals (Selin Tekin - TEZ)
• Clinicopathological effect of immune checkpoint molecule expression in papillary thyroid cancer (Berçemhan Yazırlı - TEZ)

Completed Projects

•   Cardiac steatosis, cardiovascular risk and related biomarkers in patients with acromegaly and prolactinoma (Büşra Fırlatan - 2020 - TEZ)
Angiopoietin-like protein-4 and Follistatin-like 1 protein levels and Angiopoietin-like protein-4 gene polymorphism in patients with diabetic foot (Rıza Gökhan Baykal - 2019 - TEZ)
• The role of HIF-1α, VEGF, TNF-α genes on the development of periodontal diseases in type 2 diabetes mellitus (Selin Küçükyurt Kaya - 2015 - TEZ)
•   Comparison of brain magnetic resonance images of patients with polycystic ovary syndrome and healthy women without polycystic ovary syndrome, and determination of their relationship with body mass index and hormone levels (Basak Özgen Saydam - 2015 - TEZ)
Investigation of the changes in muscle strength, muscle quality and total body fat distribution in obese and non-obese patients diagnosed with PCOS, depending on clinical or biochemical hyperandrogenism, by comparing them with obese and non-obese control groups (Ezgi Çalışkan Güzelce - 2019 - TEZ)
•   Comparison of intestinal microbiota members prevotella melaninogenica, ruminococcus torques and clostridium difficile in healthy women with polycystic ovary syndrome (Gülnar Mammadova - 2017 - TEZ)
•   Evaluation of eating behavior and sense of taste in women with PCOS (Sıla Çetik - 2020 - TEZ)
• The effect of different high-intensity interval training protocols on cardiorespiratory parameters in patients with type 2 diabetes (Cemile Bozdemir - 2020 - PhD Thesis)
•   Biological origins of lifestyle associated with susceptibility to chronic diseases in healthy youth. (Dr. Mert Sold - 2019 -TEZ)
•   Comparison of cardiorespiratory fitness parameters in type 2 diabetes, prediabetic and healthy individuals. (Beyza Nur Karadüz - 2019 - THESIS)
•   The effects of taste sensation on incretin system in healthy young people
•   Taste sensitivity is related to incretin response to oral glucose challenge, dietary habits and body composition: A novel link with energy metabolism
•    Effect of new onset diabetes after renal transplantation on cardiovascular disease and mortality
•   Endocrinological evaluation of adult thalassemia patients
•   Circulating gut microbiota metabolite trimethylamine N-oxide and oral contraceptive use in polycystic ovary syndrome.
•   Microbiota and oral contraceptive use in overweight and obese patients with polycystic ovary syndrome.
•   Effect of subclinical hypothyroidisim on plasma oxysterols by auto-oxidation
•    The effects of period3 gene polymorphism and GH/IGF-1/IGFBP3 system and hypothalamopituitary adrenal axis in autoimmune thyroid diseases
• Evaluation of plasma macrophage apoptosis inhibitor (AIM) and plasma monocyte chemotactic protein-1 (MKP-1) levels in patients with metabolic syndrome

