Neurology Department EEG Laboratories

About

Research Infrastructure

•   1 Portable digital EEG device
•   3 Digital EEG devices
•   Computers, scanners and printers

Researchers

•    Prof. Dr. Serap Saygı
•    Prof. Dr. F. İrsel Tezer Filik PhD

Ongoing Projects

•   Ictal crying
•   Epilepsy surgery and psychogenic nonepileptic seizures-videoEEG recordings of 2,000 patients and approximately 500 patients undergoing surgery
•   Interictal fast rhythmic activities in routine EEGs
•   Temoral encephalocele in patients who underwent VideoEEG and were considered for surgery
•   Symptomatic focal epilepsy and Fixation off sensitivity in routine EEG
•   Ictal and periictal oxygen saturation changes, EEG-Clinical relationship
•   frequency, clinical relevance and importance of subclinical seizures during video-EEG
• Prognosis in cases with extratemporal lobe epilepsy who underwent epilepsy surgery
•   Comparison of cases with temporal encephalocele and HS with synthetic MRI

Completed Projects

   •    The relationship between wakefulness and seizures during sleep and serum orexin level (Dr. Gökçe Ayhan's specialty thesis)
•   The lateralization-localization value of leg automatisms
• Investigation of immunological causes that may be effective in the development of epilepsy in patients who underwent temporal lobectomy and amygdalahippocampectomy due to drug-resistant temporal lobe epilepsy, using immunohistochemistry method in tissue samples
•    The relationship of seizure onset with awakening and arousal
•   EEG-Clinical features of cases with TLE-HS according to the last histopathological classification
• HLA research in patients who develop a skin rash associated with the use of AEDs
•   Agreement Between Modalities in Epilepsy Imaging (MRG_PET_Klinik_EEG)
•   SREDA frequency, clinical significance
•   Aphasic status, EEG-Clinical features
•   Apnea frequency in TLE
•   Sleep disease symptoms-survey study of patients who applied to epilepsy outpatient clinic (Dr. Vefa İsmayilova's specialty thesis)
•   Sleep and epilepsy with StereoEEG (Infrastructure project)
•   Intraoperative Neurophysiologic Examination in Central Nervous System Tumor Surgery
•   Functional MRI at rest and Diffusion Tensor MRI in refractory temporal lobe epilepsy
• Evaluation of Findings with Surgical Results
•   Reporting of interesting cases followed in VEMU (Postoperative NMDA –herpesencephalitis, neurofibromatosis and HS, ictal lacrimation.)

