Medical Biochemistry Research Laboratories

About

Research Infrastructure

• Chemidoc Touch imaging system
• Polyacrylamide gel and agarose gel electrophoresis devices in different sizes
• Electrophoresis power supplies
• Transblot device
• Gel dryer
• Thermocycle
• Nanodrop
• Spectrophotometer
• Fluorometer
• Microplate Reader
• SpectraMax M2
• Microcentrifuge
• -freezers 20, -30 and -80
• Refrigerators
• Ice machine
• Thin layer chromatography tank
• Vortexes
• Distilled pure water device
• Cold rooms
• Clinical centrifuge
• Fume hoods
• Nitrogen tube
• Oven
• Refrigerated microfuge
• Supercentrifuge
• Ultracentrifuge
• Precision balance
• pH meters
• Magnetic stirrers
• Glass-glass homogenizer
• Glass-teflon homogenizer
• Water baths
• Shimadzu 1700 Kinetic Spectrophotometer
• Shimadzu 1200 Spectrophotometer
• PCR Devices
• UV gel imaging device
• Sonicator
• Analytical scale
• Microfuge
• Homogenizers
• Shakers and mixers
• Imax3 Microplate reader
• Pumps with fraction collector
• Nitrogen evaporator
• Bacterial cell culture laboratory (laminar flow cabinet, class II, sonicator, oven, refrigerator), Cell culture laboratory (laminar flow cabinet, carbon dioxide incubator, Inverted microscope, water bath, desktop centrifuge, liquid nitrogen tank, vacuum pump), analytical HPLC system, semi-preparative HPLC system, electrophoresis and transfer system, two-way electrophoresis system, thermostatic circulator

Researchers

•    Prof. Dr. H. Asuman Özkara
•    Prof. Dr. Z. Günnur Dikmen
•    Prof. Dr. Yasemin Aksoy
•    Prof. Dr. İncilay Lay
•    Prof. Dr. Ebru Bodur
•    Prof. Dr. Aslı Pınar
•    Doç. Dr. Yeşim Er Öztaş
•    Doç. Dr. Gülnihal Kulaksız Erkmen
•    Doç. Dr. Mukaddes Gürler
•    Doç. Dr. Oytun Portakal Akçin
•    Dr. Öğr. Üyesi Başak Çeltikçi
•    Araş. Gör. Dr. Esra Büber
•    Araş. Gör. Dr. Ahmet Yalçınkaya
•    Araş. Gör. Müslüm Gök
•    Araş. Gör. Mehmet Özcan
•    Araş. Gör. Dr. Furkan Yıldız
•    Araş. Gör. Dr. Feride Ongun
•    Araş. Gör. Dr. Amin Radgohar
•    Araş. Gör. Dr. Nigar Abdullazade
•    Araş. Gör. Merve Yılmaz
•    Araş. Gör. Onur Aktan
•    Araş. Gör. Ayşe Buruş
•    Araş. Gör. Esin Öz
•    Prof. Dr. Hatice Doğan Buzoğlu

Ongoing Projects

prof. Dr. H. Asuman Ozkara
• Determining the biomarker and drug target for individual medicine practice by examining the brain and gut interaction in children with autism spectrum disorder with a systems biology approach TÜSEB Strategic R&D project 2020 Project no: 2324, Project code: 2019-TA-01, Researcher, 27.04.2020- 27.04.2022, joint project with Boğaziçi University and ITU.
• Evaluation of Serum Sperm and Spermidin Levels in Primary Open Angle Glaucoma and Exfoliative Glaucoma, Position: Researcher, HÜBAB 2020, project no: THD-2020-18493, 9 June 2020- 9 March 2021, H.Ü. A joint project with the Department of Ophthalmology.
prof. Dr. Z. Gunnur Dikmen
• Syndecan 1 as a Biomarker in Alzheimer's Disease, HÜBAB (THD -2019-18288), Researcher
• The Role of Monocyte Chemoattractant Protein-1 in the Development of Malignant Pleural Effusion, HUBAB (TTU -2020-18474), Researcher
• Development of new treatment methods for idiopathic pulmonary fibrosis TUSEB, (Project No: 4569), Researcher
prof. Dr. Yasemin Aksoy
• THD-2020-18890, HUBAB. Investigation of the Relationship Between Stage of Liver Disease and Serum Branched Chain Amino Acids and Fructose Levels in NAFLD Patients, Researcher
• THD-2019-18322, HUBAB. Methionine Metabolism in Human Fetal, Adult and Cancer Stem Cells, Researcher
• THD-2019-18034, HÜBAB -Examination of oxidative stress caused by cariogenic bacteria in dental pulp cell, Manager
• THD-2019-18110, Effect of Inflammation and Post-Inflammation of Nacetylcysteine ​​on Lag3 and Tlr2 Receptors in Neurons in HÜBAB -Parkinson's Disease Cellular Model, Researcher
• THD-2019-18055, HÜBAB - Investigation of the Effects of Antioxidant Use on Breast Cancer Treatment, Manager
• TDK-2018-17483, HÜBAB - Investigation of the Effects of Antioxidant Use on Breast Cancer Treatment, Manager
• THD-2018-17226, HUBAB. Investigation of oxidative stress in healthy and inflamed dental pulp tissue, Researcher
prof. Dr. Incilay Lay
• THD-2020-18915, HUBAB. The role of muscle tissue as an endocrine organ in the development of obesity, the relationship between adipokinemyokine profile and exercise capacity (Researcher) 02.12.2020
• THD-2020-18802, HUBAB. The effect of vitamin E on colon anastomosis (Researcher) 21.09.2020
• THD-2020-18787, HUBAB. Evaluation of Noninvasive Liver Fibrosis Tests in Nonalcoholic Steatohepatitis Patients (Researcher) 10.07.2020
• TSA-2019-17525, HUBAB. Investigation of the effects of microbiota, proteomic and metabolomic analysis results on disease pathogenesis and course in rheumatic diseases. Part 2: Proteomic investigation in Henoch Schönlein Purpura/IgA vasculitis (Researcher) 31.01.2019
prof. Dr. Ebru Bodur
• Possible lipolytic activity of human serum butyrylcholinesterase and its relationship with lipid metabolism. Dr. Ebru Bodur HUBAB, TDK-2018-17028
• Investigation of the effects of Lamiaceae family species on anti-inflammatory pathway enzymes Lipooxygenase (LOX) and Cyclooxygenase (COX) Director: Prof. Dr. Ebru Bodur, Prof. Dr. Murat Ekici – Multidisciplinary study Gazi University Scientific Research Unit-
• Can late-onset depression be a precursor to Alzheimer's dementia? A biomarker study. Executive Assoc. Dr. Özlem Erden Aki- Multidisciplinary study- HÜBAB -TTU -2020-18472
• The Relationship between Orexin Levels in Serum and Cerebrospinal Fluid in Epilepsy Patients with Sleep Stages and Seizures-Executive: Prof. Dr. İrsel Tezer Kutluk - Multidisciplinary study – HÜBAB, THD-2018-17275
• The Effect of Melatonin on Cisplatin-Induced Neurotoxicity in Rats -Executive: Assoc. Dr. Meltem Tuncer -- Multidisciplinary study- HÜBAB, TTU -2020-18596
prof. Dr. Asli Pinar
• THD-2020-18747, HUBAB. Biochemical and immunological evaluation of caries status and saliva content of cystic fibrosis patients, (Researcher), 05.06.2020-07.06.2021
• THD-2019-18415, HUBAB. The effect of Lactobacillus rhamnosus GG supplementation on gastrointestinal system and pulmonary inflammation and nutritional status in patients with cystic fibrosis, (Researcher), 11.11.2019-11.03.2021
• TSA-2019-18369 HUBAB. Clinical and Biochemical Evaluation of the Efficacy of Non-Surgical Treatment Approaches in the Treatment of Peri-implantitis, (Researcher), 18.11.2019-18.05.2022
• TSA-2019-18111, HUBAB. Clinical and Biochemical Evaluation of the Efficacy of Diode Laser Application with Non-Surgical Periodontal Treatment, (Researcher), 28.11.2019-28.11.2021
• THD-2019-17801, HUBAB. Oral Health and Evaluation of Carbonic Anhydrase Enzyme in Saliva in Children with Chronic Kidney Disease, (Researcher), 10.04.2019-10.01.2021
• THD-2018-16338, HUBAB. 3D Strain Echocardiography in Determining Left Ventricular Diastolic Dysfunction, (Researcher), 09.02.2018-09.02.2019
Assoc. Dr. Yeşim Er Öztaş
• Preparation of Multifunctional Proteoliposomes and Investigation of Their Effects on Erythrocytes (THD-2019-18441) HÜBAB, (Executive)
Assoc. Dr. Gulnihal Kulaksiz Erkmen
• Investigation of cisplatin cellular response in breast cancer via DDB2 and DNA polymerase eta, Project coordinator: Gülnihal Kulaksız Erkmen, Researcher: Onur Aktan (2020-….) TYL-2020-18767, HÜBAB.
Assoc. Dr. Mukaddes Gurler
• Hair metabolomics analysis in pregnant women with pregnancy complications due to abnormal implantation and placentation HÜBAB THD 18460, Executive
Assoc. Dr. Oytun Portakal
• Investigation of Circulating MicroRNA Profile in Uveal Melanoma Cases Before and After Treatment (HUBAB project, TSA-2018-17285, Researcher)
• Measuring the effect of FSH and LH on progesterone level in human granulosa-theca cell culture (BAP project, TSA-2019-18032, Researcher)
Dr. Instructor Member Başak Çeltikçi
• Development of New Treatment Methods for Idiopathic Pulmonary Fibrosis, TÜSEB, Project No: 4569, Researcher, Start date: 17.07.2020.
Dr. Esra Buber
• Development of New Treatment Methods for Idiopathic Pulmonary Fibrosis, TÜSEB, Project No: 4569, Researcher, Start date: 17.07.2020.

