Pharmaceutical Chemistry Department Research Laboratory

About

In our department's research laboratory, rational design, synthesis, purification, and structure elucidation studies, as well as qualitative and quantitative analysis of novel molecules with biological activity potential are performed. National and international research collaborations are built for biological activity, toxicity, and pharmacokinetic studies of newly synthesized molecules.

Research Infrastructure

• Water bath
• Precision Balance
• Heated Magnetic Stirrer
• Cooled Water Circulator
• Vacuum Pump
• Heating Mantle
• Uv Observation Cabinet and Lamp
• Vacuum Oven
• Ultrasonic Bath
• Rotavopor
• Fume Hood
• HPLC, LC-MS
• Visible-Uv Spectrophotometer
• Ultra Pure Water Device, Ice Machine
• Distilled Water Device
• IR Spectrophotometer
• Microwave Synthesis Device

Researchers

•    Prof. Dr. Ayla BALKAN
•    Prof. Dr. Selma SARAC
•    Prof. Dr. Erhan PALASKA
•    Prof. Dr. Fügen ÖZKANLI
•    Prof. Dr. Birsen TOZKOPARAN
•    Prof. Dr. Nesrin GÖKHAN KELEKÇİ
•    Prof. Dr. Lightning to the womb
•    Prof. Dr. Happy AYTEMİR
•    Assoc. Prof. Dr. Oya ÜNSAL TAN
•    Assoc. Prof. Dr. Miyase Gözde GÜNDÜZ
•   Dr. Lecturer Keriman ÖZADALI SARI
•   Dr. Lecturer Suat SARI
•   Ebru KOÇAK
•   Merve ZENGİN
•   Ahmet AVCI
•   Gökalp ÇETİN
•   Hayrunnisa TAŞCI
•   Dilara AKMAN
•   Elif CANBAZ
•   Naufa HANİF
•   Gülsema KARAAGAÇLI
•   Burcu KARAYAVUZ
•   Emre MINDIZ
•   Müge İrem ÖKSÜZ
•   Ezgi PEHLİVANLAR

Ongoing Projects

• Investigation of Hdac-Specific Inhibition Activities and Neuroprotective Effects of Aryl Butenoic Acid Derivatives (Bap-Comprehensive Research Project)
• Discovery of New Antifungal Compounds Using Ligand and Structure Based Virtual Activity Screening Method (Bap-Rapid Support Project)
Synthesis and Activity Studies of New 1,2,4-Triazole Derivative Compounds That Can Be Used In The Treatment Of Alzheimer's Disease (Bap-Rapid Support Project),
• Studies on Some New Quinoxaline Derivatives Expected to Act as Egfr Inhibitors (Bap-Rapid Support Project)
• Evaluation of Protective Effect of Chlorocogic Acid Derivative Mannich Base Compound Against Uv-Induced Melanoma (Bap-Rapid Support Project)
• Clarification of the Effect of New Synthesized Kojic Acid Derivatives with Antithyrosinase Activity on Cytotoxicity and Cell Death in A375 Malign Melanoma Cell Line (Bap-Master's Thesis Project)
• New Drug Development and Formulation Studies in Parkinson's Treatment: In Vitro / In Vivo Investigation of Anti-Neurodegenerative and Neuroprotective Effect of Koji Mg84 and Pharmacokinetic Research Tüseb- Innovative Drug Development Strategic
• Preformulation Studies on 1,4-Dihydropyridine Derivative Substance Effective in Hypertension Treatment Newly Synthesized and Has Solubility Problem (Bap-Rapid Support Project)
Synthesis of Potential L- / T-Type Calcium Channel Blocker Dihydropyrimidine Derivatives (Bap-Rapid Support Project)
• Synthesis and Characterization of New Hexahydroquinoline Derivatives Investigation of Inhibitory Effects and Anticancer Activities on Transforming Growth Factor Beta (Tgf-Β) Determination of Interactions with Molecular Targets In Silico (Bap- Comprehensive Research Project)
Synthesis, Characterization of New Hexahydroquinoline Derivatives, Investigation of Transforming Growth Factor-Beta (Tgf-mesi) and Inflammation Mediators In Vitro and In Silico (Bap-Rapid Support Project)
• Synthesis of Some New Thiazole (3,2-B) -1,2,4-Triazole-6 (5h) -On Derivatives and Investigation of Their Cytotoxic Effects (Bap-Master's Thesis Project) "