Publications

•    Vural G, Irsel Tezer F, SAYGI S. Ictal movements mimicking Islamic praying rituals: localizing value in a series of 12 patients. EPILEPSY BEHAV 2015 Dec;53:92-7
•    Nar Şenol P, Tezer FI, SAYGI S. Eyelid myoclomia seizures in adults: An alternate look at the syndrome paradox EPILEPSY BEHAVIOR 2015 Apr;45:265-70
•    Soylemezoglu F, Himmetoglu C, Oguz KK, SAYGI S, Akalan N. A 41-Year-Old Man wıth Drug-Resıstant Complex Partıal Seızures. Brain Pathol. 2015 Jul;25(4):511-2.
•    Yildiz FG, Tezer FI, SAYGI S. Temporal lobe epilepsy is a predisposing factor for sleep apnea: A questionnaire study in video-EEG monitoring unit. EPILEPSY BEHAV 2015 Jul;48:1-3.
•    Erdener ŞE, Dericioğlu N, SAYGI S. Lacrimation during seizure: a case report. CLIN EEG NEUROSCI 2015 Jul;46(3):243-6
•    Güngör, M. Acar Arslan, E., Tezer Fılık, F.İ., SAYGI S.SUDEP: The first case series in Turkey. ARCH NEUROPSYCHIATRY Volume 53, Issue 1, March 2016, Pages 64-68
•    Titiz AP, Tezer I, SAYGI S.  Speaking Foreign Language With Expressive Aphasia of Native Language During Postictal Period. J NEUROLOGICAL SCIENCES 33:(1): 47; 147-154, 2016
•    Erdener ŞE, Tezer FI, Oğuz KK, Kamışlı Ö, Ergün EL, Söylemezoğlu F, SAYGI S. Reflex Seizures Triggered by Exposure to Characters With Numerical Value: A Case With Right Temporal Cortical Dysplasia. CLIN EEG NEUROSCI  2016 Jul;47(3):220-3.
•    Gumusyayla S, Erdal A, Tezer FI, SAYGI S. The temporal relation between seizure onset and arousal-awakening in temporal lobe seizures. SEIZURE. 2016 Jul;39:24-7.
•    Ergün EL, SAYGI S, Yalnizoglu D, Oguz KK, Erbas B. SPECT-PET in Epilepsy and Clinical Approach in Evaluation. SEMIN NUCL MED 2016 Jul;46(4):294-307.
•    Kursun O, Karatas H, Dericioglu N, SAYGI S. Refractory Lesional Parietal Lobe Epilepsy: Clinical, Electroencephalographic and Neurodiagnostic Findings. ARCH NEUROPSYCHIATRY 2016; 53: 213-221.
•    Tezer I, Xasiyev F, Söylemezoglu F, Bilginer B, Oguz KK, SAYGI S.  Clinical and Electrophysiological Findings in Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis, Based on the Recent Histopathological Classifications EPILEPSY RESEARCH  2016 Nov;127:50-54.
•    Erkent I, Gocmen R, Tezer FI, Oguz KK, Kucuksahin N, Soylemezoglu F, Bilginer B, SAYGI S. Postherpetic Anti-N-methyl-D-aspartate Receptor Encephalitis after Hemispherotomy in a Patient with Intractable Startle Epilepsy. NEUROPEDIATRICS. 2018 Feb;49(1):63-67. doi: 10.1055/s-0037-1606640. Epub 2017 Sep 22
•    SAYGI S. İnvaziv EEG ve haritalama. Türkiye Klinikleri, EEG özel sayısı 2017
•    Tezer FI, Firat A, Tuzun E, Unal I, Soylemezoglu F, Bilginer B, Kaymaz F, Oguz KK, SAYGI S.  Immunopathology in Drug Resistant Mesial Temporal Lobe Epilepsy with Different Types of Hippocampal Sclerosis. INT J NEUROSCI. 2018 May;128(5):421-428. doi: 10.1080/00207454.2017.1389928.
•    Büyüköztürk S, Kekik Ç, Gökyiğit A.Z. , Tezer Filik F.İ., Karakaya G, SAYGI S, A.B. Dursun, S. Kirbaş, A. Tüfekçi, A.Z. Sin, İ. Aydoğdu, M.H. Sorgun, N. Aydin, A. Gelincik, B. Çolakoğlu, G. Çelik, F. Oğuz Cutaneous drug reactions to antiepileptic drugs and relation with HLA alleles in the Turkish population. Eur Ann Allergy Clin Immunol 2018 Jan;50(1):36-41. doi: 10.23822/EurAnnACI.1764-1489.23.
•    Urgen BM, Topac Y; Ustun FS; Demirayak P; Oguz KK ; Kansu T; SAYGI S; Ozcelik T; Boyaci H; Doerschner K. Homozygous LAMC3 mutation links to structural and functional changes in visual attention Networks NEUROIMAGE 2018 Apr 4. pii: S1053-8119(18)30287-8.  doi: 10.1016/j.neuroimage.2018.03.077.
