Pediatric Infection Research Laboratory

About

Research Infrastructure

•   Portable Generators 1360511 Power Supply Consort Brand
•   Freezers 5107133 Freezer -20
•   Freezers Vertical Type Refrigerator
•   Scales 1812136 Scales Analytical Electronics
•   Scales 2206022 Scale Top Pan
•   General Purpose Medical Devices and Instruments 1141155 Bio-Rad Brand Chef Dr II Chiller And Gel Doc Xr Electrophoresis System
•   General Purpose Medical Devices and Instruments 1141156 Bio-Rad Brand Chef Dr II Chiller And For Gel Doc Xr Electrophoresis System: For Imaging
•   General Purpose Medical Devices and Instruments Laminar Flow Cabinet Class II Bioair Brand
•    Microbiology and Gene Transfer Devices 1605930 Pipette Automatic 0.5-10 Ul Gilson Brand
•    Micro Biology and Gene Transfer Devices Pipette Dispenser 1-1250(03.03.2009)
•   Molecular Biology Special Working Devices 1389911 220 V for Heater Block. 5 Hz. Stuart Brand Sht. 10 Madeles
•   Chest Diseases Diagnosis and Treatment Device 1846921 Vortex Fast Automatic Stuart Brand Sa2 Model Adjustable
•   Child Service Diagnosis and Treatment Device and L Prc Device Real Time 5-Channel Hrm (31.03.2009)
•   Device Used in Biological Research and / 1606911 Pipette Multi-Channel
•   Device Used in Biological Research and / 1607111 Automatic Pipette
•   Device Used in Biological Research and / 1607271 Pipette Automatic 30-200 Ul (Gilson Brand)
•    Device Used in Biological Research and / 1607414 Pipette Automatic 1 Ml - 5 Ml Gilson Brand
•   Medical Used in Other Specialization Departments 1387961 Innoculator Denley Brand A400 Model Multipoint 15%
•   Medicine Used in Other Specialization Departments 2179891 MULTIVVASH AUTO BINS Elisa Device Elx808 Bio Single Brand
•   Medical Electrophoresis Device Horizontal Midi Gel Used in Other Specialized Departments(26.03.09)
•    Ultraviolet UV-Visible Spectrophotometers 1773411 Spectrophotometer UV-Vis Du 530 Model Beckman Coulter Brand 517601
•   PH Measuring Devices 1575611 P.H. Metre
•   Friction Testers 1157311 Centurfuge Mod. K 230 2939 Bll Core Brand
•   Friction Testers 1683311 Centrifuge Rotina 380r
•    Incubators 1387741 INCUBATOR CELL AND TISSUE CULTURES Elektromag Brand
•   Incubators 70379 Incubator Carbon Dioxide 188 Lt. Internal Volume Stainless Steel Heraus Brand
•   Shaker-Mixer incubators 1228411 Shaker Mikrotlip Sbs-Brand-Avo-1-Model
•   Water Purification Devices 2119725 Device Reverse Osmosis And Ultra Pure Water Treatment Tka Brand
•   Micro Centrifuges 1191911 Device Microcentrifuge
•   Other Chemical, Physical and Physical Chemistry 1400511 Mixer Vartex Mixer 220 V. Cyc Sn:12315-12279-12254-12302
•   Heated Magnetic Stirrers 1400211 Stuart Brand Sm-3-Model with Stirrer Magnetic Heater
•   Heated Magnetic Stirrers 1400811 Stirrer (Magnetic)
•   Water Baths 1793781 Water Bath Thelco Model 83,
•   Binocular Microscopes 1528011 Microscope Various Brands
•   Deep Freezers Deep Freezer Sanyo -80
•   Deep Freezers Vertical Freezer Thermo Revco Brand (13.01.09)
•   Biology Study or Activity Sets 1174511 Device Electrophoresis Bio-Rad-Brand -Mini-Prokan
•   Child Service Diagnosis and Treatment Device and L Gene Amp Pcr System 9700

Researchers

•    Dr. Mehmet Ceyhan
•    Dr. Yasemin Özsürekci
•    Uzm. Biyolog A. Emre Aycan

