Mass Spectrometry Research Laboratory (SAREG)

About

Mass Spectrometry is a dynamic and continually evolving discipline which covers worldwide discoveries and plays an integral role to understand the world around us. Our primary aim is to train young scientists who can reach the increasing rate of today’s science and technology.

Research Infrastructure

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Matrix Assisted Laser Desorption Ionizing – Time of Flight Mass Spectrometer (MALDI-TOF/TOF MS) (Bruker Daltonics, Rapiflex)

 

 

 

 

 

 


Matrix Assisted Laser Desorption Ionization – Time of Flight Mass Spectrometer (MALDI-TOF MS) (Applied Biosystems,Voyager DePro)

 

 

 

 

Nano Electrospray Ionizing Hybrid Quadrupole-Orbitrap Mass Spectrometer (Thermo Scientific, Q-Exactive Plus Hybrid Quadrupole-Orbitrap MS)

 

 

 

Electrospray Ionization - Quadrupole / Time of Flight Mass Spectrometer (ESI-QTOF-MS) (Agilent Technologies 6530 ESI-QTOF-MS)

 

 

 

 

 

MALDI plate sample preparation device with micro fraction collection (SunChrom)

 

 

 

 

Enzymatic lysis incubation unit (SunChrom)

 

 

 

 


• Nano Electrospray Ionization Trapped Ion Mobility – Time of Flight Mass Spectrometer (TIMS-TOF-MS) (Bruker Daltonics)
• Liquid chromatography providing nanoscale flow (Thermo Scientific, UltiMate 3000 RSLCnano System) (2 pcs)
• High Pressure Liquid Chromatography (Agilent 1200 HPLC) (with fraction collection unit)
• HPLC-Chip Cube (Agilent 1260)
• Capillary Electrophoresis Device (Agilent 7100 CE)
• Fluorescence and UV-DAD detectors (Agilent)
• Gas chromatography – mass spectrometry (GC-MS) and gas chromatography (GC-ECD) system with Electron capture detector, gas-trapped thermal desorber front probe
• Curie Point Flash Pyrolyzer-GC-MS (gas chromatography with fast pyrolysis unit) system
• Solid probe - mass spectrometry (Direct Insertion Probe – MS)
• Flame atomic absorption spectrophotometer (FAAS)
• One and two dimensional separable polyacrylamide gel electrophoresis system (SDS-PAGE and 2D-PAGE)
• UV/ Visible Spectrophotometer
• Vacuum Quick Dryer (Speedvac)
• Vacuum Oven
• Lyophilizer
• Heated Mixer (Thermomixer)
• Ultra pure water system
• Ultrasonic Bath
• Shaking water bath with adjustable temperature
• Refrigerated Centrifuge System
• Microelectrode pH meter
• Precision analytical balance
• Vertical type -80 ̊C 80 L deep freezer
• Refrigerators with deep freezer (-20 oC and +4 oC) (2 units)

Researchers

Faculty Members
•    Prof. Dr. Bekir Salih
•    Asst. Prof. Üyesi Mehmet Atakay
•    Res. Asst. Dr. Ülkü Güler
•    Res. Asst. Emre Birol

Students (PhD)
•    Ayşegül Özgen
•    Serhat Öztürk
•    Marwa Abu Aisheh  
•    Buse Varlıoğlu
•    İzzet Avcı
•    Hacer Dağaşan

Students (Msc.)
•    Buse Aklar
•    Buğra Balaban
•    Sema Baltacı

Ongoing Projects

• Development of New Generation Ion Mobility-Mass Spectrometry Analysis Methods for Conformational Analysis of Monoclonal Antibody Based Biotech Drugs, 120Z532, TÜBİTAK 1001 Project, (2020-Continuing)
• Determination of Changes in Basic Components of Milk in Kefir Fermentation and Storage Processes Using Mass Spectrometry-Based Omic-Approaches, 219Z117, TÜBİTAK 1001 Project, 15.06.2020- (Continued)
• Direct Connection of New Coated Blade Spray Obtained by Electrospinning Method to Mass Spectrometer for Rapid Clinical Diagnostic Applications, 119Z863, TUBITAK 1001 Project, 01.02.2020- (Continued)
• Comprehensive Analysis of Milk Whey N-Glycoms with MALDI-TOF/TOF-MS Using a Binding-Specific Sialic Acid Esterification Approach and Site-Specific N- and O-Glycosylation Analysis of Milk Whey Proteomes, 218Z139, TÜBİTAK 3501 Project, 01.09.2019 – ( Continues)
• Comprehensive Site-Specific Glycosylation Analyzes of Human Thyroglobulin Protein Using Advanced Mass Spectrometric Methods, 119Z066, TÜBİTAK 1002 Project, 15.12.2019 - (Continued)
• Detection of Phosphorylation Signatures Specific to P110alpha and P110beta Activity from Cancer-Associated Phosphoinositide 3-Kinase Isoforms, 119Z068, TÜBİTAK 1002 Project, 01.10.2019 - (Continued)
• Discovery of New Aptamer-Based Surface Markers in Acute Myeloblastic Leukemia (AML) Disease, 117S275, TÜBİTAK 1001 Project, 15.03.2018 - (Continued)
• Advanced Mass Spectrometry Research Laboratory, 2016 K 121230, Ministry of Development Project, 10.06.2016 – (Continued)
• Development of a Chemical Sensor Based Prototype Device That Can Detect Volatile Markers in Breath Air in Early Stage Lung Cancer Diagnosis and Screening, 115E046, TÜBİTAK 1003 Project, 01.10.2015 - (Continuing)
• Analysis of Pathogenetic Pathways and Determination of Target Therapy Molecules by Differential Mass Spectrometry Based Metabolomic Profiling in Autosomal Recessive Congenital Ichthyosis Cases, TSA-2017-14439, Scientific research project supported by Higher Education Institutions, 22.09.2017 - (Continued)

Completed Projects

• Biomarker Discovery by Mass Spectrometry-Based Metabolomic Profiling for Differential Diagnosis in Patients with Gene Defects in the Lands Lipid Remodeling Pathway, 116S377, TÜBİTAK 3501 PROJECT, 01.07.2017 – 01.10.2019
• Origin and Characterization of Fir, Spruce, Oak and Cedar Secretion Honeys, General Directorate of Forestry, 18.05.2016 – 12.12.2018
• Development of Various Materials and Analytical Methods for Fast and Efficient Analysis of Glycopeptides Using Advanced Mass Spectrometric Techniques, 115Z241, TÜBİTAK 1001 PROJECT, 15.09.2015 – 20.12.2017
• Improvement of Laboratory Infrastructure for Sustainable Mass Spectrometric Studies, FAY-2015-7201, scientific research project supported by Higher Education Institutions, 02.10.2015 – 06.10.2017
• Determination of Ubiquitination Regions of Proteins, FHD-2015-6189, Scientific research project supported by Higher Education Institutions, 29.04.2015 - 28.12.2015
• Selective Enrichment of Sialic Acid Containing Glycopeptides Using Transition Metal Oxides for Fast and Efficient Mass Spectrometric Analysis, 014 D04 601 007-605, Scientific research project supported by Higher Education Institutions, 22.04.2014 – 21.03.2015