Completed Projects

• New Azole Compounds with Potential Antifungal and Anticonvulsant Effect: Molecular Modeling, Synthesis and Biological Activity Studies (Tübitak-1001 Project),
• Studies On New Oxime Ester Derivatives In Arilalkylazole Structure Synthesis Biological Activity And Molecular Modeling (Bap-PhD Thesis Project),
• Discovery of New Alpha-Glucosidase Inhibitor Compounds by Scanning Virtual Activity Within an In-House Azole Library (Bap-Rapid Support Project),
• Studies on Some 5-Chloro-2-Benzoxazolinone Thiosemicarbazide, 1,3,4-Thiadiazole and 1,2,4-Triazole-5-Thione Derivatives (Bap-Master's Thesis Project),
• Studies on Some Aryloxymethyl 1,3,4-Oxadiazole, 1,3,4-Thiadiazole And 1,2,4-Triazole And 1,2,4-Triazole-5 Thione Derivatives (Bap-Rapid Support Project),
• Studies on 2-Phenylbenzothiazole Derivatives (Bap-Fast Support Project),
• Studies on Some 2,3-DisüBstitüE-5-Methyl- 4-Thiazolidinone TüR Houses Expected to Show Antimycobacterial Activity (Bap-Master Thesis Project),
• Anticancer Drug Design and Activity Screening (Bap-International Research Collaboration Project),
• Molecular Modeling, Synthesis and Biological Activity Studies of New 2-Pyrazoline and Benzimidazole Derivatives Expected to Show Multiple Goal Oriented Effects in the Treatment of Alzheimer's Disease (Tübitak-1001 Project),
• Synthesis of Acrylonitrile Structure Taşiyan Benzimidazole Derivatives and Investigation of Their Antimicobacterial Activities (Bap-Rapid Support Project)
• Synthesis of Allomaltol Derivative New Mannich Bases and Evaluation of Tyrosinase Inhibitor Effects (Bap-Rapid Support Project)
• Tyrosinase Inhibitory Effects of New Mannich Bases and Evaluation of Cell Viability on A375 Human Melanoma Cells (Tübitak-1002 Project

Publications

Links

About

In our department's research laboratory, rational design, synthesis, purification, and structure elucidation studies, as well as qualitative and quantitative analysis of novel molecules with biological activity potential are performed. National and international research collaborations are built for biological activity, toxicity, and pharmacokinetic studies of newly synthesized molecules.

Research Infrastructure

• Water bath
• Precision Balance
• Heated Magnetic Stirrer
• Cooled Water Circulator
• Vacuum Pump
• Heating Mantle
• Uv Observation Cabinet and Lamp
• Vacuum Oven
• Ultrasonic Bath
• Rotavopor
• Fume Hood
• HPLC, LC-MS
• Visible-Uv Spectrophotometer
• Ultra Pure Water Device, Ice Machine
• Distilled Water Device
• IR Spectrophotometer
• Microwave Synthesis Device

Researchers

•    Prof. Dr. Ayla BALKAN
•    Prof. Dr. Selma SARAC
•    Prof. Dr. Erhan PALASKA
•    Prof. Dr. Fügen ÖZKANLI
•    Prof. Dr. Birsen TOZKOPARAN
•    Prof. Dr. Nesrin GÖKHAN KELEKÇİ
•    Prof. Dr. Lightning to the womb
•    Prof. Dr. Happy AYTEMİR
•    Assoc. Prof. Dr. Oya ÜNSAL TAN
•    Assoc. Prof. Dr. Miyase Gözde GÜNDÜZ
•   Dr. Lecturer Keriman ÖZADALI SARI
•   Dr. Lecturer Suat SARI
•   Ebru KOÇAK
•   Merve ZENGİN
•   Ahmet AVCI
•   Gökalp ÇETİN
•   Hayrunnisa TAŞCI
•   Dilara AKMAN
•   Elif CANBAZ
•   Naufa HANİF
•   Gülsema KARAAGAÇLI
•   Burcu KARAYAVUZ
•   Emre MINDIZ
•   Müge İrem ÖKSÜZ
•   Ezgi PEHLİVANLAR