Ongoing Projects

•   Bacterial agents causing meningitis and the prevalence of different serogroups of Neisseria meningitidis, Haemophilus influenzae type b, and Streptococcus pneumoniae: a multicenter, prospective study
•   Serotype Distribution and Antibiotic Susceptibility of Streptococcus pneumoniae Causing Invasive Diseases in Children in Turkey: A Multicenter, Retrospective Laboratory Study
•   Evaluating the Interchangeability of V114 and Prevnar 13 in terms of Safety, Tolerability and Immunogenicity in Healthy Infants Phase 3, Multicenter, Randomized, Double-Blind Study (PNEU-DIRECTION)” titled “V-114-027 (Ministry code: 18-MSD- 07)

Completed Projects

)•   A phase III clinical trial to study the tolerability and immunogenicity of V503, a multivalent human papillomavirus (HPV) L1 virus-like particle (VLP) vaccine, in 16- to 26- year-old men and 16- to 26-year- old women
•   A phase III, randomised, open, controlled, multicenter, primary vaccination study to evaluate the immunogenicity and persistence of 1 and 2 doses of MenACWY-TT in toddlers (up to 5 years) and to demonstrate non-inferiority of co-administration of MenACWY-TT and Prevenar-13 versus separate administration of the 2 vaccines
•   Bacterial agents causing meningitis and the prevalence of different serogroups of Neisseria meningitis, Haemophilus influenzae type b and Streptococcus pneumoniae in Turkey; a multicenter, prospective study
•   Serotype distribution and antibiotic susceptibility of Streptococcus pneumoniae, which causes invasive diseases in children in Turkey: a multicenter study
•   Serogrouping, prevalence, distribution by age, and typing by Mats method of Neisseria meningitidis strains causing invasive meningococcal diseases in Turkey: a multicenter prospective study
•   Phase III clinical trials examining the tolerability and immunogenicity of a 2-dose regimen of the multivalent human papillomavirus (HPV) L1 virus-like particle (VLP) vaccine V503 administered to preadolescents and adolescents (9 to 14 years) compared to young women (16 to 26 years of age). study
•   Genotyping of Brucella Isolates in Turkey by Multiple-Locus Variable-Number Tandem-Repeat Analysis or Whole Genome Sequencing Methods: A Multicenter Prospective Laboratory Study
•   The effect on PVL frequency and clinical findings in invasive Staphylococcus aureus infections in children

Publications

•    Özsürekci Y, Birdsell DN, Çelik M, Karadağ-Öncel E, Johansson A, Forsman M, Vogler AJ, Keim P, Ceyhan M, Wagner DM. Diverse Francisella tularensis strains cause oropharyngeal tularemia in Turkey. Emerg Infect Dis. 2015; 21:173-5.
•    Ceyhan M, Ozsurekci Y, Aydin MM, Akcali KC, Talim B, Celik M, Karadag Oncel E, Gurbuz V, Aycan AE, Onbasilar I, Buzgan T. Determination of the presence of Diphtheria toxin in the myocardial tissue of rabbits and a female subject by using an immunofluorescent antibody method. J Clin Med Res. 2015; 7: 472-478.
•    Ceyhan M, Ozsurekci Y, Gürler N, Öksüz L, Aydemir S, Ozkan S, Yuksekkaya S, Emiroglu MK, Gültekin M, Yaman A, Kiremitci A, Yanık K, Karli A, Ozcinar H, Aydin F, Bayramoglu G, Zer Y, Gulay Z, Gayyurhan ED, Gül M, Özakın C, Güdücüoğlu H, Perçin D, Akpolat N, Ozturk C, Camcıoğlu Y, Öncel EK, Çelik M, Şanal L, Uslu H. Serotype distribution of Streptococcus pneumoniae in children with invasive diseases in Turkey: 2008-2014. Hum Vaccin Immunother. 2016;1:308-13.
•    Ozsurekci Y, Arikan KO, Bayhan C, Karadag Oncel E, Aycan AE, Gurbuz V, Hascelik G, Ceyhan M. Can procalcitonin be a diagnostic marker for catheter-related bloodstream infection in children? J Pediatr 2016;92:414-20.
•    Ceyhan M, Ozsurekci Y, Gurler N, Karadag Oncel E, Camcioglu Y, Salman N, et al. Bacterial agents causing meningitis during 2013-2014 in Turkey: A multi-center hospital-based prospective surveillance study. Hum Vaccin Immunother 2016;12:2940-2945.
•    Tanır G, Ozsurekci Y, Lucidarme J, Durmuş SY, Lekshmi A, Akişoğlu Ö, Aycan AE, Borrow R, Ceyhan M. Neisseria meningitidis Serogroup X ST-5799 (ST-22 complex) in Turkey: A unique pediatric case. Human Vaccin Immunother 2018;14:209-2012.
•    Birdsell DN, Ozsurekci Y, Rawat A, Aycan AE, Mitchell CL, Sahl JW, Johansson A, Colman RE, Schupp JM, Ceyhan M, Keim PS, Wagner DM. Coinfections identified from metagenomic analysis of cervical lymph nodes from tularemia patients. BMC Infect Dis 2018;18:319.
•    Karadag Oncel E, Ceyhan M, Tanır Basaranoglu S, Gurbuz V, Aycan AE, Ozsurekci Y, Kurugol Z, Keser Emiroglu M, Devrim I, Karbuz A, Altay Akisoglu HO, Gurler N. Surveillance of penicillin resistance of Neisseria meningitidis strains from invasive infections between 2013 and 2018 in Turkey. J Chemother 2020 Fe 7: 1-4. doi: 10.1080/1120009X.2020.1721176.
•    Ceyhan M, Ozsurekci Y, Tanır Basaranoglu S, et al. Multicenter Hospital-Based Prospective Surveillance Study of Bacterial Agents Causing Meningitis and Seroprevalence of Different Serogroups of Neisseria meningitidis, Haemophilus influenza Type B, and Streptococcus pneumonia during 2015 to 2018 in Turkey. mSphere. 2020 Mar 25;5(2). doi: 10.1128/mSphere.00060-20
•    Ceyhan M, Aykac K, Gurler N, Ozsurekci Y, et al. Serotype distribution of Streptococcus pneumonia in children with invasive disease in Turkey: 2015-2018. Hum Vaccin Immunother 2020 Jun 12:1-6.
•    Cura Yayla BC, Ozsurekci Y, Aykac K, et al. Characteristics and Management of Children with COVID-19 in Turkey. Balkan Med J 2020 Aug 31.
•    Aykac K, Ozsurekci Y, Tanir Basaranoglu S, Demir OO, et a. Oxidant and antioxidant balance in children with bacteremia. Minerva Pediatr 2020 Sep 3.
•    Akca UK, Kesici S, Ozsurekci Y, et al. Kawasaki-like disease in children with COVID-19. Rheumatol Int 2020 Sep 16.