Publications

•   E. Çatıker, M. Atakay, B. Salih, Novel ABA–type Block Copolymers from Telechelic PEG–initiated Hydrogen–transfer Polymerization, Soft Mater. 20 (2022) 232–239. https://doi.org/10.1080/1539445X.2021.1996392.
•   A. Ozleyen, Z.O. Cinar, S. Karav, A. Bayraktar, A. Arslan, H.M. Kayili, B. Salih, T.B. Tumer, Biofortified Whey/Deglycosylated Whey and Chickpea Protein Matrices: Functional Enrichment by Black Mulberry Polyphenols, Plant Foods Hum. Nutr. 77 (2022) 51–61. https://doi.org/10.1007/s11130-021-00943-2.
•   M. Nesterkina, D. Barbalat, I. Konovalova, S. Shishkina, M. Atakay, B. Salih, I. Kravchenko, Novel (‒)-carvone derivatives as potential anticonvulsant and analgesic agents, Nat. Prod. Res. 35 (2021) 4978–4987. https://doi.org/10.1080/14786419.2020.1756804.
•   F.K. Eroglu, V. Yazar, U. Guler, M. Yıldırım, T. Yildirim, T. Gungor, E. Celikkaya, D. Karakaya, N. Turay, E. Ciftci Dede, P. Korkusuz, B. Salih, M. Bulbul, I. Gursel, Circulating extracellular vesicles of patients with steroid-sensitive nephrotic syndrome have higher RAC1 and induce recapitulation of nephrotic syndrome phenotype in podocytes, Am. J. Physiol. Physiol. 321 (2021) F659–F673. https://doi.org/10.1152/ajprenal.00097.2021.
•   K. Zeki, E. Lokmacı, E. Doğu, S. Khene, B. Salih, M. Canlıca, Photophysicochemical properties of [Tetrakis 6-(tert-butyl)-2,3-dihydrobenzo [b] [1,4] dioxine) phthalocyaninato] In(III) and Zn(II) with very high singlet oxygen quantum yield, Inorganica Chim. Acta. 527 (2021) 120545. https://doi.org/https://doi.org/10.1016/j.ica.2021.120545.
•   H.M. AU  - Kayili, B. AU  - Salih, N-glycan Profiling of Glycoproteins by Hydrophilic Interaction Liquid Chromatography with Fluorescence and Mass Spectrometric Detection, JoVE. (2021) e62751. https://doi.org/doi:10.3791/62751.
•   M.E. Yaman, I. Avci, N.E. Atila, A. Atila, H.M. Kayili, B. Salih, Characterization of serum N-glycome alterations in seasonal allergic rhinitis using MALDI-TOF-MS: A pilot study, J. Carbohydr. Chem. 40 (2021) 269–282. https://doi.org/10.1080/07328303.2021.2009502.
•   B. AU  - Sucu, A. AU  - Bayraktar, H. AU  - Duman, A. AU  - Arslan, M. AU  - Kaplan, M. AU  - Karyelioğlu, E. AU  - Ntelitze, T. AU  - Taştekin, S. AU  - Yetkin, M. AU  - Ertürk, S.A. AU  - Frese, B.M. AU  - Henrick, H.M. AU  - Kayili, B. AU  - Salih, S. AU  - Karav, Recombinant Production of Bifidobacterial Endoglycosidases for N-glycan Release, JoVE. (2021) e62804. https://doi.org/doi:10.3791/62804.
•   K. Demirelli, A.M. Abubakar, H. Tuncer, B. Salih, Preparation, characterization and electrical behaviors of greenish single-chain polymeric molecule-via intramolecular ball type cobalt phthalocyanines/ graphite oxide composites, J. Mol. Struct. 1235 (2021) 130132. https://doi.org/https://doi.org/10.1016/j.molstruc.2021.130132.
•   A.M. Abubakar, K. Demirelli, H. Tuncer, B. Salih, Characterization and preparation of green colored intramolecular novel ball type cobalt phthalocyanine complexes with single-chain polymer structure, J. Mol. Struct. 1227 (2021) 129389. https://doi.org/https://doi.org/10.1016/j.molstruc.2020.129389.
•   S. Saitarly, Y. Pushkarev, M. Nesterkina, S. Öztürk, B. Salih, I. Kravchenko, Rheological properties of hyaluronic acid diluted solutions as components of cosmetics, Biointerface Res. Appl. Chem. 12 (2022) 1907–1915. https://doi.org/10.33263/BRIAC122.19071915.
•   M.E. Yaman, H.M. Kayili, M. Albayrak, Y. Kadioglu, B. Salih, Differential N-glycosylation profiling of formalin-fixed paraffin-embedded (FFPE) invasive ductal carcinoma tissues using MALDI-TOF-MS, Mol. Omi. 17 (2021) 394–404. https://doi.org/10.1039/D0MO00150C.
•   M.E. Yaman, E. Aladağ, H.M. KAYILI, Y. KADIOĞLU, B. Salih, N-Glycosylation Profiles of the Green Microalgae Chlorella Zofingiensis, Hacettepe J. Biol. Chem. 49 (2021) 147–155.
•   H. Niron, N. Barlas, B. Salih, M. Türet, Comparative Transcriptome, Metabolome, and Ionome Analysis of Two Contrasting Common Bean Genotypes in Saline Conditions   , Front. Plant Sci.  . 11 (2020). https://www.frontiersin.org/article/10.3389/fpls.2020.599501.

