As Epithelial Cell Research Group, we investigate the effects of exposomes on epithelial cells at the molecular and cellular levels using molecular biology and bioengineering methods.
• Fume hood, refrigerators, centrifuge, shaker, Heater blocks, PCR devices, Plate shakers, tube rotators (Assoc. Dr. İ. Çağatay Karaaslan)
• Sequence device, real-time PCR device, refrigerated centrifuge, oven, Perkin Elmer EnSight Plate Reader, Bio-Rad ChemiDoc Imaging System, Thermo Scientific EVOS Floid Cell Imaging Station, (Joint lab: Prof. Dr. Hatice Mergen and Assoc. İ. Çağatay Karaaslan)
• Supervisor: Assoc. Prof. Dr. Ibrahim Cagatay Karaaslan
• Dr. Research Asst. Hayriye Akel Bilgiç
• Research Asst. Basak Ezgi Sarac
• Research Asst. Dilara Karagüzel
• Sema Tuncer (D)
• Gizem Imrak (D)
• Seçil Subaşı (YL)
• Selcan Genç (YL)
• Murat Yolu (YL)
• Büşra Kılıç (YL)
• Serhat Yildirim (YL)
• Emine Beyza Doğan (YL)
• Berfin Doğa Koçkaya (YL)
• Ali Doruk Uzunkaya (YL)
• 3D Modeling of Airway Cell Culture Systems and Development of Tissue Grafts for Clinical Use / 2020-Ongoing - TÜBİTAK 1005 (Executive)
• Investigation of the Role of Platelet-Leukocyte Clusters in Airway Disease (N-ERD) Inflamed by Nonsteroidal Anti-Inflammatory Drugs / 2020-Ongoing - Hacettepe University Comprehensive Research Project (Researcher)
• Investigation of oxidative stress and antioxidant response in human neutrophil cell line stimulated with cigarette smoke condensate and tert-Butyl Hydroperoxide / 2020-Ongoing - Hacettepe University Rapid Support Project- (Researcher)
• Investigation of the Role of Sindekan1 in the Entry of Foot-and-Mouth Virus to the Cell / 2020-Ongoing - Hacettepe University Master's Thesis Project- (Researcher)
• Investigation of the Mechanism of Allergen-Related MMPs and TIMPs Released from Epithelial Cells and Their Contribution to Airway Reconstruction / 2019-Ongoing- TÜBİTAK Turkey-Poland Bilateral Cooperation (Executive)
• Development of Engineering Product 3D Cell Culture Systems Designed for Airline Modeling / 2019-Ongoing - Hacettepe University Thesis Project (Executive)
• Establishment of 3D Cell Culture Systems with Deselularized Tissue Scaffolds for Lung Airway Modeling / 2019-Ongoing -Hacettepe University Rapid Support Project (Executive)
• The Role of Dectin-1 Receptor in Airway Epithelial Cells / 2019-Ongoing - Hacettepe University Thesis Project (Executive)
• The Effect of Epithelial Cell Originated SERPINB1 on Neutrophil Elastase Associated Anti-Apoptotic and Pro-Apoptotic Pathways / 2019- Ongoing - Hacettepe University Thesis Project - (Executive)
• Investigation of Antioxidant Response in Airway Inflammatory and Structural Cells Against Oxidative Stress / 2017-2020 - Hacettepe University Comprehensive Research Project (Leader)
• The Effect of Protease-Activated Receptors on Protease Inhibitor Expression in Bronchial Epithelial Cells / 2017-2018 - Hacettepe University Career Transition Project (Executive)
• Investigation of the Effect of SERPINB1 Expression Changed After Encounter with Der p 1 on Inflammatory Cytokine Chemokine and Growth Factors in BEAS2B Cells / 2016-2018 - Hacettepe University Scientific Success Project (Executive)
• Use and Validation of New Generation DNA Analysis Method in Honey Analysis / 2017-2020 - Hacettepe University Comprehensive Research Project (Researcher)
• Mechanism and pathogenetic effects of different SERPIN B3 expression caused by allergen proteases in asthmatic and healthy bronchial epithelium / 2015-2018 - TÜBİTAK-1001 (Executive)
• Plant Origin Determination with Balda DNA Isolation / 2015-2016 - Hacettepe University Rapid Support Project (Researcher)
• DNA Barcoding Study on Some Walkers of the Ampedus (Coleotera: Elateridae) genus / 2015-2017 - Hacettepe University Rapid Support Project (Researcher)
• Mosayyebi S., Sarac B.E., Akel H., Sahiner U.S., Sackesen C Kalayci O, Karaaslan C. J Interferon Cytokine Res. Volume 40, Number 12, 2020. DOI: 10.1089 / jir.2020.0172
• Guvenir H, Buyuktiryaki B, Kulhas Celik I, Civelek E, Kilic Suloglu A, Karaaslan C, Genc S, Dibek Misirlioglu E, Toyran M, Ginis T, Kocabas CN. Can serum periostin, YKL-40, and osteopontin levels in pre-school children with recurrent wheezing predict later development of asthma? Pediatr Allergy Immunol. 2020 Aug 12.doi: 10.1111 / pai.13329.
