Medical Microbiology Department Parasitology Laboratory

About

Research Infrastructure

• Oven
• Light microscope
• Fluorescent microscope
• Vortex
• Centrifuge
•  Weight
• Automatic pipette

Researchers

•    Prof. Dr. Yakut Akyön Yılmaz
 

Ongoing Projects

  1. Development of Antimicrobial Peptide Nanofiber Based Mucoadhesive Release System for Helicobacter pylori Treatment (TÜBİTAK) (Konya Food and Agriculture University- Faculty of Agriculture and Natural Sciences- Molecular Biology and Genetics)
  2. The relationship of intestinal microbiota with ambulatory blood pressure variables and clinical parameters in individuals with newly diagnosed hypertensive, pre-hypertensive and white coat hypertension (Hacettepe University, Faculty of Medicine, Department of Internal Medicine-Nephrology)
  3. Evaluation of submucosal microbiota profile in periimplant health and periimplant mucositis (Hacettepe University, Faculty of Dentistry, Department of Periodontology)
  4. Evaluation of submucosal microbiota profile in periimplantitis patients with different stages of bone loss (Hacettepe University, Faculty of Dentistry, Department of Periodontology)
  5. Detection of Plasmodium species by molecular methods in the female Anopheles  (A study to be carried out with Hacettepe University, Faculty of Science, Biology Department-Ecology group)
  6. Cultivation of Entamoeba gingivalis in xenic culture (preliminary study)

Completed Projects

  • • Project Code: THD-2021-19344, Investigation of the prevalence of Entamoeba gingivalis in the Flora of the Mouth and determination of molecular subtypes
  • • Project Code: THD-2021-19430, Detection of Helicobacter pylori infection from stool and stomach biopsy specimens and
  • determination of clarithromycin resistance by molecular methods
  • • Project Code: THD-2017-12888TWO DIFFERENT DECONTAMINATIONS APPLIED BEFORE MYCOBACTERIUM TUB ERCULOSIS ISOLATION COMPARISON OF PROCESS
  • •   Project Code: TAY-2017-12936 The Role of Gut Microbiota in the Pathogenesis of Various Diseases
  • •   Project Code: THD-2016-11786 Intestinal microbiota in healthy women with polycystic ovarian syndrome Comparison of Prevotella melaninogenica and Ruminococcus torques
  • Investigation of Intestinal Protozoon Prevalence in Immunocompromised Patients at a University Hospital.
  • MicroRNA expression profile in patients with cystic echinococcosis and identification of possible cellular pathways.
  • Probeable alterations in fecal bacterial microbiota by somatostatin receptor analogs in acromegaly.
  • Gut microbiota and oral contraceptive use in overweight and obese patients with polycystic ovary syndrome.
  • Investigation of the relationship between CE cyst characteristics and genetic diversity of Echinococcus granulosus sensu lato in humans from Turkey.
  • Effects of Regular Kefir Consumption on Gut Microbiota in Patients with Metabolic Syndrome: A Parallel-Group, Randomized, Controlled Study.
  • The investigation of Strongloides stercoralis seroprevalence in immunosuppressed patients in Turkey.