•    Bulut, E.A., Kocabas, B.B., Yazar, V., Aykut, G., Guler, U., Salih, B., Yilmaz, N.S., Ayanoglu, I.C., Polat, M.M., Akcali, K.C., Gursel, I., Gursel, M., Human gut commensal membrane vesicles modulate inflammation by generating m2-like macrophages and myeloid-derived suppressor cells, (2020) Journal of Immunology, 205 (10), pp. 2707-2718.
•    Işik Buÿükekşi, S., Karatay, A., Orman, E.B., Acąr Selçuki, N., Özkaya, A., Salih, B., Elmali, A., Şengül, A., A novel AB3-type trimeric zinc(ii)-phthalocyanine as an electrochromic and optical limiting material, (2020) Dalton Transactions, 49 (40), pp. 14068-14080.
•    Çatıker, E., Öztürk, T., Atakay, M., Salih, B., Synthesis and characterization of the ABA-type poly(ester-ether-ester) block copolymers, (2020) Journal of Macromolecular Science, Part A: Pure and Applied Chemistry, 57 (8), pp. 600-609.
•    Çelikbıçak, Ö., Hamaloğlu, K.Ö., Salih, B., Pişkin, E., Following hybridization on sensor/array platforms by using SPR, elipsometer and MALDI-MS, (2020) Nucleosides, Nucleotides and Nucleic Acids, 39 (7), pp. 1057-1072.
•    Yuzbasioglu Baran, M., Guvenalp, Z., Saracoglu, I., Kazaz, C., Salih, B., Demirezer, L.O., Kuruuzum-Uz, A., Cytotoxic naphthoquinones from Arnebia densiflora (Nordm.) Ledeb and determining new apoptosis inducers, (2020) Natural Product Research, 34 (12), pp. 1669-1677.
•    Şenoğlu, S., Özer, M., Dumludağ, F., Acar, N., Salih, B., Bekaroğlu, Ö., Synthesis, characterization, DFT study, conductivity and effects of humidity on CO2 sensing properties of the novel tetrakis-[2-(dibenzylamino)ethoxyl] substituted metallophthalocyanines, (2020) Sensors and Actuators, B: Chemical, 310, art. no. 127860.
•    Molla, F., Yazlcl, A., Selçuki, N.A., Altlndal, A., Salih, B., Bekaroǧlu, Ö., Synthesis, characterization, OFET, and DFT study of the novel ball-type metallophthalocyanines bridged with four diaminopyrimidine-dithiol, (2020) Journal of Porphyrins and Phthalocyanines, 24 (5-7), pp. 662-674.
•    Bayramoglu, G., Salih, B., Arica, M.Y., Catalytic Activity of Immobilized Chymotrypsin on Hybrid Silica-Magnetic Biocompatible Particles and Its Application in Peptide Synthesis, (2020) Applied Biochemistry and Biotechnology, 190 (4), pp. 1224-1241.
•    Atakay, M., Aksakal, F., Bozkaya, U., Salih, B., Wesdemiotis, C., Conformational Characterization of Polyelectrolyte Oligomers and Their Noncovalent Complexes Using Ion Mobility-Mass Spectrometry, (2020) Journal of the American Society for Mass Spectrometry, 31 (2), pp. 441-449.
•    Abubakar, A.M., Demirelli, K., Tuncer, H., Salih, B., Characterization and preparation of green colored intramolecular novel ball type cobalt phthalocyanine complexes with single-chain polymer structure, (2020) Journal of Molecular Structure, art. no. 129389.
•    Ülkü, Ö., Atakay, M., Kohneshahri, M.Y., Uzun, C., Salih, B., Site-Specific characterization of peptide-polymer conjugates in various stoichiometries by MALDI-Tandem mass spectrometry, (2020) Microchemical Journal, 152, art. no. 104467.
•    Bayramoglu, G., Kayili, H.M., Oztekin, M., Salih, B., Arica, M.Y., Hydrophilic spacer-arm containing magnetic nanoparticles for immobilization of proteinase K: Employment for speciation of proteins for mass spectrometry-based analysis, (2020) Talanta, 206, art. no. 120218.
•    Nesterkina, M., Barbalat, D., Konovalova, I., Shishkina, S., Atakay, M., Salih, B., Kravchenko, I., Novel (‒)-carvone derivatives as potential anticonvulsant and analgesic agents, (2020) Natural Product Research.
•    Atakay, M., Kayılı, H.M., Güler, Ü., Salih, B. (2020). Ion Mobility-Mass Spectrometry for Macromolecule Analysis. Applications of Modern Mass Spectrometry Vol. 2, Chapter 3, 1-35 (Kabul Edildi, Basım Aşamasında).
•    Hamaloğlu, K.Ö., Çelikbıçak, Ö., Salih, B., Pişkin, E., Performances of protein array platforms prepared by soft lithography and self-assemblying monolayers-approach by using SPR, ellipsometry and MALDI-MS, (2019) Journal of Molecular Structure, 1198, art. no. 126856.
•    Koçak, Ö.F., Kayili, H.M., Albayrak, M., Yaman, M.E., Kadıoğlu, Y., Salih, B., N-glycan profiling of papillary thyroid carcinoma tissues by MALDI-TOF-MS, (2019) Analytical Biochemistry, 584, art. no. 113389.
•    Kayili, H.M., Ertürk, A.S., Elmacı, G., Salih, B., Poly(amidoamine) dendrimer-coated magnetic nanoparticles for the fast purification and selective enrichment of glycopeptides and glycans, (2019) Journal of Separation Science, 42 (20), pp. 3209-3216.
•    Pekdemir, F., Orman, E.B., Selçuki, N.A., Özkaya, A.R., Salih, B., Şengül, A., Spectroscopic, electrochemical and electrocolorimetric properties of novel 2-(2′-pyridyl)-1H-benzimidazole appended bay-substituted perylene diimide triads, (2019) Journal of Photochemistry and Photobiology A: Chemistry, 379, pp. 54-62.
•    Nesterkina, M., Barbalat, D., Zheltvay, I., Rakipov, I., Atakay, M., Salih, B., Kravchenko, I., (2s,5r)-2-isopropyl-5-methylcyclohexanone hydrazones, (2019) MolBank, 2019 (2), art. no. M1062.
•    Salimi, K., Kip, Ç., Çelikbıçak, Ö., Usta, D.D., Pınar, A., Salih, B., Tuncel, A., Ti (IV) attached-phosphonic acid functionalized capillary monolith as a stationary phase for in-syringe-type fast and robust enrichment of phosphopeptides, (2019) Biomedical Chromatography, 33 (6), art. no. e4488.
•    Canlıca, M., Ömür, B.C., Salih, B., Synthesis, photophysical, photochemical and SO 2 sensing properties of ball-type phthalocyanines substituted with carboxyl groups, (2019) Inorganic Chemistry Communications, 103, pp. 75-81.
•    Çatıker, E., Öztürk, T., Atakay, M., Salih, B., Synthesis and characterization of novel ABA type poly(Ester-ether) triblock copolymers, (2019) Journal of Polymer Research, 26 (5), art. no. 123.
•    Bayramoglu, G., Salih, B., Akbulut, A., Arica, M.Y., Biodegradation of Cibacron Blue 3GA by insolubilized laccase and identification of enzymatic byproduct using MALDI-ToF-MS: Toxicity assessment studies by Daphnia magna and Chlorella vulgaris, (2019) Ecotoxicology and Environmental Safety, 170, pp. 453-460.
•    Çatıker, E., Meyvacı, E., Atakay, M., Salih, B., Öztürk, T., Synthesis and characterization of amphiphilic triblock copolymers including β-alanine/α-methyl-β-alanine and ethylene glycol by “click” chemistry, (2019) Polymer Bulletin, 76 (4), pp. 2113-2128.
•    Şener, S., Tahir Bayraç, A., Bilgenur Şener, B., Tozlu, C., Acar, N., Salih, B., Yüksel, M., Bekaroğlu, Ö., Synthesis, characterization, and DFT study of novel metallo phtalocyanines with four carboranyl clusters as photosensitisers for the photodynamic therapy of breast cancer cells, (2019) European Journal of Pharmaceutical Sciences, 129, pp. 124-131.
•    Şener, S., Selçuki, N.A., Dumludağ, F., Salih, B., Bekaroğlu, Ö., Synthesis, Conductivity, and Impedance Studies on Metallophthalocyanines Formed Across Adjacent Rings, (2019) European Journal of Inorganic Chemistry, 2019 (6), pp. 770-779.
•    Wei, B., Gerislioglu, S., Atakay, M., Salih, B., Wesdemiotis, C., Characterization of supramolecular peptide-polymer bioconjugates using multistage tandem mass spectrometry, (2019) International Journal of Mass Spectrometry, 436, pp. 130-136.
•    Kakl, E., Gögsu, N., Altlndal, A., Salih, B., Bekarolu, O., Synthesis, characterization and VOCs adsorption kinetics of diethylstilbestrol-substituted metallophthalocyanines, (2019) Journal of Porphyrins and Phthalocyanines, 23 (1-2), pp. 166-174.
•    Bayramoglu, G., Ozalp, C., Oztekin, M., Guler, U., Salih, B., Arica, M.Y., Design of an aptamer-based magnetic adsorbent and biosensor systems for selective and sensitive separation and detection of thrombin, (2019) Talanta, 191, pp. 59-66.
