In our laboratory, research projects are carried out on the detection and typing of microorganisms from clinical samples, the identification of mutations that cause drug resistance, and the development of new rapid diagnostic methods by using different molecular microbiological methods.
Ice maker, microwave oven, power supply for electrophoresis (2), precision balance (2), thermocycler (3), microcentrifuge (2), shaker, gel imaging device, refrigerator (3), biosafety cabinet, -20◦C freezer (3), water bath, midicentrifuge, hybridization incubator, plate centrifuge, heat block, magnetic stirrer, vortex, water bath, incubator (2)
• Prof. Dr. Alpaslan Alp
• Prof. Dr. Ozgen Eser
• Prof. Dr. Zeynep Saribas
• Faculty members of the department
• Research assistants of the department
• PhD students
• Graduate students
Evaluation of the Effectiveness of the Laboratory-Made LAMP Method for the Detection of Human Papilloma Virus. Hacettepe University Scientific Research Projects Coordination Unit, Project No:THD-2023-20805
Detection of Mycobacterium tuberculosis Complex by a Laboratory-Made PCR Method. Hacettepe University Scientific Research Projects Coordination Unit, Project No: TDK-2023-20650
Investigation of Biofilm Formation and Clarithromycin Susceptibility in Mycobacterium fortuitum Isolates. Hacettepe University Scientific Research Projects Coordination Unit, Project No: THD-2023-20584
Investigation of Ganciclovir Resistance in Cytomegalovirus Strains Isolated from Patients with Primary and Secondary Immunodeficiency Using Genotypic Methods. Hacettepe University Scientific Research Projects Coordination Unit, Project No: THD-2022-20069
Hacettepe Health Cohort: Prospective follow-up study to monitor the general health status, vaccine effectiveness, immunity duration and adverse effects in students of the Faculties of Medicine and Dentistry vaccinated for COVID19: HUCoVaCS (Hacettee University Covid-19 Vaccinated Cohort - Students of Faculties of Health Sciences). Hacettepe University Scientific Research Projects Coordination Unit, Project No: TCP-2021-19467
Comparing the effectiveness of different methods in detecting Pneumocystis jirovecii in clinical samples and investigating the relationship between genotype and drug resistance. Hacettepe University Scientific Research Projects Coordination Unit, Project No: TSA-2021-19496
Determination of drug sensitivity pattern of Mycobacteroides (Mycobacterium) abscessus subspecies abscessus isolates. Hacettepe University Scientific Research Projects Coordination Unit, Project No: TYL-2019-18134
Comparison of the systemic and local inflammatory response occurring in videothoracoscopic VAT and open surgery by measuring serum pleural fluid and bronchoalveolar lavage cytokine levels in patients who underwent pulmonary resection with single lung ventilation for non-small cell lung cancer. Hacettepe University Scientific Research Projects Coordination Unit, Project No:TSA-2019-18221
Comparison of serum endocan Icam1 and vegf levels before and after resection in non-small cell lung cancer. Hacettepe University Scientific Research Projects Coordination Unit, Project No: TTU-2020-18824
Detection of efflux pumps causing isoniazid resistance in Mycobacterium tuberculosis complex clinical isolates. 2015-2016. Hacettepe University Scientific Research Projects Coordination Unit, Project No: THD2015-7116
Comparison of two different decontamination processes applied prior to Mycobacterium tuberculosis isolation. 2017-2018. Hacettepe University Scientific Research Projects Coordination Unit, Project No:THD-2017-12888
Correlation of serum spd1 and spdl1 levels with clinical pathological features and lymph node metastasis in early stage female small cell lung cancer patients. 2019-2020. Hacettepe University Scientific Research Projects Coordination Unit, Project No: TTU-2019-18220
Relationship between colon cancer and salivary microbiome. 2017-2018. Hacettepe University Scientific Research Projects Coordination Unit, Project No: THD-2017-12288.
Determining the role of viral factors in etiology in cystic fibrosis patients with acute pulmonary exacerbation and investigating the effects of viruses on clinical laboratory and radiological parameters. Hacettepe University Scientific Research Projects Coordination Unit, Project No:: THD-2017-15159.
Can the Good Clinical Course in COVID19 Positive Children Compared to Adults Be Explained by Cytokine and Chemokine Responses? 2020-2023. Hacettepe University Scientific Research Projects Coordination Unit, Project No: THD-2020-18774.
