• 5 incubators
• 3 refrigerators
• Deep freezer: -20°C (n=3) -80°C (n=2)
• Vortex (n=2)
• 2 biosafety cabinets (Class 2)
• Spectrophotometer (measurement in cuvette)
• Spectrophotometer (measurement on microplate, reading software and laptop included)
• 2 microscopes
• Dry block (n=1)
Faculty Members:
Prof. Dr. Sevtap Arıkan Akdağlı (Unit Head)
Prof. Dr. Dolunay Gülmez Kıvanç
Research Assistants who have completed their Residency Training Programs on Medical Microbiology or Medical Mycology / Master Degree in Microbiology / PhD Thesis:
Dr. Özlem Doğan (Medical Mycology)
Dr. Ali Korhan Sığ (Medical Mycology)
Dr. Serhat Duyan (Medical Mycology)
Dr. Nida Akar (Medical Mycology)
Dr. İlke Toker Önder (Medical Microbiology)
Dr. Selay Demirci Dos Santos Duarte (Medical Microbiology)
Assoc. Prof. Dr. Gülşen Hazırolan (Medical Microbiology) Prof. Dr. Şehnaz Alp (Medical Microbiology)
MSc. Hacer Aslan (Microbiology - Master Degree)
MSc. Beyzanur Kaşaltı (Microbiology - Master Degree)
Dr. Hüseyin Avcılar (Microbiology - PhD Program)
ONGOING:
Dr. Tuğçe Ünalan Altıntop (Microbiology - PhD student)
Dr. Bengü Sayar (Medical Microbiology - Resident)
Dr. Ali Ersin Korkmazoğlu (Medical Microbiology - Resident)
Within the scope of their education, all residents, Master and PhD students rotate in the Mycology Laboratory for a determined period of time.
TSA-2023-20443: Synthesis and biological activity studies of new monoterpenepiperazine derivative azole compounds
with antifungal effects
Identification of filamentous fungi of the Mucorales order obtained from clinical samples at the genus level using
different methods and determination of antifungal susceptibility status.
THD-2022-19827: Identification of Clinical Saprochaete
Isolates at Species Level, Comparison of Antifungal
Susceptibility Test Results Obtained by Two Different
Reference Methods and Investigation of Virulence Factors
THD-2021-19385: Identification of non-Aspergillus hyaline
filamentous fungi isolated from clinical samples at the genus
level and determination of antifungal sensitivity profiles
THD-2020-18554: Evaluation of the effects of clinical
phenotypes caused by Aspergillus on respiratory functions in
cystic fibrosis
THD-2020-18901: Discovery of new antifungal compounds
by ligand and structure-based virtual activity screening
method
TOA-2021-19069: Frequency of invasive pulmonary
aspergillosis and associated factors in COVID-19 patients
TSA-2018-17112: Determination of species in Candida
parapsilosis complex isolates isolated as fungemia agents in
Hacettepe University Clinical Mycology Laboratory and
examination of resistance to azoles and molecular
mechanisms of resistance in these species.
WS776070: First multicentre report of in vitro resistance rates
in candidaemia isolates in Turkey
• S. Alp, S. Arıkan-Akdağlı, D. Gülmez, S. Aşçıoğlu, Ö. Uzun, M. Akova. Epidemiology of candidaemia in a tertiary care university hospital: 10-year experience with 381 candidaemia episodes between 2001 and 2010. Mycoses 2015; 58 (8): 498-505. doi:10.1111/myc.12349
• Van der Linden JWM, Arendrup MC, Warris A, K Lagrou, H Pelloux, PM Hauser, E Chryssanthou, E Mellado, SE Kidd, AM Tortorano, E Dannaoui, P Gaustad, JW Baddley, A Uekötter, C Lass-Flörl, N Klimko, CB Moore, DW Denning, AC Pasqualotto, C Kibbler, S Arikan-Akdagli, D Andes, J Meletiadis, L Naumiuk, M Nucci, WJG Melchers, PE Verweij. Prospective multicenter international surveillance of azole resistance in Aspergillus fumigatus. Emerg Infect Dis 2015; 21.6: 1041.
• Klingspor L, Tortorano AM, Peman J, B Willinger, P Hamal, B Sendid, A Velegraki, C Kibbler, J F Meis, R Sabino, M Ruhnke, S Arikan-Akdagli, J Salonen, I Dóczi. Invasive Candida infections in surgical patients in intensive care units: a prospective, multicentre survey initiated by the European Confederation of Medical Mycology (ECMM) (2006–2008). Clin Microbiol Infect 2015; 21.1:87.e1-87. e10.H. Aslan, D. Gulmez. Investigation of the Relationship between the Biofilm Forming Feature of Urinary Candida Isolates and the Use of Urinary Catheter and the Change of Antifungal Susceptibility in the Presence of Biofilm. Find Microbiology 2016; 50(2):266-277. Doi: 10.5578/mb.24248
• HE. Dogan, A. C. İnkaya, D. Gülmez, Ö. Uzun, M. Akova, S. Arikan Akdagli. Direct Identification of Candida Species Isolated from Blood Cultures of PNA-FISH Method and Evaluation of Possible Effect on Antifungal Treatment Plan. Short Notice. Find Microbiology 2016; 50(4): 580-589. doi: 10.5578/mb.27948
• HE. Dogan, D. Gulmez, S. Arikan Akdagli. A Rapid Identification Test in Fungemia Cases: Evaluation of Direct Germ Tube Test from Positive Blood Culture Bottle. ANKEM Journal 2016; 30 (3): 102-108. doi: 10.5222/ankem.2016.102
• Ullmann AJ, Aguado JM, Arikan-Akdagli S, et al. Diagnosis and management of Aspergillus diseases: executive summary of the 2017 ESCMID-ECMM-ERS guideline. Clin Microbiol Infect 2018; 24: e1-e38.
