Pharmaceutical Toxicology Department Research Laboratory

About

Research Infrastructure

• Acid purification device
• (ICP-MS preliminary)
• Acid etching device
• (ICP-MS preliminary)
• Biosafety Cabinet, 3 units
• Refrigerator (+4°C), 10 units
• Comet Computerized Imaging System (Comet Analysis Software, version 3.0, Kinetic Imaging)
• Fume Hood, 4 pcs.
• Deionized water device
• Deep Freezer (-20°C), 7 pcs.
• Deep Freezer (-80 °C), 2 pcs.
• Distilled Water Device (MES ultrapure )
• Tissue homogenizer
• Electrophoresis (Biometra Analytical)
• Electrophoresis Power Supply
• (Power Pack P 25)
• Fluorescent Microscope (Leica)
• Fraction Collector
• Precision Balance, 2 pcs.
• ICP-MS
• Inverted Microscope, Leica
• Heater, Multi-Block (Lab-Line)
• Incubator
• Incubator (with CO2), 2 pcs.
• Incubator (Oven), 3 pcs.
• Mixer-Heater
• (Jankel&Kunkel, Ikamag)
• Cracked Ice Machine
• (Scotsman AF100)
• Air conditioner, 5 units
• Labware Washing Machine
• Lyophilizer
• Magnetic Stirrer
• (Stuart Scientific)
• Membrane Filter (0.2 µm pore diameter) Brand
• Microwave Oven (Vestel)
• Microcentrifuge, 2 pcs.
• Nanodrop
• Autoclave Rodwell (Monarch MP)
• pH meter (Cyberscan)
• Real Time PCR Device and Software
• Pure water device
• Centrifuge, 2 units
• Refrigerated centrifuge
• Spectrophotometer, 2 pcs.
• Spectrophotometer (Plate reader)
• Spectrophotometer / Spectrofluorometer (Plate reader)
• Water Bath (2 units)
• Libra (Schimadzu Libror)
• Ultrasonic Bath
• (Transsonic 460/H)
• Ultrasonic Probe (Bandelin Sonoplus)
• Top-loading scales (2 pcs.)
• Vacuum pump
• Vortex (7 pieces)
• Horizontal shaker (Edmund Bühler)
• High Pressure Liquid Chromatography (2 units)

Researchers

•    Prof. Dr. Ayşe Nurşen BAŞARAN
•    Prof. Dr. Terken BAYDAR
•    Prof. Dr. Ülkü ÜNDEĞER BUCURGAT
•    Prof. Dr. Aylin GÜRBAY
•    Prof. Dr. Pınar ERKEKOĞLU
•    Prof. Dr. Sevtap AYDIN DİLSİZ
•    Doç. Dr. Gözde GİRGİN
•    Doç. Dr. Suna SABUNCUOĞLU
•    Dr. Aydan ÇAĞLAYAN
•    Dr. Duygu PASLI
•    Dr. Aylin BALCI ÖZYURT
•    Uzm. Ecz. Tuğbagül ÇAL
•    Uzm. Ecz. Ünzile SUR
•    Uzm. Ecz. Anıl YİRÜN
•    Selinay Başak ERDEMLİ KÖSE
•    Uzm. Ecz. Can BABACANOĞLU
•    Uzm. Ecz. Merve BECİT
•    Uzm. Ecz. Aysun ÖKÇESİZ
•    Zeynep BAYDAŞ
•    Yücel YÜZBAŞIOĞLU
•    Sultan Pınar ÇETİNTEPE
•    Özlem KAR KURT
•    Hediye Gamze Nur ÇELEBİOĞLU
•    Fundanur YAZICI

Ongoing Projects

• “Evaluation of Oxidative Stress Parameters and Genotoxic Effects in Patients Diagnosed with Work-Related Asthma and Silicosis” Hacettepe University BAP Unit, PhD Thesis Project, TDK-2020-18450 (Project Coordinator: Prof. Dr. Nurşen Başaran, Researcher: Özlem Kar Kurt, Dilek Ergün , Mevlüt Karataş, Merve Bacanlı, Merve Hazar) (14.02.2020-) Budget: 30.000 TL.