Investigation of the effectiveness of the multiplex real-time polymerase chain reaction method in patients with pre-diagnosis of meningitis and encephalitis in the emergency department. 2021-2023. Hacettepe University Scientific Research Projects Coordination Unit, Project No: THD-2021-19581
Evaluation of the effectiveness of the vaccine in cancer patients who received the COVID 19 vaccine by measuring the COVID 19 antibody level. 2021-2023. Hacettepe University Scientific Research Projects Coordination Unit, Project No: THD-2021-19639
Examination of the Clinical Effects of Coenzyme Q10 Level in Covid 19 Patients in Intensive Care. 2021-2023. Hacettepe University Scientific Research Projects Coordination Unit, Project No: THD -2021-19423
Evaluation of antifungal susceptibility profiles of clinical Candida and Aspergillus strains by matrix-supported laser desorption ionization time-of-flight mass spectrometry MALDITOF MS method. 2021-2023. Hacettepe University Scientific Research Projects Coordination Unit, Project No:THD-2021-19334
Frequency of Invasive Pulmonary Aspergillosis and Associated Factors in COVID-19 Patients. 2021-2022. Hacettepe University Scientific Research Projects Coordination Unit, Project No: TOA-2021-19069
Evaluation of the effects of clinical phenotypes caused by Aspergillus on respiratory functions in cystic fibrosis. 2020-2023. Hacettepe University Scientific Research Projects Coordination Unit, Project No: THD-2020-18554
Determination of MIC values and resistance-causing mutations of new antituberculosis drugs, bedaquiline and delamanid, in Mycobacterium tuberculosis clinical isolates. 2019-2022. Hacettepe University Scientific Research Projects Coordination Unit, Project No: TSA-2019-18169
Identification of Mycobacteria species by MALDITOF MS method. 2018-2022. Hacettepe University Scientific Research Projects Coordination Unit, Project No: TSA-2018-17321
Evaluation of the presence of Malassezia species in basal cell carcinoma lesions using conventional and molecular methods. 2015-2020. Hacettepe University Scientific Research Projects Coordination Unit, Project No: THD-2015-7168
Detection of Drug Resistance in Mycobacterium tuberculosis Clinical Isolates by Multiplex "Real-time PCR" Method. 2012-2016. Hacettepe University Scientific Research Projects Coordination Unit, Project No: 012 D10 101 001-22
Alp A, Sarıbaş Z. Klinik örneklerden Mycobacterium tuberculosis saptanmasında Anyplex MTB/NTM testinin değerlendirilmesi. Mikrobiyol Bült 2019; 53(4): 355-363. DOI: 10.5578/mb.67783.
Er B, Er AG, Metan G, Halaçlı B, Ersoy EO, Hazırolan G, Alp A, Sarıbaş Z, Akdağlı SA, Topeli A, Uzun Ö. Is COVID-19 a risk factor for invasive pulmonary aspergillosis in critically ill patients? Tüberküloz ve Toraks 2021; 69:118-120. DOI: 10.5578/tt.20219918
Özdemir A, Çuha MD, Dizman GT, Alp A, Metan G, Şener B. SARS-CoV-2 Seroprevalence Among Healthcare Workers: Retrospective Analysis of the Data From A University Hospital in Turkey. Mikrobiyol Bult 2021; 55:223-232. DOI: 10.5578/mb.20219908
Alp A. Hasta başı moleküler testlerde son gelişmeler. Mikrobiyol Bul 2022; 56 (3): 580-591. doi: 10.5578/mb.20229717.
Alp A, Taşçı O, Ergin A, Köseoğlu Eser Ö. COVID-19 pandemisi öncesi ve sonrasında solunum yolu virüs paneli PCR test sonuçlarının değerlendirilmesi. Mikrobiyol Bul 2022; 56(4):667-681. doi: 10.5578/mb.20229605
Sertçelik A, Metan G, Telli Dizman G, Atılmış D, Şahan C, Kalaycı D, Alp A, Çakır B, Zarakolu P, Ünal S, Uzun Ö. Salgının ilk günlerine dönelim: Sağlık çalışanlarında COVID-19’u teşhis etme konusunda ne kadar başarılı olduk? Flora 2022; 27(4):555-561. doi: 10.5578/flora.20229604
Guven DC, Ergunay K, Brinkmann A, Alp A, Kittana FN, Akyon Y, Yilmaz E, Karakoc D, Hamaloglu E, Yalcin S, Nitsche A, Hayran M, Dizdar O. A snapshot of oral microbiota in patients with colorectal cancer. Eurasian J Med Invest 2021; 5(2):166-171. doi: 10.14744/ejmi.2021.34738
Yildiz LA, Unal B, Aydin O, Oygar PD, Gurlevic SL, Gungor E, Kaynak MO, Korgal N, Kukul MG, Ilbay S, Alp A, Ozsurekci Y, Teksam O. Respiratory tract pathogens in the COVID-19 era: Data from a pediatric emergency department. J Ped Infect Dis 2022; 17:11-17. Doi: 1055/s-0041-173621.