Completed Projects

Prof. Dr. Hatice Asuman Özkara
•    “Gaucher ve Metakromatik Lökodistrofi hastalıklarına yönelik farmakolojik şaperonların belirlenmesi” TÜBİTAK 1001 projesi 2015-2018 proje no: 115S208 (Danışman), Boğaziçi Üniv ile ortak proje.
•    “Metakromatik Lökodistrofi hastalığının farklı alt tiplerinin tanımlanması, patojenik mutasyonların belirlenmesi, patogenezde inflamasyonun rolünün incelenmesi” HÜBAB Kapsamlı proje 2017-2019 proje no: TSA-2017-12891 (Yürütücü)
Prof. Dr. Z. Günnur Dikmen
•    Yeni Nesil Kanser Terapisi Için Bir Yaklasım G4 DNA yı Kararlı Kılan Floren Fluorenon Temelli Yeni Nesil Floresans Ligandların Sentezi Ligand DNA Etkilesim Mekanizmalarının ve Anti telomeraz Aktivitesinin incelenmesi (2015-2017) TUBİTAK KBAG 113Z704, Araştırmacı
•    Tirozin kinaz inhibitörlerini kullanan Kronik Myeloid Lösemi hastalarında trombosit fonksiyonlarının değerlendirilmesi (2016-2017) HÜBAB (Proje No: THD -2015-6345), Yürütücü
•    Trombositopenik hastalarda platelet yüzey antijenlerinin flow sitometri ile incelenmesi ve kanama diyatezi ile ilişkisinin araştırılması (2018-2020) HÜBAB (Proje No:THD -2018-17020), Yürütücü
•    Psödoeksfoliasyon Sendromu ve Glokomun Serum Apelin ve Asimetrik Dimetilarjin düzeyi ile İlişkisi, Hacettepe Üniversitesi BAB, Yardımcı araştırmacı (2018-2019) HÜBAB (Proje No:THD -2018-16690), Araştırmacı
•    Endometrial patoloji ve anormal uterin kanama ile başvuran hastalarda Anti-Mullerian hpormon, CA125, HE4 ve Östradiol ilişkisi (2017-2019) HÜBAB (Proje No:THD -2017-15828), Araştırmacı
•    Nöroloji Yoğun Bakım Ünitesindeki İnme Hastalarında Yoğun Bakım Ünitesinde Edinilmiş Güçsüzlüğün (YBÜEG) Multimodal İncelemesi (2018-2020) HÜBAB (Proje No:THD -2018-17114), Araştırmacı
•    Acil Servise Kalp Yetmezliği Semptomları ile Başvuran Hastalara Uygulanan Diüretik Tedavi Neticesinde Karşılaşılabilecek Akut Böbrek Yetmezliği Tablosunu Önceden Belirlemede TIMP2 ve IGFB P7’nin Rolü (2019-2020), HÜBAB (Proje No: TTU -2019-17881), Araştırmacı
Prof. Dr. Yasemin Aksoy
•    014 D04 101 005-537, GST P1-1 Özgül İnhibitörlerin Belirlenmesi İçin Bulut Temelli Sanal Tarama ve Otomasyon Yönteminin Geliştirilmesi, Yönetici, 01.04.2014,
•    TBB-2017-16499, HÜBAB. İnsan Glutatyon S Transferaz P1-1 Spesifik İnhibitör Moleküllerin Bilgisayar Destekli ve Yapı Temelli de novo Tasarımında Veri Analizi, Yönetici, 07.05.2018-20.11.2017
•    TAY-2015-7227, HÜBAB. İnsan Glutatyon S Transferaz P1-1 Spesifik İnhibitör Moleküllerin Bilgisayar Destekli ve Yapı Temelli de novo Tasarımı, Yönetici, (09.09.2015-11.06.2018)
•    012 D09 101 001-20. Chlorophyllide Cu Kompleksinin GSTP1-1 İnhibitörü Olarak İncelenmesi ve meme kanser hücre dizilerinde Sitotoksitesinin Belirlenmesi, Yönetici, ( 07.09.2012-26.04.2016)
Prof. Dr. İncilay Lay
•    THD-2018-16921 HÜBAB. Kolestaz Hastalarında Safra Asitlerinin LC-MS/MS ile Araştırılması ve Olası Biyobelirteçlerin Belirlenmesi (Yürütücü) 30.11.2020
•    THD-2018-16849, HÜBAB. Nörofibromatozis Tip 1'de Hipotoni Etiyolojisi ve Hipotoninin Motor ve Dil Alanına Etkileri (Araştırmacı) 07.01.2020
•    THD-2017-16295, HÜBAB. Organik Asidemi Hastalarında Oksisterollerin LC-MS/MS Yöntemi ile İncelenmesi (Araştırmacı) 17.03.2020
•    TSA-2017-14407, HÜBAB. Kurşun Maruziyetinin ve Şelasyon Tedavisinin Toksisiteyi Etkileyen Bazı Parametreler Üzerine Etkisi (Araştırmacı) 02.01.2020
•    THD-2017-13469, HÜBAB. Tat Duyusu Renin Anjiyotensin Aldosteron Sisteminin İnkretin Fizyolojisi ve İnsulin Direncine Etkisi (Araştırmacı) 07.01.2020
•    THD-2017-13423, HÜBAB. Metabolik Sendromlu Hastalarda Plazma Makrofaj Apoptozis İnhibitör (AIM) ve Plazma Monosit Kemotaktik Protein-1 (MKP-1) Düzeylerinin Değerlendirilmesi (Araştırmacı) 15.01.2018
•    THD-2017-13012, HÜBAB. Silikozis Hastalarında Oksisterol Düzeylerinin Değerlendirilmesi (Araştırmacı) 28.09.2018
•    THD-2016-12638, HÜBAB. Kistik fibrozisli hastalarda alevlenme ve remisyon dönemlerinde plazma sfingomyelin ve seramid düzeylerinin sıvı kromatografisikütle spektrometresi ile belirlenmesi ve bazı enflamasyon belirteçleriyle ilişkisinin incelenmesi (Yardımcı araştırmacı) 11.06.2018
•    THD-2016-10908, HÜBAB. Tip 1 ve Tip 2 Diabetes Mellitusta oksisterol türlerinin LCMSMS metodu ile incelenmesi (Yürütücü) 28.06.2017
•    TSA-2016-7276, HÜBAB. Orak hücre hastalığında lipit metabolizmasındaki değişimlerin araştırılması ve hastalık patogeneziyle ilişkilendirilmesi (Yardımcı araştırmacı) 08.12.2017
Prof. Dr. Ebru Bodur
•    Fenilketonüride öğrenme ve bellek mekanizmasının dişi ve erkek sıçanlarda cAMP/PKA/CREB/BDNF yolağı üzerinden incelenmesi (2020) Yürütücü: Prof. Dr. Ebru Bodur -Multidisipliner çalışma HÜBAB, TDK-2018-16969.
•    Over kanserlerinde BMP7 ve BMP2'nin invazyon ve metastazdaki etkisi (2019) Yürütücü: N. Dilara Zeybek Multidispliner çalışma, HÜBAB, TSA-2017-13046
•    İnsan serum bütirilkolinesterazının karaciğer HepG2 hücrelerinde lipid metabolizması ile etkileşiminin incelenmesi (2018) Yürütücü: Prof. Dr. Ebru Bodur -Multidisipliner çalışma HÜBAB, 014D11101001-750
•    Serebral iskemi modelinde oluşan nöroinflamasyon üzerine 12/15 lipooksijenaz inhibitörlerinin etkisi (2018) Yürütücü: Prof. Dr. Hülya Karataş Kurşun- Multidisipliner çalışma HÜBAB, THD -2016-11381
•    Nöroprotektif etkin madde içeren nano formülasyonların geliştirilmesi ve periferik sinir hasarı modelinde etkinliklerinin değerlendirilmesi (2018) Yürütücü: Prof. Dr. Hakan Eroğlu- Prof. Dr. Ebru Bodur (İş paketi 3,4), TÜBİTAK SBAG Bilimsel Araştırma Projesi 115S202
Prof. Dr. Aslı Pınar
•    THD-2016-12089, HÜBAB. Diş Eti Oluğu Sıvısı ile Peri implant Oluk Sıvısındaki Sklerostin, TWEAK, RANKL ve OPG Oranlarının Karşılaştırılması, (Araştırmacı) 10.11.2016-04.12.2017
Doç. Dr. Yeşim Er Öztaş
•    Kistik fibrozisli hastalarda alevlenme ve remisyon dönemlerinde plazma sfingomyelin ve seramid düzeylerinin sıvı kromatografisikütle spektrometresi ile belirlenmesi ve bazı enflamasyon belirteçleriyle ilişkisinin incelenmesi, 2018 (THD-2016-12638) HÜBAB, Yürütücü
•    Orak hücre hastalığında lipit metabolizmasındaki değişimlerin araştırılması ve hastalık patogeneziyle ilişkilendirilmesi, 2017 (TSA-2016-7276) HÜBAB, Yürütücü
Doç. Dr. Mukaddes Gürler
•    Anne ve kordon kanında organoklorin pestisit düzeylerinin belirlenerek annenin biyokimyasal parametreleri ve yenidoğan üzerindeki etkilerinin araştırılması. HÜBAB THD6492, Araştırmacı
Doç. Dr. Oytun Portakal
•    Tip 1 diyabetli adölesanlarda protein ve yağların postprandiyal glisemik yanıta etkisi ve bu yanıtın insülin rejimiyle yönetiminin incelenmesi (HÜBAB projesi, THD-2019-18425, Araştırmacı)
•    Dikkat Eksikliği Hiperaktivite Bozukluğu Olan Prepubertal Erkek Çocuklarda Otizm Benzeri Belirtilerin ve Agresyonun Testesteron Oksitosin Kortizol ve Androstenedion ile İlişkisi (HÜBAB projesi, THD-2018-15955, Araştırmacı)
•    Genel cerrahi Yoğun Bakım Ünitesindeki hastalarda serum omentin değerinin saptanması ve prognostik bir faktör olarak kullanılabilirliğinin değerlendirilmesi. HÜBAB projesi, THD-2017-11872,Yürütücü
Dr. Esra Büber
•    “Dental Pulpa Kök Hücrelerinde Melatoninin Hippo Sinyal Yolağı Üzerinde Etkisi”, HÜBAB (TYL-2018-17575), Araştırmacı, 25.11.2020.
•    “Trombositten Zengin Fibrin hazırlanmasında farklı santrifüj parametrelerinin büyüme faktörleri ve sitokin değerleri üzerine etkisi”, HÜBAB (THD-2017-15113), Araştırmacı, 28.05.2018.
•    “Asiyanotik ve Siyanotik Konjenital Kalp Hastalığı Olan Çocuklarda Antioksidan Rezerv Kapasitesinin Karşılaştırılması”, HÜBAB, Araştırmacı, 21.04.2015.

