Functional BioNano Materials Research Laboratory

About

Lipid based micro/nanoparticles, Metal Organic Frameworks, Nanozymes and functional surfactants are being designed/synthesized. We use these materials as a synergic therapy agent for chemo/chemo-dynamic/photodynamic/photo-thermal therapy of cancer, as drug delivery system through lungs or from nose to brain.

Research Infrastructure

•   Pendant Drop Device
•   Deep freeze
•   Lyophilizer
•   Diode Laser Device
•   Precision Balance
•   LB Minitrough
•   Vaporizer
•   Micro Through
•   Oven
•   Cooled Water Bath
•   Tensiometer
•   HPLC
•   Heated Magnetic Stirrer
•   Magnetic Stirrer
•   Heated Mantle
•   Magnetic Stirrer
•   AFM
•   Ultrasonic Bathroom
•   Fluorescence Microscope
•   Pump
•   Pure Water Device
•   Centrifuge-1
•   Centrifuge-3
•   pH meter
•   Spectrophotometer-1
 

Researchers

•    Prof. Dr. Nihal Aydoğan
•    Assist. Prof. Gökçe Dicle Kalaycıoğlu

Ph.D. Students

Rers. Assist. Burcu Ökmen Altaş,

Pınar Kırlı

 

MSc. Students

Hürmet Kınalı, 

Çiğdem Naz Ersöz, 

Güşta İrem Sakız, 

Emin Uysal, 

Büşra Toprak,

Emine Yılmaz,

 

  

Ongoing Projects

•    TÜBİTAK MAG Support Program, “Development of Multifunctional Smart Nanostructured Lipid Carriers for Combined Cancer Treatment” Project Code: 119M377, Project Start: 01.11.2019, Project End: 01.07.2021

Completed Projects

•    113M259 Use of Special Surfactants to Maintain Healthy Respiration in Lungs, Start Date: 01/10/2013
•   Colloidal Microcapsule Production Using 215M759 Solid Lipid Nanoparticle, Start Date : 01/05/2016

Publications

Sengul S., Aydogan,N.; Bukusoglu E., (2022) Nanoparticle adsorption induced configurations of nematic liquid crystal droplets, JCIS, 608, 2310-2320.

Kalaycioglu, G.D., D. Yuksel, , B. Okmen, N. Aydogan, (2021) ‘Interfacial properties and aggregates of novel redox-active surfactant to synthesize silver nanoparticles at the air/water interface’  Colloids and Surfaces A: Physicochemical and Engineering Aspects, 624, art. no. 126759.

Kalaycioglu, G.D., N. Aydogan, (2021) ‘Fluorocarbon/hydrocarbon hybrid surfactant decorated gold nanoparticles and their interaction with model cell membranes’  Journal of Molecular Liquids, 326, art. no. 115346.

Kalaycioglu, G.D., A.A. Elamin, H. Kinali, N. Aydogan, (2021) ‘pH-Sensitive Polymeric Poly (ϵ-caprolactone) Core- Chitosan/Alginate Shell Particle System for Oral Insulin Delivery’ ChemistrySelect, 6 (4), pp. 695-704.

Aydogan, N., G.D Kalaycioglu, H. Unsal, M. Ozkan, M. (2021)  Custom-made lipid nanotubes as a tissue and hydrogel adhesive Colloids and Surfaces A: Physicochemical and Engineering Aspects, 608, art. no. 125609.

 Aydogan, N., Kalaycioglu, G. D., Unsal, H., Ozkan, M. (2020) Custom-made lipid nanotubes as a tissue and hydrogel adhesive. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 608, 125609.

Alp, G., Aydogan, N. (2020). Lipid-based mucus penetrating nanoparticles and their biophysical interactions with pulmonary mucus layer. European Journal of Pharmaceutics and Biopharmaceutics, 149, 45-57.

Alp, G., Alp, E., Aydogan, N. (2020). Magnetic liquid marbles to facilitate rapid manipulation of the oil phase: Synergistic effect of semifluorinated ligand and catanionic surfactant mixtures. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 585, 124051.