•    Çatıker, E., Atakay, M., Salih, B., & Güven, O. (2019). Novel Aliphatic Polyester-Based Macromonomers. Science and Technology of Polymers and Advanced Materials: Applied Research Methods, 135.
•    Bayram, N.E., Sorkun, K., Öz, G.C., Salih, B., Topçu, G., Chemical characterization of 64 propolis samples from hakkari, Turkey, (2018) Records of Natural Products, 12 (6), pp. 569-581.
•    Yabaş, E., Sülü, M., Dumludağ, F., Salih, B., Bekaroğlu, Ö., Imidazole octasubstituted novel mono and double-decker phthalocyanines: Synthesis, characterization, electrical and gas sensing properties, (2018) Polyhedron, 153, pp. 51-63.
•    Ersoy, N., Taşçi, İ., Özgürtaş, T., Salih, B., Doruk, H., Rakicioğlu, N., Effect of seasonal changes on nutritional status and biochemical parameters in Turkish older adults, (2018) Nutrition Research and Practice, 12 (4), pp. 315-323.
•    Günay, İ., Orman, E.B., Altındal, A., Salih, B., Özer, M., Özkaya, A.R., Novel tetrakis 4-(hydroxymethyl)-2,6-dimethoxyphenoxyl substituted metallophthalocyanines: Synthesis, electrochemical redox, electrocatalytic oxygen reducing, and volatile organic compounds sensing and adsorption properties, (2018) Dyes and Pigments, 154, pp. 172-187.
•    Kayili, H.M., Barlas, N., Atakay, M., Salih, B., Fast purification of glycans and glycopeptides using silk-packed micropipette tip for matrix-assisted laser desorption/ionization-mass spectrometry and high-performance liquid chromatography-fluorescence detection analysis, (2018) Microchemical Journal, 139, pp. 492-499.
•    Stavenhagen, K., Kayili, H.M., Holst, S., Koeleman, C.A.M., Engel, R., Wouters, D., Zeerleder, S., Salih, B., Wuhrer, M., N- and O-glycosylation Analysis of Human C1-inhibitor Reveals Extensive Mucin-type O-Glycosylation*□S, (2018) Molecular and Cellular Proteomics, 17 (6), pp. 1225-1238.
•    Atakay, M., Çelikbıçak, Ö., Salih, B., Use of Sulfonates as Desorption Agents for Phosphopeptide Elution from an Anion-exchange Material, (2018) Analytical Letters, 51 (5), pp. 760-772.
•    Çatıker, E., Güven, O., Salih, B., Novel hydrophobic macromonomers for potential amphiphilic block copolymers, (2018) Polymer Bulletin, 75 (1), pp. 47-60.
•    Yazlcl, A., Avcl, A., Altlndal, A., Salih, B., Bekaroǧlu, O., Synthesis, characterization and OFET property of four diaminouracil bridged novel ball-type phthalocyanines, (2018) Journal of Porphyrins and Phthalocyanines, 22 (1-3), pp. 149-156.
•    Arica, M.Y., Salih, B., Celikbicak, O., Bayramoglu, G., Immobilization of laccase on the fibrous polymer-grafted film and study of textile dye degradation by MALDI–ToF-MS, (2017) Chemical Engineering Research and Design, 128, pp. 107-119.
•    Salimi, K., Usta, D.D., Çelikbıçak, Ö., Pınar, A., Salih, B., Tuncel, A., Highly selective enrichment of phosphopeptides by titanium (IV) attached monodisperse-porous poly(vinylphosphonic acid-co-ethylene dimethacrylate) microspheres, (2017) Journal of Chromatography A, 1496, pp. 9-19.
•    Salimi, K., Usta, D.D., Çelikbıçak, Ö., Pinar, A., Salih, B., Tuncel, A., Ti(IV) carrying polydopamine-coated, monodisperse-porous SiO2 microspheres with stable magnetic properties for highly selective enrichment of phosphopeptides, (2017) Colloids and Surfaces B: Biointerfaces, 153, pp. 280-290.
•    Koçyiğit, N., Özen, Ü.E., Özer, M., Salih, B., Özkaya, A.R., Bekaroğlu, Ö., Electrocatalytic Activity of Novel Ball-Type Metallophthalocyanines with Trifluoro Methyl Linkages in Oxygen Reduction Reaction and Application as Zn-Air Battery Cathode Catalyst, (2017) Electrochimica Acta, 233, pp. 237-248.
•    Akıllıoğlu, H.G., Çelikbıçak, Ö., Salih, B., Gökmen, V., Monitoring protein glycation by electrospray ionization (ESI) quadrupole time-of-flight (Q-TOF) mass spectrometer, (2017) Food Chemistry, 217, pp. 65-73.
•    Sen, P., Yildiz, S.Z., Dege, N., Atakay, M., Salih, B., Functional Substituted Phthalocyanines Bearing Ter–pyridine Complexes as Macromolecular Oxidation Catalysts for Bleaching Systems, (2017) ChemistrySelect, 2 (9), pp. 2643-2650.
•    Kayili, H. M., Atakay, M., & Salih, B. (2017). Sol‐Gel Materials Used in Phosphoproteomics and Glycoproteomics Applications. In Recent Applications in Sol-Gel Synthesis. InTech.
•    Patir, S., Tezeren, M.A., Salih, B., Ertürk, E., Stereoselective Total Synthesis of (±)-Dasycarpidol and (±)-Dasycarpidone, (2016) Synthesis (Germany), 48 (23), art. no. ss-2016-n0374-op, pp. 4175-4180.
•    Kayili, H.M., Salih, B., Fast and efficient proteolysis by reusable pepsin-encapsulated magnetic sol-gel material for mass spectrometry-based proteomics applications, (2016) Talanta, 155, pp. 78-86.
•    Doǧan, E., Özer, M., Altlndal, A., Özkaya, A.R., Salih, B., Bekaroǧlu, Ö., Novel 4,4′-{(diphenylmethylene) bis(4,1-phenylene)bis(oxy)}-bridged ball-type phthalocyanines: Electrochemical, electrocatalytic oxygen reducing and heavy metals ions sensing properties, (2016) Journal of Porphyrins and Phthalocyanines, 20 (8-11), pp. 1319-1333.
•    Dündar, H., Salih, B., Bozoğlu, F., Purification and characterization of a bacteriocin from an oenological strain of Leuconostoc mesenteroides subsp. Cremoris, (2016) Preparative Biochemistry and Biotechnology, 46 (4), pp. 354-359.
•    Bayramoglu, G., Arica, M.Y., Liman, G., Celikbicak, O., Salih, B., Removal of bisphenol A from aqueous medium using molecularly surface imprinted microbeads, (2016) Chemosphere, 150, pp. 275-284.
•    Yazici, A., Dalbul, N., Altindal, A., Salih, B., Bekaroʇlu, Ö., Partition coefficient-Lewis basicity correlation in four dioxycyclobutenedion-bridged novel ball-type phthalocyanines, (2016) Synthetic Metals, 212, pp. 25-30.
•    Dündar, H., Atakay, M., Çelikbçak, O., Salih, B., Bozoʇlu, F., Comparison of Two Methods for Purification of Enterocin B, a Bacteriocin Produced by Enterococcus faecium W3, (2015) Preparative Biochemistry and Biotechnology, 45 (8), pp. 796-809.
•    Guvenalp, Z., Ozbek, H., Karadayi, M., Gulluce, M., Kuruuzum-Uz, A., Salih, B., Demirezer, O., Two antigenotoxic chalcone glycosides from Mentha longifolia subsp. Longifolia, (2015) Pharmaceutical Biology, 53 (6), pp. 888-896.
•    Kavruk, M., Celikbicak, O., Ozalp, V.C., Borsa, B.A., Hernandez, F.J., Bayramoglu, G., Salih, B., Arica, M.Y., Antibiotic loaded nanocapsules functionalized with aptamer gates for targeted destruction of pathogens, (2015) Chemical Communications, 51 (40), pp. 8492-8495.
•    Kaki, E., Altindal, A., Salih, B., Bekaroʇlu, O., Synthesis, characterization and gas sensing properties of novel homo and hetero dinuclear ball-type phthalocyanines, (2015) Dalton Transactions, 44 (17), pp. 8293-8299.
•    Bayramoglu, G., Ozalp, V.C., Yilmaz, M., Guler, U., Salih, B., Arica, M.Y., Lysozyme specific aptamer immobilized MCM-41 silicate for single-step purification and quartz crystal microbalance (QCM)-based determination of lysozyme from chicken egg White, (2015) Microporous and Mesoporous Materials, 207, pp. 95-104.
•    Yazici, A., Sariçiçek, B., Altindal, A., Salih, B., Bekaroʇlu, Ö., Synthesis and characterization, electrical and gas sensing properties of N,N′-bis(salicylidene)-1,2-phenylendiamine substituted novel mono and ball-type metallo phthalocyanines, (2015) Inorganica Chimica Acta, 428, pp. 83-92.
•    Pekdemir, F., Kurnali, S., Şengül, A., Altindal, A., Riza Özkaya, A., Salih, B., Bekaroʇlu, O., A conformationally stressed novel ball-type perylenediimide appended zinc(ii)phthalocyanine hybrid: Spectroelectrochemical, electrocolorimetric and photovoltaic properties, (2015) Dalton Transactions, 44 (1), pp. 158-166.