• Acar NV, Cavkaytar O, Yilmaz EA, Buyuktiryaki B, Soyer O, Sahiner UM, Sekerel BE, Karaaslan C, Sackesen C. Rare occurrence of common filaggrin mutations in Turkish children with food allergy and atopic dermatitis. Turk J Med Sci. 2020 Jun 15.doi: 10.3906 / right-1910-162.
• Bilgic HA, Gurel SC, Ayhan Y, Karahan S, Karakaya I, Babaoglu M, Dilbaz N, Ulug B, Demir B, Karaaslan C. Relationship Between Alcohol Dependence and Neuropeptide Y (NPY) Gene Promoter Polymorphisms in A Turkish Sample. Turkish Journal of Psychiatry. 2020; 31 (4): 233-40
• Radzikowska, U .; Rinaldi, A.O .; Çelebi Sözener, Z .; Karaguzel, D .; Wojcik, M .; Cypryk, K .; Akdis, M .; Akdis, C.A .; Sokolowska, M. The Influence of Dietary Fatty Acids on Immune Responses. Nutrients 2019, 11, 2990.
Emine Sonmez H, Karaaslan C, de Jesus AA, Deniz Batu E, Anlar B, Sözeri B, Bilginer Y, Karaguzel D, Cagdas Ayvaz D, Tezcan I, Goldbach-Mansky R, Ozen S. A clinical score to guide in decision making for monogenic type I IFNopathies. Pediatr Res. 2019 Oct 22.doi: 10.1038 / s41390-019-0614-2.
• Süloğlu AK, Karacaoğlu E, Bilgic HA, Selmanoğlu G, Koçkaya EA, Karaaslan C. Osteogenic Differentiation of Adipose Tissue-derived Mesenchymal Stem Cells on Fibrin Glue or Fibronectin Coated Ceraform® J Biomater Appl. 2019 Jun 5: 885328219853421.
• Çetinkaya P, Karagüzel D, Esenboğa S, Şahiner Ü, Soyer OU, Büyüktiryaki B, Birben E, Karaaslan C, Şekerel B., Pistachio and Cashew Nut Allergy in Childhood: Predictive Factors Towards Development of a Decision Tree. Asian Pac J Allergy Immunol. 2019 Jul 16.doi: 10.12932 / AP-281018-0429. Online ahead of print.
• Ugurlu N., Asık M.D, Çakmak H.B., Tuncer S., Turk M., Çağıl N., and Denkbaş E.B., '' Transscleral Delivery of Bevacizumab Loaded Chitosan Nanoparticles '', Journal of Biomedical Nanotechnology, 2019.
• Keskin O, Farzan N, Birben E, Akel H, Karaaslan C, Maitland-van der Zee AH, Wechsler ME, Vijverberg SJ, Kalayci O Genetic associations of the response to inhaled corticosteroids in asthma: a systematic review. Clin Transl Allergy. 2019 Jan 9; 9: 2. doi: 10.1186 / s13601-018-0239-2.
• Berings M, Karaaslan C *, Altunbulakli C, Gevaert P, Akdis M, Bachert C, Akdis CA. Advances and Highlights in Allergen Immunotherapy: On the way to sustained clinical and immunologic tolerance. J Allergy Clin Immunol. 2017 Nov; 140 (5): 1250-1267. doi: 10.1016 / j.jaci.2017.08.025. Epub 2017 Sep 20.
• Sungur T, Aslim B, Karaaslan C, Aktas B. Impact of Exopolysaccharides (EPSs) of Lactobacillus gasseri strains isolated from human vagina on cervical tumor cells (HeLa). Anaerobe 2017 May 26; 47: 137-144.
• Gürel Ş. C., Ayhan Y., Karaaslan C., Akel H., Babaoğlu M., Yaşar Ü., Bozkurt A., Dilbaz N., Uluğ B. D., Demir B., Karaca R., Ö. µ-Opioid Receptor Gene (OPRM1) Polymorphisms A118G and C17T in Alcohol Dependence. Turkish Psychiatry Journal. 2016 Summer; 27 (2): 0. DOI: 10.5080 / u12336.
• Kılıç Süloğlu A, Karacaoğlu E., Selmanoğlu G., Akel H, Karaaslan C. Evaluation of apoptotic cell death mechanisms induced by hypericin mediated photodynamic therapy in colon cancer cells. Turkish Journal of Biology (2016) 40: 539-546 DOI: 10.3906 / bio-1504-6.
• Yu CW, Liang X, Lipsky S, Karaaslan C, Kozakewich H, Hotamisligil GS, Bischoff J, Cataltepe S. Dual role of fatty acid-binding protein 5 on endothelial cell fate: a potential link between lipid metabolism and angiogenic responses. Angiogenesis. 2016 Jan; 19 (1): 95-106. doi: 10.1007 / s10456-015-9491-4. Epub 2015 Dec 1.
Official Web Page
asthmalab18.wixsite.com/cagataykaraaslan