•    Angın Dİ, Tezer İF, Oguz KK, Bilginer B, Söylemezoğlu F, SAYGI S Pharmacoresistant seizures in neurofibromatosis type 1 related to hippocampal sclerosis: Three case presentation and review J of Clin Neurosci 2019 Jun;64:14-17. doi: 10.1016/j.jocn.2019.03.055 .
•    Güneş A, Tezer FI, Yalnızoğlu D, Günbey C, Volkan Salancı B, Söylemezoğlu F, Bilginer B, Lay Ergun E, Turanlı G, Erbaş B, Topçu M, Saygı S,Karlı Oğuz K Intertechnique Agreement in Epilepsy Imaging - Epilepsi Görüntülemesinde Modaliteler Arası Uyum, Turkısh Journal of Pediatric Disease 2019, 4: 292-301  DOI: 10.12956/tchd.541114
•    Khasiyev F, Tezer FI, SAYGI S. Lower limb automatism in surgically treated temporal lobe epilepsy patients: Clinical and electrophysiological features. J CLIN NEUROSCI 2019 Nov;69:51-54. doi: 10.1016/j.jocn.2019.08.038.
•    Azman Iste F, Tezer Filik FI, SAYGI S. SREDA: A Rare but Confusing Benign EEG Variant. J CLIN NEUROPHYSIOL 2019 Aug 5. doi: 10.1097/WNP.0000000000000623. Epub ahead of print]
•    Yon MI, Azman F, Tezer FI, SAYGI S The coexistence of psychogenic nonepileptic and epileptic seizures in the same patient is more frequent than expected: Is there any clinical feature for defining these patients? EPILEPSY BEHAV. 2020 Apr;105:106940. doi: 10.1016/j.yebeh.2020.106940.
•    Yalnizoglu D, Ardicli D, Bilginer B, Konuskan B, Karli Oguz K, Akalan N, Turanli G, SAYGI S, Topcu  M. Long-term effects of vagus nerve stimulation in refractory pediatric epilepsy: A single-center experience Epilepsy Behav. 2020 Sep;110:107147. doi: 10.1016/j.yebeh.2020.107147. Epub 2020 Jun 27.
•    Azman Iste F, Tezer Filik FI, SAYGI S. Aphasic status epilepticus in a tertiary referral center in Turkey: Clinical features, etiology, and outcome. EPILEPSY RESEARCH. 2020 Nov;167:106479. doi: 10.1016/j.eplepsyres.2020.106479.
•    YILDIZ SARIKAYA FATMA GÖKÇEM,TEZER FILIK FADIME IRSEL,MUT ASKUN MELIKE,VARLI KUBILAY (2017). Intraoperative Neurophysiologic Examination in Central Nervous System Tumor Surgery: Four-year Single-institution Experience. Turkish Journal Of Neurology, 23(3), 112-116., Doi: 10.4274/tnd.75418
Kitap – Kitap Bölümü
•   LONG-TERM VIDEO EEG MONITORING, SERAP SAYGI, Clinical Neurophysiology Society Publications, 2020 İZMİR
•    EEG, SERAP SAYGI. NEUROLOGY Textbook-Hacettepe Bookstore, Ankara,1. Edition 2019
•   Epilepsy, SERAP SAYGI. Neurology Textbook- Hacettepe Bookstore, Ankara, 1st Edition,2019
•   Surgery in extratemporal lobe epilepsy, Serap Saygı. (Bora IH, editor). Treatment in Epilepsy. 1st Edition. Ankara: Turkey Clinics; 2019. p.40-6.
•   DIFFERENTIAL DIAGNOSIS IN NEUROLOGY, Department Name: Etiologies Underlying Synchronous Slow Waves) TEZER FILIK FADIME IRSEL, O'xxTIP KITABEVI, Editor: BEBEK NERSES, KOCASOY ORHAN ELIF, Edition number:1, ISBN:3209-078-605-84 , Turkish (Scientific Book), EEG Differential Diagnosis, (2017).,)
•   Epilpsis, Title of the Department:(infectious and inflammatory epilepsies) (2018)., TEZER FILIK FADIME IRSEL, TÜZÜN ERDEM, Kınay Demet, Nobel, Editor: Ibrahim Bora, Naz Yeni, Candan Gürses, Number of Publications: 2, ISBN:978- 605-335-376-8, Turkish (Scientific Book), (Publication No: 2899642)
•   Cannabinoid pharmacology in seizures, status and epilepsy. Olcay Meriç, Nalan Küçükşahin, İrsel Tezer (Ed. Oğuz Erdinç) Turkey Clinics 2016
•   Turkey Clinics Treatment in Epilepsy Department Name: Treatment in Epilepsy and Comorbid Conditions, Filiz Azman, İrsel Tezer, (Ed. İbrahim Bora 2019)