• “Evaluation of the Effects of Different Storage Conditions and Durations on Genotoxic Damage” Hacettepe University BAP Unit, Yüksel Undergraduate Thesis Project, TYL-2019-17701 (Project Coordinator: Prof. Dr. Nurşen Başaran, Researcher: Merve Bacanlı, Zeynep Baydaş) (12.02. 2019-) 27.999.48 TL
• “Evaluation of Oxidative Stress Immune System Indicators Genotoxicity and Heavy Metal Levels in Mothers and Babies with Diabetes and Preeclampsia” Hacettepe University BAP Unit, Comprehensive Research Project, TSA-2017-14441 (Project Coordinator: Prof. Dr. Nurşen Başaran, Researcher: Merih Bayram, Merve Bacanlı, Hatice Gül Anlar, Pınar Çalış) (25.12.2017-) 18,8423,84 TL.
• "Evaluation of the Effects of Genistein on DNA Damage in Colon Cancer Cells by Single Cell Gel Electrophoresis Comet Method", (Executive) Hacettepe University Scientific Research Thesis Project (TDK-2019-18077), 2021.
• "In Vitro Evaluation of Possible Genotoxic Effects of Acrylamide and 5-Hydroxymethylfurfural by Single Cell Gel Electrophoresis Method", (Executive) Hacettepe University Scientific Research Thesis Project (TDK-2019-17708) 2021.
• Evaluation of Possible Cytotoxic, Genotoxic and Epigenotoxic Effects of Titanium Dioxide Nanoparticles with 3T3 Fibroblast Cells Compared to Normal Size Titanium Dioxide and Possible Protective Effect of Melatonin, Hacettepe University Scientific Research Unit Research Project, Project ID: THD-2019-18423. Project Manager: Dr. Aylin Balci. Researcher: Prof.Dr. Pınar Erkekoğlu Budget: 29.999.99 TL (20.11.2019-…)
• Comparative Evaluation of Methyl Mercury and Thiomersalin Toxicity in Human Neuroblastoma Cells for Gender Differences. Hacettepe University Executive: Prof.Dr. Pınar Erkekoğlu, Researcher Dr. Aylin Balcı Budget: 36.000 TL (29.01.2020-…)
• Evaluation of Possible Cytotoxic, Genotoxic and Immunotoxic Effects of Bisphenol Derivatives in HepG2 Cells. Executive Prof.Dr. Pınar Erkekoğlu, Researcher Dr.Aylin Balcı. Hacettepe University Budget: 36.000 TL (29.01.2020-…)
• The Relationship Between Bisphenol A and Vitamin D Levels in Cord Blood. Researcher/Specialist Assoc. Dr. Pınar Erkekoğlu, Dr.Aylin Balcı. Budget: 30.000 TL Hacettepe University 16.03.2020-16.06.2021
• Evaluation of the Effect of Smoking on Possible Oxidative Damage and Serum Heavy Metal Levels in Silicosis Patients. Researcher/Specialist Prof.Dr. Pinar Erkekoglu. Hacettepe University Budget: 30.000 TL (21.05.2020-…)
• Synthesis and Characterization of New Hexahydroquinoline Derivatives. In Vitro and In Silico Investigation of Inhibitory Effects on Transforming Growth Factor-Beta (TGF-beta) and Inflammation Mediators. Researcher/Specialist Assoc. Dr. Pınar Erkekoğlu, Dr.Aylin Balcı. Hacettepe University Budget: 30.000 TL (21.05.2020-…)
• Evaluation of Possible Toxic Effects of Protective and Adjuvant Substances Used in Vaccines. Executive Assoc. Dr. Pinar Erkekoglu. Hacettepe University Budget: 30.000 TL (21.06.2020-…)
• Peptide Based Vaccine Research and Development Studies against COVID-19. Researcher/Specialist Prof. Dr. Pinar Erkekoglu. National TUSEB Project Budget: 842,600 TL (10.06.2020-…)
• Discovery of new antifungal compounds by ligand and structure-based virtual activity screening method. Hacettepe University Scientific Research Unit Project, Assistant Researcher Assoc. Dr. Suna Sabuncuoglu
• The Roles of Changes in Respiratory Function, Exercise Capacity and Quality of Life in Oxidant and Antioxidant Response in Patients with Primary Ciliary Dyskinesia. Hacettepe University Scientific Research Unit Project, Assistant Researcher Assoc. Dr. Suna Sabuncuoglu

Completed Projects

• H.U. Faculty of Pharmacy, Department of Pharmaceutical Toxicology, Department of Pharmaceutical Toxicology Laboratory "In Vitro Investigation of Genotoxicity of Nandrolone by Single Cell Gel Electrophoresis Technique" Hacettepe University BAP Unit Master's Project, TYL-2019-17945. (Project Coordinator: Associate Professor Sevtap Aydın Dilsiz, Researcher: Pharmacist Emre Korkmaz). (28.05.2019-07.02.2020) Budget: 27,868,13 TL
• “In vitro evaluation of the effects of sinapic acid on cytotoxic, genotoxic and apoptosis” Hacettepe University BAP Unit, Support Project, 014 D11 301 002-775 (Project coordinator, Associate Professor Sevtap Aydın; Researcher, Prof.Dr.A.Nurşen Başaran ). (13.11.2014-24.10.2016). Budget: 19,766 TL
• "In Vitro Epigenetic Evaluation of Dinitroaniline Herbicide Compound Trifluralin and Pendimethalin" (Executive), Hacettepe University Scientific Research Rapid Support Project, 2015.