Publications

Prof. Dr. H. Asuman Özkara
•    Emel Örün, Songül Yalçın, İncilay Lay, Arzu Dursun, Asuman Özkara. Determination of intestinal enzyme activities during infancy period. J Curr Pediatr 2016; 14: 53-59.
•    Hamza Sunman, Adem Ozkan, Hikmet Yorgun, Ugur Canpolat, Naresh Maharjan, Serkan Asil, Ergun Baris Kaya, Tulin Bayrak, Lale Tokgozoglu, Asuman Ozkara, Kudret Aytemir, Ali Oto. Vitamin D Levels Predict the Response to Cardiac Resynchronization Therapy in Patients with Systolic Heart Failure. Archives of the Turkish Society of Cardiology 2016 Dec; 44(8): 670-676.
•    Özkan A, Özkara HA. Metachromatic Leukodystrophy: biochemical characterization of two (p.307Glu→Lys, p.318Trp→Cys) Arylsulfatase A mutations. Intractable Rare Dis Res 2016 Nov;5(4):280-283.
•    Sunman H, Özkan A, Yorgun H, Canpolat U, Karabulut E, Bayrak T, Kaya EB, Tokgözoğlu L, Özer N, Özkara A, Aytemir K, Oto A. Evaluating the effects of cardiac resynchronization therapy on pathophysiological pathways of heart failure using surrogate biomarkers. Cardiol J. 2018;25(1):42-51.
•    Sunman H, Canpolat U, Yorgun H, Özkan A, Yalçın MU, Bayrak T, Şahiner L, Kaya EB, Özkara A, Aytemir K, Oto A. Association between reverse electrical remodeling and cardiac fibrosis markers in patients with cardiac resynchronization therapy. Turk Kardiyol Dern Ars. 2018 Mar;46(2):84-91. doi: 10.5543/tkda.2017.80236.
•    Yagci ZB, Esvap E, Ozkara HA, Ulgen KO, Olmez EO. Inflammatory response and its relation to sphingolipid metabolism proteins: Chaperones as potential indirect anti-inflammatory agents. Adv Protein Chem Struct Biol. 2019;114:153-219. doi: 10.1016/bs.apcsb.2018.09.004. ISSN: 1876-1623
•    Unal C, Ozkara HA, Tanacan A, Fadiloglu E, Lay I, Topçu M, Cakar AN, Beksac MS. Prenatal enzymatic diagnosis of lysosomal storage diseases using cultured amniotic cells, uncultured chorionic villus samples, and fetal blood cells: Hacettepe experience. Prenat Diagn. 2019 Nov;39(12):1080-1085. doi: 10.1002/pd.5547. Epub 2019 Aug 22.Prenat Diagn. 2019. PMID: 31411753.
•    Özen S, Batu ED, Taşkıran EZ, Özkara HA, Ünal Ş, Güleray N, Erden A, Karadağ Ö, Gümrük F, Çetin M, Sönmez HE, Bilginer Y, Ayvaz DÇ, Tezcan I. A Monogenic Disease with a Variety of Phenotypes: Deficiency of Adenosine Deaminase 2. J Rheumatol. 2020 Jan;47(1):117-125.
•    Özkara HA. Hücre içi trafiği. Dursun A, editör. Kalıtsal Metabolik Hastalıklarda Hareket Bozuklukları. 1. Baskı. Ankara: Türkiye Klinikleri; 2020. p.1-8. ISBN: 978-625-401-117-7
•    Faruk Pekgül, Nesibe Gevher Eroğlu-Ertuğrul, Can Ebru Bekircan-Kurt, Sevim Erdem-Ozdamar, Arda Çetinkaya, Ersin Tan, Bahadır Konuşkan, Ergun Karaağaoğlu, Meral Topçu, Nurten Ayşe Akarsu, Kader K. Oguz, Banu Anlar, Hatice Asuman Özkara. Comprehensive clinical, biochemical, radiological and genetic analysis of 28 Turkish cases with suspected metachromatic leukodystrophy and their relatives. Mol Genet Metab Rep 2020 Dec 11;25:100688. doi: 10.1016/j.ymgmr.2020.100688.
Prof. Dr. Z. Günnur Dikmen
•    Akarsu S, Akbiyik F, Karaismailoglu E, Dikmen ZG. Gestation specific reference intervals for thyroid   function tests in pregnancy. Clin Chem Lab Med. 2016 Aug 1;54(8):1377-83.
•    Işeri-Erten SÖ, Dikmen ZG, Ulusu NN. Comparison of Spectrophotometric and Fluorimetric Methods in Evaluation of Biotinidase Deficiency.J Med Biochem. 2016 Apr;35(2):123-129.
•    Beyramzadeh M, Dikmen ZG, Erturk NK, Tuncer ZS, Akbiyik F. Placental respiratory chain complex activities in high risk pregnancies. J Matern Fetal Neonatal Med. 2017;30(24):2911-2917
•    Akarsu S, Gode F, Isik AZ, Dikmen ZG, Tekindal MA. The association between coenzyme Q10 concentrations in follicular fluid with embryo morphokinetics and pregnancy rate in assisted reproductive techniques. J Assist Reprod Genet. 2017 May;34(5):607
•    Watson ID, Oosterhuis WP, Jorgensen PE, Dikmen ZG, Siodmiak J, Jovicic S, Aakre KM, Palicka V, Kutt M; European Federation of Clinical Chemistry and Laboratory Medicine Working Group on Patient Focused Laboratory Medicine. A survey of patients' views from eight European countries of interpretive support from Specialists in Laboratory Medicine. Clin Chem Lab Med. 2017 Aug 28;55(10):1496-1500.
•    Kumbasar U, Dikmen ZG, Dikmen E, Dogan R. Serum HE4 as a diagnostic and follow-up biomarker in patients with non-small cell lung cancer. UHOD-Uluslararası Hematoloji-Onkoloji dergisi 2017; 27(3)
•    Karaismailoğlu E, Dikmen ZG, Akbıyık F, Karaağaoğlu AE. A statistical approach to evaluate the performance of cardiac biomarkers in predicting death due to acute myocardial infarction: time-dependent ROC curve. Turk J Med Sci. 2018 Apr 30;48(2):237-245.
•    Korkmaz ET, Koksal D, Aksu F, Dikmen ZG, Icen D, Maden E, Onder S, Akbiyik F, Emri S. Triple test with tumor markers CYFRA 21.1, HE4, and ProGRP might contribute to diagnosis and subtyping of lung cancer. Clin Biochem. 2018;58:15-19.
•    Z.Gunnur Dikmen, İlgen Mender. How can I protect my telomeres and slow aging? Turk J Biochem 2017; 42(6): 587–590
•    Naime Meric Konar, Eda Karaismailoğlu, Oytun Portakal, Aslı Pınar, Zeliha Gunnur Dikmen, Ahmet Ergun Karaağaoğlu. Birleşik Modelleme Yaklaşımı ile Tekrarlı C-Reaktif Protein Ölcümlerinin Tanısal Performansını Etkileyen Faktörlerin İncelenmesi.    Turkiye Klinikleri J Biostat, 10(1):52-64, 2018
•    Sener Y, Okay M, Aydin S, Buyukasik Y, Akbiyik F, Dikmen ZG. TKI-Related Platelet Dysfunction Does Not Correlate With Bleeding in Patients With Chronic Phase-Chronic Myeloid Leukemia With Complete Hematological Response.Clin Appl Thromb Hemost. 2019; 25:1076029619858409.
•    Ruslan Jafarov, Erman Ceyhan, Oguzhan Kahraman, Taner Ceylan, Zeliha G. Dikmen, Serdar Tekgul, Hasan S. Dogan. Efficacy of transcutaneous posterior tibial nevre stimulation in children with functional voiding disorders. Neurourology and Urodynamics, 2020 Nov 18
•    Bezci Aygun F, Kocabeyoglu S, Irkec M, Dikmen ZG, Umaroglu MM, Konstas AGP. Serum Apelin and Asymmetric Dimethylarginine Levels in Patients With Exfoliation Syndrome or Exfoliative Glaucoma. J Glaucoma. 2020 Jul;29(7):593-597.
Prof. Dr. Yasemin Aksoy
•    Ozcan M, Altay O, Lam S, Turkez H, Aksoy Y, Nielsen J, Uhlen M, Boren J, Mardinoglu A. Improvement in the Current Therapies for Hepatocellular Carcinoma Using a Systems Medicine Approach. Adv Biosyst. 2020 Jun;4(6):e2000030. doi: 10.1002/adbi.202000030. Epub 2020 Apr 8.
•    Yilmaz D, Caglayan F, Buber E, Könönen E, Aksoy Y, Gursoy UK, Guncu GN. Gingival crevicular fluid levels of human beta-defensin-1 in type 2 diabetes mellitus and periodontitis. Clin Oral Investig. 2018 Jun;22(5):2135-2140.
•    Ozcan M, Esendagli G, Musdal Y, Canpinar H, Bacanlı M, Anlar HG, Esendağlı-Yılmaz G, Beyramzadeh M, Aksoy Y. Dual actions of the antioxidant chlorophyllin, a glutathione transferase P1-1 inhibitor, in tumorigenesis and tumor progression. J Cell Biochem. 2018 120(5)Nov 28. doi: 10.1002/jcb.27974.
•    Pinar Karapinar S, Ulum YZ, Ozcelik B, Dogan Buzoglu H, Ceyhan D, Balci Peynircioglu B, Aksoy Y. The effect of N-acetylcysteine and calcium hydroxide on TNF-α and TGF-β1 in lipopolysaccharide-activated macrophages. Arch Oral Biol. 2016 Aug;68:48-54.
•    Aslantas EE, Buzoglu HD, Karapinar SP, Cehreli ZC, Muftuoglu S, Atilla P, Aksoy Y. Age-related Changes in the Alkaline Phosphatase Activity of Healthy and Inflamed Human Dental Pulp. J Endod. 2016 Jan;42(1):131-4.
Prof. Dr. İncilay Lay
•    Demir S, Kaplan O, Celebier M, Sag E, Bilginer Y, Lay I, Ozen S. Predictive biomarkers of IgA vasculitis with nephritis by metabolomic analysis. Semin Arthritis Rheum. 2020 Dec;50(6):1238-1244.
•    Helvaci N, Kabacam S, Dagdelen S, Lay I, Karabulut E, Mut M, Alikasifoglu M, Erbas T. Klotho gene G395A and C1818T polymorphisms in acromegaly: Association with clinical presentation and comorbidities. Clin Endocrinol (Oxf). 2020 Dec 9. doi: 10.1111/cen.14380.
•    Isgin-Atici K, Alsulami S, Turan-Demirci B, Surendran S, Sendur SN, Lay I, Karabulut E, Ellahi B, Lovegrove JA, Alikasifoglu M, Erbas T, Vimaleswaran KS, Buyuktuncer Z. FTO gene-lifestyle interactions on serum adiponectin concentrations and central obesity in a Turkish population. Int J Food Sci Nutr. 2020 Aug 4:1-11.
•    Bal Topçu D, Tugcu G, Ozcan F, Aslan M, Yalcinkaya A, Polat SE, Hizal M, Yalcin EE, Ersoz DD, Ozcelik U, Kiper N, Lay I, Oztas Y. Plasma Ceramides and Sphingomyelins of Pediatric Patients Increase in Primary Ciliary Dyskinesia but Decrease in Cystic Fibrosis. Lipids. 2020 May;55(3):213-223.
•    Aksu N, Samadi A, Yalçınkaya A, Çetin T, Eser B, Lay İ, Öziş TN, Öztaş Y, Sabuncuoğlu S. Evaluation of oxysterol levels of patients with silicosis by LC-MS/MS method. Mol Cell Biochem. 2020 Apr;467(1-2):117-125.
•    Savaş EM, Oğuz SH, Samadi A, Yılmaz Işıkhan S, Ünlütürk U, Lay İ, Gürlek A. Apoptosis Inhibitor of Macrophage, Monocyte Chemotactic Protein-1, and C-Reactive Protein Levels Are Increased in Patients with Metabolic Syndrome: A Pilot Study. Metab Syndr Relat Disord. 2020 May;18(4):197-205.
•    Samadi A, Isikhan SY, Tinkov AA, Lay I, Doşa MD, Skalny AV, Skalnaya MG, Chirumbolo S, Bjørklund G. Zinc, copper, and oxysterol levels in patients with type 1 and type 2 diabetes mellitus. Clin Nutr. 2020 Jun;39(6):1849-1856.
•    Acar I, Cetinkaya A, Lay I, Ileri-Gurel E. The role of calcium sensing receptors in GLP-1 and PYY secretion after acute intraduodenal administration of L-Tryptophan in rats. Nutr Neurosci. 2020 Jun;23(6):481-489.
•    Samadi A, Gurlek A, Sendur SN, Karahan S, Akbiyik F, Lay I. Oxysterol species: reliable markers of oxidative stress in diabetes mellitus. J Endocrinol Invest. 2019 Jan;42(1):7-17.
•    Hayran Y, Lay I, Mocan MC, Bozduman T, Ersoy-Evans S. Vascular endothelial growth factor gene polymorphisms in patients with rosacea: A case-control study. J Am Acad Dermatol. 2019 Aug;81(2):348-354.
•    Savaş Ö, Süslü AE, Lay I, Özer S. Assessment of the relationship between polysomnography parameters and plasma malondialdehyde levels in patients with obstructive sleep apnea. Eur Arch Otorhinolaryngol. 2019 Dec;276(12):3533-3538.
•    Yalcinkaya A, Samadi A, Lay I, Unal S, Sabuncuoglu S, Oztas Y. Oxysterol concentrations are associated with cholesterol concentrations and anemia in pediatric patients with sickle cell disease. Scand J Clin Lab Invest. 2019 Oct;79(6):381-387.
•    Unal C, Ozkara HA, Tanacan A, Fadiloglu E, Lay I, Topçu M, Cakar AN, Beksac MS. Prenatal enzymatic diagnosis of lysosomal storage diseases using cultured amniotic cells, uncultured chorionic villus samples, and fetal blood cells: Hacettepe experience. Prenat Diagn. 2019 Nov;39(12):1080-1085.
•    Keles ME, Samadi A, Isikhan SY, Sener YZ, Sezgin A, Keles E, Lay I, Canpolat U. The Effect of Effort Test on the Levels of Ischemia Modified Albumin, 7-ketocholesterol and Cholestan-3β, 5α, 6β -triol and their Role in the Diagnosis of Coronary Artery Disease. J Med Biochem. 2019 May 11;38(3):249-255.
•    El Moustafa K, Sivri S, Karahan S, Coşkun T, Akbıyık F, Lay İ. Screening for mucopolysaccharidoses in the Turkish population: Analytical and clinical performance of an age-range specific, dye-based, urinary glycosaminoglycan assay. Clin Chim Acta. 2017 Jan;464:72-78.
•    Bozduman T, Ersoy Evans S, Karahan S, Hayran Y, Akbiyik F, Lay I. Genetic Risk Factors for Psoriasis in Turkish Population: -1540 C/A, -1512 Ins18, and +405 C/G Polymorphisms within the Vascular Endothelial Growth Factor Gene. Ann Dermatol. 2016 Feb;28(1):30-9.
Prof. Dr. Ebru Bodur
•    Haidar MK, Timur SS, Kazanci A, Turkoglu OF, Gürsoy RN, Nemutlu E, Sargon MF, Bodur E, Gök M, Ulubayram K, Öner L, Eroğlu H. (2020) Composite nanofibers incorporating alpha lipoic acid and atorvastatin provide neuroprotection after peripheral nerve injury in rats. Eur J Pharm Biopharm. 153:1-13.
•    Sarıgöl E, Ekizoğlu M, Bozdağ Pehlivan S, Bodur E, Sağıroğlu M, Çalış S (2018) A thermosensitive gel loaded with an enzyme and an antibiotic drug for the treatment of periprosthetic joint infection. Journal of Drug Delivery Science and Technology 43 (2018) 423–429
•    Gurcan O, Gurcay AG, Kazanci A, Senturk S, Bodur E, Karaca EU, Turkoglu OF, Bavbek M. (2017) Effect of Asiatic Acid on the Treatment of Spinal Cord Injury: An Experimental Study in Rats Turk Neurosurg. 27(2):259-264.
•    Bayrak A, Bayrak T, Bodur E, Kılınç K, Demirpençe E. (2016) The effect of HDL-bound and free PON1 on copper-induced LDL oxidation. Chem Biol Interact. 257:141-6.
•    Gok M, Zeybek ND, Bodur E. (2016) Butyrylcholinesterase expression is regulated by fatty acids in HepG2 cells. Chem Biol Interact. 259(Pt B):276-281.
•    Gurcay AG, Gurcan O, Kazanci A, Bozkurt I, Senturk S, Bodur E, Turkoglu OF, Bavbek M. (2016) Comparative Biochemical and Motor Function Analysis of Alpha Lipoic Acid and N-Acetyl Cysteine Treatment on Rats with Experimental Spinal Cord Injury. Turk Neurosurg 26(1):119-26.
•    Senturk S, Gurcay AG, Bozkurt I, Gurcan O, Eroglu H, Turkoglu OF, Bodur E, Bavbek M. (2015) Effects of tadalafil-Type-V phosphodiesterase enzyme inhibitor-On rats with spinal trauma. Br J Neurosurg. 29(2):254-9
Prof. Dr. Aslı Pınar
•    Dikmen, Z. G.; Pinar, A.; Akbiyik, F. Specimen rejection in laboratory medicine: Necessary for patient safety? 2015 Biochemia Medica Volume: 25 (3) Pages: 377-385.
•    Usta DD, Salimi K, Pinar A, Coban İ, Tekinay T, Tuncel A. A Boronate Affinity-Assisted SERS Tag Equipped with a Sandwich System for Detection of Glycated Hemoglobin in the Hemolysate of Human Erythrocytes. ACS Applied Materials and Interfaces. 2016 May 18;8(19):11934-44
•    Aydemir, Y, Pınar, A., Hızal, G.A, Demir, H., Saltık Temizel, İ.N., Özen, H., Akbıyık, F., Yüce, A. Neutrophil volume distribution width as a new marker in detecting inflammatory bowel disease activation.International Journal of Laboratory Hematology, Volume 39 (1), 1 February 2017, Pages 51-57.
•    Salimi K, Usta DD, Çelikbıçak Ö, Pınar A, Salih B, Tuncel A. Highly selective enrichment of phosphopeptides by titanium (IV) attached monodisperse-porous poly(vinylphosphonic acid-co-ethylene dimethacrylate) microspheres. Journal of Chromatography A. 2017 May 5;1496:9-19.
•    Salimi K, Usta DD, Çelikbıçak Ö, Pınar A, Salih B, Tuncel A. Ti(IV) carrying polydopamine-coated, monodisperse-porous SiO2 microspheres with stable magnetic properties for highly selective enrichment of phosphopeptides. Colloids and Surfaces B- Biointerfaces. 2017 May 1;153:280-290.
•    Küme T, Karakükcü Ç, Pınar A, Coşkunol H. The Scope, Quality and Safety Requirements of Drug Abuse Testing. Türk Psikiyatri Dergisi. 2017 Fall;28(3):198-207.
•    Pınar A, Kurne A Lay İ, Acar NP, Karahan S, Karabudak R, Akbıyık F. Cerebrospinal fluid oligoclonal banding patterns and intrathecal immunoglobulin synthesis: Data comparison from a widepatient group.  Journal of Neurological Sciences-Turkish (Neurological Sciences and Neurophysiology) 2018; 35: 21-28.
•    Yakar N, Guncu GN, Akman AC, Pınar A, Karabulut E, Nohutcu RM. Evaluation of gingival crevicular fluid and peri-implant crevicular fluid levels of sclerostin, TWEAK, RANKL and OPG. Cytokine. 2019; Oct 27. pii: S1043-4666(18)30409-5.
•    Küme T, Mercan F, Topsakal H, Karakukcu C, Şeneş M, Pınar A, Gürler M, Kalafat H, Ünal B, Verstraete AG, Hamurtekin Y, Aydınlı A, Şenol Y, Eğin ME, Cihan A, Kazancı EG, Gümüş E. Assessment of the results of a three-year program for National Standardization and Quality Improvement of Medical Laboratories on Drug of Abuse Testing by the Ministry of Health in Turkey. Drug Test Anal. 2018 Aug 14.
•    Taş D, Akman Öden A, Akgül S, Metin ZE, Pınar A, Kanbur N. The effect of the pubertal stage on irisin levels in male adolescents: A novel myokine. Journal of Clinical Research in Pediatric Endocrinology 2019 J Clin Res Pediatr Endocrinol. 2019 Sep 13.
•    Salimi K, Kip Ç, Çelikbıçak Ö, Usta DD, Pınar A, Salih B, Tuncel A. Ti (IV) attached-phosphonic acid functionalized capillary monolith as a stationary phase for in-syringe-type fast and robust enrichment of phosphopeptides. Biomed Chromatogr. 2019 Jun;33(6):e4488.
•    Yaprak DS, Yalçın B, Pınar AA, Büyükpamukçu M. Assessment of nutritional status in children with cancer: Significance of arm anthropometry and serum visceral proteins. Pediatr Blood Cancer.2021 Jan;68(1):e28752
Doç. Dr. Yeşim Er Öztaş
•    Plasma Ceramides and Sphingomyelins of Pediatric Patients Increase in Primary Ciliary Dyskinesia but Decrease in Cystic Fibrosis. Bal Topçu D, Tugcu G, Ozcan F, Aslan M, Yalcinkaya A, Polat SE, Hizal M, Yalcin EE, Ersoz DD, Ozcelik U, Kiper N, Lay I, Oztas Y. Lipids. 2020 May;55(3):213-223
•    Altered HDL particle in sickle cell disease: decreased cholesterol content is associated with hemolysis, whereas decreased Apolipoprotein A1 is linked to inflammation. Yalcinkaya A, Unal S, Oztas Y. Lipids Health Dis. 2019 Dec 20;18(1):225.
•    Oxysterol concentrations are associated with cholesterol concentrations and anemia in pediatric patients with sickle cell disease. Yalcinkaya A, Samadi A, Lay I, Unal S, Sabuncuoglu S, Oztas Y. Scand J Clin Lab Invest. 2019 Oct;79(6):381-387. doi: 10.1080/00365513.2019.1627578. Epub 2019 Jun 12.
•    Vitamin D Deficiency and Its Association with Inflammatory Markers, Lipid Profile and Regulatory T-cells in Pediatric Sickle Cell Disease Patients. Oztas Y, Unal S, Eskandari G, Tamer L, Ozgunes N. Indian J Hematol Blood Transfus. 2018 Jul;34(3):480-485.
•    The serum leptin level in non-obese patients with obstructive sleep apnea. Pamuk AE, Süslü AE, Yalçınkaya A, Öztaş YE, Pamuk G, Özer S, Önerci M. Auris Nasus Larynx. 2018 Aug;45(4):796-800.
•    Preparation of L-Glutamine Loaded Liposomes for Drug Delivery to Erythrocytes. Gokce Alp and Yesim Oztas Journal of Hematology Research, 2020, 7, 4-12
•    Aquaporins: A Multidisciplinary Perspective on The Water Channel Proteins G Alp, II Bosgelmez, Y Oztas. Acta Medica 51 (2), 30-42
•    Oxidative alterations in sickle cell disease: possible involvement in disease pathogenesis Y Oztas, A Yalcinkaya World J. Hematol 6, 55 2017
•    Hypocholesterolemia and Increased Plasma 7-ketocholesterol Levels in Pediatric Sickle Cell Patients A Yalçınkaya, İ Lay, A Samadi, S Ünal, F Akbıyık, Y Öztaş. Acta Medica 48 (1), 1-4
•    An Introduction to Lipidomics: From Laboratory to Clinic Y Öztaş, İ Boşgelmez. Acta Medica 48 (1), 14-23
•    Hypocholesterolemia: A Neglected Laboratory Finding Y Oztas Acta Medica 47 (1), 19-22 2016
Doç. Dr. Gülnihal Kulaksız Erkmen
•    Nucleotide excision repair by dual incisions in plants. Canturk F, Karaman M, Selby CP, Kemp MG, Kulaksiz-Erkmen G, Hu J, Li W, Lindsey-Boltz LA, Sancar A. Proc Natl Acad Sci U S A. 2016 Apr 26;113(17):4706-10.
•    Fluoxetine-induced toxicity results in human placental glutathione S-transferase-π (GST-π) dysfunction. Dalmizrak O, Kulaksiz-Erkmen G, Ozer N. Drug Chem Toxicol. 2016 Oct;39(4):439-44.
•    Purification of Glutathione S-Transferase pi from Erythrocytes and Evaluation of the Inhibitory Effect of Hypericin. Turk S, Kulaksiz Erkmen G, Dalmizrak O, Ogus IH, Ozer N. Protein J. 2015 Dec;34(6):434-43.
•    Regulation And Effect Of Telomerase And Telomeric Length In Stem Cells. Celtikci B, Kulaksiz Erkmen G, Dikmen G, Cell Res Ther. 2020 Apr 21.
Doç. Dr. Mukaddes Gürler
•    Betül İşiner Kaya, Mukaddes Gürler & Eda Karaismailoğlu (2020): Maternal and umbilical cord blood serum concentrations of organochlorine pesticides and investigation of possible effects on newborn, International Journal of Environmental Analytical Chemistry. https://doi.org/10.1080/03067319.2020.1813731
Doç. Dr. Oytun Portakal
•    Comparison of term and preterm labor procalcitonin and leukocyte cell volume, conductivity and light scatter (VCS) parameters in order to demonstrate the impact of inflammation on the triggering mechanisms of preterm uterin contractions. Unal C, Karatas E, Fadıloglu E, Portakal O, Beksac MS. J Obstet Gynaecol Res. 2020 May;46(5):694-698. doi: 10.1111/jog.14216. Epub 2020 Mar 3. PMID: 32128965
•    5 Years' Experience of a Tertiary Center with Thrombocytopenic Pregnancies: Gestational Thrombocytopenia, Idiopathic Thrombocytopenic Purpura and Hypertensive Disorders of Pregnancy.
•    Fadiloglu E, Unal C, Tanacan A, Portakal O, Beksac MS. Geburtshilfe Frauenheilkd. 2020 Jan;80(1):76-83. doi: 10.1055/a-0865-4442. Epub 2019 Jul 24. PMID: 31949322 Free PMC article.
•    Cord blood delta neutrophil index values of term neonates. Büyükeren M, Çelik HT, Portakal O, Fadıloğlu E, Örgül G, Yiğit Ş, Beksaç MS, Yurdakök M. Turk J Pediatr. 2020;62(1):35-38. PMID: 32253864 Free article.
•    Effect of anti-epileptic drugs on first trimester screening test results. Unal C, Tanacan A, Fadiloglu E, Portakal O, Beksac MS. Taiwan J Obstet Gynecol. 2020 Nov;59(6):835-837. PMID: 33218397
•    Joint Modeling Approach on Evaluating Time-Dependent CutOff Values for C-Reactive Protein in Mixed Intensive Care Unit Population. Konar NM, Karaismailoglu E, Portakal O, Pinar A, Dikmen ZG, Karaagaoglu AE. Clin Lab. 2020 Sep 1;66(9). doi: 10.7754/Clin Lab.2020.191239. PMID: 32902226
•    Uropathogens and Gestational Outcomes of Urinary Tract Infections in Pregnancies that Necessitate Hospitalization. Beksac AT, Orgul G, Tanacan A, Uckan H, Sancak B, Portakal O, Beksac MS.
•    Curr Urol. 2019 Oct;13(2):70-73. doi: 10.1159/000499290. Epub 2019 Oct 1. PMID: 31768172 Free PMC article.
•    Is muscle mechanical function altered in polycystic ovary syndrome? Caliskan Guzelce E, Eyupoglu D, Torgutalp S, Aktoz F, Portakal O, Demirel H, Yildiz BO. Arch Gynecol Obstet. 2019 Sep;300(3):771-776. doi: 10.1007/s00404-019-05229-2. Epub 2019 Jul 1. PMID: 31263987
•    Corrigendum to "Factors associated with pulmonary hypertension and long-term survival in bronchiectasis subjects" [Respir. Med. (2016) 119 109-114]. Öcal S, Portakal O, Öcal A, Demir AU, Topeli A, Çöplü L. Respir Med. 2019 Nov-Dec;160:105706. doi: 10.1016/j.rmed.2019.05.013. Epub 2019 Jun 11. PMID: 31200983 No abstract available.
•    Human papillomavirus infection and autoimmune disorders: a tertiary center experience. Donmez HG, Tanacan A, Unal C, Fadiloglu E, Onder SC, Portakal O, Beksac MS. Pathog Dis. 2019 Apr 1;77(3):ftz028. doi: 10.1093/femspd/ftz028. PMID: 31034015
•    Comparison of the novel ARCHITECT procalcitonin assay with established procalcitonin assay systems.
•    Soh A, Binder L, Clough M, Hernandez MH, Lefèvre G, Mostert K, Nguyen TB, Otte KM, Portakal O, Sandri MS, Yen JL, Huang J, Beshiri A. Pract Lab Med. 2018 Nov 9;12:e00110.
•    Emerging biomarker for predicting acute kidney injury after cardiac surgery: cystatin C. Saydam O, Türkmen E, Portakal O, Arıcı M, Doğan R, Demircin M, Paşaoğlu İ, Yılmaz M. Turk J Med Sci. 2018 Dec 12;48(6):1096-1103. doi: 10.3906/sag-1704-96. PMID: 30541232 Free article.
•    Relationship Between First Trimester Maternal TSH Levels and Down Syndrome Screening Tests
•    Orgul, Gokcen; Dogan, Devrim Ruzgar; Portakal, Oytun; Et Al. CUKUROVA MEDICAL JOURNAL  Volume: 43 Supplement: 1 Pages: 94-99  Published: 2018
•    The Impact of 17B Estradiol Level Variations On Blood Lymphocyte Counts Among Healthy Females
•    Orgul, Gokcen; Yucesoy, H. Meltem; Portakal, Oytun. CLINICAL AND EXPERIMENTAL HEALTH SCIENCES Volume: 8 Issue: 2 Pages: 118-121 Published: JUN 2018
Dr. Öğr. Üyesi Başak Çeltikçi
•    Protein Kinase-mediated decisions between life and death, Chapter 12, Springer International Publishing, Engin&Engin (ed.s), 2020.
•    Regulation And Effect Of Telomerase And Telomeric Length In Stem Cells. Celtikci B, Erkmen GK, Dikmen ZG. Curr Stem Cell Res Ther. 2020 Apr 21.
Dr. Esra Büber
•    Yildirim D, Gokcal B, Buber E, Kip C, Demir MC, Tuncel A. (2021), A new nanozyme with peroxidase-like activity for simultaneous phosphoprotein isolation and detection based on metal oxide affinity chromatography: Monodisperse-porous cerium oxide microspheres. Chemical Engineering Journal, 403, DOI: 10.1016/j.cej.2020.126357.
•    Gokcal B, Hamaloglu KO, Kip C, Gungor SY, Buber E, Tuncel A. (2020), Glutathione detection in human serum using gold nanoparticle decorated, monodisperse porous silica microspheres in the magnetic form. Analytical Methods, 12 (43), 5219-5228, DOI: 10.1039/d0ay01292k.
•    Yılmaz D, Çağlayan F, Büber E, Könönen E, Aksoy Y, Gürsoy KU, Güncü GN (2018), Gingival crevicular fluid levels of human beta-defensin-1 in type 2 diabetes mellitus and periodontitis. Clinical Oral Investigations, 22(5), 2135-2140.
•    Ertürk Z, Büber E, Özen AH, Çelikbıçak Ö, Salih B, Açan NL (2017). Mycobacterium Brumae Extract Fractions with Potential Immunotherapeutic Activity for Bladder Cancer. Üroonkoloji Bülteni, 16(3), 70-76.
Dr. Esra Büber- Patentler
•    GST P1 Enzimine Spesifik, Özgün ve Yeni Nesil İnhibitör Bileşikleri (2020), Patent No: 2018/19936.
•    Yüzeyel mesane tümörü tedavisinde kullanılabilecek Mycobacterium brumae hücre duvarı ekstreleri (2016), Patent No: TR 2011 01874.
•    Yüzeysel mesane tümörü tedavisinde kullanılabilecek Mycobacterium chubuense hücre duvarı ekstreleri (2015), Patent No: 2011/01873.
•    Yüzeyel mesane tümörü tedavisinde kullanılabilecek Mycobacterium murale hücre duvarı ekstreleri (2015), Patent No: 2011/00759.
•    Yüzeyel mesane tümörü tedavisinde kullanılabilecek Mycobacterium chitae hücre duvarı ekstreleri (2015), Patent No: 2011/01872.