• D. Gulmez, O. Doğan, B. Boral, A. Döğen, M. İlkit, G.S. de Hoog, S. Arikan-Akdagli. In vitro activities of antifungal drugs against environmental Exophiala isolates and review of the literature. Mycoses 2018 (61); 561-569. https://doi.org/10.1111/myc.12779.
• D. Gulmez. Aspergillus fumigatus complex: A new challenge in a challenging pathogen, azole resistance. Turkish Microbiol Cem Journal 2018, 48 (3): 153-166. doi:10.5222/TMCD.2018.153
• S. Arikan Akdagli, M. Ghannum, J. Meis. Antifungal Resistance: Specific Focus on Multidrug Resistance in Candida auris and Secondary Azole Resistance in Aspergillus fumigatus. J Fungi 2018, 4(4):129.
• T Zoran, B Sartori, L Sappl, M Aigner, F Sánchez-Reus, A Rezusta, A Chowdhary, SJ Taj-Aldeen, MC Arendrup, S Oliveri, DP Kontoyiannis, A Alastruey-Izquierdo, K Lagrou, G Lo Cascio, JF Meis, W Buzina, C Farina, M Drogari-Apiranthitou, A Grancini, AM Tortorano, B Willinger, A Hamprecht, E Johnson, L Klingspor, V Arsic-Arsenijevic, OA Cornely, J Meletiadis, W Prammer, V Tullio, J Vehreschild, L Trovato, RE Lewis, E Segal, P Rath, P Hamal, M Rodriguez-Iglesias, E Roilides, S Arikan-Akdagli, A Chakrabarti, AL Colombo, MS Fernández, MT Martin-Gomez, H Badali, G Petrikkos, N Klimko, SM Heimann, O Long, M Roudbary, S de la Fuente, J Houbraken, B Risslegger, C Lass-Florl, M Lackner. Azole-resistance in Aspergillus terreus and related species: an emerging problem or a rare phenomenon? Front Microbiol 2018; 9: 516.
• S. Arikan-Akdagli, D. Gulmez, O. Doğan, N. Çerikçioğlu, M. Doluca Dereli, A. First, Ş.T. Yıldıran, B. Ener, Y. Öz, D.Y. Metin, S. Hilmioğlu-Polat, A. Kalkancı, N. Koç, Z. Erturan, D. Fındık. First multicenter report of in vitro resistance rates in candidemia isolates in Turkey. J Glob Antimicrob Resist 2019,18:230-234. doi: 10.1016/j.jgar.2019.04.003.
• Bassetti M, Scudeller L, Giacobbe DR, F Lamoth, E Righi, V Zuccaro, C Grecchi, C Rebuffi, M Akova, A Alastruey-Izquierdo, S Arikan-Akdagli, E Azoulay, SI Blot, OA Cornely, C Lass- Flörl, P Koehler, M Cuenca-Estrella, DW de Lange, FG De Rosa, JJ De Waele, G Dimopoulos, J Garnacho-Montero, M Hoenigl, SS Kanj, J Maertens, I Martin-Loeches, P Muñoz, BJ Kullberg, C Agvald-Ohman, G Poulakou, J Rello, M Sanguinetti, FS Taccone, J Timsit, A Torres, JA Vazquez, T Calandra, Study Group for Infections in Critically Ill Patients (ESGCIP) and the Fungal Infection Study Group (EFISG) of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID); European Society of Intensive Care Medicine (ESICM); European Confederation of Medical Mycology (ECMM); Mycoses Study Group Education and Research Consortium (MSGERC). Developing definitions for invasive fungal diseases in critically ill adult patients in intensive care units. Protocol of the FUN gal infections Definitions in ICU patients (FUNDICU) project. Mycoses 2019; 62.4:310-319.