• "Determination of Heavy Metal Levels in Drinking Water of Provinces in the Central Anatolia Region" (Researcher), Hacettepe University Scientific Research Rapid Support Project (THD-15735), 2017.
• "Evaluation of Possible Apoptotic Effects of Genistein, TNF-Related Apoptosis Inducing Ligand (TRAIL) and 5-Fluorouracil in Colon Cancer Cells", (Executive) TÜBİTAK Rapid Support Project (219S200), 2020.
• "In Vitro Evaluation of Oxidative DNA Damage and Repair in Stem Cells by Single Cell Gel Electrophoresis" (Executive), Hacettepe University Scientific Research Rapid Support Project, 2015.
• "In Vitro Evaluation of the Cytotoxic, Apoptotic and Genotoxic Effects of Metformin" (Executive), Hacettepe University Scientific Research Rapid Support Project (THD-13153), 2017.
• "Hela Evaluation of Possible Apoptotic Antioxidant and Genotoxic Effects of Pitavastatin in Human Cervical Cancer Cell Line", (Executive) Hacettepe University Scientific Research Rapid Support Project (THD-2019-17809), 2020.
• “Determination of Heavy Metal Levels in Drinking Waters of Ankara Province” Hacettepe University BAP Unit, Rapid Support Project, THD-2016-9360, (Project Coordinator: Merve Bacanlı; Researcher: Prof.Dr.Nurşen Başaran, Hatice Gül Anlar (21.03.2016- 24.07.2017) 27,377.67 TL.
• “Investigation of the toxic effects of boron exposure on reproductive function of humans-II” ETİ Mining General Directorate Research Project (Project coordinator, Prof.Dr.A.Nurşen Başaran, Prof.Dr.Yalçın Duydu; Researcher, Merve Bacanlı, Hatice Gül Göktaş, Zehra Sarıgöl, Can Özgür Yalçın, Kaan Aydos, Cem Somer Atabekoğlu, Sevtap Aydın,) (28.08.2014-28.08.2017)
• “Effects of Pycnogenol, Cinnamic Acid, Ursolic Acid and Limonene on Oxidative Stress and Genotoxicity in Wistar Albino Rats with Experimental Diabetes” 3001-TUBITAK Initial R&D Projects Support Program, 114S919. (Project Coordinator: Dr. Merve BACANLI, Assistant Researcher: Associate Professor Sevtap Aydın, Prof. Dr. Ülkü Ün Değer Bucurgat, Prof. Dr. Nurşen Başaran). (01.12.2014-11.05.2017) 81.000 TL
• “Evaluation of Toxic Effects of Aroclor 1254 in HEPG2 Cells and Possible Protective Effect of Curcumin” Hacettepe University BAP Unit, Rapid Support Project, 013 D01 301 002 (Project Coordinator: Prof.Dr.A. Nurşen Başaran Researcher: Merve Bacanlı, Hatice Gül Anlar (16.01.2013 - 11.08.2017) 11.400 TL
• “Determination of Blood Metal Levels in Welding Workers” Hacettepe University BAP Unit, Rapid Support Project, THD-2017-15736 (Project Coordinator: Prof.Dr.A. Nurşen Başaran Researcher: Merve Bacanlı, Hatice Gül Anlar (07.09.2017 - 07.08. 2018) 27,909.36 TL
• “Evaluation of the Effects of Quantum Dot Nanoparticles on Cytotoxicity and Apoptosis in V79 Fibroblast Cells” 3001-TUBITAK Initial R&D Projects Support Program, 114S861 (Project coordinator, Associate Professor Sevtap Aydın; Researcher, Prof.Dr.A.Nurşen Başaran, Deniz Ozkan Vardar). (01.10.2014-21.02.2017).