Links

About

Research Infrastructure

•   Portable Generators 1360511 Power Supply Consort Brand
•   Freezers 5107133 Freezer -20
•   Freezers Vertical Type Refrigerator
•   Scales 1812136 Scales Analytical Electronics
•   Scales 2206022 Scale Top Pan
•   General Purpose Medical Devices and Instruments 1141155 Bio-Rad Brand Chef Dr II Chiller And Gel Doc Xr Electrophoresis System
•   General Purpose Medical Devices and Instruments 1141156 Bio-Rad Brand Chef Dr II Chiller And For Gel Doc Xr Electrophoresis System: For Imaging
•   General Purpose Medical Devices and Instruments Laminar Flow Cabinet Class II Bioair Brand
•    Microbiology and Gene Transfer Devices 1605930 Pipette Automatic 0.5-10 Ul Gilson Brand
•    Micro Biology and Gene Transfer Devices Pipette Dispenser 1-1250(03.03.2009)
•   Molecular Biology Special Working Devices 1389911 220 V for Heater Block. 5 Hz. Stuart Brand Sht. 10 Madeles
•   Chest Diseases Diagnosis and Treatment Device 1846921 Vortex Fast Automatic Stuart Brand Sa2 Model Adjustable
•   Child Service Diagnosis and Treatment Device and L Prc Device Real Time 5-Channel Hrm (31.03.2009)
•   Device Used in Biological Research and / 1606911 Pipette Multi-Channel
•   Device Used in Biological Research and / 1607111 Automatic Pipette
•   Device Used in Biological Research and / 1607271 Pipette Automatic 30-200 Ul (Gilson Brand)
•    Device Used in Biological Research and / 1607414 Pipette Automatic 1 Ml - 5 Ml Gilson Brand
•   Medical Used in Other Specialization Departments 1387961 Innoculator Denley Brand A400 Model Multipoint 15%
•   Medicine Used in Other Specialization Departments 2179891 MULTIVVASH AUTO BINS Elisa Device Elx808 Bio Single Brand
•   Medical Electrophoresis Device Horizontal Midi Gel Used in Other Specialized Departments(26.03.09)
•    Ultraviolet UV-Visible Spectrophotometers 1773411 Spectrophotometer UV-Vis Du 530 Model Beckman Coulter Brand 517601
•   PH Measuring Devices 1575611 P.H. Metre
•   Friction Testers 1157311 Centurfuge Mod. K 230 2939 Bll Core Brand
•   Friction Testers 1683311 Centrifuge Rotina 380r
•    Incubators 1387741 INCUBATOR CELL AND TISSUE CULTURES Elektromag Brand
•   Incubators 70379 Incubator Carbon Dioxide 188 Lt. Internal Volume Stainless Steel Heraus Brand
•   Shaker-Mixer incubators 1228411 Shaker Mikrotlip Sbs-Brand-Avo-1-Model
•   Water Purification Devices 2119725 Device Reverse Osmosis And Ultra Pure Water Treatment Tka Brand
•   Micro Centrifuges 1191911 Device Microcentrifuge
•   Other Chemical, Physical and Physical Chemistry 1400511 Mixer Vartex Mixer 220 V. Cyc Sn:12315-12279-12254-12302
•   Heated Magnetic Stirrers 1400211 Stuart Brand Sm-3-Model with Stirrer Magnetic Heater
•   Heated Magnetic Stirrers 1400811 Stirrer (Magnetic)
•   Water Baths 1793781 Water Bath Thelco Model 83,
•   Binocular Microscopes 1528011 Microscope Various Brands
•   Deep Freezers Deep Freezer Sanyo -80
•   Deep Freezers Vertical Freezer Thermo Revco Brand (13.01.09)
•   Biology Study or Activity Sets 1174511 Device Electrophoresis Bio-Rad-Brand -Mini-Prokan
•   Child Service Diagnosis and Treatment Device and L Gene Amp Pcr System 9700