Publications

•    Helvaci N, Kabacam S, Dagdelen S, Lay I, Karabulut E, Mut M, Alikasifoglu M, Erbas T. Klotho gene G395A and C1818T polymorphisms in acromegaly: Association with clinical presentation and comorbidities. Clin Endocrinol (Oxf). 2020 Dec 9. doi: 10.1111/cen.14380. Epub ahead of print. PMID: 33296101.
•    Atici K, Alsulami S, Turan-Demirci B, Surendran S, Sendur SN, Lay I, Karabulut E, Ellahi B, Lovegrove JA, Alikasifoglu M, Erbas T, Vimaleswaran KS, Buyuktuncer Z. FTO gene-lifestyle interactions on serum adiponectin concentrations and central obesity in a Turkish population. Int J Food Sci Nutr. 2020 Aug 4:1-11. doi: 10.1080/09637486.2020.1802580. Epub ahead of print. PMID: 32746650.
•   Sendur SN, Koray Ergunay K, Akyon Y, Brinkmann A, Serdar M, Dagdelen D, Erbas T, Nitsche A, E. Yılmaz. Probeable alterations in fecal bacterial microbiota by somatostatin receptor analogs in acromegaly Turkish Journal of Biochemistry, 22 Oct 2020.
•   Sendur SN, Oguz S, Dagdelen S, Erbas T. Assessment of static and dynamic plantar data of patients with acromegaly. pituitary 2019 Aug;22(4):373-380. doi: 10.1007/s11102-019-00964-w. PMID: 31025226.
•    Ozer FF, Dagdelen S, Erbas T. Relation of RANKL and OPG Levels with Bone Resorption in Patients with Acromegaly and Prolactinoma. Horm Metab Res. 2018 Jul;50(7):562-567. doi: 10.1055/a-0630-1529. Epub 2018 Jun 12. PMID: 29895074.
•    Erbas T, Cinar N, Dagdelen S, Gedik A, Yorgun H, Canpolat U, Kabakci G, Alikasifoglu M. Association between ACE and AGT polymorphism and cardiovascular risk in acromegalic patients. pituitary 2017 Oct;20(5):569-577. doi: 10.1007/s11102-017-0819-5. PMID: 28712073.
•   Cinar N, Dagdelen S, Yorgun H, Canpolat U, Kabakçı G, Erbas T. The clinical and cardiometabolic effects of d3-growth hormone receptor polymorphism in acromegaly. pituitary 2015 Feb;18(1):116-25. doi: 10.1007/s11102-014-0564-y. PMID: 24706164.
•    Ozgen Saydam B, Has AC, Bozdag G, Oguz KK, Yildiz BO. Structural imaging of the brain reveals decreased total brain and total gray matter volumes in obese but not in lean women with polycystic ovary syndrome compared to body mass index-matched counterparts. Gynecol Endocrinol. 2017 Jul;33(7):519-523.( Başak Özgen Saydam – THESIS)
•   Caliskan Guzelce E, Eyupoglu D, Torgutalp S, Aktoz F, Portakal O, Demirel H, Yildiz BO. Is muscle mechanical function altered in polycystic ovary syndrome? Arch Gynecol Obstet. 2019 Sep;300(3):771-776. (Ezgi Caliskan Guzelce - THESIS)
•   Mammadova G, Ozkul C, Yilmaz Isikhan S, Acikgoz A, Yildiz BO. Characterization of Gut Microbiota in Polycystic Ovary Syndrome: Findings from a Lean Population. EurJ Clin Invest. 2020 Sep 2:e13417. (Gulnar Mammadova - THESIS)
•    Eyupoglu ND, Caliskan Guzelce E, Acikgoz A, Uyanik E, Bjørndal B, Berge RK, Svardal A, Yildiz BO. Circulating gut microbiota metabolite trimethylamine N-oxide and oral contraceptive use in polycystic ovary syndrome. Clin Endocrinol (Oxf). 2019 Dec;91(6):810-815.
•    Eyupoglu ND, Ergunay K, Acikgoz A, Akyon Y, Yilmaz E, Yildiz BO. Gut Microbiota and Oral Contraceptive Use in Overweight and Obese Patients with Polycystic Ovary Syndrome. J Clin Endocrinol Metab. 2020 Dec 1;105(12):dgaa600.
•    Savas EM, Oğuz SH, Samadi A, Yılmaz Işıkhan S, Ünlütürk U, Lay İ, Gürlek A. Apoptosis Inhibitor of Macrophage, Monocyte Chemotactic Protein-1, and C-Reactive Protein Levels Are Increased in Patients with Metabolic Syndrome: A Pilot study. Metab Syndr Relat Disord. 2020 May;18(4):197-205.
•   Samadi A, Gurlek A, Sendur SN, Karahan S, Akbiyik F, Lay I. Oxysterol species: reliable markers of oxidative stress in diabetes mellitus. J Endocrinol Invest. 2019 Jan;42(1):7-17
•    Helvaci N, Oguz SH, Kabacam S, Karabulut E, Akbiyik F, Alikasifoglu M, Gurlek A. Clock gene PERIOD3 polymorphism is associated with susceptibility to Graves' disease but not to Hashimoto's thyroiditis. Chronobiol Int. 2019 Oct;36(10):1343-1350.
•   Aydin K, Canpolat U, Akın S, Dural M, Karakaya J, Aytemir K, Özer N, Gürlek A. Chemerin is not associated with subclinical atherosclerosis markers in prediabetes and diabetes. Anatol J Cardiol. 2016 Oct;16(10):749-755
•    Kilic MK, Yesilkaya Y, Tezcan K, Cinar N, Akin S, Karakaya J, Akata D, Usman A, Gurlek A. The association between thyroid volume, L-thyroxine therapy and hepatocyte growth factor levels among patients with euthyroid and hypothyroid goitrous and non-goitrous Hashimoto's thyroiditis versus healthy subjects. Endocr Res. 2016 May;41(2):110-5.
•    Gurses KM, Tokgozoglu L, Yalcin MU, Kocyigit D, Evranos B, Yorgun H, Sahiner L, Kaya EB, Kabakci G, Gurlek A, Ozer N, Aytemir K. Epicardial Fat Thickness is Increased in Vitamin D Deficient Premenopausal Women and does not Decrease after Short-term Replacement. J Atheroscler Thromb. 2015;22(6):582-9.

Links