Publications

  1. Serra Örsten, Cem Şahin, Engin Yılmaz, Yakut Akyön. First molecular detection of Entamoeba gingivalis subtypes in individuals from Turkey. Pathog Dis. 2023 Jan 17;81:ftad017. doi: 10.1093/femspd/ftad017.
  2. Örsten S, Yılmaz E, Akyön Y. Molecular Characterization of Clarithromycin Resistance in Helicobacter pylori Strains. Turk J Gastroenterol. 2023 Feb 15. doi: 10.5152/tjg.2023.21954.
  3. Unalan-Altintop T, Vahabov C, Ergunay K, Kurt O, Kav T, Akyon Y, Erguven S. Investigation of Dientamoeba fragilis and Blastocystis in patients from Turkey with ulcerative colitis and irritable bowel syndrome: Any relation with genotypes? Acta Trop. 2022 Jul;231:106451. doi: 0.1016/j.actatropica.2022.106451.
  4. Serra Örsten, İpek Baysal, Neslihan Akdoğan, Neşe İnal, Ecem Bostan, Samiye Yabanoğlu Çiftçi, Yakut Akyön. Possible microRNA-based mechanism underlying relationship between chronic spontaneous urticaria and Blastocystis. Exp Parasitol. 2023 Feb;245:108453. doi: 10.1016/j.exppara.2022.108453
  5. Aslan AT, Kırbas E, Sancak B, Tanrıverdi ES, Otlu B , GürsoyN C, Akyön Yılmaz Y, Tozluyurt A, Liste Ü, Bıçakcıgil A, Hazırolan G, Dağ O, Sain Güven G , Akova M,  on behalf of the Study Group for Carbapenem Resistance (SCARE). A retrospective observational cohort study of the clinical epidemiology of bloodstream infections due to carbapenem-resistant Klebsiella pneumoniae in an OXA-48 endemic setting. Int. J Ant. Agents (2022) 59/4:  https://doi.org/10.1016/j.ijantimicag.2022.106554
  6. S Orsten, İ Baysal, S Yabanoglu-Ciftci, T Ciftci, A Azizova, D Akinci, Y Akyon, O Akhan. MicroRNA expression profile in patients with cystic echinococcosis and identification of possible cellular pathways. J Helminthol. 2021 Jan 14;95:e1. doi: 10.1017/S0022149X2000098X.
  7. Sendur SN, Ergunay K, Akyon Y, Brinkmann A, Serdar M, Dagdelen S, Erbas T, Nitsche A, Yilmaz E. Probable alterations in fecal bacterial microbiota by somatostatin receptor analogs in acromegaly. Turk J Biochem 2020; 45(6): 695–700. DOI: https://doi.org/10.1515/tjb-2020-0293
  8. Yılmaz E, Akyon Y, Serdar M. The molecular footprints of COVID-19. Turkish J Biochem. 2020 Vol 45, Issue 3, , Pages 241-248.
  9. Serra Örsten, Türkmen Çiftçi, Aynur Azizova, Gökhan Yüce, Aycan Uysal, Çetin İmamoğlu, Ergun Karaağaoğlu, Devrim Akıncı, Yakut Akyön, Adriano Casulli, Okan Akhan. Investigation of the relationship between CE cyst characteristics and genetic diversity of Echinococcus granulosus sensu lato in humans from Turkey. Parasitology. 2020 Aug 17:1-19. doi: 10.1017/S0031182020001535.
  10. Nesrin Damla Eyupoglu, Koray Ergunay, Aylin Acikgoz, Yakut Akyon, Engin Yilmaz, Bulent Okan Yildiz. Gut microbiota and oral contraceptive use in overweight and obese patients with polycystic ovary syndrome. J Clin Endocrinol Metab. 2020 Aug 29:dgaa600. doi: 10.1210/clinem/dgaa600.
  11. Kaya F, İnkaya AÇ, Ertenli Aİ, Abbasoğlu O, Aksoy S, Akyön Y, Ergüven S. The investigation of Strongloides stercoralis seroprevalence in immunosuppressed patients in Turkey. Turk J Med Sci. 2019 Feb 11;49(1):16-19. doi: 10.3906/sag-1804-16.
  12. Büşra Betül Özmen Çapın, Meliha Çağla Sönmezer, Sema Tortop, Tuğçe Ünalan, Hatice Bölek, Sabri Engin Altıntop, Ahmet Çağkan İnkaya, Gökhan Metan, Sibel Ergüven. The Importance of Awareness for Malaria Regarding Prophylaxis and Early Diagnosis: Two Imported Malaria Cases in Turkey. Mikrobiyol Bul. 2019 Oct;53(4):472-479. doi: 10.5578/mb.68419.
