The main research subjects studied in the research laboratories operating within the Department of Nanotechnology and Nanomedicine are summarized below:
• 3-Axis CNC
• Atomic Force Microscope
• X-Y Dispenser
• Potentiostat,
• SPR Incubation
• Pressure Controller
• Syringe pump
• Fluorospectrometer
• Stereo microscope
• Laser Cutting Device
• 3D stereolithography printer
• 3D FDM printer
• Vortex
• Microwave oven
• Magnetic Stirrer
• Ultrasonic water bath
• Centrifuge
• Mini centrifuge
• Mechanical mixers
• Analytical precision balances
• Shaking Oven
• pH meters
• 120 V DC Power Supply
• 100 V DC Power Supply
• Ultrasonic homogenizer
• Heated magnetic stirrer
• Sintering furnace (1000 °C)
• Shaking water bath
• ELISA reader
• Magnetic stirrers
• Ultrasonic probe
• Shaking oven
• Electrospinning unit
• Electrohydrodynamic Direct Writing unit
• 365 nm UV Lamp
• 312 nm UV Lamp
• Basket heaters
• Vacuum pump and desiccators
• Peristaltic pumps
• Fume Hood
• Chemical storage cabinet
• Reverse Osmosis Water purifier
• Ultra pure water purifier
• Prof. Dr. Necdet Sağlam
• Prof. Dr. Memed Duman
• Assoc. Prof. Dr. Eylem Güven
• Assist. Prof. Dr. Mehmet Burak Kaynar
• Assist. Prof. Dr. Cem Bayram
• Assist. Prof. Dr. Telem Şimşek
• Dr. İpek Akyılmaz
• PhD Candidate Yağız Demir
• PhD Candidate Seda Nur Aras
• PhD Candidate Boğaç Kılıçarslan
• MSc Candidate Zahid Doğan
• MSc Candidate Banu Usluoğlu
• MSc Candidate Mervenur Keleş
• MSc Candidate Altuğ İlbay
• Development of a Bedside Diagnostic System for Early Diagnosis and Follow-up of Phenylketonuria
• Preparation of Decellularized Myocardial-Elastomer Hybrid Cardiac Patches and Investigation of Their In vitro Performance with Stem Cells in a Mechanically Stimulated Bioreactor
• Investigation of Neural Recording and Stimulation Capability of Doped Graphene-Based Nanomaterials (FYL-2021-19678)
• Production and Characterization of Titanium Dioxide Nanotube Based Membrane Systems for Blood Filtration Applications (FYL-2021-119673)
• Development of Flexible Capacitive Tactile D-Pad Sensors by Near Field Electrospinning Method (FBA-2021-19435)
• Development of Radar Cross Section Reducing Lightened Covers, TÜBİTAK 1001
• Testing treatment resistance in breast cancer in three-dimensional spheroid cell co-cultures and developing an inferential mathematical model (TÇP-2019-18245)
• Production of Titanium Surfaces with Titanium Dioxide Nanotube Arrays and Electroanalytical Biosensor Applications” Hacettepe University, Scientific Research Projects Coordination Unit, Project no: (FBA-2017-15431). (Budget 175k TRY)
• Synthesis, Characterization and Investigation of Cell Transport Vehicle Potential of Hydrogels with Self-Healing Feature with Dynamic Covalent Bonds” TUBITAK 1001 Research Project, KBAG, Project no: 117Z334, 2017 (Budget: 255 k TRY)
• Characterization of Bipolar Phosphorylcholine Based Brush Type Polymer Chains on Titanium Surfaces by Surface-Initiated Polymerization and Its Effect on Mineralization (FHD-2017-13320) (Budget : 20 k TRY)
• Preparation and characterization of nanobiomaterials for use in urethral repair, Hacettepe University Scientific Research Unit Project, Project No: 11603.