• OA Cornely, A Alastruey-Izquierdo, D Arenz, SCA Chen, E Dannaoui, B Hochhegger, M Hoenigl, HE Jensen, K Lagrou, RE Lewis, SC Mellinghoff, M Mer, ZD Pana, D Seidel, DC Sheppard, R Wahba , M Akova, A Alanio, AMS Al-Hatmi, S Arikan-Akdagli, H Badali, R Ben-Ami, Alexandro Bonifaz, S Bretagne, E Castagnola, M Chayakulkeeree, AL Colombo, DE Corzo-León, L Drgona, AH Groll , J Guinea, C Heussel, AS Ibrahim, SS Kanj, N Klimko, M Lackner, F Lamoth, F Lanternier, C Lass-Floerl, D Lee, T Lehrnbecher, BE Lmimouni, M Mares, G Maschmeyer, Jacques F Meis, J Meletiadis, CO Morrissey, M Nucci, R Oladele, L Pagano, A Pasqualotto, A Patel, Z Racil, M Richardson, E Roilides, M Ruhnke, S Seyedmousavi, N Sidharthan, N Singh, J Sinko, A Skiada, M Slavin, R Soman, B Spellberg, W Steinbach, BH Tan, AJ Ullmann, JJ Vehreschild, MJGT Vehreschild, TJ Walsh, PL White, NP Wiederhold, T Zaoutis, A Chakrabarti, Mucormycosis ECMM MSG Global Guideline Writing Group.Global guideline for the diagnosis and management of mucormycosis: an initiative of the European Confederation of Medical Mycology in cooperation with the Mycoses Study Group Education and Research Consortium. Lancet Infect Dis 2019 Dec;19(12):e405-e421
• J Guinea, PE Verweij, J Meletiadis, JW Mouton, F Barchiesi, MC Arendrup, Subcommittee on Antifungal Susceptibility Testing (AFST) of the ESCMID European Committee for Antimicrobial Susceptibility Testing (EUCAST). How to: EUCAST recommendations on the screening procedure E. Def 10.1 for the detection of azole resistance in Aspergillus fumigatus isolates using four-well azole-containing agar plates. Clin Microbiol Infect 2019; 25.6: 681-687.
• D. Gulmez. Candida auris: Fungal pathogen that managed to spread around the world in ten years. FLORA 2019;24(4):263-271. doi: 10.5578/flora.69056
• R. Kean, J. Brown, D. Gulmez, A. Ware, G. Ramage. Candida auris: A Decade of Understanding of an Enigmatic Pathogenic Yeast. J Fungi 2020, 6 (1):30. doi:10.3390/jof6010030.
• S. Alp, D. Gulmez, C. M. Ayaz, S. Arikan-Akdagli, M. Akova. Fungemia due to rare yeasts in a tertiary care university center within 18 years. Mycoses 2020, 63(5): 488-493. doi:10.1111/MYC.13072.
• D. Gülmez, Ş. Alp, G. Gursoy, C. M. Ayaz, O. Dogan, S. Arikan-Akdagli, M. Akova. Mixed fungemia: an 18-year report from a tertiary care university hospital and a systematic review. Clin Microbiol Infect 2020, 26: 833-841. doi: 10.1016/j.cmi.2020.03.030
• O. Karcıoğlu, R. Doğan, Ö. Uzun, F. Tokat, D. Gulmez, S. Arikan-Akdagli, Z. T. Selcuk. A Rare Presentation of Pulmonary Aspergillosis Bronchial Stump Aspergillosis J Bronchol Intervent Pulmonol 2020, 27 (2): e28-e33. DOI: 10.1097/LBR.0000000000000655. letter
• HE. Doğan, D. Gülmez, S. Arikan-Akdağlı. Phenotypic and genotypic evaluation of azole resistance in Aspergillus fumigatus isolates obtained from clinical and environmental samples. Find Microbiome 2020, 54 (2): 291-305. doi: 10.5578/mb.69024.
• N. Emiralioğlu, D.Dogru, Ö. Doğan, D. Gülmez, S. Arıkan-Akdağlı, S. Eryılmaz, G. Tuğcu, M. Hızal, E. Yalçın, U. Özçelik, B. Şener, N. Kiper. Diverse clinical characteristics of Aspergillus growth in patients with cystic fibrosis. Turk J Ped 2020, 62 (4): 560-568. doi: 10.24953/turkjped.2020.04.005
• Glampedakis E, Cassaing S, Fekkar A, E Dannaoui, M Bougnoux, S Bretagne, D Neofytos, PW Schreiber, C Hennequin, F Morio, O Shadrivova, F Bongomin, M Fernández-Ruiz, AP Bellanger, S Arikan-Akdagli, V Erard, M Aigner, M Paolucci, N Khanna, E Charpentier, C Bonnal, S Brun, F Gabriel, A Riat, R Zbinden, P Le Pape, N Klimko, RE Lewis, M Richardson, AC Inkaya, AT Coste, P Bochud, F Lamoth. Invasive aspergillosis due to Aspergillus section Usti: a multicenter retrospective study. Clin Infect Dis 2020; doi: 10.1093/cid/ciaa230
• D. Gulmez, A.K. Sığ, N. Akar, S. Duyan, S. Arikan Akdagli. Changes in Frequency and Species Distribution of Infecting Fungi over Time: What Do Mycology Laboratory Data Say for Twelve Years (2008-2019)? Find Microbiome (Accepted)
https://tip.hacettepe.edu.tr/tr/tibbi_mikrobiyoloji_anabilim_dali-102