Links

About

Research Infrastructure

• Chemidoc Touch imaging system
• Polyacrylamide gel and agarose gel electrophoresis devices in different sizes
• Electrophoresis power supplies
• Transblot device
• Gel dryer
• Thermocycle
• Nanodrop
• Spectrophotometer
• Fluorometer
• Microplate Reader
• SpectraMax M2
• Microcentrifuge
• -freezers 20, -30 and -80
• Refrigerators
• Ice machine
• Thin layer chromatography tank
• Vortexes
• Distilled pure water device
• Cold rooms
• Clinical centrifuge
• Fume hoods
• Nitrogen tube
• Oven
• Refrigerated microfuge
• Supercentrifuge
• Ultracentrifuge
• Precision balance
• pH meters
• Magnetic stirrers
• Glass-glass homogenizer
• Glass-teflon homogenizer
• Water baths
• Shimadzu 1700 Kinetic Spectrophotometer
• Shimadzu 1200 Spectrophotometer
• PCR Devices
• UV gel imaging device
• Sonicator
• Analytical scale
• Microfuge
• Homogenizers
• Shakers and mixers
• Imax3 Microplate reader
• Pumps with fraction collector
• Nitrogen evaporator
• Bacterial cell culture laboratory (laminar flow cabinet, class II, sonicator, oven, refrigerator), Cell culture laboratory (laminar flow cabinet, carbon dioxide incubator, Inverted microscope, water bath, desktop centrifuge, liquid nitrogen tank, vacuum pump), analytical HPLC system, semi-preparative HPLC system, electrophoresis and transfer system, two-way electrophoresis system, thermostatic circulator