Links

Prof. Dr. Bekir SALİH: GoogleScholar, AVESİS, TÜBA, ORCID, SCOPUS

Asst. Prof. Mehmet ATAKAY: GoogleScholar, AVESİS, ORCID, SCOPUS

Res. Asst. Dr. Ülkü GÜLER: GoogleScholar, AVESİS, ORCID, SCOPUS

Res. Asst. Emre BİROL: AVESİS

 

Website
sareglab.org

 

About

Mass Spectrometry is a dynamic and continually evolving discipline which covers worldwide discoveries and plays an integral role to understand the world around us. Our primary aim is to train young scientists who can reach the increasing rate of today’s science and technology.

Research Infrastructure

If you wish to see images in high resolution, you can right click on images and use "Open image in new tab" button.

 

 

 

Matrix Assisted Laser Desorption Ionizing – Time of Flight Mass Spectrometer (MALDI-TOF/TOF MS) (Bruker Daltonics, Rapiflex)

 

 

 

 

 

 


Matrix Assisted Laser Desorption Ionization – Time of Flight Mass Spectrometer (MALDI-TOF MS) (Applied Biosystems,Voyager DePro)

 

 

 

 

Nano Electrospray Ionizing Hybrid Quadrupole-Orbitrap Mass Spectrometer (Thermo Scientific, Q-Exactive Plus Hybrid Quadrupole-Orbitrap MS)

 

 

 

Electrospray Ionization - Quadrupole / Time of Flight Mass Spectrometer (ESI-QTOF-MS) (Agilent Technologies 6530 ESI-QTOF-MS)

 

 

 

 

 

MALDI plate sample preparation device with micro fraction collection (SunChrom)

 

 

 

 

Enzymatic lysis incubation unit (SunChrom)

 

 

 

 


• Nano Electrospray Ionization Trapped Ion Mobility – Time of Flight Mass Spectrometer (TIMS-TOF-MS) (Bruker Daltonics)
• Liquid chromatography providing nanoscale flow (Thermo Scientific, UltiMate 3000 RSLCnano System) (2 pcs)
• High Pressure Liquid Chromatography (Agilent 1200 HPLC) (with fraction collection unit)
• HPLC-Chip Cube (Agilent 1260)
• Capillary Electrophoresis Device (Agilent 7100 CE)
• Fluorescence and UV-DAD detectors (Agilent)
• Gas chromatography – mass spectrometry (GC-MS) and gas chromatography (GC-ECD) system with Electron capture detector, gas-trapped thermal desorber front probe
• Curie Point Flash Pyrolyzer-GC-MS (gas chromatography with fast pyrolysis unit) system
• Solid probe - mass spectrometry (Direct Insertion Probe – MS)
• Flame atomic absorption spectrophotometer (FAAS)
• One and two dimensional separable polyacrylamide gel electrophoresis system (SDS-PAGE and 2D-PAGE)
• UV/ Visible Spectrophotometer
• Vacuum Quick Dryer (Speedvac)
• Vacuum Oven
• Lyophilizer
• Heated Mixer (Thermomixer)
• Ultra pure water system
• Ultrasonic Bath
• Shaking water bath with adjustable temperature
• Refrigerated Centrifuge System
• Microelectrode pH meter
• Precision analytical balance
• Vertical type -80 ̊C 80 L deep freezer
• Refrigerators with deep freezer (-20 oC and +4 oC) (2 units)

Researchers

Faculty Members
•    Prof. Dr. Bekir Salih
•    Asst. Prof. Üyesi Mehmet Atakay
•    Res. Asst. Dr. Ülkü Güler
•    Res. Asst. Emre Birol

Students (PhD)
•    Ayşegül Özgen
•    Serhat Öztürk
•    Marwa Abu Aisheh  
•    Buse Varlıoğlu
•    İzzet Avcı
•    Hacer Dağaşan

Students (Msc.)
•    Buse Aklar
•    Buğra Balaban
•    Sema Baltacı

Ongoing Projects

• Development of New Generation Ion Mobility-Mass Spectrometry Analysis Methods for Conformational Analysis of Monoclonal Antibody Based Biotech Drugs, 120Z532, TÜBİTAK 1001 Project, (2020-Continuing)
• Determination of Changes in Basic Components of Milk in Kefir Fermentation and Storage Processes Using Mass Spectrometry-Based Omic-Approaches, 219Z117, TÜBİTAK 1001 Project, 15.06.2020- (Continued)
• Direct Connection of New Coated Blade Spray Obtained by Electrospinning Method to Mass Spectrometer for Rapid Clinical Diagnostic Applications, 119Z863, TUBITAK 1001 Project, 01.02.2020- (Continued)
• Comprehensive Analysis of Milk Whey N-Glycoms with MALDI-TOF/TOF-MS Using a Binding-Specific Sialic Acid Esterification Approach and Site-Specific N- and O-Glycosylation Analysis of Milk Whey Proteomes, 218Z139, TÜBİTAK 3501 Project, 01.09.2019 – ( Continues)
• Comprehensive Site-Specific Glycosylation Analyzes of Human Thyroglobulin Protein Using Advanced Mass Spectrometric Methods, 119Z066, TÜBİTAK 1002 Project, 15.12.2019 - (Continued)
• Detection of Phosphorylation Signatures Specific to P110alpha and P110beta Activity from Cancer-Associated Phosphoinositide 3-Kinase Isoforms, 119Z068, TÜBİTAK 1002 Project, 01.10.2019 - (Continued)
• Discovery of New Aptamer-Based Surface Markers in Acute Myeloblastic Leukemia (AML) Disease, 117S275, TÜBİTAK 1001 Project, 15.03.2018 - (Continued)
• Advanced Mass Spectrometry Research Laboratory, 2016 K 121230, Ministry of Development Project, 10.06.2016 – (Continued)
• Development of a Chemical Sensor Based Prototype Device That Can Detect Volatile Markers in Breath Air in Early Stage Lung Cancer Diagnosis and Screening, 115E046, TÜBİTAK 1003 Project, 01.10.2015 - (Continuing)
• Analysis of Pathogenetic Pathways and Determination of Target Therapy Molecules by Differential Mass Spectrometry Based Metabolomic Profiling in Autosomal Recessive Congenital Ichthyosis Cases, TSA-2017-14439, Scientific research project supported by Higher Education Institutions, 22.09.2017 - (Continued)

Completed Projects

• Biomarker Discovery by Mass Spectrometry-Based Metabolomic Profiling for Differential Diagnosis in Patients with Gene Defects in the Lands Lipid Remodeling Pathway, 116S377, TÜBİTAK 3501 PROJECT, 01.07.2017 – 01.10.2019
• Origin and Characterization of Fir, Spruce, Oak and Cedar Secretion Honeys, General Directorate of Forestry, 18.05.2016 – 12.12.2018
• Development of Various Materials and Analytical Methods for Fast and Efficient Analysis of Glycopeptides Using Advanced Mass Spectrometric Techniques, 115Z241, TÜBİTAK 1001 PROJECT, 15.09.2015 – 20.12.2017
• Improvement of Laboratory Infrastructure for Sustainable Mass Spectrometric Studies, FAY-2015-7201, scientific research project supported by Higher Education Institutions, 02.10.2015 – 06.10.2017
• Determination of Ubiquitination Regions of Proteins, FHD-2015-6189, Scientific research project supported by Higher Education Institutions, 29.04.2015 - 28.12.2015
• Selective Enrichment of Sialic Acid Containing Glycopeptides Using Transition Metal Oxides for Fast and Efficient Mass Spectrometric Analysis, 014 D04 601 007-605, Scientific research project supported by Higher Education Institutions, 22.04.2014 – 21.03.2015