• “Examination of the combined effects of cisplatin and pycnogenol in cervical cancer cell lines” Hacettepe University BAP Unit, Rapid Support Project, THD-2016-11838 (Project coordinator, Associate Professor Sevtap Aydın). (30.11.2016-28.02.2018). 22,107 TL
• Investigation of cytotoxic action mechanisms of zinc oxide and copper oxide nanoparticles in vitro (Project Coordinator: Prof. Dr. Aylin Gürbay, Researcher: Dr. Pharmacist Duygu Paslı), Hacettepe University Scientific Research Support Project 6080, Project no: THD-2017- 14012. (03.05.2017-06.11.2018, Budget: 29.991.78 TL.
• Evaluation of the cytotoxic effects of zinc oxide and copper oxide nanoparticles (Project Coordinator: Prof. Dr. Aylin Gürbay, Researcher: Pharmacist Duygu Paslı), Hacettepe University Scientific Research Support Project 6080, Project no: 014 D12 301 001-830. (15.01.2015-09.12.2016), Budget: 19.799.23 TL.
• Evaluation of respiratory CO and urinary cotinine levels of electronic cigarette (e-cigarette) users (Project Leader: Prof. Dr. Dilek Aslan, Researchers: Lecturer Meltem Şengelen, Dr. Pharm Duygu Paslı, Dr. Beril Chousein, Prof. Dr. Aylin Gurbay, Prof. Dr. Kadir Mutlu Fan). Hacettepe University Scientific Research Infrastructure Project, Project no: TAY-2016-9469 (19.04.2016-29.12.2017) Budget: 15,957.64 TL.
• Vaccine Development and Analysis Studies. Researcher/Specialist (National) (Prof.Dr. Pınar Erkekoğlu) Hacettepe University Budget: 1.387.207 TL (01.08.2014-01.08.2016)
• Domestic Vaccine Research and Development Studies. Researcher/Specialist Industry/Private Sector (Prof.Dr. Pınar Erkekoğlu) Ministry of Industry and Trade. Budget: 2.132.000 TL (01.02.2015-01.02.2017)
• Investigation of Bisphenol A and Phthalate Levels in Adolescent Cases with Polycystic Ovary Syndrome, Hacettepe University Scientific Research Unit Research Project, Project Id: 13147 Project Manager: Prof.Dr. Nuray Kanbur (Associate Researcher: Dr. Aylin Balcı, Prof. Dr. Pınar Erkekoğlu, Specialist Pharmacist Ünzile Sur) THD-2017-13147. Budget 20,699.84, (23.03.2017-23.07.2018)
• Investigation of the Effects of Bisphenol A and Di-2-ethyl Hexyl Phthalate Exposure on Male Reproductive System during Prenatal and Lactation Period, Hacettepe University Scientific Research Unit Research Project, Project Manager: Prof.Dr. Belma Gümüşel Project ID:12150 (Assistant Researcher: Dr. Aylin Balcı, Prof.Dr. Pınar Erkekoğlu, Budget 21,831.80 TL (17.01.2017-22.01.2018)
• Evaluation of the Effects of Prenatal Bisphenol A and Phthalate Exposure on Reproductive System and Thyroid Hormones in Newborns, TÜBİTAK 1001, 115S477, Associate Researcher: Prof.Dr. Pınar Erkekoğlu, Scholar Dr. Aylin Balcı, Budget 301,142,96 TL (15.09.2015-15.09.2017)
• Domestic Vaccine Research and Development Studies SAN-TEZ Project (0687.STZ.2014). 2014-2019 Researcher/Specialist Prof.Dr. Pınar Erkekoğlu (National) SAN-TEZ project Budget: 2.500.000 TL
• Metabolomics Studies in Children with Central and Peripheral Precocious Puberty, Hacettepe University Scientific Research Unit Research Project, Project Id: THD-2017-14278 Project Manager: Assoc. Pınar Erkekoğlu Assistant Researcher Dr. Aylin Balci. Budget: 29.999.97 TL (31.07.2017-25.06.2018)
• Toxic Effects of Bisphenol A in Thyroid Cells and Evaluation of the Protective Role of Selenium Compounds. Executive Prof.Dr. Pınar Erkekoğlu (National) Hacettepe University Budget: 20.700 TL (02.07.2018-07.01.2020)
• Evaluation of Neuroendocrine Disruptive Effects of Prenatal Bisphenol A And/or Di-2-EthyL Hexyl Phthalate Exposure, Hacettepe University Scientific Research Unit Research Project, Project Id: TYL-2018 17006 Project Manager: Assoc. Pınar Erkekoğlu Assistant Researcher Dr. Aylin Balcı Budget: 29.999.52 TL (09.07.2018-04.03.2019)
• Evaluation of Toxic Effects of Dibutyl Phthalate on Human Lung Cell Line and Possible Protective Effects of Ascorbic Acid and N Acetylcysteine ​​Hacettepe University BAB Director: Prof.Dr.Pınar Erkekoğlu, Associate Researcher: Dr.Aylin Balcı. Budget: 20700 12.06.2018-12.05.2020