Researchers

•    Dr. Mehmet Ceyhan
•    Dr. Yasemin Özsürekci
•    Uzm. Biyolog A. Emre Aycan

Ongoing Projects

•   Bacterial agents causing meningitis and the prevalence of different serogroups of Neisseria meningitidis, Haemophilus influenzae type b, and Streptococcus pneumoniae: a multicenter, prospective study
•   Serotype Distribution and Antibiotic Susceptibility of Streptococcus pneumoniae Causing Invasive Diseases in Children in Turkey: A Multicenter, Retrospective Laboratory Study
•   Evaluating the Interchangeability of V114 and Prevnar 13 in terms of Safety, Tolerability and Immunogenicity in Healthy Infants Phase 3, Multicenter, Randomized, Double-Blind Study (PNEU-DIRECTION)” titled “V-114-027 (Ministry code: 18-MSD- 07)

Completed Projects

)•   A phase III clinical trial to study the tolerability and immunogenicity of V503, a multivalent human papillomavirus (HPV) L1 virus-like particle (VLP) vaccine, in 16- to 26- year-old men and 16- to 26-year- old women
•   A phase III, randomised, open, controlled, multicenter, primary vaccination study to evaluate the immunogenicity and persistence of 1 and 2 doses of MenACWY-TT in toddlers (up to 5 years) and to demonstrate non-inferiority of co-administration of MenACWY-TT and Prevenar-13 versus separate administration of the 2 vaccines
•   Bacterial agents causing meningitis and the prevalence of different serogroups of Neisseria meningitis, Haemophilus influenzae type b and Streptococcus pneumoniae in Turkey; a multicenter, prospective study
•   Serotype distribution and antibiotic susceptibility of Streptococcus pneumoniae, which causes invasive diseases in children in Turkey: a multicenter study
•   Serogrouping, prevalence, distribution by age, and typing by Mats method of Neisseria meningitidis strains causing invasive meningococcal diseases in Turkey: a multicenter prospective study
•   Phase III clinical trials examining the tolerability and immunogenicity of a 2-dose regimen of the multivalent human papillomavirus (HPV) L1 virus-like particle (VLP) vaccine V503 administered to preadolescents and adolescents (9 to 14 years) compared to young women (16 to 26 years of age). study
•   Genotyping of Brucella Isolates in Turkey by Multiple-Locus Variable-Number Tandem-Repeat Analysis or Whole Genome Sequencing Methods: A Multicenter Prospective Laboratory Study
•   The effect on PVL frequency and clinical findings in invasive Staphylococcus aureus infections in children