Publications

•   E. Çatıker, M. Atakay, B. Salih, Novel ABA–type Block Copolymers from Telechelic PEG–initiated Hydrogen–transfer Polymerization, Soft Mater. 20 (2022) 232–239. https://doi.org/10.1080/1539445X.2021.1996392.
•   A. Ozleyen, Z.O. Cinar, S. Karav, A. Bayraktar, A. Arslan, H.M. Kayili, B. Salih, T.B. Tumer, Biofortified Whey/Deglycosylated Whey and Chickpea Protein Matrices: Functional Enrichment by Black Mulberry Polyphenols, Plant Foods Hum. Nutr. 77 (2022) 51–61. https://doi.org/10.1007/s11130-021-00943-2.
•   M. Nesterkina, D. Barbalat, I. Konovalova, S. Shishkina, M. Atakay, B. Salih, I. Kravchenko, Novel (‒)-carvone derivatives as potential anticonvulsant and analgesic agents, Nat. Prod. Res. 35 (2021) 4978–4987. https://doi.org/10.1080/14786419.2020.1756804.
•   F.K. Eroglu, V. Yazar, U. Guler, M. Yıldırım, T. Yildirim, T. Gungor, E. Celikkaya, D. Karakaya, N. Turay, E. Ciftci Dede, P. Korkusuz, B. Salih, M. Bulbul, I. Gursel, Circulating extracellular vesicles of patients with steroid-sensitive nephrotic syndrome have higher RAC1 and induce recapitulation of nephrotic syndrome phenotype in podocytes, Am. J. Physiol. Physiol. 321 (2021) F659–F673. https://doi.org/10.1152/ajprenal.00097.2021.
•   K. Zeki, E. Lokmacı, E. Doğu, S. Khene, B. Salih, M. Canlıca, Photophysicochemical properties of [Tetrakis 6-(tert-butyl)-2,3-dihydrobenzo [b] [1,4] dioxine) phthalocyaninato] In(III) and Zn(II) with very high singlet oxygen quantum yield, Inorganica Chim. Acta. 527 (2021) 120545. https://doi.org/https://doi.org/10.1016/j.ica.2021.120545.
•   H.M. AU  - Kayili, B. AU  - Salih, N-glycan Profiling of Glycoproteins by Hydrophilic Interaction Liquid Chromatography with Fluorescence and Mass Spectrometric Detection, JoVE. (2021) e62751. https://doi.org/doi:10.3791/62751.
•   M.E. Yaman, I. Avci, N.E. Atila, A. Atila, H.M. Kayili, B. Salih, Characterization of serum N-glycome alterations in seasonal allergic rhinitis using MALDI-TOF-MS: A pilot study, J. Carbohydr. Chem. 40 (2021) 269–282. https://doi.org/10.1080/07328303.2021.2009502.
•   B. AU  - Sucu, A. AU  - Bayraktar, H. AU  - Duman, A. AU  - Arslan, M. AU  - Kaplan, M. AU  - Karyelioğlu, E. AU  - Ntelitze, T. AU  - Taştekin, S. AU  - Yetkin, M. AU  - Ertürk, S.A. AU  - Frese, B.M. AU  - Henrick, H.M. AU  - Kayili, B. AU  - Salih, S. AU  - Karav, Recombinant Production of Bifidobacterial Endoglycosidases for N-glycan Release, JoVE. (2021) e62804. https://doi.org/doi:10.3791/62804.
•   K. Demirelli, A.M. Abubakar, H. Tuncer, B. Salih, Preparation, characterization and electrical behaviors of greenish single-chain polymeric molecule-via intramolecular ball type cobalt phthalocyanines/ graphite oxide composites, J. Mol. Struct. 1235 (2021) 130132. https://doi.org/https://doi.org/10.1016/j.molstruc.2021.130132.
•   A.M. Abubakar, K. Demirelli, H. Tuncer, B. Salih, Characterization and preparation of green colored intramolecular novel ball type cobalt phthalocyanine complexes with single-chain polymer structure, J. Mol. Struct. 1227 (2021) 129389. https://doi.org/https://doi.org/10.1016/j.molstruc.2020.129389.
•   S. Saitarly, Y. Pushkarev, M. Nesterkina, S. Öztürk, B. Salih, I. Kravchenko, Rheological properties of hyaluronic acid diluted solutions as components of cosmetics, Biointerface Res. Appl. Chem. 12 (2022) 1907–1915. https://doi.org/10.33263/BRIAC122.19071915.
•   M.E. Yaman, H.M. Kayili, M. Albayrak, Y. Kadioglu, B. Salih, Differential N-glycosylation profiling of formalin-fixed paraffin-embedded (FFPE) invasive ductal carcinoma tissues using MALDI-TOF-MS, Mol. Omi. 17 (2021) 394–404. https://doi.org/10.1039/D0MO00150C.
•   M.E. Yaman, E. Aladağ, H.M. KAYILI, Y. KADIOĞLU, B. Salih, N-Glycosylation Profiles of the Green Microalgae Chlorella Zofingiensis, Hacettepe J. Biol. Chem. 49 (2021) 147–155.
•   H. Niron, N. Barlas, B. Salih, M. Türet, Comparative Transcriptome, Metabolome, and Ionome Analysis of Two Contrasting Common Bean Genotypes in Saline Conditions   , Front. Plant Sci.  . 11 (2020). https://www.frontiersin.org/article/10.3389/fpls.2020.599501.