• Evaluation of Toxic Effects of Combined Exposure to Endocrine Disrupting Chemicals in Different Cell Lines: Endoplasmic Reticulum Stress and Oxidative Stress, Hacettepe University Scientific Research Unit Research Project, Project Id: 12882 Project Manager: Assoc.Prof.Dr. Pınar Erkekoğlu Associate Researcher: Dr. Aylin Balcı Budget: 111,875.50 TL (07.06.2017-18.02.2020)
• Examining the relationship between speech delay and plasma phthalate level in children aged 2-6 years Hacettepe University Researcher: Prof.Dr. Pinar Erkekoglu. BAB Budget: 30.000 TL (20.12.2019-20.12.2020)
• Bringing Erzincan Medicinal and Aromatic Plants to the Local Economy. TANAP project Researcher/Specialist Prof.Dr. Pınar Erkekoğlu, Budget: 1.500.000 TL (2017-2019)
• Geranium Psilostemon Ledeb. Evaluation of Possible Cytotoxic and Genotoxic Activity of Some Pure Substances Extracted from the Plant, Hacettepe University Scientific Research Unit Project, Executive Assoc. Suna Sabuncuoglu
• Establishment of Pharmaceuticals and Cosmetics Research, Development and Quality Control Laboratory affiliated to Hacettepe University Faculty of Pharmacy, Ankara Development Agency, Hacettepe University Scientific Research Unit Project, Assistant Researcher Assoc. Suna Sabuncuoglu
• Investigation of Cytotoxic Potentials of Some Tannin and Tannin Precursors, Hacettepe University Scientific Research Unit Project, Assistant Researcher Assoc. Suna Sabuncuoglu
• Investigation of in vitro radical scavenging effects of some 1,4 dihydropyridine derivative calcium channel blocker substances, Hacettepe University Scientific Research Unit Project, Executive Assoc. Suna Sabuncuoglu
• The Effect of HBO Treatment on Kidney Damage Due to Muscle Waste: The Role of Heme Oxygenase 1, 3001 TÜBİTAK Initial Project, Assistant Researcher Assoc. Suna Sabuncuoglu
• Accreditation Project of Hacettepe University Faculty of Pharmacy Pharmaceuticals and Cosmetics R&D and Quality Control Laboratory (HÜNİKAL) within the scope of TS EN ISO/IEC 17025 Standard, Hacettepe University Scientific Research Unit Project, Assistant Researcher Assoc. Suna Sabuncuoglu
• Anti-cancer drug activity prediction with cell line susceptibility signatures and collective machine learning methods, TÜBİTAK 3501, Assistant Researcher Doç.Dr. Suna Sabuncuoglu
• In vitro evaluation of the interaction of metformin with some chemotherapeutic drugs, Hacettepe University Scientific Research Unit Project, Executive Assoc. Suna Sabuncuoglu
• Investigation of changes in lipid metabolism in sickle cell disease and associating it with the pathogenesis of the disease, Assistant Researcher Doç.Dr. Suna Sabuncuoglu
• Evaluation of Oxidant and Antioxidant Parameters in Children with Carbon Monoxide Poisoning, Hacettepe University Scientific Research Unit Project, Assistant Researcher Assoc. Suna Sabuncuoglu
• Investigation of in vitro radical scavenging effects of some 1,4 dihydropyridine derivative calcium channel blocker substances, Hacettepe University Scientific Research Unit Project, Assistant Researcher, Assoc. Gozde Girgin
• Evaluation of Oxidant and Antioxidant Parameters in Children with Carbon Monoxide Poisoning, Hacettepe University Scientific Research Unit Project, Assistant Researcher Assoc. Gozde Girgin
• Evaluation of Pteridine and Related Pathways in Pterygium Patients, Hacettepe University Scientific Research Unit Project, Assistant Researcher Assoc. Gozde Girgin
• The Effect of Lead Exposure and Chelation Therapy on Some Parameters Affecting Toxicity, Hacettepe University Scientific Research Unit Project, Assistant Researcher Assoc. Gozde Girgin
• Determination of Various Mycotoxin Levels in Animal Feeds and Milk, Hacettepe University Scientific Research Unit Project, Executive Assoc. Gozde Girgin
• Evaluation of Pteridine and Related Pathways in Pterygium Patients, Hacettepe University Scientific Research Unit Project, Executive Prof.Dr. Terken Baydar, Bilge Kılıçarslan (2016-2018)

Publications

• Abdallah, M.F., Girgin, G., Baydar, T., “Mycotoxin Detection in Maize, Commercial Feed, and Raw Dairy Milk Samples from Assiut City, Egypt” Vet Sci, 6 (2), 57 (2019).