Goker ETA, Cagdas D, Bajin IY, Kukul MG, Aytekin ES, Orhan D, Alp A, Uzar S, Sarac F, Kara A, Kutluk MT. Multicentric Castleman disease in a DOCK8-deficient patient with Orf virus infection. Pediatr Allergy Immunol 2022; 33: e13666. DOI: 10.1111/pai.13666
Sonmezer MC, Dizman GT, Erul E, Sahin TK, Saricaoglu T, Alp A, Tanriover MD, Uzun O, Unal S, Akova M. Relative Vaccine Effectiveness of the Third Dose of CoronaVac or BNT162b2 Following a Two-Dose CoronaVac Regimen: A Prospective Observational Cohort Study from an Adult Vaccine Center in Turkey. Vaccines 2022; 10, 1140. Doi: 10.3390/vaccines10071140
Er B, Er AG, Gülmez D, Şahin TK, Halaçlı B, Durhan G, Ersoy EO, Alp A, Metan G, Saribas Z, Arikan-Akdagli S, Hazırolan G, Akıncı SB, Arıyürek M, Topeli A, Uzun Ö. A screening study for COVID-19-associated pulmonary aspergillosis in critically ill patients during the third wave of the pandemic. Mycoses. 2022;00:1–9. Doi: 10.1111/myc.13466
Aykaç K, Özsürekçi Y, Yayla BCC, Evren K, Gürlevik SL, Oygar PD, Yücel M, Karakoç AE, Alp A, Cengiz AB, Ceyhan M. Pneumococcal carriage in children with COVID-19. Human Vaccine Immunotherapy 2021; 17:1628-1634. DOI: 10.1080/21645515.2020.1849516
Özdemir N, Dizdar Ö, Yazıcı O, Aksoy S, Dede DS, Budakoğlu B, Metan G, Alp A, Budakoğlu Iİ, Öksüzoğlu ÖBÇ, Özet A, Kılıçkap S, Turhal NS, Çelik İ, Erman M, Ata N, Çelik O, Hayran M. Clinical features and outcomes of COVID-19 in patients with solid tumors: Turkish National Registry Data. Int J Cancer 2021; 148:2407-2415. DOI: 10.1002/ijc.33426
Özsürekçi Y, Aykaç K, Er AG, Halacli B, Araslı M, Oygar PD, Gürlevik S, Cura Yayla BC, Karakaya J, Alp A, Topeli A, Cengiz AB, Akova M, Ceyhan M. Predictive value of cytokine/chemokine responses for the disease severity and management in children and adult cases with COVID-19. J Med Virol 2021; 93:2828-2837. DOI: 10.1002/jmv.26683
Ademhan Tural D, Emiralioglu N, Ozsezen B, Saribas Z, Ozcan N, Alp A, Sunman B, Hizal M, Polat SE, Yalcin E, Dogru D, Ozcelik U, Kiper. The frequency and related factors of non-tuberculosis mycobacteria infections among patients with cystic fibrosis. Pediatrics International 2021; 63:1369-1375. doi: 10.1111/ped.14688
Aykac K, Yayla BCC, Ozsurekci Y, Evren K, Oygar PD, Gurlevik SL, Coşkun T, Taşçı O, Kaya FD, Fidanci İ, Taşar MA, Alp A, Cengiz AB, Karahan S, Ceyhan M. The association of viral load and disease severity in children with COVID-19. J Med Virol 2021; 93:3077-3083. DOI: 10.1002/jmv.26853
Özsürekçi Y, Aykaç K, Bal F, Bayhan C, Başaranoğlu ST, Alp A, Cengiz AB, Kara A, Ceyhan M. Outcome predictors of influenza for hospitalization and mortality in children. J Med Virol 2021; 93:6148-6154. DOI: 10.1002/jmv.26833
Balaban HY, Dağ O, Alp A, Tseveldorj N, Vahabov C, Göktaş MA, Purnak T, Hasçelik G, Demir H, Sivri B, Şimşek H. Retrospective Evaluation of Hepatitis C Awareness in Turkey Through Two Decades. Turkish J Gastroenterol 2021; 32:88-96. DOI: 10.5152/tjg.2020.19949
Aladag E, Tas Z, Ozdemir BS, Akbaba TH, Akpınar MG, Goker H, Unalan-Altintop T, Inkaya AÇ, Alp A, Metan G, Haznedaroglu IC, Balci-Peynircioglu B, Sayinalp N. Human Ace D/I Polymorphism Could Affect the Clinicobiological Course of COVID-19. J Renin-Angiotensin-Aldosterone System 2021; Article ID 5509280, 7 pages. https://doi.org/10.1155/2021/5509280
Rifat D, Campodonico VL, Tao J, Miller JA, Alp A, Yao Y, Karakousis PC. In vitro and in vivo fitness costs associated with Mycobacterium tuberculosis RpoB mutation H526D. Future Microbiol 2017, https://doi.org/10.2217/fmb-2017-0022.