•    Bulut, E.A., Kocabas, B.B., Yazar, V., Aykut, G., Guler, U., Salih, B., Yilmaz, N.S., Ayanoglu, I.C., Polat, M.M., Akcali, K.C., Gursel, I., Gursel, M., Human gut commensal membrane vesicles modulate inflammation by generating m2-like macrophages and myeloid-derived suppressor cells, (2020) Journal of Immunology, 205 (10), pp. 2707-2718.
•    Işik Buÿükekşi, S., Karatay, A., Orman, E.B., Acąr Selçuki, N., Özkaya, A., Salih, B., Elmali, A., Şengül, A., A novel AB3-type trimeric zinc(ii)-phthalocyanine as an electrochromic and optical limiting material, (2020) Dalton Transactions, 49 (40), pp. 14068-14080.
•    Çatıker, E., Öztürk, T., Atakay, M., Salih, B., Synthesis and characterization of the ABA-type poly(ester-ether-ester) block copolymers, (2020) Journal of Macromolecular Science, Part A: Pure and Applied Chemistry, 57 (8), pp. 600-609.
•    Çelikbıçak, Ö., Hamaloğlu, K.Ö., Salih, B., Pişkin, E., Following hybridization on sensor/array platforms by using SPR, elipsometer and MALDI-MS, (2020) Nucleosides, Nucleotides and Nucleic Acids, 39 (7), pp. 1057-1072.
•    Yuzbasioglu Baran, M., Guvenalp, Z., Saracoglu, I., Kazaz, C., Salih, B., Demirezer, L.O., Kuruuzum-Uz, A., Cytotoxic naphthoquinones from Arnebia densiflora (Nordm.) Ledeb and determining new apoptosis inducers, (2020) Natural Product Research, 34 (12), pp. 1669-1677.
•    Şenoğlu, S., Özer, M., Dumludağ, F., Acar, N., Salih, B., Bekaroğlu, Ö., Synthesis, characterization, DFT study, conductivity and effects of humidity on CO2 sensing properties of the novel tetrakis-[2-(dibenzylamino)ethoxyl] substituted metallophthalocyanines, (2020) Sensors and Actuators, B: Chemical, 310, art. no. 127860.
•    Molla, F., Yazlcl, A., Selçuki, N.A., Altlndal, A., Salih, B., Bekaroǧlu, Ö., Synthesis, characterization, OFET, and DFT study of the novel ball-type metallophthalocyanines bridged with four diaminopyrimidine-dithiol, (2020) Journal of Porphyrins and Phthalocyanines, 24 (5-7), pp. 662-674.
•    Bayramoglu, G., Salih, B., Arica, M.Y., Catalytic Activity of Immobilized Chymotrypsin on Hybrid Silica-Magnetic Biocompatible Particles and Its Application in Peptide Synthesis, (2020) Applied Biochemistry and Biotechnology, 190 (4), pp. 1224-1241.
•    Atakay, M., Aksakal, F., Bozkaya, U., Salih, B., Wesdemiotis, C., Conformational Characterization of Polyelectrolyte Oligomers and Their Noncovalent Complexes Using Ion Mobility-Mass Spectrometry, (2020) Journal of the American Society for Mass Spectrometry, 31 (2), pp. 441-449.
•    Abubakar, A.M., Demirelli, K., Tuncer, H., Salih, B., Characterization and preparation of green colored intramolecular novel ball type cobalt phthalocyanine complexes with single-chain polymer structure, (2020) Journal of Molecular Structure, art. no. 129389.
•    Ülkü, Ö., Atakay, M., Kohneshahri, M.Y., Uzun, C., Salih, B., Site-Specific characterization of peptide-polymer conjugates in various stoichiometries by MALDI-Tandem mass spectrometry, (2020) Microchemical Journal, 152, art. no. 104467.
•    Bayramoglu, G., Kayili, H.M., Oztekin, M., Salih, B., Arica, M.Y., Hydrophilic spacer-arm containing magnetic nanoparticles for immobilization of proteinase K: Employment for speciation of proteins for mass spectrometry-based analysis, (2020) Talanta, 206, art. no. 120218.
•    Nesterkina, M., Barbalat, D., Konovalova, I., Shishkina, S., Atakay, M., Salih, B., Kravchenko, I., Novel (‒)-carvone derivatives as potential anticonvulsant and analgesic agents, (2020) Natural Product Research.
•    Atakay, M., Kayılı, H.M., Güler, Ü., Salih, B. (2020). Ion Mobility-Mass Spectrometry for Macromolecule Analysis. Applications of Modern Mass Spectrometry Vol. 2, Chapter 3, 1-35 (Kabul Edildi, Basım Aşamasında).
•    Hamaloğlu, K.Ö., Çelikbıçak, Ö., Salih, B., Pişkin, E., Performances of protein array platforms prepared by soft lithography and self-assemblying monolayers-approach by using SPR, ellipsometry and MALDI-MS, (2019) Journal of Molecular Structure, 1198, art. no. 126856.
•    Koçak, Ö.F., Kayili, H.M., Albayrak, M., Yaman, M.E., Kadıoğlu, Y., Salih, B., N-glycan profiling of papillary thyroid carcinoma tissues by MALDI-TOF-MS, (2019) Analytical Biochemistry, 584, art. no. 113389.
•    Kayili, H.M., Ertürk, A.S., Elmacı, G., Salih, B., Poly(amidoamine) dendrimer-coated magnetic nanoparticles for the fast purification and selective enrichment of glycopeptides and glycans, (2019) Journal of Separation Science, 42 (20), pp. 3209-3216.
•    Pekdemir, F., Orman, E.B., Selçuki, N.A., Özkaya, A.R., Salih, B., Şengül, A., Spectroscopic, electrochemical and electrocolorimetric properties of novel 2-(2′-pyridyl)-1H-benzimidazole appended bay-substituted perylene diimide triads, (2019) Journal of Photochemistry and Photobiology A: Chemistry, 379, pp. 54-62.
•    Nesterkina, M., Barbalat, D., Zheltvay, I., Rakipov, I., Atakay, M., Salih, B., Kravchenko, I., (2s,5r)-2-isopropyl-5-methylcyclohexanone hydrazones, (2019) MolBank, 2019 (2), art. no. M1062.
•    Salimi, K., Kip, Ç., Çelikbıçak, Ö., Usta, D.D., Pınar, A., Salih, B., Tuncel, A., Ti (IV) attached-phosphonic acid functionalized capillary monolith as a stationary phase for in-syringe-type fast and robust enrichment of phosphopeptides, (2019) Biomedical Chromatography, 33 (6), art. no. e4488.
•    Canlıca, M., Ömür, B.C., Salih, B., Synthesis, photophysical, photochemical and SO 2 sensing properties of ball-type phthalocyanines substituted with carboxyl groups, (2019) Inorganic Chemistry Communications, 103, pp. 75-81.
•    Çatıker, E., Öztürk, T., Atakay, M., Salih, B., Synthesis and characterization of novel ABA type poly(Ester-ether) triblock copolymers, (2019) Journal of Polymer Research, 26 (5), art. no. 123.
•    Bayramoglu, G., Salih, B., Akbulut, A., Arica, M.Y., Biodegradation of Cibacron Blue 3GA by insolubilized laccase and identification of enzymatic byproduct using MALDI-ToF-MS: Toxicity assessment studies by Daphnia magna and Chlorella vulgaris, (2019) Ecotoxicology and Environmental Safety, 170, pp. 453-460.
•    Çatıker, E., Meyvacı, E., Atakay, M., Salih, B., Öztürk, T., Synthesis and characterization of amphiphilic triblock copolymers including β-alanine/α-methyl-β-alanine and ethylene glycol by “click” chemistry, (2019) Polymer Bulletin, 76 (4), pp. 2113-2128.
•    Şener, S., Tahir Bayraç, A., Bilgenur Şener, B., Tozlu, C., Acar, N., Salih, B., Yüksel, M., Bekaroğlu, Ö., Synthesis, characterization, and DFT study of novel metallo phtalocyanines with four carboranyl clusters as photosensitisers for the photodynamic therapy of breast cancer cells, (2019) European Journal of Pharmaceutical Sciences, 129, pp. 124-131.
•    Şener, S., Selçuki, N.A., Dumludağ, F., Salih, B., Bekaroğlu, Ö., Synthesis, Conductivity, and Impedance Studies on Metallophthalocyanines Formed Across Adjacent Rings, (2019) European Journal of Inorganic Chemistry, 2019 (6), pp. 770-779.
•    Wei, B., Gerislioglu, S., Atakay, M., Salih, B., Wesdemiotis, C., Characterization of supramolecular peptide-polymer bioconjugates using multistage tandem mass spectrometry, (2019) International Journal of Mass Spectrometry, 436, pp. 130-136.
•    Kakl, E., Gögsu, N., Altlndal, A., Salih, B., Bekarolu, O., Synthesis, characterization and VOCs adsorption kinetics of diethylstilbestrol-substituted metallophthalocyanines, (2019) Journal of Porphyrins and Phthalocyanines, 23 (1-2), pp. 166-174.
•    Bayramoglu, G., Ozalp, C., Oztekin, M., Guler, U., Salih, B., Arica, M.Y., Design of an aptamer-based magnetic adsorbent and biosensor systems for selective and sensitive separation and detection of thrombin, (2019) Talanta, 191, pp. 59-66.