• Production of Smart Biodegradable Bone Repair Plaques. Hacettepe University, Scientific Research Project Coordination Unit, Project No: TSA-2017-14307. 2017. (Budget: ~180k TRY)
• A Surface Plasmon Resonance (SPR) Sensor System using Molecular Imprinted Polymer- Nanoparticle Composites for Ultrasensitive detection of Pharmaceutical Emerging Contaminants in Fresh Water Sources. Royal Society, Advance Newton Fund, Project No: NA140378. 2018. (Budget: ~72k GBP)
• Design and Development of Microfluidic based Platelet Rich Plasma Separation Kit. TUBITAK, Project No:0815.STZ.2014, 2017. (Budget: ~185 k TRY)
• Nanoparticle Based Capacitive Sensor Array System for Biomedical Sensing. Hacettepe University, Scientific Research Project Coordination Unit, Project No: FHD-2015-5270. 2016. (Budget: ~20k TRY)
• Development of Molecular Imprinted Polymer Based Cantilever Sensor System for Detection of Pharmaceutical Emerging Contaminants in Water Sources. COST TD1002 action, Project No:113Z222. 2015. (Budget: ~200 k TRY)
• Development and Production of Point of Care Test Kit for Detection of Fecal Occult Blood. TUBITAK 1003 Project No: TC0101-113S076. 2016. (Budget: ~456 k TRY)
• Microfluidic biofabrication of homogeneous porous gelatin nanohydroxyapatite scaffolds and its effect on osteogenic differentiation of dental pulp stem cells (FHD-2019-18144)
• The Effect of Zinc Additives on Ferromagnetic Resonance (FMR) Frequency in Cobalt-Ferrite Based Composite Films and Investigation of Possible Spintronic Applications, Hacettepe University-BAP, Rapid Support Project, 2020.
• Kilicarslan, B., Bozyel, İ., Gokcen, D., Bayram, C. (2022). Sustainable Macromolecular Materials in Flexible Electronics. Macromolecular Materials and Engineering (DOI:10.1002/mame.202100978)
• Aylaz G., Okan M., Duman M., Aydin HM., (2020) Study on Cost-Efficient Carbon Aerogel to Remove Antibiotics from Water Resources. ACS Omega, 5: 16635-16644.
• Heseltine, P. L., Bayram, C., Gultekinoglu, M., Homer-Vanniasinkam, S., Ulubayram, K., Edirisinghe, M. (2022). Facile One-Pot Method for All Aqueous Green Formation of Biocompatible Silk Fibroin-Poly(Ethylene Oxide) Fibers for Use in Tissue Engineering. ACS Biomater. Sci. Eng. 2022, 8, 3, 1290–1300.
• Mahalingam, S., Bayram, C., Gultekinoglu, M., Ulubayram, K., Homer‐Vanniasinkam, S., & Edirisinghe, M. (2021). Co‐Axial Gyro‐Spinning of PCL/PVA/HA Core‐Sheath Fibrous Scaffolds for Bone Tissue Engineering. Macromolecular Bioscience, 21(10), 2100177.
• Ahmed, J., Gultekinoglu, M., Bayram, C., Kart, D., Ulubayram, K., & Edirisinghe, M. (2021). Alleviating the toxicity concerns of antibacterial cinnamon‐polycaprolactone biomaterials for healthcare‐related biomedical applications. MedComm, 2(2), 236-246.
• Tevlek A., Atya AM., Almemar M., Duman M, Dincer G., Ganin AY., Yiu HH., Aydin HM., (2020). Synthesis of conductive carbon Aerogels Decorated with β-tricalcium phosphate nanocrystallites. Scientific Reports, 10: 5758.
• Khun J., Aylaz G., Sari E., Marco M., Yiu HHP., Duman M., (2020). Selective Binding of Antibiotics Using Magnetic Molecular Imprint Polymer (MMIP) networks Prepared from Vinyl-Functionalized Magnetic Nanoparticles. Journal of Hazardous Materials, 387: 121709.
• Khan A. H. , Jiang X., Surwase S., Gültekinoğlu Bayram M. , Bayram C. , Sathisaran I., “ Effectiveness of Oil-Layered Albumin Microbubbles Produced Using Microfluidic T-Junctions in Series for In Vitro Inhibition of Tumor Cells”, Langmuir, 2020, 36, 11429-11441.