Links

About

Research Infrastructure

•   1 Portable digital EEG device
•   3 Digital EEG devices
•   Computers, scanners and printers

Researchers

•    Prof. Dr. Serap Saygı
•    Prof. Dr. F. İrsel Tezer Filik PhD

Ongoing Projects

•   Ictal crying
•   Epilepsy surgery and psychogenic nonepileptic seizures-videoEEG recordings of 2,000 patients and approximately 500 patients undergoing surgery
•   Interictal fast rhythmic activities in routine EEGs
•   Temoral encephalocele in patients who underwent VideoEEG and were considered for surgery
•   Symptomatic focal epilepsy and Fixation off sensitivity in routine EEG
•   Ictal and periictal oxygen saturation changes, EEG-Clinical relationship
•   frequency, clinical relevance and importance of subclinical seizures during video-EEG
• Prognosis in cases with extratemporal lobe epilepsy who underwent epilepsy surgery
•   Comparison of cases with temporal encephalocele and HS with synthetic MRI

Completed Projects

   •    The relationship between wakefulness and seizures during sleep and serum orexin level (Dr. Gökçe Ayhan's specialty thesis)
•   The lateralization-localization value of leg automatisms
• Investigation of immunological causes that may be effective in the development of epilepsy in patients who underwent temporal lobectomy and amygdalahippocampectomy due to drug-resistant temporal lobe epilepsy, using immunohistochemistry method in tissue samples
•    The relationship of seizure onset with awakening and arousal
•   EEG-Clinical features of cases with TLE-HS according to the last histopathological classification
• HLA research in patients who develop a skin rash associated with the use of AEDs
•   Agreement Between Modalities in Epilepsy Imaging (MRG_PET_Klinik_EEG)
•   SREDA frequency, clinical significance
•   Aphasic status, EEG-Clinical features
•   Apnea frequency in TLE
•   Sleep disease symptoms-survey study of patients who applied to epilepsy outpatient clinic (Dr. Vefa İsmayilova's specialty thesis)
•   Sleep and epilepsy with StereoEEG (Infrastructure project)
•   Intraoperative Neurophysiologic Examination in Central Nervous System Tumor Surgery
•   Functional MRI at rest and Diffusion Tensor MRI in refractory temporal lobe epilepsy
• Evaluation of Findings with Surgical Results
•   Reporting of interesting cases followed in VEMU (Postoperative NMDA –herpesencephalitis, neurofibromatosis and HS, ictal lacrimation.)