Researchers

•    Prof. Dr. H. Asuman Özkara
•    Prof. Dr. Z. Günnur Dikmen
•    Prof. Dr. Yasemin Aksoy
•    Prof. Dr. İncilay Lay
•    Prof. Dr. Ebru Bodur
•    Prof. Dr. Aslı Pınar
•    Doç. Dr. Yeşim Er Öztaş
•    Doç. Dr. Gülnihal Kulaksız Erkmen
•    Doç. Dr. Mukaddes Gürler
•    Doç. Dr. Oytun Portakal Akçin
•    Dr. Öğr. Üyesi Başak Çeltikçi
•    Araş. Gör. Dr. Esra Büber
•    Araş. Gör. Dr. Ahmet Yalçınkaya
•    Araş. Gör. Müslüm Gök
•    Araş. Gör. Mehmet Özcan
•    Araş. Gör. Dr. Furkan Yıldız
•    Araş. Gör. Dr. Feride Ongun
•    Araş. Gör. Dr. Amin Radgohar
•    Araş. Gör. Dr. Nigar Abdullazade
•    Araş. Gör. Merve Yılmaz
•    Araş. Gör. Onur Aktan
•    Araş. Gör. Ayşe Buruş
•    Araş. Gör. Esin Öz
•    Prof. Dr. Hatice Doğan Buzoğlu

Ongoing Projects

prof. Dr. H. Asuman Ozkara
• Determining the biomarker and drug target for individual medicine practice by examining the brain and gut interaction in children with autism spectrum disorder with a systems biology approach TÜSEB Strategic R&D project 2020 Project no: 2324, Project code: 2019-TA-01, Researcher, 27.04.2020- 27.04.2022, joint project with Boğaziçi University and ITU.
• Evaluation of Serum Sperm and Spermidin Levels in Primary Open Angle Glaucoma and Exfoliative Glaucoma, Position: Researcher, HÜBAB 2020, project no: THD-2020-18493, 9 June 2020- 9 March 2021, H.Ü. A joint project with the Department of Ophthalmology.
prof. Dr. Z. Gunnur Dikmen
• Syndecan 1 as a Biomarker in Alzheimer's Disease, HÜBAB (THD -2019-18288), Researcher
• The Role of Monocyte Chemoattractant Protein-1 in the Development of Malignant Pleural Effusion, HUBAB (TTU -2020-18474), Researcher
• Development of new treatment methods for idiopathic pulmonary fibrosis TUSEB, (Project No: 4569), Researcher
prof. Dr. Yasemin Aksoy
• THD-2020-18890, HUBAB. Investigation of the Relationship Between Stage of Liver Disease and Serum Branched Chain Amino Acids and Fructose Levels in NAFLD Patients, Researcher
• THD-2019-18322, HUBAB. Methionine Metabolism in Human Fetal, Adult and Cancer Stem Cells, Researcher
• THD-2019-18034, HÜBAB -Examination of oxidative stress caused by cariogenic bacteria in dental pulp cell, Manager
• THD-2019-18110, Effect of Inflammation and Post-Inflammation of Nacetylcysteine ​​on Lag3 and Tlr2 Receptors in Neurons in HÜBAB -Parkinson's Disease Cellular Model, Researcher
• THD-2019-18055, HÜBAB - Investigation of the Effects of Antioxidant Use on Breast Cancer Treatment, Manager
• TDK-2018-17483, HÜBAB - Investigation of the Effects of Antioxidant Use on Breast Cancer Treatment, Manager
• THD-2018-17226, HUBAB. Investigation of oxidative stress in healthy and inflamed dental pulp tissue, Researcher
prof. Dr. Incilay Lay
• THD-2020-18915, HUBAB. The role of muscle tissue as an endocrine organ in the development of obesity, the relationship between adipokinemyokine profile and exercise capacity (Researcher) 02.12.2020
• THD-2020-18802, HUBAB. The effect of vitamin E on colon anastomosis (Researcher) 21.09.2020
• THD-2020-18787, HUBAB. Evaluation of Noninvasive Liver Fibrosis Tests in Nonalcoholic Steatohepatitis Patients (Researcher) 10.07.2020
• TSA-2019-17525, HUBAB. Investigation of the effects of microbiota, proteomic and metabolomic analysis results on disease pathogenesis and course in rheumatic diseases. Part 2: Proteomic investigation in Henoch Schönlein Purpura/IgA vasculitis (Researcher) 31.01.2019
prof. Dr. Ebru Bodur
• Possible lipolytic activity of human serum butyrylcholinesterase and its relationship with lipid metabolism. Dr. Ebru Bodur HUBAB, TDK-2018-17028
• Investigation of the effects of Lamiaceae family species on anti-inflammatory pathway enzymes Lipooxygenase (LOX) and Cyclooxygenase (COX) Director: Prof. Dr. Ebru Bodur, Prof. Dr. Murat Ekici – Multidisciplinary study Gazi University Scientific Research Unit-
• Can late-onset depression be a precursor to Alzheimer's dementia? A biomarker study. Executive Assoc. Dr. Özlem Erden Aki- Multidisciplinary study- HÜBAB -TTU -2020-18472
• The Relationship between Orexin Levels in Serum and Cerebrospinal Fluid in Epilepsy Patients with Sleep Stages and Seizures-Executive: Prof. Dr. İrsel Tezer Kutluk - Multidisciplinary study – HÜBAB, THD-2018-17275
• The Effect of Melatonin on Cisplatin-Induced Neurotoxicity in Rats -Executive: Assoc. Dr. Meltem Tuncer -- Multidisciplinary study- HÜBAB, TTU -2020-18596
prof. Dr. Asli Pinar
• THD-2020-18747, HUBAB. Biochemical and immunological evaluation of caries status and saliva content of cystic fibrosis patients, (Researcher), 05.06.2020-07.06.2021
• THD-2019-18415, HUBAB. The effect of Lactobacillus rhamnosus GG supplementation on gastrointestinal system and pulmonary inflammation and nutritional status in patients with cystic fibrosis, (Researcher), 11.11.2019-11.03.2021
• TSA-2019-18369 HUBAB. Clinical and Biochemical Evaluation of the Efficacy of Non-Surgical Treatment Approaches in the Treatment of Peri-implantitis, (Researcher), 18.11.2019-18.05.2022
• TSA-2019-18111, HUBAB. Clinical and Biochemical Evaluation of the Efficacy of Diode Laser Application with Non-Surgical Periodontal Treatment, (Researcher), 28.11.2019-28.11.2021
• THD-2019-17801, HUBAB. Oral Health and Evaluation of Carbonic Anhydrase Enzyme in Saliva in Children with Chronic Kidney Disease, (Researcher), 10.04.2019-10.01.2021
• THD-2018-16338, HUBAB. 3D Strain Echocardiography in Determining Left Ventricular Diastolic Dysfunction, (Researcher), 09.02.2018-09.02.2019
Assoc. Dr. Yeşim Er Öztaş
• Preparation of Multifunctional Proteoliposomes and Investigation of Their Effects on Erythrocytes (THD-2019-18441) HÜBAB, (Executive)
Assoc. Dr. Gulnihal Kulaksiz Erkmen
• Investigation of cisplatin cellular response in breast cancer via DDB2 and DNA polymerase eta, Project coordinator: Gülnihal Kulaksız Erkmen, Researcher: Onur Aktan (2020-….) TYL-2020-18767, HÜBAB.
Assoc. Dr. Mukaddes Gurler
• Hair metabolomics analysis in pregnant women with pregnancy complications due to abnormal implantation and placentation HÜBAB THD 18460, Executive
Assoc. Dr. Oytun Portakal
• Investigation of Circulating MicroRNA Profile in Uveal Melanoma Cases Before and After Treatment (HUBAB project, TSA-2018-17285, Researcher)
• Measuring the effect of FSH and LH on progesterone level in human granulosa-theca cell culture (BAP project, TSA-2019-18032, Researcher)
Dr. Instructor Member Başak Çeltikçi
• Development of New Treatment Methods for Idiopathic Pulmonary Fibrosis, TÜSEB, Project No: 4569, Researcher, Start date: 17.07.2020.
Dr. Esra Buber
• Development of New Treatment Methods for Idiopathic Pulmonary Fibrosis, TÜSEB, Project No: 4569, Researcher, Start date: 17.07.2020.