• Keçeli H. G. , Bayram C. , Celik E., Ercan N., Demirbilek M. , Nohutcu R. M., “Dual delivery of platelet-derived growth factor and bone morphogenetic factor-6 on titanium surface to enhance the early period of implant osseointegration”, J Periodontal Res., 2020, 55, 694-704.
• Gultekinoglu M. , Jiang X., Bayram C. , Wu H., Ulubayram K. , Edirisinghe M. “ Self-assembled micro-stripe patterning of sessile polymeric nanofluid droplets” J Colloid and Inter Sci, 2020, 561, 470-480.
• Guven, E. Lipid-based nanoparticles in the treatment of erectile dysfunction. International journal of Impotence Research. 32(6), 578-586 (2020)
• Cakir M. C. , Kocer H., Durna Y., Yildirim D. U. , Ghobadi A., Hajian H., Aydin K., Kurt H., Saglam N., Ozbay E., Unveiling the optical parameters of vanadium dioxide in the phase transition region: a hybrid modeling approach. RSC Advances, 10, 50 29945-29955 (2020).
• Tanis S. N. , İlhan H., Güven B. , Tayyarcan E. K. , Çiftçi H., Sağlam N., Boyaci İH., Tamer U., A disposable gold-cellulose nanofibril platform for SERS mapping. Analytical Methods., 12, 24, 3164-3172 (2020).
• Bachimam K., Emul E., Sağlam N. , Korkusuz F., Baicalein Nanofiber Scaffold Containing Hyaluronic Acid and Polyvinyl Alcohol: Preparation and Evaluation. Turkish Journal of Medical Sciences, 50, 1139-1146 (2020).
• Bilir A., Emul E., Sağlam N., Development of albumin macroinitiator for polymers to use in DNA origami coating, Turkish Journal of Medical Sciences, 50, 1461-1469 (2020).
• Ilk S., Tan G., Emul E., Sağlam N. I nvestigation the potential use of silver nanoparticles synthesized by propolis extract as N-acyl-homoserine lactone-mediated quorum sensing systems inhibitör. Turkish Journal of Medical Sciences, 50, 1147-1156 (2020).
• Şimşek T., Ceylan A., Aşkın G. Ş. ve Özcan Ş., “Band gap engineering of ZnO nanocrystallites prepared via ball-milling”, Journal of Polytechnic, in press. doi: 10.2339/politeknik.647702
• Celik O., Duman M., (2019). High Temperature Coefficient of Resistance and Low Noise Tungsten Oxide Doped Amorphous Vanadium Oxide Thin Films for Microbolometer Applications. Thin Solid Films, 691: 137590.
• Kocaman, B., Harmandalı, M., Köprü, M., Solak, B., Ergin, T., Yılmaz, E., Güven, E. Total ionizing dose anaysis of a native detector and a satellite on orbit. AIP Conference Proceedings 2178, 030006 (2019).
• Alp, E., Damkaci, F., Guven, E., Tenniswood, M., Starch nanoparticles for delivery of the histone deacetylase inhibitor CG-1521 in breast cancer treatment. International Journal of Nanomedicine. 14, 1335-1346 (2019).
• Asik, M.D., Kaplan, M., Yalınay, M., Ozturk Guven, E., Bozkurt, M. Developmet of a sequential antibiotic releasing system for two-stage total joint replacement surgery. Journal of Biomedical Nanotechnology, 15, 2193-2201(2019).
• Kızıltan D, Vural T, Bayram C, Ozturk S, Bozdogan B, Yaman YT, Abacı S, Denkbaş EB, “Development of Titania Nanotube-based Electrochemical Immunosensor and Determination of Prostate Specific Antigen” , Analytical Sciences, 2018, 34: 789-794.
• Bayram C, Jiang X, Gultekinoglu M, Ozturk S, Ulubayram K, Edirisinghe M, “Biofabrication of Gelatin Tissue Scaffolds with Uniform Pore Size via Microbubble Assembly” Macromolecular Materials and Engineering, 2019, 1900394.