Publications

•    Vural G, Irsel Tezer F, SAYGI S. Ictal movements mimicking Islamic praying rituals: localizing value in a series of 12 patients. EPILEPSY BEHAV 2015 Dec;53:92-7
•    Nar Şenol P, Tezer FI, SAYGI S. Eyelid myoclomia seizures in adults: An alternate look at the syndrome paradox EPILEPSY BEHAVIOR 2015 Apr;45:265-70
•    Soylemezoglu F, Himmetoglu C, Oguz KK, SAYGI S, Akalan N. A 41-Year-Old Man wıth Drug-Resıstant Complex Partıal Seızures. Brain Pathol. 2015 Jul;25(4):511-2.
•    Yildiz FG, Tezer FI, SAYGI S. Temporal lobe epilepsy is a predisposing factor for sleep apnea: A questionnaire study in video-EEG monitoring unit. EPILEPSY BEHAV 2015 Jul;48:1-3.
•    Erdener ŞE, Dericioğlu N, SAYGI S. Lacrimation during seizure: a case report. CLIN EEG NEUROSCI 2015 Jul;46(3):243-6
•    Güngör, M. Acar Arslan, E., Tezer Fılık, F.İ., SAYGI S.SUDEP: The first case series in Turkey. ARCH NEUROPSYCHIATRY Volume 53, Issue 1, March 2016, Pages 64-68
•    Titiz AP, Tezer I, SAYGI S.  Speaking Foreign Language With Expressive Aphasia of Native Language During Postictal Period. J NEUROLOGICAL SCIENCES 33:(1): 47; 147-154, 2016
•    Erdener ŞE, Tezer FI, Oğuz KK, Kamışlı Ö, Ergün EL, Söylemezoğlu F, SAYGI S. Reflex Seizures Triggered by Exposure to Characters With Numerical Value: A Case With Right Temporal Cortical Dysplasia. CLIN EEG NEUROSCI  2016 Jul;47(3):220-3.
•    Gumusyayla S, Erdal A, Tezer FI, SAYGI S. The temporal relation between seizure onset and arousal-awakening in temporal lobe seizures. SEIZURE. 2016 Jul;39:24-7.
•    Ergün EL, SAYGI S, Yalnizoglu D, Oguz KK, Erbas B. SPECT-PET in Epilepsy and Clinical Approach in Evaluation. SEMIN NUCL MED 2016 Jul;46(4):294-307.
•    Kursun O, Karatas H, Dericioglu N, SAYGI S. Refractory Lesional Parietal Lobe Epilepsy: Clinical, Electroencephalographic and Neurodiagnostic Findings. ARCH NEUROPSYCHIATRY 2016; 53: 213-221.
•    Tezer I, Xasiyev F, Söylemezoglu F, Bilginer B, Oguz KK, SAYGI S.  Clinical and Electrophysiological Findings in Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis, Based on the Recent Histopathological Classifications EPILEPSY RESEARCH  2016 Nov;127:50-54.
•    Erkent I, Gocmen R, Tezer FI, Oguz KK, Kucuksahin N, Soylemezoglu F, Bilginer B, SAYGI S. Postherpetic Anti-N-methyl-D-aspartate Receptor Encephalitis after Hemispherotomy in a Patient with Intractable Startle Epilepsy. NEUROPEDIATRICS. 2018 Feb;49(1):63-67. doi: 10.1055/s-0037-1606640. Epub 2017 Sep 22
•    SAYGI S. İnvaziv EEG ve haritalama. Türkiye Klinikleri, EEG özel sayısı 2017
•    Tezer FI, Firat A, Tuzun E, Unal I, Soylemezoglu F, Bilginer B, Kaymaz F, Oguz KK, SAYGI S.  Immunopathology in Drug Resistant Mesial Temporal Lobe Epilepsy with Different Types of Hippocampal Sclerosis. INT J NEUROSCI. 2018 May;128(5):421-428. doi: 10.1080/00207454.2017.1389928.
•    Büyüköztürk S, Kekik Ç, Gökyiğit A.Z. , Tezer Filik F.İ., Karakaya G, SAYGI S, A.B. Dursun, S. Kirbaş, A. Tüfekçi, A.Z. Sin, İ. Aydoğdu, M.H. Sorgun, N. Aydin, A. Gelincik, B. Çolakoğlu, G. Çelik, F. Oğuz Cutaneous drug reactions to antiepileptic drugs and relation with HLA alleles in the Turkish population. Eur Ann Allergy Clin Immunol 2018 Jan;50(1):36-41. doi: 10.23822/EurAnnACI.1764-1489.23.
•    Urgen BM, Topac Y; Ustun FS; Demirayak P; Oguz KK ; Kansu T; SAYGI S; Ozcelik T; Boyaci H; Doerschner K. Homozygous LAMC3 mutation links to structural and functional changes in visual attention Networks NEUROIMAGE 2018 Apr 4. pii: S1053-8119(18)30287-8.  doi: 10.1016/j.neuroimage.2018.03.077.