Completed Projects

Prof. Dr. Hatice Asuman Özkara
•    “Gaucher ve Metakromatik Lökodistrofi hastalıklarına yönelik farmakolojik şaperonların belirlenmesi” TÜBİTAK 1001 projesi 2015-2018 proje no: 115S208 (Danışman), Boğaziçi Üniv ile ortak proje.
•    “Metakromatik Lökodistrofi hastalığının farklı alt tiplerinin tanımlanması, patojenik mutasyonların belirlenmesi, patogenezde inflamasyonun rolünün incelenmesi” HÜBAB Kapsamlı proje 2017-2019 proje no: TSA-2017-12891 (Yürütücü)
Prof. Dr. Z. Günnur Dikmen
•    Yeni Nesil Kanser Terapisi Için Bir Yaklasım G4 DNA yı Kararlı Kılan Floren Fluorenon Temelli Yeni Nesil Floresans Ligandların Sentezi Ligand DNA Etkilesim Mekanizmalarının ve Anti telomeraz Aktivitesinin incelenmesi (2015-2017) TUBİTAK KBAG 113Z704, Araştırmacı
•    Tirozin kinaz inhibitörlerini kullanan Kronik Myeloid Lösemi hastalarında trombosit fonksiyonlarının değerlendirilmesi (2016-2017) HÜBAB (Proje No: THD -2015-6345), Yürütücü
•    Trombositopenik hastalarda platelet yüzey antijenlerinin flow sitometri ile incelenmesi ve kanama diyatezi ile ilişkisinin araştırılması (2018-2020) HÜBAB (Proje No:THD -2018-17020), Yürütücü
•    Psödoeksfoliasyon Sendromu ve Glokomun Serum Apelin ve Asimetrik Dimetilarjin düzeyi ile İlişkisi, Hacettepe Üniversitesi BAB, Yardımcı araştırmacı (2018-2019) HÜBAB (Proje No:THD -2018-16690), Araştırmacı
•    Endometrial patoloji ve anormal uterin kanama ile başvuran hastalarda Anti-Mullerian hpormon, CA125, HE4 ve Östradiol ilişkisi (2017-2019) HÜBAB (Proje No:THD -2017-15828), Araştırmacı
•    Nöroloji Yoğun Bakım Ünitesindeki İnme Hastalarında Yoğun Bakım Ünitesinde Edinilmiş Güçsüzlüğün (YBÜEG) Multimodal İncelemesi (2018-2020) HÜBAB (Proje No:THD -2018-17114), Araştırmacı
•    Acil Servise Kalp Yetmezliği Semptomları ile Başvuran Hastalara Uygulanan Diüretik Tedavi Neticesinde Karşılaşılabilecek Akut Böbrek Yetmezliği Tablosunu Önceden Belirlemede TIMP2 ve IGFB P7’nin Rolü (2019-2020), HÜBAB (Proje No: TTU -2019-17881), Araştırmacı
Prof. Dr. Yasemin Aksoy
•    014 D04 101 005-537, GST P1-1 Özgül İnhibitörlerin Belirlenmesi İçin Bulut Temelli Sanal Tarama ve Otomasyon Yönteminin Geliştirilmesi, Yönetici, 01.04.2014,
•    TBB-2017-16499, HÜBAB. İnsan Glutatyon S Transferaz P1-1 Spesifik İnhibitör Moleküllerin Bilgisayar Destekli ve Yapı Temelli de novo Tasarımında Veri Analizi, Yönetici, 07.05.2018-20.11.2017
•    TAY-2015-7227, HÜBAB. İnsan Glutatyon S Transferaz P1-1 Spesifik İnhibitör Moleküllerin Bilgisayar Destekli ve Yapı Temelli de novo Tasarımı, Yönetici, (09.09.2015-11.06.2018)
•    012 D09 101 001-20. Chlorophyllide Cu Kompleksinin GSTP1-1 İnhibitörü Olarak İncelenmesi ve meme kanser hücre dizilerinde Sitotoksitesinin Belirlenmesi, Yönetici, ( 07.09.2012-26.04.2016)
Prof. Dr. İncilay Lay
•    THD-2018-16921 HÜBAB. Kolestaz Hastalarında Safra Asitlerinin LC-MS/MS ile Araştırılması ve Olası Biyobelirteçlerin Belirlenmesi (Yürütücü) 30.11.2020
•    THD-2018-16849, HÜBAB. Nörofibromatozis Tip 1'de Hipotoni Etiyolojisi ve Hipotoninin Motor ve Dil Alanına Etkileri (Araştırmacı) 07.01.2020
•    THD-2017-16295, HÜBAB. Organik Asidemi Hastalarında Oksisterollerin LC-MS/MS Yöntemi ile İncelenmesi (Araştırmacı) 17.03.2020
•    TSA-2017-14407, HÜBAB. Kurşun Maruziyetinin ve Şelasyon Tedavisinin Toksisiteyi Etkileyen Bazı Parametreler Üzerine Etkisi (Araştırmacı) 02.01.2020
•    THD-2017-13469, HÜBAB. Tat Duyusu Renin Anjiyotensin Aldosteron Sisteminin İnkretin Fizyolojisi ve İnsulin Direncine Etkisi (Araştırmacı) 07.01.2020
•    THD-2017-13423, HÜBAB. Metabolik Sendromlu Hastalarda Plazma Makrofaj Apoptozis İnhibitör (AIM) ve Plazma Monosit Kemotaktik Protein-1 (MKP-1) Düzeylerinin Değerlendirilmesi (Araştırmacı) 15.01.2018
•    THD-2017-13012, HÜBAB. Silikozis Hastalarında Oksisterol Düzeylerinin Değerlendirilmesi (Araştırmacı) 28.09.2018
•    THD-2016-12638, HÜBAB. Kistik fibrozisli hastalarda alevlenme ve remisyon dönemlerinde plazma sfingomyelin ve seramid düzeylerinin sıvı kromatografisikütle spektrometresi ile belirlenmesi ve bazı enflamasyon belirteçleriyle ilişkisinin incelenmesi (Yardımcı araştırmacı) 11.06.2018
•    THD-2016-10908, HÜBAB. Tip 1 ve Tip 2 Diabetes Mellitusta oksisterol türlerinin LCMSMS metodu ile incelenmesi (Yürütücü) 28.06.2017
•    TSA-2016-7276, HÜBAB. Orak hücre hastalığında lipit metabolizmasındaki değişimlerin araştırılması ve hastalık patogeneziyle ilişkilendirilmesi (Yardımcı araştırmacı) 08.12.2017
Prof. Dr. Ebru Bodur
•    Fenilketonüride öğrenme ve bellek mekanizmasının dişi ve erkek sıçanlarda cAMP/PKA/CREB/BDNF yolağı üzerinden incelenmesi (2020) Yürütücü: Prof. Dr. Ebru Bodur -Multidisipliner çalışma HÜBAB, TDK-2018-16969.
•    Over kanserlerinde BMP7 ve BMP2'nin invazyon ve metastazdaki etkisi (2019) Yürütücü: N. Dilara Zeybek Multidispliner çalışma, HÜBAB, TSA-2017-13046
•    İnsan serum bütirilkolinesterazının karaciğer HepG2 hücrelerinde lipid metabolizması ile etkileşiminin incelenmesi (2018) Yürütücü: Prof. Dr. Ebru Bodur -Multidisipliner çalışma HÜBAB, 014D11101001-750
•    Serebral iskemi modelinde oluşan nöroinflamasyon üzerine 12/15 lipooksijenaz inhibitörlerinin etkisi (2018) Yürütücü: Prof. Dr. Hülya Karataş Kurşun- Multidisipliner çalışma HÜBAB, THD -2016-11381
•    Nöroprotektif etkin madde içeren nano formülasyonların geliştirilmesi ve periferik sinir hasarı modelinde etkinliklerinin değerlendirilmesi (2018) Yürütücü: Prof. Dr. Hakan Eroğlu- Prof. Dr. Ebru Bodur (İş paketi 3,4), TÜBİTAK SBAG Bilimsel Araştırma Projesi 115S202
Prof. Dr. Aslı Pınar
•    THD-2016-12089, HÜBAB. Diş Eti Oluğu Sıvısı ile Peri implant Oluk Sıvısındaki Sklerostin, TWEAK, RANKL ve OPG Oranlarının Karşılaştırılması, (Araştırmacı) 10.11.2016-04.12.2017
Doç. Dr. Yeşim Er Öztaş
•    Kistik fibrozisli hastalarda alevlenme ve remisyon dönemlerinde plazma sfingomyelin ve seramid düzeylerinin sıvı kromatografisikütle spektrometresi ile belirlenmesi ve bazı enflamasyon belirteçleriyle ilişkisinin incelenmesi, 2018 (THD-2016-12638) HÜBAB, Yürütücü
•    Orak hücre hastalığında lipit metabolizmasındaki değişimlerin araştırılması ve hastalık patogeneziyle ilişkilendirilmesi, 2017 (TSA-2016-7276) HÜBAB, Yürütücü
Doç. Dr. Mukaddes Gürler
•    Anne ve kordon kanında organoklorin pestisit düzeylerinin belirlenerek annenin biyokimyasal parametreleri ve yenidoğan üzerindeki etkilerinin araştırılması. HÜBAB THD6492, Araştırmacı
Doç. Dr. Oytun Portakal
•    Tip 1 diyabetli adölesanlarda protein ve yağların postprandiyal glisemik yanıta etkisi ve bu yanıtın insülin rejimiyle yönetiminin incelenmesi (HÜBAB projesi, THD-2019-18425, Araştırmacı)
•    Dikkat Eksikliği Hiperaktivite Bozukluğu Olan Prepubertal Erkek Çocuklarda Otizm Benzeri Belirtilerin ve Agresyonun Testesteron Oksitosin Kortizol ve Androstenedion ile İlişkisi (HÜBAB projesi, THD-2018-15955, Araştırmacı)
•    Genel cerrahi Yoğun Bakım Ünitesindeki hastalarda serum omentin değerinin saptanması ve prognostik bir faktör olarak kullanılabilirliğinin değerlendirilmesi. HÜBAB projesi, THD-2017-11872,Yürütücü
Dr. Esra Büber
•    “Dental Pulpa Kök Hücrelerinde Melatoninin Hippo Sinyal Yolağı Üzerinde Etkisi”, HÜBAB (TYL-2018-17575), Araştırmacı, 25.11.2020.
•    “Trombositten Zengin Fibrin hazırlanmasında farklı santrifüj parametrelerinin büyüme faktörleri ve sitokin değerleri üzerine etkisi”, HÜBAB (THD-2017-15113), Araştırmacı, 28.05.2018.
•    “Asiyanotik ve Siyanotik Konjenital Kalp Hastalığı Olan Çocuklarda Antioksidan Rezerv Kapasitesinin Karşılaştırılması”, HÜBAB, Araştırmacı, 21.04.2015.