Kalaycioglu, G. D., Aydogan, N. (2020). Layer-by-layer coated microcapsules with lipid nanodomains for dual-drug delivery. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 584, 124037.

Unsal, H., Kalaycioglu, G. D., Aydogan, N., Karakuscu, N. (2019). Smart Lipid Nanotubes for Easy Formation of Gold‐Lipid Hybrid Nanotubes and Tunable Gold Superstructures. ChemistrySelect, 4(35), 10276-10287.

Alp, G., Aydogan, N. (2018). Enhancing the spreading behavior on pulmonary mucus mimicking subphase via catanionic surfactant solutions: toward effective drug delivery through the lungs. Molecular pharmaceutics, 15(3), 1361-1370.

Atila Dinçer, C., Yildiz, N., Karakeçili, A., Aydoğan, N., Calimli, A. (2017). Synthesis and characterization of Fe3O4-MPTMS-PLGA nanocomposites for anticancer drug loading and release studies. Artificial Cells, Nanomedicine, and Biotechnology, 45(7), 1408-1414.

Kalaycioglu, G. D., Aydogan, N. (2016). Preparation and investigation of solid lipid nanoparticles for drug delivery. Colloids and Surfaces A: Physicochemical and engineering aspects, 510, 77-86.

Alp, E., Aydogan, N. (2016). A comparative study: synthesis of superparamagnetic iron oxide nanoparticles in air and N2 atmosphere. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 510, 205-212.

Ilbasmis-Tamer, S., Unsal, H., Tugcu-Demiroz, F., Kalaycioglu, G. D., Degim, I. T.,  Aydogan, N. (2016). Stimuli-responsive lipid nanotubes in gel formulations for the delivery of doxorubicin. Colloids and Surfaces B: Biointerfaces, 143, 406-414.

Unsal, H., Schmidt, J., Talmon, Y., Yildirim, L. T.,  Aydogan, N. (2016). Dual-Responsive Lipid Nanotubes: Two-Way Morphology Control by pH and Redox Effects. Langmuir, 32(21), 5324-5332.

Links

About

Lipid based micro/nanoparticles, Metal Organic Frameworks, Nanozymes and functional surfactants are being designed/synthesized. We use these materials as a synergic therapy agent for chemo/chemo-dynamic/photodynamic/photo-thermal therapy of cancer, as drug delivery system through lungs or from nose to brain.

Research Infrastructure

•   Pendant Drop Device
•   Deep freeze
•   Lyophilizer
•   Diode Laser Device
•   Precision Balance
•   LB Minitrough
•   Vaporizer
•   Micro Through
•   Oven
•   Cooled Water Bath
•   Tensiometer
•   HPLC
•   Heated Magnetic Stirrer
•   Magnetic Stirrer
•   Heated Mantle
•   Magnetic Stirrer
•   AFM
•   Ultrasonic Bathroom
•   Fluorescence Microscope
•   Pump
•   Pure Water Device
•   Centrifuge-1
•   Centrifuge-3
•   pH meter
•   Spectrophotometer-1
 

Researchers

•    Prof. Dr. Nihal Aydoğan
•    Assist. Prof. Gökçe Dicle Kalaycıoğlu

Ph.D. Students

Rers. Assist. Burcu Ökmen Altaş,

Pınar Kırlı

 

MSc. Students

Hürmet Kınalı, 

Çiğdem Naz Ersöz, 

Güşta İrem Sakız, 

Emin Uysal, 

Büşra Toprak,

Emine Yılmaz,

 

  

Ongoing Projects

•    TÜBİTAK MAG Support Program, “Development of Multifunctional Smart Nanostructured Lipid Carriers for Combined Cancer Treatment” Project Code: 119M377, Project Start: 01.11.2019, Project End: 01.07.2021

Completed Projects

•    113M259 Use of Special Surfactants to Maintain Healthy Respiration in Lungs, Start Date: 01/10/2013
•   Colloidal Microcapsule Production Using 215M759 Solid Lipid Nanoparticle, Start Date : 01/05/2016

Publications

Sengul S., Aydogan,N.; Bukusoglu E., (2022) Nanoparticle adsorption induced configurations of nematic liquid crystal droplets, JCIS, 608, 2310-2320.