Ongoing Projects

• Investigation of Hdac-Specific Inhibition Activities and Neuroprotective Effects of Aryl Butenoic Acid Derivatives (Bap-Comprehensive Research Project)
• Discovery of New Antifungal Compounds Using Ligand and Structure Based Virtual Activity Screening Method (Bap-Rapid Support Project)
Synthesis and Activity Studies of New 1,2,4-Triazole Derivative Compounds That Can Be Used In The Treatment Of Alzheimer's Disease (Bap-Rapid Support Project),
• Studies on Some New Quinoxaline Derivatives Expected to Act as Egfr Inhibitors (Bap-Rapid Support Project)
• Evaluation of Protective Effect of Chlorocogic Acid Derivative Mannich Base Compound Against Uv-Induced Melanoma (Bap-Rapid Support Project)
• Clarification of the Effect of New Synthesized Kojic Acid Derivatives with Antithyrosinase Activity on Cytotoxicity and Cell Death in A375 Malign Melanoma Cell Line (Bap-Master's Thesis Project)
• New Drug Development and Formulation Studies in Parkinson's Treatment: In Vitro / In Vivo Investigation of Anti-Neurodegenerative and Neuroprotective Effect of Koji Mg84 and Pharmacokinetic Research Tüseb- Innovative Drug Development Strategic
• Preformulation Studies on 1,4-Dihydropyridine Derivative Substance Effective in Hypertension Treatment Newly Synthesized and Has Solubility Problem (Bap-Rapid Support Project)
Synthesis of Potential L- / T-Type Calcium Channel Blocker Dihydropyrimidine Derivatives (Bap-Rapid Support Project)
• Synthesis and Characterization of New Hexahydroquinoline Derivatives Investigation of Inhibitory Effects and Anticancer Activities on Transforming Growth Factor Beta (Tgf-Β) Determination of Interactions with Molecular Targets In Silico (Bap- Comprehensive Research Project)
Synthesis, Characterization of New Hexahydroquinoline Derivatives, Investigation of Transforming Growth Factor-Beta (Tgf-mesi) and Inflammation Mediators In Vitro and In Silico (Bap-Rapid Support Project)
• Synthesis of Some New Thiazole (3,2-B) -1,2,4-Triazole-6 (5h) -On Derivatives and Investigation of Their Cytotoxic Effects (Bap-Master's Thesis Project) "

Completed Projects

• New Azole Compounds with Potential Antifungal and Anticonvulsant Effect: Molecular Modeling, Synthesis and Biological Activity Studies (Tübitak-1001 Project),
• Studies On New Oxime Ester Derivatives In Arilalkylazole Structure Synthesis Biological Activity And Molecular Modeling (Bap-PhD Thesis Project),
• Discovery of New Alpha-Glucosidase Inhibitor Compounds by Scanning Virtual Activity Within an In-House Azole Library (Bap-Rapid Support Project),
• Studies on Some 5-Chloro-2-Benzoxazolinone Thiosemicarbazide, 1,3,4-Thiadiazole and 1,2,4-Triazole-5-Thione Derivatives (Bap-Master's Thesis Project),
• Studies on Some Aryloxymethyl 1,3,4-Oxadiazole, 1,3,4-Thiadiazole And 1,2,4-Triazole And 1,2,4-Triazole-5 Thione Derivatives (Bap-Rapid Support Project),
• Studies on 2-Phenylbenzothiazole Derivatives (Bap-Fast Support Project),
• Studies on Some 2,3-DisüBstitüE-5-Methyl- 4-Thiazolidinone TüR Houses Expected to Show Antimycobacterial Activity (Bap-Master Thesis Project),
• Anticancer Drug Design and Activity Screening (Bap-International Research Collaboration Project),
• Molecular Modeling, Synthesis and Biological Activity Studies of New 2-Pyrazoline and Benzimidazole Derivatives Expected to Show Multiple Goal Oriented Effects in the Treatment of Alzheimer's Disease (Tübitak-1001 Project),
• Synthesis of Acrylonitrile Structure Taşiyan Benzimidazole Derivatives and Investigation of Their Antimicobacterial Activities (Bap-Rapid Support Project)
• Synthesis of Allomaltol Derivative New Mannich Bases and Evaluation of Tyrosinase Inhibitor Effects (Bap-Rapid Support Project)
• Tyrosinase Inhibitory Effects of New Mannich Bases and Evaluation of Cell Viability on A375 Human Melanoma Cells (Tübitak-1002 Project

Publications

Links