Pediatric Rheumatology Laboratory

About

Research Infrastructure

•   Flow Cytometry
•  ELISA reader (with 450, 540, 570, 630, 650nm filters)
•   ELISA washer
•   Shaker
•   Vortex
•   Laminar hood
•   Biosafety cabinet
•   Centrifuge
•   Refrigerator -80
•   Refrigerator -30
•    Refrigerator
•   Microcentrifuge
•   Pipet-Multichanel
•   Microscope
•   Incubator
•   Hot water bath
•   Autoclave
•   CO2 tubes (2 pcs)
•   Pipette Set
•   Multi pipette
•   Pipette Set

Researchers

•    Prof Dr Seza Özen
•    Prof Dr Yelda Bilginer
•    Uzm Dr Erdal Sağ
•    Doç Dr Özge Başaran
•    Uzm Dr Zeynep Balık

Ongoing Projects

•   Effect of T-cell exhaustion profiles of synovial fluid and peripheral blood from JIA patients on disease pathogenesis and prognosis, FOREUM Foundation for Research in Rheumatology; International Exchange Fellowship Grant 2018-2021, collaboration project with Aarhus University
•    TÜBİTAK 2247-A National Leading Researchers Program application – evaluation, presence of disease findings in Otulipenia patients and their family members, and functional analysis of the disease-causing otlin gene. Collaboration project with Zheijang University (China) and Rockefeller University (USA)
• In vitro analysis of the effects of Sting-mediated immunosuppression on inflammation in mononuclear cells of SAVI (STING-associated vasculopathy of infancy) patients, a collaboration project with the University of Tokyo (Japan) and METU
•   Evaluation of the difference between vasculitic and hematological phenotypes with proteomic studies in cases with Adenosine Deaminase-2 deficiency, in TÜBİTAK 1002 evaluation
•   Evaluation of cytokine and peripheral inflammatory cell profiles in familial Mediterranean fever and macrophage activation syndrome, in TÜBİTAK 1002-evaluation
•   “Examination of the effects of depleted T cells in childhood systemic lupus erythematosus patients” Research Assistant Kübra Yüksel, Hacettepe University BAP Rapid Support project. (THD-2020-18803)
•   “Examination of the differences in the plasma metabolomic analysis results of Familial Mediterranean Fever Patients at the time of attack and in remission" Araş Gör Armağan Keskin (ETH Zurich University collaboration project)
•   “Examination of Depleted T Cells in Childhood Familial Mediterranean Fever and Commonly Concomitant Diseases” Research Assistant Sena Bocutcu

Completed Projects

Publications

•    Erdal Sag, Selcan Demir, Maithri Aspari, Morten Aagaard Nielsen, Cæcilie Skejø, Malene Hvid, Egemen Turhan, Yelda Bilginer, Stinne Greisen, Seza Ozen, Bent Deleuran, LAG-3 IS A CENTRAL IMMUNE RECEPTOR IN OLIGOARTICULAR JUVENILE IDIOPATHIC ARTHRITIS., Frontiers in Immunology- in the evaluation
•    Erdal Sag, Selcan Demir, Yelda Bilginer, Seza Ozen, CAN WE PREDICT THE DEVELOPMENT OF NEPHRITIS IN PEDIATRIC IGA VASCULITIS PATIENTS?, Rheumatology Internaitonal- in the evaluation
•    Kubra Yuksel, Erdal Sag, Selcan Demir, Semanur Özdel, Ummusen Akca Kaya, Erdal Atalay, Muserref Kasap Cuceoglu, Rezan Topaloglu, Yelda Bilginer, Seza Ozen, PLASMA CHECKPOINT PROTEIN LEVELS AND GALECTIN-9 IN JUVENILE SYSTEMIC LUPUS ERYTHEMATOSUS, Lupus, in the evaluation

Links

About

Research Infrastructure

•   Flow Cytometry
•  ELISA reader (with 450, 540, 570, 630, 650nm filters)
•   ELISA washer
•   Shaker
•   Vortex
•   Laminar hood
•   Biosafety cabinet
•   Centrifuge
•   Refrigerator -80
•   Refrigerator -30
•    Refrigerator
•   Microcentrifuge
•   Pipet-Multichanel
•   Microscope
•   Incubator
•   Hot water bath
•   Autoclave
•   CO2 tubes (2 pcs)
•   Pipette Set
•   Multi pipette
•   Pipette Set

Researchers

•    Prof Dr Seza Özen
•    Prof Dr Yelda Bilginer
•    Uzm Dr Erdal Sağ
•    Doç Dr Özge Başaran
•    Uzm Dr Zeynep Balık

Ongoing Projects

•   Effect of T-cell exhaustion profiles of synovial fluid and peripheral blood from JIA patients on disease pathogenesis and prognosis, FOREUM Foundation for Research in Rheumatology; International Exchange Fellowship Grant 2018-2021, collaboration project with Aarhus University
•    TÜBİTAK 2247-A National Leading Researchers Program application – evaluation, presence of disease findings in Otulipenia patients and their family members, and functional analysis of the disease-causing otlin gene. Collaboration project with Zheijang University (China) and Rockefeller University (USA)
• In vitro analysis of the effects of Sting-mediated immunosuppression on inflammation in mononuclear cells of SAVI (STING-associated vasculopathy of infancy) patients, a collaboration project with the University of Tokyo (Japan) and METU
•   Evaluation of the difference between vasculitic and hematological phenotypes with proteomic studies in cases with Adenosine Deaminase-2 deficiency, in TÜBİTAK 1002 evaluation
•   Evaluation of cytokine and peripheral inflammatory cell profiles in familial Mediterranean fever and macrophage activation syndrome, in TÜBİTAK 1002-evaluation
•   “Examination of the effects of depleted T cells in childhood systemic lupus erythematosus patients” Research Assistant Kübra Yüksel, Hacettepe University BAP Rapid Support project. (THD-2020-18803)
•   “Examination of the differences in the plasma metabolomic analysis results of Familial Mediterranean Fever Patients at the time of attack and in remission" Araş Gör Armağan Keskin (ETH Zurich University collaboration project)
•   “Examination of Depleted T Cells in Childhood Familial Mediterranean Fever and Commonly Concomitant Diseases” Research Assistant Sena Bocutcu

Completed Projects

Publications

•    Erdal Sag, Selcan Demir, Maithri Aspari, Morten Aagaard Nielsen, Cæcilie Skejø, Malene Hvid, Egemen Turhan, Yelda Bilginer, Stinne Greisen, Seza Ozen, Bent Deleuran, LAG-3 IS A CENTRAL IMMUNE RECEPTOR IN OLIGOARTICULAR JUVENILE IDIOPATHIC ARTHRITIS., Frontiers in Immunology- in the evaluation
•    Erdal Sag, Selcan Demir, Yelda Bilginer, Seza Ozen, CAN WE PREDICT THE DEVELOPMENT OF NEPHRITIS IN PEDIATRIC IGA VASCULITIS PATIENTS?, Rheumatology Internaitonal- in the evaluation
•    Kubra Yuksel, Erdal Sag, Selcan Demir, Semanur Özdel, Ummusen Akca Kaya, Erdal Atalay, Muserref Kasap Cuceoglu, Rezan Topaloglu, Yelda Bilginer, Seza Ozen, PLASMA CHECKPOINT PROTEIN LEVELS AND GALECTIN-9 IN JUVENILE SYSTEMIC LUPUS ERYTHEMATOSUS, Lupus, in the evaluation

Links