  13. Bellikci-Koyu E, Sarer-Yurekli BP, Akyon Y, Aydin-Kose F, Karagozlu C, Ozgen AG, Brinkmann A, Nitsche A, Ergunay K, Yilmaz E, Buyuktuncer Z. Effects of Regular Kefir Consumption on Gut Microbiota in Patients with Metabolic Syndrome: A Parallel-Group, Randomized, Controlled Study. Nutrients. 2019 Sep 4;11(9). pii: E2089. doi: 10.3390/nu11092089.
  14. Sürmeli M, Maçin S, Akyön Y, Kayikçioğlu AU. The protective effect of Lactobacillus plantarum against meticillin-resistant Staphylococcus aureus infections: an experimental animal model. J Wound Care. 2019 Mar 2;28(Sup3b):s29-s34. doi: 10.12968/jowc.2019.28.Sup3b.S29.
  15. Maçin S, Alp A, Sener B, Sökmensüer C, Orhan D, Özen H, Kav T, Akyön Y. Comparison of culture, Real-time PCR, ELISA and histopathological examination methods for identification of Helicobacter pylori. Istanbul Medical Journal 19 (2): 138-142, 2018. DOI: 10.5152/imj.2018.94834.
  16. Kaya F, İnkaya A, Maçin S, Akyön Y, Ergüven S. Refractory Giardiasis in an Immunosuppressed Patient in Turkey. J Infect Dev Ctries 12: 204-207, 2018. Doi: https.//doi.org/10.3855/jidc.9669
  17. Süzük Yıldız S, Şimşek H, Çöplü N, Gülay Z; UAMDS Study Group. [National Antimicrobial Resistance Surveillance System (NAMRSS) external quality assessment studies: 2011-2016]. Mikrobiyol Bul. 2017 Jul;51(3):247-259. doi: 10.5578/mb.57421.
  18. Maçin S, Akyön Y. Phenotypic and Genotypic virulence Factors in Pseudomonas aeruginosa strains according to pigment presence. Acta Medica Mediterranea. 2017: 6: DOI: 10.19193/0393-6384
  19. Macin S, Kittana FNA, İnkaya AÇ, Akyön Y, Ünal S. Rare tracheobronchitis agent in a patient with AIDS: Bordetella bronchiseptica. Jundishapur J Microbiol. 2017 10 (7) DOI: 10.5812/jjm.12851
  20. Maçin S, İnkaya AÇ, Doğan O, Bozkurt G, Göçmen R, Şardan YC, Akyön Y. Mastoiditis brain abscess and sinus thrombosis as complications of chronic otitis media: A case report. Jundishapur J Microbiol. 2017 10 (2) DOI: 10.5812/jjm.41352
  21. Macin S, İnkaya AÇ, Tuncer Ö, Ünal S, Akyön Y. Infections related to Granulicatella adiacens: Report of two cases and review of literature. Indian J Med Microbiol. 2016 Oct-Dec;34(4):547-550. doi: 10.4103/0255-0857.195377.
  22. Inkaya AC, Macin S, Bozkurt G, Gocmen R, Akyon Y, Unal S. Aggregatibacter aphrophilus misidentified as Brucella spp. in an immunocompetent patient with brain abscess. J Pak Med Assoc. 2016 Aug;66(8):1032-4.
  23. Aydın Teke T, Akyön Y, Gunes Yalcin E, Ozen H, Doğru D, Kiper N, Ozcelik U. Does Helicobacter pylori play a role in the pathogenesis of non-cystic fibrosis bronchiectasis? Pediatr Int. 2016 Jan 14.
  24. Çakar A, Akyön Y, Gür D, Karatuna O, Öğünç D, Özhak Baysan B, Çöplü N, Çağatay M, Kılıç A, Baysallar M, Bakıcı Z, Çelik C, Gülay Z, Aydemir Ş, Tünger A, Kılıç H, Erçal BD, Aşçı Toraman Z, Zer Y, Büyüktaş A, Ay S, Aktaş Z, Kayacan Ç, Bayramoğlu G, Aydın F, Dündar D, Hasdemir U, Ayaş R, Yanık K, Günaydın M, Güdücüoğlu H, Parlak M. Investigation of carbapenemases in carbapenem-resistant Escherichia coli and Klebsiella pneumoniae strains isolated in 2014 in Turkey. Mikrobiyol Bul. 2016 Jan;50(1):21-33.
  25. Maçin S, Kaya F, Çağdaş D, Hizarcioglu-Gulsen H, Saltik-Temizel IN, Tezcan İ, Demir H, Ergüven S, Akyön Y. Detection of parasites in children with chronic diarrhea. Pediatr Int. 2016 Jun;58(6):531-3.