Publications

•    Özsürekci Y, Birdsell DN, Çelik M, Karadağ-Öncel E, Johansson A, Forsman M, Vogler AJ, Keim P, Ceyhan M, Wagner DM. Diverse Francisella tularensis strains cause oropharyngeal tularemia in Turkey. Emerg Infect Dis. 2015; 21:173-5.
•    Ceyhan M, Ozsurekci Y, Aydin MM, Akcali KC, Talim B, Celik M, Karadag Oncel E, Gurbuz V, Aycan AE, Onbasilar I, Buzgan T. Determination of the presence of Diphtheria toxin in the myocardial tissue of rabbits and a female subject by using an immunofluorescent antibody method. J Clin Med Res. 2015; 7: 472-478.
•    Ceyhan M, Ozsurekci Y, Gürler N, Öksüz L, Aydemir S, Ozkan S, Yuksekkaya S, Emiroglu MK, Gültekin M, Yaman A, Kiremitci A, Yanık K, Karli A, Ozcinar H, Aydin F, Bayramoglu G, Zer Y, Gulay Z, Gayyurhan ED, Gül M, Özakın C, Güdücüoğlu H, Perçin D, Akpolat N, Ozturk C, Camcıoğlu Y, Öncel EK, Çelik M, Şanal L, Uslu H. Serotype distribution of Streptococcus pneumoniae in children with invasive diseases in Turkey: 2008-2014. Hum Vaccin Immunother. 2016;1:308-13.
•    Ozsurekci Y, Arikan KO, Bayhan C, Karadag Oncel E, Aycan AE, Gurbuz V, Hascelik G, Ceyhan M. Can procalcitonin be a diagnostic marker for catheter-related bloodstream infection in children? J Pediatr 2016;92:414-20.
•    Ceyhan M, Ozsurekci Y, Gurler N, Karadag Oncel E, Camcioglu Y, Salman N, et al. Bacterial agents causing meningitis during 2013-2014 in Turkey: A multi-center hospital-based prospective surveillance study. Hum Vaccin Immunother 2016;12:2940-2945.
•    Tanır G, Ozsurekci Y, Lucidarme J, Durmuş SY, Lekshmi A, Akişoğlu Ö, Aycan AE, Borrow R, Ceyhan M. Neisseria meningitidis Serogroup X ST-5799 (ST-22 complex) in Turkey: A unique pediatric case. Human Vaccin Immunother 2018;14:209-2012.
•    Birdsell DN, Ozsurekci Y, Rawat A, Aycan AE, Mitchell CL, Sahl JW, Johansson A, Colman RE, Schupp JM, Ceyhan M, Keim PS, Wagner DM. Coinfections identified from metagenomic analysis of cervical lymph nodes from tularemia patients. BMC Infect Dis 2018;18:319.
•    Karadag Oncel E, Ceyhan M, Tanır Basaranoglu S, Gurbuz V, Aycan AE, Ozsurekci Y, Kurugol Z, Keser Emiroglu M, Devrim I, Karbuz A, Altay Akisoglu HO, Gurler N. Surveillance of penicillin resistance of Neisseria meningitidis strains from invasive infections between 2013 and 2018 in Turkey. J Chemother 2020 Fe 7: 1-4. doi: 10.1080/1120009X.2020.1721176.
•    Ceyhan M, Ozsurekci Y, Tanır Basaranoglu S, et al. Multicenter Hospital-Based Prospective Surveillance Study of Bacterial Agents Causing Meningitis and Seroprevalence of Different Serogroups of Neisseria meningitidis, Haemophilus influenza Type B, and Streptococcus pneumonia during 2015 to 2018 in Turkey. mSphere. 2020 Mar 25;5(2). doi: 10.1128/mSphere.00060-20
•    Ceyhan M, Aykac K, Gurler N, Ozsurekci Y, et al. Serotype distribution of Streptococcus pneumonia in children with invasive disease in Turkey: 2015-2018. Hum Vaccin Immunother 2020 Jun 12:1-6.
•    Cura Yayla BC, Ozsurekci Y, Aykac K, et al. Characteristics and Management of Children with COVID-19 in Turkey. Balkan Med J 2020 Aug 31.
•    Aykac K, Ozsurekci Y, Tanir Basaranoglu S, Demir OO, et a. Oxidant and antioxidant balance in children with bacteremia. Minerva Pediatr 2020 Sep 3.
•    Akca UK, Kesici S, Ozsurekci Y, et al. Kawasaki-like disease in children with COVID-19. Rheumatol Int 2020 Sep 16.

Links