• Eroğlu İ, Gultekinoğlu M, Bayram C, Erikçi A, Çiftçi SY, Aksoy EA, Ulubayram K, “Gel network comprising UV crosslinked PLGA-b-PEG-MA nanoparticles for ibuprofen topical delivery”, Pharmaceutical Development and Technology, 2019, 24(9), 1144-1154.
• Daban G, Bayram C, Bozdoğan B ,Denkbaş EB, “Porous polyurethane film fabricated via the breath figure approach for sustained drug release”, Journal of Applied Polymer Science, 2019, 47658, Doi: 10.1002/app.47658
• Sari E., Uzek R., Duman M., Alagoz HY., Denizli A., (2018). Prism Coupler-Based Sensor System for Simultaneous Screening of Synthetic Glucocorticosteroid as Doping Control Agent. Sensors & Actuators: B. Chemical, 260: 432-444.
• Okan M., Duman M., (2018). Functional Polymeric Nanoparticle Decorated Microcantilever Sensor for Specific Detection of Erythromycin. Sensors & Actuators: B. Chemical, 256: 325-333.
• Sari E., Uzek R., Duman M., Denizli A., (2018). Detection of Ciprofloxacin Through Surface Plasmon Resonance Nanosensor with Specific Recognition Sites. Journal of Biomaterials Science, Polymer Edition, 29: 1302-1318.
• Gultekinoglu M, Jiang X, Bayram C, Ulubayram K, Edirisinghe M, “Honeycomb-like PLGA-b-PEG Structure Creation with T-junction Micro Droplets”, Langmuir, 2018, 34:7989-7997.
• Gözde Mutlu, Semih Çalamak, Kezban Ulubayram, Eylem Güven. Curcumin loaded electrospun PHBV nanofibers as potential wound dressing material. Journal of Drug Delivery Science and Technology, 43, 185-193 (2018).
• Eroğlu H, Haidar MK, Nemutlu E, Ozturk S, Bayram C, Ulubayram K, Oner L, “Dual release behavior of atorvastatin and alpha-lipoic acid from PLGA microspheres for the combination therapy in peripheral nerve injury”, Journal of Drug Delivery Science and Technology, 2017, 39:455-466.
• Esma Alp, Tamer Çırak, Murat Demirbilek, Mustafa Türk, Eylem Güven. Targeted delivery of etoposide to osteosarcoma cells using poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanoparticles. Turkish Journal of Biology, 41,719-733 (2017).
• İlk S., Sağlam N. , Özgen M., Korkusuz F. Chitosan nanoparticles enhances the anti-quorum sensing activity of kaempferol. Int J Biomacromol., 94, 653-662. (2017)
• İlk S., Sağlam N. , Özgen M. Kaempferol loaded lecithin/chitosan nanoparticles: preparation, characterization, and their potential applications as a sustainable antifungal agent., Artificial Cells Nanomedicine and Biotechnology, 45, 907-916. (2017)
• Emül E., Saglam S., Ates H., Korkusuz F. , Sağlam N. Characterization of Electrospun Nanofibrous Scaffolds for Nanobiomedical Applications. Journal of Electronic Materials., 45, 3835-3841. (2016)
• Malekghasemi S., Kahveci E., Duman M., (2016). Rapid and alternative fabrication method for microfluidic paper based analytical devices. Talanta, 159: 401-411.
• Erdogan H., Yilmaz M., Babur E., Duman M., Aydin H.A., Demirel G., (2016). Fabrication of Plasmonic Nanorod-Embedded Dipeptide Microspheres via the Freeze Quenching Method for Near- Infrared Laser-Triggered Drug-Delivery Applications. BioMacromolecules, 17: 1788-1794.
• Gultekinoglu M., Oh Y.J., Hinterdorfer P., Duman M., Catcat D., Ulubayram K., (2016). Nanoscale characteristics of antibacterial cationic polymeric brushes and single bacterium interactions probed by force microscopy. RSC Advances, 6: 17092-17099.
• Sari E., Uzek R., Duman M., Denizli A., (2015). Fabrication of surface plasmon resonance nanosensor for the selective determination of erythromycin via molecular imprinted nanoparticles. Talanta, 127: 607-614.