• Adak T, Samadi A, Ünal AZ, Sabuncuoğlu S. A reappraisal on metformin. Regul Toxicol Pharmacol. 2018 Feb;92:324-332.
• Akgül S, Sur Ü, Düzçeker Y, Balcı A, Kızılkan MP, Kanbur N, Bozdağ G, Erkekoğlu P, Gümüş E, Kocer-Gumusel B, Derman O. “Bisphenol A and phthalate levels in adolescents with polycystic ovary syndrome.” Gynecol Endocrinol. 2019 Jun 20:1-4.
• Aksu N, Samadi A, Yalçınkaya A, Çetin T, Eser B, Lay İ, Öziş TN, Öztaş Y, Sabuncuoğlu S. Evaluation of oxysterol levels of patients with silicosis by LC-MS/MS method. MolCell Biochem. 2020;467:117-125.
• Aksu, İ., Anlar, HG, Taner, G., Bacanlı, M., İritaş, S., Tutkun, E., Başaran, N. “Assessment of DNA damage in welders using comet and micronucleus assays”, Mutation Research /Genetic Toxicology and Environmental Mutagenesis, 2018, Accepted (doi: 10.1016/j.mrgentox.2018.11.006)
• Anlar H.G., Bacanlı M., Çal T., Aydın S., Arı N., Ün Değer Bucurgat Ü., Başaran A.A., Başaran A. N., "Effects of Cinnamic acid on complications of diabetes", Turk J. Med. sci. 47, (2018).
• Anlar HG, Galbiati V, Corsini E, Basaran N. Evaluation of the Possible Role of miRNAs in Chemical Allergen Potency. Turk J Pharm Sci. 2020; 17(4):452-456.
• Anlar, HG, Bacanlı, M., Gündüzöz, M., İritaş, S., Tutkun, E., Yılmaz, Ö.H., Başaran, N. “Evaluation of health status of Turkish ceramic workers”, Clinical and Experimental Health Sciences, 2018, 8(3), 202-206
• Anlar, HG, Bacanlı, M., İritaş, SB, Bal, C., Kurt, T., Tutkun, E., Yılmaz, Ö.H., Başaran N. Effects of Occupational Silica Exposure on Oxidative Stress and Immune System Parameters in Ceramic Workers in Turkey. Journal of Toxicology and Environmental Health (JTEH) Portugal Symposium volume, 80(13-15): 688-696 (2017).
• Anlar, H.G., Bacanlı, M., Tuğbagül, Ç., Aydın, S., Arı, N., Ün Değer Bucurgat, Ü., Başaran, A.A., Başaran, N.: Effects of cinnamic acid on complications of diabetes. Turkish J Med Sci, 48: 168-177 (2018).
• Anlar, H.G., Taner, G., Bacanlı, M., İritaş, S., Kurt, T., Tutkun, E., Yılmaz, Ö.H. ve Başaran, N. “Assessment of DNA damage in ceramic workers”, Mutagenesis, 24;33(1):97-104, 2018
• Aydın, S., Bacanlı, M., Anlar, HG, Çal, T., Arı, N., Ün Değer Bucurgat, Ü., Başaran, AA, Başaran, N.: Preventive role of Pycnogenol® against the hyperglycemia-induced oxidative stress and DNA damage in diabetic rats. Food and Chemical Toxicology, 124: 54-63 (2019).