•    Angın Dİ, Tezer İF, Oguz KK, Bilginer B, Söylemezoğlu F, SAYGI S Pharmacoresistant seizures in neurofibromatosis type 1 related to hippocampal sclerosis: Three case presentation and review J of Clin Neurosci 2019 Jun;64:14-17. doi: 10.1016/j.jocn.2019.03.055 .
•    Güneş A, Tezer FI, Yalnızoğlu D, Günbey C, Volkan Salancı B, Söylemezoğlu F, Bilginer B, Lay Ergun E, Turanlı G, Erbaş B, Topçu M, Saygı S,Karlı Oğuz K Intertechnique Agreement in Epilepsy Imaging - Epilepsi Görüntülemesinde Modaliteler Arası Uyum, Turkısh Journal of Pediatric Disease 2019, 4: 292-301  DOI: 10.12956/tchd.541114
•    Khasiyev F, Tezer FI, SAYGI S. Lower limb automatism in surgically treated temporal lobe epilepsy patients: Clinical and electrophysiological features. J CLIN NEUROSCI 2019 Nov;69:51-54. doi: 10.1016/j.jocn.2019.08.038.
•    Azman Iste F, Tezer Filik FI, SAYGI S. SREDA: A Rare but Confusing Benign EEG Variant. J CLIN NEUROPHYSIOL 2019 Aug 5. doi: 10.1097/WNP.0000000000000623. Epub ahead of print]
•    Yon MI, Azman F, Tezer FI, SAYGI S The coexistence of psychogenic nonepileptic and epileptic seizures in the same patient is more frequent than expected: Is there any clinical feature for defining these patients? EPILEPSY BEHAV. 2020 Apr;105:106940. doi: 10.1016/j.yebeh.2020.106940.
•    Yalnizoglu D, Ardicli D, Bilginer B, Konuskan B, Karli Oguz K, Akalan N, Turanli G, SAYGI S, Topcu  M. Long-term effects of vagus nerve stimulation in refractory pediatric epilepsy: A single-center experience Epilepsy Behav. 2020 Sep;110:107147. doi: 10.1016/j.yebeh.2020.107147. Epub 2020 Jun 27.
•    Azman Iste F, Tezer Filik FI, SAYGI S. Aphasic status epilepticus in a tertiary referral center in Turkey: Clinical features, etiology, and outcome. EPILEPSY RESEARCH. 2020 Nov;167:106479. doi: 10.1016/j.eplepsyres.2020.106479.
•    YILDIZ SARIKAYA FATMA GÖKÇEM,TEZER FILIK FADIME IRSEL,MUT ASKUN MELIKE,VARLI KUBILAY (2017). Intraoperative Neurophysiologic Examination in Central Nervous System Tumor Surgery: Four-year Single-institution Experience. Turkish Journal Of Neurology, 23(3), 112-116., Doi: 10.4274/tnd.75418
Kitap – Kitap Bölümü
•   LONG-TERM VIDEO EEG MONITORING, SERAP SAYGI, Clinical Neurophysiology Society Publications, 2020 İZMİR
•    EEG, SERAP SAYGI. NEUROLOGY Textbook-Hacettepe Bookstore, Ankara,1. Edition 2019
•   Epilepsy, SERAP SAYGI. Neurology Textbook- Hacettepe Bookstore, Ankara, 1st Edition,2019
•   Surgery in extratemporal lobe epilepsy, Serap Saygı. (Bora IH, editor). Treatment in Epilepsy. 1st Edition. Ankara: Turkey Clinics; 2019. p.40-6.
•   DIFFERENTIAL DIAGNOSIS IN NEUROLOGY, Department Name: Etiologies Underlying Synchronous Slow Waves) TEZER FILIK FADIME IRSEL, O'xxTIP KITABEVI, Editor: BEBEK NERSES, KOCASOY ORHAN ELIF, Edition number:1, ISBN:3209-078-605-84 , Turkish (Scientific Book), EEG Differential Diagnosis, (2017).,)
•   Epilpsis, Title of the Department:(infectious and inflammatory epilepsies) (2018)., TEZER FILIK FADIME IRSEL, TÜZÜN ERDEM, Kınay Demet, Nobel, Editor: Ibrahim Bora, Naz Yeni, Candan Gürses, Number of Publications: 2, ISBN:978- 605-335-376-8, Turkish (Scientific Book), (Publication No: 2899642)
•   Cannabinoid pharmacology in seizures, status and epilepsy. Olcay Meriç, Nalan Küçükşahin, İrsel Tezer (Ed. Oğuz Erdinç) Turkey Clinics 2016
•   Turkey Clinics Treatment in Epilepsy Department Name: Treatment in Epilepsy and Comorbid Conditions, Filiz Azman, İrsel Tezer, (Ed. İbrahim Bora 2019)

Links