Links

https://tip.hacettepe.edu.tr/tr/tibbi_mikrobiyoloji_anabilim_dali-102

About

Research Infrastructure

• Oven
• Light microscope
• Fluorescent microscope
• Vortex
• Centrifuge
•  Weight
• Automatic pipette

Researchers

•    Prof. Dr. Yakut Akyön Yılmaz
 

Ongoing Projects

  1. Development of Antimicrobial Peptide Nanofiber Based Mucoadhesive Release System for Helicobacter pylori Treatment (TÜBİTAK) (Konya Food and Agriculture University- Faculty of Agriculture and Natural Sciences- Molecular Biology and Genetics)
  2. The relationship of intestinal microbiota with ambulatory blood pressure variables and clinical parameters in individuals with newly diagnosed hypertensive, pre-hypertensive and white coat hypertension (Hacettepe University, Faculty of Medicine, Department of Internal Medicine-Nephrology)
  3. Evaluation of submucosal microbiota profile in periimplant health and periimplant mucositis (Hacettepe University, Faculty of Dentistry, Department of Periodontology)
  4. Evaluation of submucosal microbiota profile in periimplantitis patients with different stages of bone loss (Hacettepe University, Faculty of Dentistry, Department of Periodontology)
  5. Detection of Plasmodium species by molecular methods in the female Anopheles  (A study to be carried out with Hacettepe University, Faculty of Science, Biology Department-Ecology group)
  6. Cultivation of Entamoeba gingivalis in xenic culture (preliminary study)

Completed Projects

  • • Project Code: THD-2021-19344, Investigation of the prevalence of Entamoeba gingivalis in the Flora of the Mouth and determination of molecular subtypes
  • • Project Code: THD-2021-19430, Detection of Helicobacter pylori infection from stool and stomach biopsy specimens and
  • determination of clarithromycin resistance by molecular methods
  • • Project Code: THD-2017-12888TWO DIFFERENT DECONTAMINATIONS APPLIED BEFORE MYCOBACTERIUM TUB ERCULOSIS ISOLATION COMPARISON OF PROCESS
  • •   Project Code: TAY-2017-12936 The Role of Gut Microbiota in the Pathogenesis of Various Diseases
  • •   Project Code: THD-2016-11786 Intestinal microbiota in healthy women with polycystic ovarian syndrome Comparison of Prevotella melaninogenica and Ruminococcus torques
  • Investigation of Intestinal Protozoon Prevalence in Immunocompromised Patients at a University Hospital.
  • MicroRNA expression profile in patients with cystic echinococcosis and identification of possible cellular pathways.
  • Probeable alterations in fecal bacterial microbiota by somatostatin receptor analogs in acromegaly.
  • Gut microbiota and oral contraceptive use in overweight and obese patients with polycystic ovary syndrome.
  • Investigation of the relationship between CE cyst characteristics and genetic diversity of Echinococcus granulosus sensu lato in humans from Turkey.
  • Effects of Regular Kefir Consumption on Gut Microbiota in Patients with Metabolic Syndrome: A Parallel-Group, Randomized, Controlled Study.
  • The investigation of Strongloides stercoralis seroprevalence in immunosuppressed patients in Turkey.