• Aydın, S., Erkekoglu, P., Başaran, N., Kocer-Gumusel, B.: Impact of selenium status on Aroclor 1254-induced DNA damage in sperm and different tissues of rats. Toxicol Mech Methods, 12:1-10 (2017).
• Aydın, S., Şahin, T.T., Bacanlı, M., Taner, G., Basaran, A.A., Aydın, M., Basaran, N.: Resveratrol treatment protects rat kidney and liver from sepsis induced oxidative damage. Balkan Medical Journal, 33(6): 594-601 (2016).
• Aydın, S., Tokaç, D., Başaran, N., Başaran, A.A. Effect of Epigallocatechin Gallate on Oxidative DNA Damage in Human Lymphocytes. Turkish Journal of Pharmaceutical Sciences. 12 (1), 19-28, (2015)
• Aydin, M., Aydin, S., Bacanlı, M., Basaran, N. Aflatoxin levels in chronic hepatitis B patients with cirrhosis or hepatocellular carcinoma in Balıkesir, Turkey. Journal of Viral Hepatitis, 22(11):926-935 (2015).
• Bacanlı M, Anlar HG, Aydın S, Çal T, Arı N, Ün Değer Bucurgat Ü, Başaran AA, Başaran N. d-limonene ameliorates diabetes and its complications in streptozotocin-induced diabetic rats. Food and Chemical Toxicology, 110: 434-441 (2017).
• Bacanlı M., Aydın S., Anlar HG, Çal T., Arı N., Ün Değer Bucurgat Ü., Başaran AA, Başaran, N. "Protective Effects of Ursolic Acid in The Kidneys of Diabetic Rats", Turk, J. Pharm. Sci., 15 (2), 166-170, (2018).
• Bacanlı M., Başaran AA., Başaran N. Cytotoxicity Evaluation of Some Phenolic Compounds in V79 Cells. Turkish Journal of Pharmaceutical Sciences, 12(3):53-61, (2015)
• Bacanlı, M., Anlar, HG, Başaran, AA, Başaran, N. Assessment of Cytotoxicity Profiles of Different Phenolics: Comparison of Neutral Red and MTT Assays in Different Cells in Different Time Periods, Turkish Journal of Pharmaceutical Sciences, 14(2 ), 95-107, 2017
• Bacanlı, M., Aydın, S., Anlar, H.G., Çal, T., Ari, N., Bucurgat Ündeger, Ü., Başaran, A.A. ve Başaran, N., “Can ursolic acid be beneficial against diabetes in rats?”, Turkish Journal of Biochemistry, 2018, 43(5), 520-529
• Bacanlı, M., Aydın, S., Taner, G., Göktaş, H.G., Sahin, T., Başaran, A.A., Başaran, N. Does rosmarinic acid treatment have protective role against sepsis-induced damage in Wistar albino rats? Human & Experimental Toxicology, 35(8):877-86 (2015).
• Bacanli, M., Basaran, A.A. ve Başaran, N., “The antioxidant, cytotoxic and antigenotoxic effects of galangin, puerarin and ursolic acid in mammalian cells”, Drug and Chemical Toxicology, 40(3): 256-262, (2017)
• Balcı A, Özkemahlı G, Erkekoglu P, Zeybek D, Yersal N, Kocer-Gumusel B. Effects of prenatal and lactational bisphenol a and/or di(2-ethylhexyl) phthalate exposure on male reproductive system. Int J Environ Health Res. 2020;1-14.