•    Çatıker, E., Atakay, M., Salih, B., & Güven, O. (2019). Novel Aliphatic Polyester-Based Macromonomers. Science and Technology of Polymers and Advanced Materials: Applied Research Methods, 135.
•    Bayram, N.E., Sorkun, K., Öz, G.C., Salih, B., Topçu, G., Chemical characterization of 64 propolis samples from hakkari, Turkey, (2018) Records of Natural Products, 12 (6), pp. 569-581.
•    Yabaş, E., Sülü, M., Dumludağ, F., Salih, B., Bekaroğlu, Ö., Imidazole octasubstituted novel mono and double-decker phthalocyanines: Synthesis, characterization, electrical and gas sensing properties, (2018) Polyhedron, 153, pp. 51-63.
•    Ersoy, N., Taşçi, İ., Özgürtaş, T., Salih, B., Doruk, H., Rakicioğlu, N., Effect of seasonal changes on nutritional status and biochemical parameters in Turkish older adults, (2018) Nutrition Research and Practice, 12 (4), pp. 315-323.
•    Günay, İ., Orman, E.B., Altındal, A., Salih, B., Özer, M., Özkaya, A.R., Novel tetrakis 4-(hydroxymethyl)-2,6-dimethoxyphenoxyl substituted metallophthalocyanines: Synthesis, electrochemical redox, electrocatalytic oxygen reducing, and volatile organic compounds sensing and adsorption properties, (2018) Dyes and Pigments, 154, pp. 172-187.
•    Kayili, H.M., Barlas, N., Atakay, M., Salih, B., Fast purification of glycans and glycopeptides using silk-packed micropipette tip for matrix-assisted laser desorption/ionization-mass spectrometry and high-performance liquid chromatography-fluorescence detection analysis, (2018) Microchemical Journal, 139, pp. 492-499.
•    Stavenhagen, K., Kayili, H.M., Holst, S., Koeleman, C.A.M., Engel, R., Wouters, D., Zeerleder, S., Salih, B., Wuhrer, M., N- and O-glycosylation Analysis of Human C1-inhibitor Reveals Extensive Mucin-type O-Glycosylation*□S, (2018) Molecular and Cellular Proteomics, 17 (6), pp. 1225-1238.
•    Atakay, M., Çelikbıçak, Ö., Salih, B., Use of Sulfonates as Desorption Agents for Phosphopeptide Elution from an Anion-exchange Material, (2018) Analytical Letters, 51 (5), pp. 760-772.
•    Çatıker, E., Güven, O., Salih, B., Novel hydrophobic macromonomers for potential amphiphilic block copolymers, (2018) Polymer Bulletin, 75 (1), pp. 47-60.
•    Yazlcl, A., Avcl, A., Altlndal, A., Salih, B., Bekaroǧlu, O., Synthesis, characterization and OFET property of four diaminouracil bridged novel ball-type phthalocyanines, (2018) Journal of Porphyrins and Phthalocyanines, 22 (1-3), pp. 149-156.
•    Arica, M.Y., Salih, B., Celikbicak, O., Bayramoglu, G., Immobilization of laccase on the fibrous polymer-grafted film and study of textile dye degradation by MALDI–ToF-MS, (2017) Chemical Engineering Research and Design, 128, pp. 107-119.
•    Salimi, K., Usta, D.D., Çelikbıçak, Ö., Pınar, A., Salih, B., Tuncel, A., Highly selective enrichment of phosphopeptides by titanium (IV) attached monodisperse-porous poly(vinylphosphonic acid-co-ethylene dimethacrylate) microspheres, (2017) Journal of Chromatography A, 1496, pp. 9-19.
•    Salimi, K., Usta, D.D., Çelikbıçak, Ö., Pinar, A., Salih, B., Tuncel, A., Ti(IV) carrying polydopamine-coated, monodisperse-porous SiO2 microspheres with stable magnetic properties for highly selective enrichment of phosphopeptides, (2017) Colloids and Surfaces B: Biointerfaces, 153, pp. 280-290.
•    Koçyiğit, N., Özen, Ü.E., Özer, M., Salih, B., Özkaya, A.R., Bekaroğlu, Ö., Electrocatalytic Activity of Novel Ball-Type Metallophthalocyanines with Trifluoro Methyl Linkages in Oxygen Reduction Reaction and Application as Zn-Air Battery Cathode Catalyst, (2017) Electrochimica Acta, 233, pp. 237-248.
•    Akıllıoğlu, H.G., Çelikbıçak, Ö., Salih, B., Gökmen, V., Monitoring protein glycation by electrospray ionization (ESI) quadrupole time-of-flight (Q-TOF) mass spectrometer, (2017) Food Chemistry, 217, pp. 65-73.
•    Sen, P., Yildiz, S.Z., Dege, N., Atakay, M., Salih, B., Functional Substituted Phthalocyanines Bearing Ter–pyridine Complexes as Macromolecular Oxidation Catalysts for Bleaching Systems, (2017) ChemistrySelect, 2 (9), pp. 2643-2650.
•    Kayili, H. M., Atakay, M., & Salih, B. (2017). Sol‐Gel Materials Used in Phosphoproteomics and Glycoproteomics Applications. In Recent Applications in Sol-Gel Synthesis. InTech.
•    Patir, S., Tezeren, M.A., Salih, B., Ertürk, E., Stereoselective Total Synthesis of (±)-Dasycarpidol and (±)-Dasycarpidone, (2016) Synthesis (Germany), 48 (23), art. no. ss-2016-n0374-op, pp. 4175-4180.
•    Kayili, H.M., Salih, B., Fast and efficient proteolysis by reusable pepsin-encapsulated magnetic sol-gel material for mass spectrometry-based proteomics applications, (2016) Talanta, 155, pp. 78-86.
•    Doǧan, E., Özer, M., Altlndal, A., Özkaya, A.R., Salih, B., Bekaroǧlu, Ö., Novel 4,4′-{(diphenylmethylene) bis(4,1-phenylene)bis(oxy)}-bridged ball-type phthalocyanines: Electrochemical, electrocatalytic oxygen reducing and heavy metals ions sensing properties, (2016) Journal of Porphyrins and Phthalocyanines, 20 (8-11), pp. 1319-1333.
•    Dündar, H., Salih, B., Bozoğlu, F., Purification and characterization of a bacteriocin from an oenological strain of Leuconostoc mesenteroides subsp. Cremoris, (2016) Preparative Biochemistry and Biotechnology, 46 (4), pp. 354-359.
•    Bayramoglu, G., Arica, M.Y., Liman, G., Celikbicak, O., Salih, B., Removal of bisphenol A from aqueous medium using molecularly surface imprinted microbeads, (2016) Chemosphere, 150, pp. 275-284.
•    Yazici, A., Dalbul, N., Altindal, A., Salih, B., Bekaroʇlu, Ö., Partition coefficient-Lewis basicity correlation in four dioxycyclobutenedion-bridged novel ball-type phthalocyanines, (2016) Synthetic Metals, 212, pp. 25-30.
•    Dündar, H., Atakay, M., Çelikbçak, O., Salih, B., Bozoʇlu, F., Comparison of Two Methods for Purification of Enterocin B, a Bacteriocin Produced by Enterococcus faecium W3, (2015) Preparative Biochemistry and Biotechnology, 45 (8), pp. 796-809.
•    Guvenalp, Z., Ozbek, H., Karadayi, M., Gulluce, M., Kuruuzum-Uz, A., Salih, B., Demirezer, O., Two antigenotoxic chalcone glycosides from Mentha longifolia subsp. Longifolia, (2015) Pharmaceutical Biology, 53 (6), pp. 888-896.
•    Kavruk, M., Celikbicak, O., Ozalp, V.C., Borsa, B.A., Hernandez, F.J., Bayramoglu, G., Salih, B., Arica, M.Y., Antibiotic loaded nanocapsules functionalized with aptamer gates for targeted destruction of pathogens, (2015) Chemical Communications, 51 (40), pp. 8492-8495.
•    Kaki, E., Altindal, A., Salih, B., Bekaroʇlu, O., Synthesis, characterization and gas sensing properties of novel homo and hetero dinuclear ball-type phthalocyanines, (2015) Dalton Transactions, 44 (17), pp. 8293-8299.
•    Bayramoglu, G., Ozalp, V.C., Yilmaz, M., Guler, U., Salih, B., Arica, M.Y., Lysozyme specific aptamer immobilized MCM-41 silicate for single-step purification and quartz crystal microbalance (QCM)-based determination of lysozyme from chicken egg White, (2015) Microporous and Mesoporous Materials, 207, pp. 95-104.
•    Yazici, A., Sariçiçek, B., Altindal, A., Salih, B., Bekaroʇlu, Ö., Synthesis and characterization, electrical and gas sensing properties of N,N′-bis(salicylidene)-1,2-phenylendiamine substituted novel mono and ball-type metallo phthalocyanines, (2015) Inorganica Chimica Acta, 428, pp. 83-92.
•    Pekdemir, F., Kurnali, S., Şengül, A., Altindal, A., Riza Özkaya, A., Salih, B., Bekaroʇlu, O., A conformationally stressed novel ball-type perylenediimide appended zinc(ii)phthalocyanine hybrid: Spectroelectrochemical, electrocolorimetric and photovoltaic properties, (2015) Dalton Transactions, 44 (1), pp. 158-166.

Links

Prof. Dr. Bekir SALİH: GoogleScholar, AVESİS, TÜBA, ORCID, SCOPUS

Asst. Prof. Mehmet ATAKAY: GoogleScholar, AVESİS, ORCID, SCOPUS

Res. Asst. Dr. Ülkü GÜLER: GoogleScholar, AVESİS, ORCID, SCOPUS

Res. Asst. Emre BİROL: AVESİS

 

Website
sareglab.org