Aykac K, Ozsurekci Y, Kahyaoglu P, Basaranoglu ST, Ertugrul I, Alp A, Cengiz AB, Kara A, Ceyhan M. Myocarditis associated with influenza infection in five children. J Infect Public Health 2018; 11:698-701. https://doi.org/10.1016/j.jiph.2018.05.003
Macin S, Alp A, Şener B, Sökmensüer C, Orhan D, Özen H, Kav T, Akyön Y. Comparison of culture, real- time-PCR, ELISA, and histopathological examination methods for identification of Helicobacter pylori. İstanbul Med J 2018; 19: 138-42. DOI: 10.5152/imj.2018.94834
Alp A. Advancement in molecular POCT testing: The multiplex PCR POCT devices for infectious diseases. J International Fed Clin Chem Lab Med 2018; 29:205-209.
Aykac K, Karadağ-Öncel E, Basaranoglu ST, Alp A, Cengiz AB, Ceyhan M, Kara A. Respiratory viral infections in infants with possible sepsis. J Med Virol 2019; 91:171-178. https://doi.org/10.1002/jmv.25309
Güven DC, Dizdar Ö, Alp A, Akdoğan Kittana FN, Karakoç D, Hamaloğlu E, Laçin S, Karakaş Y, Kılıçkap S, Hayran M, Yalçın Ş. Analysis of Fusobacterium nucleatum and Streptococcus gallolyticus in saliva of colorectal cancer patients. Biomark Med 2019; 13 (9): 725-735. doi: 10.2217/bmm-2019-0020.
Hızal M, Yalcin E, Alp A, Özden M, Karakaya J, Polat SE, Tuğcu G, Doğru D, Özçelik U, Kiper N.Respiratory viruses: What is their role in acute exacerbations in children with cystic fibrosis? Ped Pulmonol 2020; 55:1646-1652. DOI: 10.1002/ppul.24750
Karataş A, İnkaya AÇ, Demiroğlu H, Aksu S, Haziyev T, Çinar OE, Alp A, Uzun Ö, Sayınalp N, Göker H. Prolonged viral shedding in a lymphoma patient with COVID-19 infection receiving convalescent plasma. Transfusion Apheresis Sci 2020; 59. DOI: 10.1016/j.transci.2020.102871
Emiralioğu N, Doğru Ersöz D, Oğuz B, Sarıbaş Z, Yalçın E, Özçelik U, Özsürekçi Y, Cengiz AB, Kiper N. Pulmonary Mycobacterium abscessus infection in a patient with Triple A syndrome. Journal of Tropical Pediatrics 2016; 62:324-327 (SCI).
Hazırolan G, Sarıbaş Z, Arıkan-Akdağlı S. Klinik Candida glabrata İzolatlarında Flukonazol ve Vorikonazol Duyarlılığının Saptanmasında Mikrodilüsyon ve Disk Difüzyon Yöntemlerinin Karşılaştırılması ve Yeni CLSI Direnç Sınır Değerleri ile Duyarlılık Sonuçlarındaki Değişimin Belirlenmesi. Mikrobiyoloji Bülteni 2016, 50:428-437 (SCI-EXP).
Sarıbaş Z. Tüberkülozun Mikrobiyolojik Tanısı. Katkı Pediatri Dergisi 2018; 39 (3-4):329-334.