Publications

  1. Serra Örsten, Cem Şahin, Engin Yılmaz, Yakut Akyön. First molecular detection of Entamoeba gingivalis subtypes in individuals from Turkey. Pathog Dis. 2023 Jan 17;81:ftad017. doi: 10.1093/femspd/ftad017.
  2. Örsten S, Yılmaz E, Akyön Y. Molecular Characterization of Clarithromycin Resistance in Helicobacter pylori Strains. Turk J Gastroenterol. 2023 Feb 15. doi: 10.5152/tjg.2023.21954.
  3. Unalan-Altintop T, Vahabov C, Ergunay K, Kurt O, Kav T, Akyon Y, Erguven S. Investigation of Dientamoeba fragilis and Blastocystis in patients from Turkey with ulcerative colitis and irritable bowel syndrome: Any relation with genotypes? Acta Trop. 2022 Jul;231:106451. doi: 0.1016/j.actatropica.2022.106451.
  4. Serra Örsten, İpek Baysal, Neslihan Akdoğan, Neşe İnal, Ecem Bostan, Samiye Yabanoğlu Çiftçi, Yakut Akyön. Possible microRNA-based mechanism underlying relationship between chronic spontaneous urticaria and Blastocystis. Exp Parasitol. 2023 Feb;245:108453. doi: 10.1016/j.exppara.2022.108453
  5. Aslan AT, Kırbas E, Sancak B, Tanrıverdi ES, Otlu B , GürsoyN C, Akyön Yılmaz Y, Tozluyurt A, Liste Ü, Bıçakcıgil A, Hazırolan G, Dağ O, Sain Güven G , Akova M,  on behalf of the Study Group for Carbapenem Resistance (SCARE). A retrospective observational cohort study of the clinical epidemiology of bloodstream infections due to carbapenem-resistant Klebsiella pneumoniae in an OXA-48 endemic setting. Int. J Ant. Agents (2022) 59/4:  https://doi.org/10.1016/j.ijantimicag.2022.106554
  6. S Orsten, İ Baysal, S Yabanoglu-Ciftci, T Ciftci, A Azizova, D Akinci, Y Akyon, O Akhan. MicroRNA expression profile in patients with cystic echinococcosis and identification of possible cellular pathways. J Helminthol. 2021 Jan 14;95:e1. doi: 10.1017/S0022149X2000098X.
  7. Sendur SN, Ergunay K, Akyon Y, Brinkmann A, Serdar M, Dagdelen S, Erbas T, Nitsche A, Yilmaz E. Probable alterations in fecal bacterial microbiota by somatostatin receptor analogs in acromegaly. Turk J Biochem 2020; 45(6): 695–700. DOI: https://doi.org/10.1515/tjb-2020-0293
  8. Yılmaz E, Akyon Y, Serdar M. The molecular footprints of COVID-19. Turkish J Biochem. 2020 Vol 45, Issue 3, , Pages 241-248.
  9. Serra Örsten, Türkmen Çiftçi, Aynur Azizova, Gökhan Yüce, Aycan Uysal, Çetin İmamoğlu, Ergun Karaağaoğlu, Devrim Akıncı, Yakut Akyön, Adriano Casulli, Okan Akhan. Investigation of the relationship between CE cyst characteristics and genetic diversity of Echinococcus granulosus sensu lato in humans from Turkey. Parasitology. 2020 Aug 17:1-19. doi: 10.1017/S0031182020001535.
  10. Nesrin Damla Eyupoglu, Koray Ergunay, Aylin Acikgoz, Yakut Akyon, Engin Yilmaz, Bulent Okan Yildiz. Gut microbiota and oral contraceptive use in overweight and obese patients with polycystic ovary syndrome. J Clin Endocrinol Metab. 2020 Aug 29:dgaa600. doi: 10.1210/clinem/dgaa600.
  11. Kaya F, İnkaya AÇ, Ertenli Aİ, Abbasoğlu O, Aksoy S, Akyön Y, Ergüven S. The investigation of Strongloides stercoralis seroprevalence in immunosuppressed patients in Turkey. Turk J Med Sci. 2019 Feb 11;49(1):16-19. doi: 10.3906/sag-1804-16.
  12. Büşra Betül Özmen Çapın, Meliha Çağla Sönmezer, Sema Tortop, Tuğçe Ünalan, Hatice Bölek, Sabri Engin Altıntop, Ahmet Çağkan İnkaya, Gökhan Metan, Sibel Ergüven. The Importance of Awareness for Malaria Regarding Prophylaxis and Early Diagnosis: Two Imported Malaria Cases in Turkey. Mikrobiyol Bul. 2019 Oct;53(4):472-479. doi: 10.5578/mb.68419.