Publications

Prof. Dr. H. Asuman Özkara
•    Emel Örün, Songül Yalçın, İncilay Lay, Arzu Dursun, Asuman Özkara. Determination of intestinal enzyme activities during infancy period. J Curr Pediatr 2016; 14: 53-59.
•    Hamza Sunman, Adem Ozkan, Hikmet Yorgun, Ugur Canpolat, Naresh Maharjan, Serkan Asil, Ergun Baris Kaya, Tulin Bayrak, Lale Tokgozoglu, Asuman Ozkara, Kudret Aytemir, Ali Oto. Vitamin D Levels Predict the Response to Cardiac Resynchronization Therapy in Patients with Systolic Heart Failure. Archives of the Turkish Society of Cardiology 2016 Dec; 44(8): 670-676.
•    Özkan A, Özkara HA. Metachromatic Leukodystrophy: biochemical characterization of two (p.307Glu→Lys, p.318Trp→Cys) Arylsulfatase A mutations. Intractable Rare Dis Res 2016 Nov;5(4):280-283.
•    Sunman H, Özkan A, Yorgun H, Canpolat U, Karabulut E, Bayrak T, Kaya EB, Tokgözoğlu L, Özer N, Özkara A, Aytemir K, Oto A. Evaluating the effects of cardiac resynchronization therapy on pathophysiological pathways of heart failure using surrogate biomarkers. Cardiol J. 2018;25(1):42-51.
•    Sunman H, Canpolat U, Yorgun H, Özkan A, Yalçın MU, Bayrak T, Şahiner L, Kaya EB, Özkara A, Aytemir K, Oto A. Association between reverse electrical remodeling and cardiac fibrosis markers in patients with cardiac resynchronization therapy. Turk Kardiyol Dern Ars. 2018 Mar;46(2):84-91. doi: 10.5543/tkda.2017.80236.
•    Yagci ZB, Esvap E, Ozkara HA, Ulgen KO, Olmez EO. Inflammatory response and its relation to sphingolipid metabolism proteins: Chaperones as potential indirect anti-inflammatory agents. Adv Protein Chem Struct Biol. 2019;114:153-219. doi: 10.1016/bs.apcsb.2018.09.004. ISSN: 1876-1623
•    Unal C, Ozkara HA, Tanacan A, Fadiloglu E, Lay I, Topçu M, Cakar AN, Beksac MS. Prenatal enzymatic diagnosis of lysosomal storage diseases using cultured amniotic cells, uncultured chorionic villus samples, and fetal blood cells: Hacettepe experience. Prenat Diagn. 2019 Nov;39(12):1080-1085. doi: 10.1002/pd.5547. Epub 2019 Aug 22.Prenat Diagn. 2019. PMID: 31411753.
•    Özen S, Batu ED, Taşkıran EZ, Özkara HA, Ünal Ş, Güleray N, Erden A, Karadağ Ö, Gümrük F, Çetin M, Sönmez HE, Bilginer Y, Ayvaz DÇ, Tezcan I. A Monogenic Disease with a Variety of Phenotypes: Deficiency of Adenosine Deaminase 2. J Rheumatol. 2020 Jan;47(1):117-125.
•    Özkara HA. Hücre içi trafiği. Dursun A, editör. Kalıtsal Metabolik Hastalıklarda Hareket Bozuklukları. 1. Baskı. Ankara: Türkiye Klinikleri; 2020. p.1-8. ISBN: 978-625-401-117-7
•    Faruk Pekgül, Nesibe Gevher Eroğlu-Ertuğrul, Can Ebru Bekircan-Kurt, Sevim Erdem-Ozdamar, Arda Çetinkaya, Ersin Tan, Bahadır Konuşkan, Ergun Karaağaoğlu, Meral Topçu, Nurten Ayşe Akarsu, Kader K. Oguz, Banu Anlar, Hatice Asuman Özkara. Comprehensive clinical, biochemical, radiological and genetic analysis of 28 Turkish cases with suspected metachromatic leukodystrophy and their relatives. Mol Genet Metab Rep 2020 Dec 11;25:100688. doi: 10.1016/j.ymgmr.2020.100688.
Prof. Dr. Z. Günnur Dikmen
•    Akarsu S, Akbiyik F, Karaismailoglu E, Dikmen ZG. Gestation specific reference intervals for thyroid   function tests in pregnancy. Clin Chem Lab Med. 2016 Aug 1;54(8):1377-83.
•    Işeri-Erten SÖ, Dikmen ZG, Ulusu NN. Comparison of Spectrophotometric and Fluorimetric Methods in Evaluation of Biotinidase Deficiency.J Med Biochem. 2016 Apr;35(2):123-129.
•    Beyramzadeh M, Dikmen ZG, Erturk NK, Tuncer ZS, Akbiyik F. Placental respiratory chain complex activities in high risk pregnancies. J Matern Fetal Neonatal Med. 2017;30(24):2911-2917
•    Akarsu S, Gode F, Isik AZ, Dikmen ZG, Tekindal MA. The association between coenzyme Q10 concentrations in follicular fluid with embryo morphokinetics and pregnancy rate in assisted reproductive techniques. J Assist Reprod Genet. 2017 May;34(5):607
•    Watson ID, Oosterhuis WP, Jorgensen PE, Dikmen ZG, Siodmiak J, Jovicic S, Aakre KM, Palicka V, Kutt M; European Federation of Clinical Chemistry and Laboratory Medicine Working Group on Patient Focused Laboratory Medicine. A survey of patients' views from eight European countries of interpretive support from Specialists in Laboratory Medicine. Clin Chem Lab Med. 2017 Aug 28;55(10):1496-1500.
•    Kumbasar U, Dikmen ZG, Dikmen E, Dogan R. Serum HE4 as a diagnostic and follow-up biomarker in patients with non-small cell lung cancer. UHOD-Uluslararası Hematoloji-Onkoloji dergisi 2017; 27(3)
•    Karaismailoğlu E, Dikmen ZG, Akbıyık F, Karaağaoğlu AE. A statistical approach to evaluate the performance of cardiac biomarkers in predicting death due to acute myocardial infarction: time-dependent ROC curve. Turk J Med Sci. 2018 Apr 30;48(2):237-245.
•    Korkmaz ET, Koksal D, Aksu F, Dikmen ZG, Icen D, Maden E, Onder S, Akbiyik F, Emri S. Triple test with tumor markers CYFRA 21.1, HE4, and ProGRP might contribute to diagnosis and subtyping of lung cancer. Clin Biochem. 2018;58:15-19.
•    Z.Gunnur Dikmen, İlgen Mender. How can I protect my telomeres and slow aging? Turk J Biochem 2017; 42(6): 587–590
•    Naime Meric Konar, Eda Karaismailoğlu, Oytun Portakal, Aslı Pınar, Zeliha Gunnur Dikmen, Ahmet Ergun Karaağaoğlu. Birleşik Modelleme Yaklaşımı ile Tekrarlı C-Reaktif Protein Ölcümlerinin Tanısal Performansını Etkileyen Faktörlerin İncelenmesi.    Turkiye Klinikleri J Biostat, 10(1):52-64, 2018
•    Sener Y, Okay M, Aydin S, Buyukasik Y, Akbiyik F, Dikmen ZG. TKI-Related Platelet Dysfunction Does Not Correlate With Bleeding in Patients With Chronic Phase-Chronic Myeloid Leukemia With Complete Hematological Response.Clin Appl Thromb Hemost. 2019; 25:1076029619858409.
•    Ruslan Jafarov, Erman Ceyhan, Oguzhan Kahraman, Taner Ceylan, Zeliha G. Dikmen, Serdar Tekgul, Hasan S. Dogan. Efficacy of transcutaneous posterior tibial nevre stimulation in children with functional voiding disorders. Neurourology and Urodynamics, 2020 Nov 18
•    Bezci Aygun F, Kocabeyoglu S, Irkec M, Dikmen ZG, Umaroglu MM, Konstas AGP. Serum Apelin and Asymmetric Dimethylarginine Levels in Patients With Exfoliation Syndrome or Exfoliative Glaucoma. J Glaucoma. 2020 Jul;29(7):593-597.
Prof. Dr. Yasemin Aksoy
•    Ozcan M, Altay O, Lam S, Turkez H, Aksoy Y, Nielsen J, Uhlen M, Boren J, Mardinoglu A. Improvement in the Current Therapies for Hepatocellular Carcinoma Using a Systems Medicine Approach. Adv Biosyst. 2020 Jun;4(6):e2000030. doi: 10.1002/adbi.202000030. Epub 2020 Apr 8.
•    Yilmaz D, Caglayan F, Buber E, Könönen E, Aksoy Y, Gursoy UK, Guncu GN. Gingival crevicular fluid levels of human beta-defensin-1 in type 2 diabetes mellitus and periodontitis. Clin Oral Investig. 2018 Jun;22(5):2135-2140.
•    Ozcan M, Esendagli G, Musdal Y, Canpinar H, Bacanlı M, Anlar HG, Esendağlı-Yılmaz G, Beyramzadeh M, Aksoy Y. Dual actions of the antioxidant chlorophyllin, a glutathione transferase P1-1 inhibitor, in tumorigenesis and tumor progression. J Cell Biochem. 2018 120(5)Nov 28. doi: 10.1002/jcb.27974.
•    Pinar Karapinar S, Ulum YZ, Ozcelik B, Dogan Buzoglu H, Ceyhan D, Balci Peynircioglu B, Aksoy Y. The effect of N-acetylcysteine and calcium hydroxide on TNF-α and TGF-β1 in lipopolysaccharide-activated macrophages. Arch Oral Biol. 2016 Aug;68:48-54.
•    Aslantas EE, Buzoglu HD, Karapinar SP, Cehreli ZC, Muftuoglu S, Atilla P, Aksoy Y. Age-related Changes in the Alkaline Phosphatase Activity of Healthy and Inflamed Human Dental Pulp. J Endod. 2016 Jan;42(1):131-4.
Prof. Dr. İncilay Lay
•    Demir S, Kaplan O, Celebier M, Sag E, Bilginer Y, Lay I, Ozen S. Predictive biomarkers of IgA vasculitis with nephritis by metabolomic analysis. Semin Arthritis Rheum. 2020 Dec;50(6):1238-1244.
•    Helvaci N, Kabacam S, Dagdelen S, Lay I, Karabulut E, Mut M, Alikasifoglu M, Erbas T. Klotho gene G395A and C1818T polymorphisms in acromegaly: Association with clinical presentation and comorbidities. Clin Endocrinol (Oxf). 2020 Dec 9. doi: 10.1111/cen.14380.
•    Isgin-Atici K, Alsulami S, Turan-Demirci B, Surendran S, Sendur SN, Lay I, Karabulut E, Ellahi B, Lovegrove JA, Alikasifoglu M, Erbas T, Vimaleswaran KS, Buyuktuncer Z. FTO gene-lifestyle interactions on serum adiponectin concentrations and central obesity in a Turkish population. Int J Food Sci Nutr. 2020 Aug 4:1-11.
•    Bal Topçu D, Tugcu G, Ozcan F, Aslan M, Yalcinkaya A, Polat SE, Hizal M, Yalcin EE, Ersoz DD, Ozcelik U, Kiper N, Lay I, Oztas Y. Plasma Ceramides and Sphingomyelins of Pediatric Patients Increase in Primary Ciliary Dyskinesia but Decrease in Cystic Fibrosis. Lipids. 2020 May;55(3):213-223.
•    Aksu N, Samadi A, Yalçınkaya A, Çetin T, Eser B, Lay İ, Öziş TN, Öztaş Y, Sabuncuoğlu S. Evaluation of oxysterol levels of patients with silicosis by LC-MS/MS method. Mol Cell Biochem. 2020 Apr;467(1-2):117-125.
•    Savaş EM, Oğuz SH, Samadi A, Yılmaz Işıkhan S, Ünlütürk U, Lay İ, Gürlek A. Apoptosis Inhibitor of Macrophage, Monocyte Chemotactic Protein-1, and C-Reactive Protein Levels Are Increased in Patients with Metabolic Syndrome: A Pilot Study. Metab Syndr Relat Disord. 2020 May;18(4):197-205.
•    Samadi A, Isikhan SY, Tinkov AA, Lay I, Doşa MD, Skalny AV, Skalnaya MG, Chirumbolo S, Bjørklund G. Zinc, copper, and oxysterol levels in patients with type 1 and type 2 diabetes mellitus. Clin Nutr. 2020 Jun;39(6):1849-1856.
•    Acar I, Cetinkaya A, Lay I, Ileri-Gurel E. The role of calcium sensing receptors in GLP-1 and PYY secretion after acute intraduodenal administration of L-Tryptophan in rats. Nutr Neurosci. 2020 Jun;23(6):481-489.
•    Samadi A, Gurlek A, Sendur SN, Karahan S, Akbiyik F, Lay I. Oxysterol species: reliable markers of oxidative stress in diabetes mellitus. J Endocrinol Invest. 2019 Jan;42(1):7-17.
•    Hayran Y, Lay I, Mocan MC, Bozduman T, Ersoy-Evans S. Vascular endothelial growth factor gene polymorphisms in patients with rosacea: A case-control study. J Am Acad Dermatol. 2019 Aug;81(2):348-354.
•    Savaş Ö, Süslü AE, Lay I, Özer S. Assessment of the relationship between polysomnography parameters and plasma malondialdehyde levels in patients with obstructive sleep apnea. Eur Arch Otorhinolaryngol. 2019 Dec;276(12):3533-3538.
•    Yalcinkaya A, Samadi A, Lay I, Unal S, Sabuncuoglu S, Oztas Y. Oxysterol concentrations are associated with cholesterol concentrations and anemia in pediatric patients with sickle cell disease. Scand J Clin Lab Invest. 2019 Oct;79(6):381-387.
•    Unal C, Ozkara HA, Tanacan A, Fadiloglu E, Lay I, Topçu M, Cakar AN, Beksac MS. Prenatal enzymatic diagnosis of lysosomal storage diseases using cultured amniotic cells, uncultured chorionic villus samples, and fetal blood cells: Hacettepe experience. Prenat Diagn. 2019 Nov;39(12):1080-1085.
•    Keles ME, Samadi A, Isikhan SY, Sener YZ, Sezgin A, Keles E, Lay I, Canpolat U. The Effect of Effort Test on the Levels of Ischemia Modified Albumin, 7-ketocholesterol and Cholestan-3β, 5α, 6β -triol and their Role in the Diagnosis of Coronary Artery Disease. J Med Biochem. 2019 May 11;38(3):249-255.
•    El Moustafa K, Sivri S, Karahan S, Coşkun T, Akbıyık F, Lay İ. Screening for mucopolysaccharidoses in the Turkish population: Analytical and clinical performance of an age-range specific, dye-based, urinary glycosaminoglycan assay. Clin Chim Acta. 2017 Jan;464:72-78.
•    Bozduman T, Ersoy Evans S, Karahan S, Hayran Y, Akbiyik F, Lay I. Genetic Risk Factors for Psoriasis in Turkish Population: -1540 C/A, -1512 Ins18, and +405 C/G Polymorphisms within the Vascular Endothelial Growth Factor Gene. Ann Dermatol. 2016 Feb;28(1):30-9.
Prof. Dr. Ebru Bodur
•    Haidar MK, Timur SS, Kazanci A, Turkoglu OF, Gürsoy RN, Nemutlu E, Sargon MF, Bodur E, Gök M, Ulubayram K, Öner L, Eroğlu H. (2020) Composite nanofibers incorporating alpha lipoic acid and atorvastatin provide neuroprotection after peripheral nerve injury in rats. Eur J Pharm Biopharm. 153:1-13.
•    Sarıgöl E, Ekizoğlu M, Bozdağ Pehlivan S, Bodur E, Sağıroğlu M, Çalış S (2018) A thermosensitive gel loaded with an enzyme and an antibiotic drug for the treatment of periprosthetic joint infection. Journal of Drug Delivery Science and Technology 43 (2018) 423–429
•    Gurcan O, Gurcay AG, Kazanci A, Senturk S, Bodur E, Karaca EU, Turkoglu OF, Bavbek M. (2017) Effect of Asiatic Acid on the Treatment of Spinal Cord Injury: An Experimental Study in Rats Turk Neurosurg. 27(2):259-264.
•    Bayrak A, Bayrak T, Bodur E, Kılınç K, Demirpençe E. (2016) The effect of HDL-bound and free PON1 on copper-induced LDL oxidation. Chem Biol Interact. 257:141-6.
•    Gok M, Zeybek ND, Bodur E. (2016) Butyrylcholinesterase expression is regulated by fatty acids in HepG2 cells. Chem Biol Interact. 259(Pt B):276-281.