Kalaycioglu, G.D., D. Yuksel, , B. Okmen, N. Aydogan, (2021) ‘Interfacial properties and aggregates of novel redox-active surfactant to synthesize silver nanoparticles at the air/water interface’  Colloids and Surfaces A: Physicochemical and Engineering Aspects, 624, art. no. 126759.

Kalaycioglu, G.D., N. Aydogan, (2021) ‘Fluorocarbon/hydrocarbon hybrid surfactant decorated gold nanoparticles and their interaction with model cell membranes’  Journal of Molecular Liquids, 326, art. no. 115346.

Kalaycioglu, G.D., A.A. Elamin, H. Kinali, N. Aydogan, (2021) ‘pH-Sensitive Polymeric Poly (ϵ-caprolactone) Core- Chitosan/Alginate Shell Particle System for Oral Insulin Delivery’ ChemistrySelect, 6 (4), pp. 695-704.

Aydogan, N., G.D Kalaycioglu, H. Unsal, M. Ozkan, M. (2021)  Custom-made lipid nanotubes as a tissue and hydrogel adhesive Colloids and Surfaces A: Physicochemical and Engineering Aspects, 608, art. no. 125609.

 Aydogan, N., Kalaycioglu, G. D., Unsal, H., Ozkan, M. (2020) Custom-made lipid nanotubes as a tissue and hydrogel adhesive. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 608, 125609.

Alp, G., Aydogan, N. (2020). Lipid-based mucus penetrating nanoparticles and their biophysical interactions with pulmonary mucus layer. European Journal of Pharmaceutics and Biopharmaceutics, 149, 45-57.

Alp, G., Alp, E., Aydogan, N. (2020). Magnetic liquid marbles to facilitate rapid manipulation of the oil phase: Synergistic effect of semifluorinated ligand and catanionic surfactant mixtures. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 585, 124051.

Kalaycioglu, G. D., Aydogan, N. (2020). Layer-by-layer coated microcapsules with lipid nanodomains for dual-drug delivery. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 584, 124037.

Unsal, H., Kalaycioglu, G. D., Aydogan, N., Karakuscu, N. (2019). Smart Lipid Nanotubes for Easy Formation of Gold‐Lipid Hybrid Nanotubes and Tunable Gold Superstructures. ChemistrySelect, 4(35), 10276-10287.

Alp, G., Aydogan, N. (2018). Enhancing the spreading behavior on pulmonary mucus mimicking subphase via catanionic surfactant solutions: toward effective drug delivery through the lungs. Molecular pharmaceutics, 15(3), 1361-1370.

Atila Dinçer, C., Yildiz, N., Karakeçili, A., Aydoğan, N., Calimli, A. (2017). Synthesis and characterization of Fe3O4-MPTMS-PLGA nanocomposites for anticancer drug loading and release studies. Artificial Cells, Nanomedicine, and Biotechnology, 45(7), 1408-1414.

Kalaycioglu, G. D., Aydogan, N. (2016). Preparation and investigation of solid lipid nanoparticles for drug delivery. Colloids and Surfaces A: Physicochemical and engineering aspects, 510, 77-86.

Alp, E., Aydogan, N. (2016). A comparative study: synthesis of superparamagnetic iron oxide nanoparticles in air and N2 atmosphere. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 510, 205-212.

Ilbasmis-Tamer, S., Unsal, H., Tugcu-Demiroz, F., Kalaycioglu, G. D., Degim, I. T.,  Aydogan, N. (2016). Stimuli-responsive lipid nanotubes in gel formulations for the delivery of doxorubicin. Colloids and Surfaces B: Biointerfaces, 143, 406-414.

Unsal, H., Schmidt, J., Talmon, Y., Yildirim, L. T.,  Aydogan, N. (2016). Dual-Responsive Lipid Nanotubes: Two-Way Morphology Control by pH and Redox Effects. Langmuir, 32(21), 5324-5332.

Links