  13. Bellikci-Koyu E, Sarer-Yurekli BP, Akyon Y, Aydin-Kose F, Karagozlu C, Ozgen AG, Brinkmann A, Nitsche A, Ergunay K, Yilmaz E, Buyuktuncer Z. Effects of Regular Kefir Consumption on Gut Microbiota in Patients with Metabolic Syndrome: A Parallel-Group, Randomized, Controlled Study. Nutrients. 2019 Sep 4;11(9). pii: E2089. doi: 10.3390/nu11092089.
  14. Sürmeli M, Maçin S, Akyön Y, Kayikçioğlu AU. The protective effect of Lactobacillus plantarum against meticillin-resistant Staphylococcus aureus infections: an experimental animal model. J Wound Care. 2019 Mar 2;28(Sup3b):s29-s34. doi: 10.12968/jowc.2019.28.Sup3b.S29.
  15. Maçin S, Alp A, Sener B, Sökmensüer C, Orhan D, Özen H, Kav T, Akyön Y. Comparison of culture, Real-time PCR, ELISA and histopathological examination methods for identification of Helicobacter pylori. Istanbul Medical Journal 19 (2): 138-142, 2018. DOI: 10.5152/imj.2018.94834.
  16. Kaya F, İnkaya A, Maçin S, Akyön Y, Ergüven S. Refractory Giardiasis in an Immunosuppressed Patient in Turkey. J Infect Dev Ctries 12: 204-207, 2018. Doi: https.//doi.org/10.3855/jidc.9669
  17. Süzük Yıldız S, Şimşek H, Çöplü N, Gülay Z; UAMDS Study Group. [National Antimicrobial Resistance Surveillance System (NAMRSS) external quality assessment studies: 2011-2016]. Mikrobiyol Bul. 2017 Jul;51(3):247-259. doi: 10.5578/mb.57421.
  18. Maçin S, Akyön Y. Phenotypic and Genotypic virulence Factors in Pseudomonas aeruginosa strains according to pigment presence. Acta Medica Mediterranea. 2017: 6: DOI: 10.19193/0393-6384
  19. Macin S, Kittana FNA, İnkaya AÇ, Akyön Y, Ünal S. Rare tracheobronchitis agent in a patient with AIDS: Bordetella bronchiseptica. Jundishapur J Microbiol. 2017 10 (7) DOI: 10.5812/jjm.12851
  20. Maçin S, İnkaya AÇ, Doğan O, Bozkurt G, Göçmen R, Şardan YC, Akyön Y. Mastoiditis brain abscess and sinus thrombosis as complications of chronic otitis media: A case report. Jundishapur J Microbiol. 2017 10 (2) DOI: 10.5812/jjm.41352
  21. Macin S, İnkaya AÇ, Tuncer Ö, Ünal S, Akyön Y. Infections related to Granulicatella adiacens: Report of two cases and review of literature. Indian J Med Microbiol. 2016 Oct-Dec;34(4):547-550. doi: 10.4103/0255-0857.195377.
  22. Inkaya AC, Macin S, Bozkurt G, Gocmen R, Akyon Y, Unal S. Aggregatibacter aphrophilus misidentified as Brucella spp. in an immunocompetent patient with brain abscess. J Pak Med Assoc. 2016 Aug;66(8):1032-4.
  23. Aydın Teke T, Akyön Y, Gunes Yalcin E, Ozen H, Doğru D, Kiper N, Ozcelik U. Does Helicobacter pylori play a role in the pathogenesis of non-cystic fibrosis bronchiectasis? Pediatr Int. 2016 Jan 14.
  24. Çakar A, Akyön Y, Gür D, Karatuna O, Öğünç D, Özhak Baysan B, Çöplü N, Çağatay M, Kılıç A, Baysallar M, Bakıcı Z, Çelik C, Gülay Z, Aydemir Ş, Tünger A, Kılıç H, Erçal BD, Aşçı Toraman Z, Zer Y, Büyüktaş A, Ay S, Aktaş Z, Kayacan Ç, Bayramoğlu G, Aydın F, Dündar D, Hasdemir U, Ayaş R, Yanık K, Günaydın M, Güdücüoğlu H, Parlak M. Investigation of carbapenemases in carbapenem-resistant Escherichia coli and Klebsiella pneumoniae strains isolated in 2014 in Turkey. Mikrobiyol Bul. 2016 Jan;50(1):21-33.
  25. Maçin S, Kaya F, Çağdaş D, Hizarcioglu-Gulsen H, Saltik-Temizel IN, Tezcan İ, Demir H, Ergüven S, Akyön Y. Detection of parasites in children with chronic diarrhea. Pediatr Int. 2016 Jun;58(6):531-3.

Links

https://tip.hacettepe.edu.tr/tr/tibbi_mikrobiyoloji_anabilim_dali-102