•    Gurcay AG, Gurcan O, Kazanci A, Bozkurt I, Senturk S, Bodur E, Turkoglu OF, Bavbek M. (2016) Comparative Biochemical and Motor Function Analysis of Alpha Lipoic Acid and N-Acetyl Cysteine Treatment on Rats with Experimental Spinal Cord Injury. Turk Neurosurg 26(1):119-26.
•    Senturk S, Gurcay AG, Bozkurt I, Gurcan O, Eroglu H, Turkoglu OF, Bodur E, Bavbek M. (2015) Effects of tadalafil-Type-V phosphodiesterase enzyme inhibitor-On rats with spinal trauma. Br J Neurosurg. 29(2):254-9
Prof. Dr. Aslı Pınar
•    Dikmen, Z. G.; Pinar, A.; Akbiyik, F. Specimen rejection in laboratory medicine: Necessary for patient safety? 2015 Biochemia Medica Volume: 25 (3) Pages: 377-385.
•    Usta DD, Salimi K, Pinar A, Coban İ, Tekinay T, Tuncel A. A Boronate Affinity-Assisted SERS Tag Equipped with a Sandwich System for Detection of Glycated Hemoglobin in the Hemolysate of Human Erythrocytes. ACS Applied Materials and Interfaces. 2016 May 18;8(19):11934-44
•    Aydemir, Y, Pınar, A., Hızal, G.A, Demir, H., Saltık Temizel, İ.N., Özen, H., Akbıyık, F., Yüce, A. Neutrophil volume distribution width as a new marker in detecting inflammatory bowel disease activation.International Journal of Laboratory Hematology, Volume 39 (1), 1 February 2017, Pages 51-57.
•    Salimi K, Usta DD, Çelikbıçak Ö, Pınar A, Salih B, Tuncel A. Highly selective enrichment of phosphopeptides by titanium (IV) attached monodisperse-porous poly(vinylphosphonic acid-co-ethylene dimethacrylate) microspheres. Journal of Chromatography A. 2017 May 5;1496:9-19.
•    Salimi K, Usta DD, Çelikbıçak Ö, Pınar A, Salih B, Tuncel A. Ti(IV) carrying polydopamine-coated, monodisperse-porous SiO2 microspheres with stable magnetic properties for highly selective enrichment of phosphopeptides. Colloids and Surfaces B- Biointerfaces. 2017 May 1;153:280-290.
•    Küme T, Karakükcü Ç, Pınar A, Coşkunol H. The Scope, Quality and Safety Requirements of Drug Abuse Testing. Türk Psikiyatri Dergisi. 2017 Fall;28(3):198-207.
•    Pınar A, Kurne A Lay İ, Acar NP, Karahan S, Karabudak R, Akbıyık F. Cerebrospinal fluid oligoclonal banding patterns and intrathecal immunoglobulin synthesis: Data comparison from a widepatient group.  Journal of Neurological Sciences-Turkish (Neurological Sciences and Neurophysiology) 2018; 35: 21-28.
•    Yakar N, Guncu GN, Akman AC, Pınar A, Karabulut E, Nohutcu RM. Evaluation of gingival crevicular fluid and peri-implant crevicular fluid levels of sclerostin, TWEAK, RANKL and OPG. Cytokine. 2019; Oct 27. pii: S1043-4666(18)30409-5.
•    Küme T, Mercan F, Topsakal H, Karakukcu C, Şeneş M, Pınar A, Gürler M, Kalafat H, Ünal B, Verstraete AG, Hamurtekin Y, Aydınlı A, Şenol Y, Eğin ME, Cihan A, Kazancı EG, Gümüş E. Assessment of the results of a three-year program for National Standardization and Quality Improvement of Medical Laboratories on Drug of Abuse Testing by the Ministry of Health in Turkey. Drug Test Anal. 2018 Aug 14.
•    Taş D, Akman Öden A, Akgül S, Metin ZE, Pınar A, Kanbur N. The effect of the pubertal stage on irisin levels in male adolescents: A novel myokine. Journal of Clinical Research in Pediatric Endocrinology 2019 J Clin Res Pediatr Endocrinol. 2019 Sep 13.
•    Salimi K, Kip Ç, Çelikbıçak Ö, Usta DD, Pınar A, Salih B, Tuncel A. Ti (IV) attached-phosphonic acid functionalized capillary monolith as a stationary phase for in-syringe-type fast and robust enrichment of phosphopeptides. Biomed Chromatogr. 2019 Jun;33(6):e4488.
•    Yaprak DS, Yalçın B, Pınar AA, Büyükpamukçu M. Assessment of nutritional status in children with cancer: Significance of arm anthropometry and serum visceral proteins. Pediatr Blood Cancer.2021 Jan;68(1):e28752
Doç. Dr. Yeşim Er Öztaş
•    Plasma Ceramides and Sphingomyelins of Pediatric Patients Increase in Primary Ciliary Dyskinesia but Decrease in Cystic Fibrosis. Bal Topçu D, Tugcu G, Ozcan F, Aslan M, Yalcinkaya A, Polat SE, Hizal M, Yalcin EE, Ersoz DD, Ozcelik U, Kiper N, Lay I, Oztas Y. Lipids. 2020 May;55(3):213-223
•    Altered HDL particle in sickle cell disease: decreased cholesterol content is associated with hemolysis, whereas decreased Apolipoprotein A1 is linked to inflammation. Yalcinkaya A, Unal S, Oztas Y. Lipids Health Dis. 2019 Dec 20;18(1):225.
•    Oxysterol concentrations are associated with cholesterol concentrations and anemia in pediatric patients with sickle cell disease. Yalcinkaya A, Samadi A, Lay I, Unal S, Sabuncuoglu S, Oztas Y. Scand J Clin Lab Invest. 2019 Oct;79(6):381-387. doi: 10.1080/00365513.2019.1627578. Epub 2019 Jun 12.
•    Vitamin D Deficiency and Its Association with Inflammatory Markers, Lipid Profile and Regulatory T-cells in Pediatric Sickle Cell Disease Patients. Oztas Y, Unal S, Eskandari G, Tamer L, Ozgunes N. Indian J Hematol Blood Transfus. 2018 Jul;34(3):480-485.
•    The serum leptin level in non-obese patients with obstructive sleep apnea. Pamuk AE, Süslü AE, Yalçınkaya A, Öztaş YE, Pamuk G, Özer S, Önerci M. Auris Nasus Larynx. 2018 Aug;45(4):796-800.
•    Preparation of L-Glutamine Loaded Liposomes for Drug Delivery to Erythrocytes. Gokce Alp and Yesim Oztas Journal of Hematology Research, 2020, 7, 4-12
•    Aquaporins: A Multidisciplinary Perspective on The Water Channel Proteins G Alp, II Bosgelmez, Y Oztas. Acta Medica 51 (2), 30-42
•    Oxidative alterations in sickle cell disease: possible involvement in disease pathogenesis Y Oztas, A Yalcinkaya World J. Hematol 6, 55 2017
•    Hypocholesterolemia and Increased Plasma 7-ketocholesterol Levels in Pediatric Sickle Cell Patients A Yalçınkaya, İ Lay, A Samadi, S Ünal, F Akbıyık, Y Öztaş. Acta Medica 48 (1), 1-4
•    An Introduction to Lipidomics: From Laboratory to Clinic Y Öztaş, İ Boşgelmez. Acta Medica 48 (1), 14-23
•    Hypocholesterolemia: A Neglected Laboratory Finding Y Oztas Acta Medica 47 (1), 19-22 2016
Doç. Dr. Gülnihal Kulaksız Erkmen
•    Nucleotide excision repair by dual incisions in plants. Canturk F, Karaman M, Selby CP, Kemp MG, Kulaksiz-Erkmen G, Hu J, Li W, Lindsey-Boltz LA, Sancar A. Proc Natl Acad Sci U S A. 2016 Apr 26;113(17):4706-10.
•    Fluoxetine-induced toxicity results in human placental glutathione S-transferase-π (GST-π) dysfunction. Dalmizrak O, Kulaksiz-Erkmen G, Ozer N. Drug Chem Toxicol. 2016 Oct;39(4):439-44.
•    Purification of Glutathione S-Transferase pi from Erythrocytes and Evaluation of the Inhibitory Effect of Hypericin. Turk S, Kulaksiz Erkmen G, Dalmizrak O, Ogus IH, Ozer N. Protein J. 2015 Dec;34(6):434-43.
•    Regulation And Effect Of Telomerase And Telomeric Length In Stem Cells. Celtikci B, Kulaksiz Erkmen G, Dikmen G, Cell Res Ther. 2020 Apr 21.
Doç. Dr. Mukaddes Gürler
•    Betül İşiner Kaya, Mukaddes Gürler & Eda Karaismailoğlu (2020): Maternal and umbilical cord blood serum concentrations of organochlorine pesticides and investigation of possible effects on newborn, International Journal of Environmental Analytical Chemistry. https://doi.org/10.1080/03067319.2020.1813731
Doç. Dr. Oytun Portakal
•    Comparison of term and preterm labor procalcitonin and leukocyte cell volume, conductivity and light scatter (VCS) parameters in order to demonstrate the impact of inflammation on the triggering mechanisms of preterm uterin contractions. Unal C, Karatas E, Fadıloglu E, Portakal O, Beksac MS. J Obstet Gynaecol Res. 2020 May;46(5):694-698. doi: 10.1111/jog.14216. Epub 2020 Mar 3. PMID: 32128965
•    5 Years' Experience of a Tertiary Center with Thrombocytopenic Pregnancies: Gestational Thrombocytopenia, Idiopathic Thrombocytopenic Purpura and Hypertensive Disorders of Pregnancy.
•    Fadiloglu E, Unal C, Tanacan A, Portakal O, Beksac MS. Geburtshilfe Frauenheilkd. 2020 Jan;80(1):76-83. doi: 10.1055/a-0865-4442. Epub 2019 Jul 24. PMID: 31949322 Free PMC article.
•    Cord blood delta neutrophil index values of term neonates. Büyükeren M, Çelik HT, Portakal O, Fadıloğlu E, Örgül G, Yiğit Ş, Beksaç MS, Yurdakök M. Turk J Pediatr. 2020;62(1):35-38. PMID: 32253864 Free article.
•    Effect of anti-epileptic drugs on first trimester screening test results. Unal C, Tanacan A, Fadiloglu E, Portakal O, Beksac MS. Taiwan J Obstet Gynecol. 2020 Nov;59(6):835-837. PMID: 33218397
•    Joint Modeling Approach on Evaluating Time-Dependent CutOff Values for C-Reactive Protein in Mixed Intensive Care Unit Population. Konar NM, Karaismailoglu E, Portakal O, Pinar A, Dikmen ZG, Karaagaoglu AE. Clin Lab. 2020 Sep 1;66(9). doi: 10.7754/Clin Lab.2020.191239. PMID: 32902226
•    Uropathogens and Gestational Outcomes of Urinary Tract Infections in Pregnancies that Necessitate Hospitalization. Beksac AT, Orgul G, Tanacan A, Uckan H, Sancak B, Portakal O, Beksac MS.
•    Curr Urol. 2019 Oct;13(2):70-73. doi: 10.1159/000499290. Epub 2019 Oct 1. PMID: 31768172 Free PMC article.
•    Is muscle mechanical function altered in polycystic ovary syndrome? Caliskan Guzelce E, Eyupoglu D, Torgutalp S, Aktoz F, Portakal O, Demirel H, Yildiz BO. Arch Gynecol Obstet. 2019 Sep;300(3):771-776. doi: 10.1007/s00404-019-05229-2. Epub 2019 Jul 1. PMID: 31263987
•    Corrigendum to "Factors associated with pulmonary hypertension and long-term survival in bronchiectasis subjects" [Respir. Med. (2016) 119 109-114]. Öcal S, Portakal O, Öcal A, Demir AU, Topeli A, Çöplü L. Respir Med. 2019 Nov-Dec;160:105706. doi: 10.1016/j.rmed.2019.05.013. Epub 2019 Jun 11. PMID: 31200983 No abstract available.
•    Human papillomavirus infection and autoimmune disorders: a tertiary center experience. Donmez HG, Tanacan A, Unal C, Fadiloglu E, Onder SC, Portakal O, Beksac MS. Pathog Dis. 2019 Apr 1;77(3):ftz028. doi: 10.1093/femspd/ftz028. PMID: 31034015
•    Comparison of the novel ARCHITECT procalcitonin assay with established procalcitonin assay systems.
•    Soh A, Binder L, Clough M, Hernandez MH, Lefèvre G, Mostert K, Nguyen TB, Otte KM, Portakal O, Sandri MS, Yen JL, Huang J, Beshiri A. Pract Lab Med. 2018 Nov 9;12:e00110.
•    Emerging biomarker for predicting acute kidney injury after cardiac surgery: cystatin C. Saydam O, Türkmen E, Portakal O, Arıcı M, Doğan R, Demircin M, Paşaoğlu İ, Yılmaz M. Turk J Med Sci. 2018 Dec 12;48(6):1096-1103. doi: 10.3906/sag-1704-96. PMID: 30541232 Free article.
•    Relationship Between First Trimester Maternal TSH Levels and Down Syndrome Screening Tests
•    Orgul, Gokcen; Dogan, Devrim Ruzgar; Portakal, Oytun; Et Al. CUKUROVA MEDICAL JOURNAL  Volume: 43 Supplement: 1 Pages: 94-99  Published: 2018
•    The Impact of 17B Estradiol Level Variations On Blood Lymphocyte Counts Among Healthy Females
•    Orgul, Gokcen; Yucesoy, H. Meltem; Portakal, Oytun. CLINICAL AND EXPERIMENTAL HEALTH SCIENCES Volume: 8 Issue: 2 Pages: 118-121 Published: JUN 2018
Dr. Öğr. Üyesi Başak Çeltikçi
•    Protein Kinase-mediated decisions between life and death, Chapter 12, Springer International Publishing, Engin&Engin (ed.s), 2020.
•    Regulation And Effect Of Telomerase And Telomeric Length In Stem Cells. Celtikci B, Erkmen GK, Dikmen ZG. Curr Stem Cell Res Ther. 2020 Apr 21.
Dr. Esra Büber
•    Yildirim D, Gokcal B, Buber E, Kip C, Demir MC, Tuncel A. (2021), A new nanozyme with peroxidase-like activity for simultaneous phosphoprotein isolation and detection based on metal oxide affinity chromatography: Monodisperse-porous cerium oxide microspheres. Chemical Engineering Journal, 403, DOI: 10.1016/j.cej.2020.126357.
•    Gokcal B, Hamaloglu KO, Kip C, Gungor SY, Buber E, Tuncel A. (2020), Glutathione detection in human serum using gold nanoparticle decorated, monodisperse porous silica microspheres in the magnetic form. Analytical Methods, 12 (43), 5219-5228, DOI: 10.1039/d0ay01292k.
•    Yılmaz D, Çağlayan F, Büber E, Könönen E, Aksoy Y, Gürsoy KU, Güncü GN (2018), Gingival crevicular fluid levels of human beta-defensin-1 in type 2 diabetes mellitus and periodontitis. Clinical Oral Investigations, 22(5), 2135-2140.
•    Ertürk Z, Büber E, Özen AH, Çelikbıçak Ö, Salih B, Açan NL (2017). Mycobacterium Brumae Extract Fractions with Potential Immunotherapeutic Activity for Bladder Cancer. Üroonkoloji Bülteni, 16(3), 70-76.
Dr. Esra Büber- Patentler
•    GST P1 Enzimine Spesifik, Özgün ve Yeni Nesil İnhibitör Bileşikleri (2020), Patent No: 2018/19936.
•    Yüzeyel mesane tümörü tedavisinde kullanılabilecek Mycobacterium brumae hücre duvarı ekstreleri (2016), Patent No: TR 2011 01874.
•    Yüzeysel mesane tümörü tedavisinde kullanılabilecek Mycobacterium chubuense hücre duvarı ekstreleri (2015), Patent No: 2011/01873.
•    Yüzeyel mesane tümörü tedavisinde kullanılabilecek Mycobacterium murale hücre duvarı ekstreleri (2015), Patent No: 2011/00759.
•    Yüzeyel mesane tümörü tedavisinde kullanılabilecek Mycobacterium chitae hücre duvarı ekstreleri (2015), Patent No: 2011/01872.

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