• Balci A, Ozkemahli G, Erkekoglu P, Zeybek ND, Yersal N, Kocer-Gumusel B. “Histopathologic, apoptotic and autophagic, effects of prenatal bisphenol A and/or di(2-ethylhexyl) phthalate exposure on prepubertal rat testis.” Environ Sci Pollut Res Int. 2020 Apr 1
• Başaran, N., Duydu, Y., Bacanlı, M., Anlar, H.G., Aydın Dilsiz, S., Üstündağ, A., Yalçın, C.Ö., Schwerdtle, T., Bolt, H.M. Evaluation of oxidative stress and immune parameters of boron exposed males and females. Food and Chemical Toxicology, 142, 1114888 (2020)
• Başaran, N., Duydu, Y., Üstündağ, A., Taner G., Aydın, S., Anlar, HG, Yalçın, C.Ö., Bacanlı, M., Aydos, K., Atabekoğlu, CS, Golka, K., Ickstadt, K., Schwerdtle, T., Werner, M., Meyer, S., Bolt, HM Evaluation of the DNA damage in lymphocytes, sperm and buccal cells of workers under environmental and occupational boron exposure conditions. Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 843:33-39 (2019)
• Başaran, N., Duydu, Y., Üstündağ, A., Taner, G., Aydın Dilsiz, S., Anlar, HG, Yalçın, C.Ö., Bacanlı, M., Golka, K., Schwerdtle, T., Bolt, HM: Environmental boron exposure does not induce DNA damage in lymphocytes and buccal cells of females: DNA damage in lymphocytes and buccal cells of boron exposed females. Journal of Trace Elements in Medicine and Biology, 53: 150-153 (2019).
• Baydar T, Kemer Evren Ö, Çakmak A, Kılıçarslan B, Girgin G, “Detection of neopterin in tear samples” Pteridines, 27 (1-2), 13-16, 2016.
• Bostanci, E.I., Dikmen, A.U., Girgin, G., Gungor, T., Baydar, T., Consultant, A.N. “A New Diagnostic and Prognostic Marker in Endometrial Cancer: Neopterin” Int J Gynecol Cancer, 27 (4), 754-758 (2017).
• Buyuktiryaki B, Sahiner UM, Girgin G, Birben E, Soyer OU, Cavkaytar O, Cetin C, Arik Yilmaz E, Yavuz ST, Kalayci O, Baydar T, Sackesen C, “Low indoleamine 2,3-dioxygenase activity in persistent food allergy in children” Allergy: European Journal of Allergy and Clinical Immunology, 71 (2), 258-266, 2016.
• Cebi G, Yildiz S, Uzun G, Oztas Y, Sabuncuoglu S, Kutlu A, Ilgaz Y, Karatop-Cesur I, Dogan E, Oztas E. The effect of hyperbaric oxygen therapy on rhabdomyolysis-induced myoglobinuric acute renal failure in rats. Ren Fail. 2016 Oct;38(9):1554-1559.
• Charehsaz M., Hougaard KS, Sipahi H., Doğan Ekici AI, Kapsar Ç., Culha M., Ün Değer Bucurgat Ü., Aydın A. "Effects of developmental exposure to silver in ionic and nanoparticle form: A study in rats" , DARU J.Pharm. Sci., 24:24 (DOI 10.1186/s40199-016-0162-9) (2016).
• Çal T, Ün Değer Bucurgat Ü. "In vitro investigation of the effects of boron nitride nanotubes and curcumin on DNA damage", DARU J. Pharm. Sci., 27(1):203-218 (2019).
• Demir N., Aydın S., Ün Değer Bucurgat Ü. "Assessment of Genotoxic Effects of Pendimethaline in Chinese Hamster Over (CHO) Cells by The Single Cell Gel Electrophoresis (Comet) Assay", Turk J.Pharm.Sci., 14(2), 185-190, (2017).
• Didem Şöhretoğlu, Yasin Genç, Ü. Sebnem Harput, Suna Sabuncuoğlu, Michal Šoral, Gülin Renda, Tibor Liptaj. Phytochemical Content, Antioxidant and cytotoxic Activities of Sedum spurium. Nat Prod Com 2016, 11 (11).
• Duydu Y, Başaran N, Üstündağ A, Aydın S, Ün Değer Ü, YavuzAtaman O, Aydos K, Düker Y, Ickstadt K, Waltrup BS, Golka K, Bolt HM. Is Boric Acid Toxic to Reproduction in Humans? Assessment of the Animal Reproductive Toxicity Data and Epidemiological Study Results. Current Drug Delivery, 13(3):324-9 (2016).
• Duydu Y, Başaran N, Üstündağ A, Aydın S, Yalçın CÖ, Anlar HG, Bacanlı M, Aydos K, Atabekoğlu CS, Golka K, Ickstadt K, Schwerdtle T, Werner M, Meyer S, Bolt HM. Birth weights of newborns and pregnancy outcomes of environmentally boron-exposed females in Turkey. Arch Toxicol. 92(8):2475-2485 (2018).
• Duydu Y, Başaran N, Yalçın CÖ, Üstündağ A, Aydın S, Anlar HG, Bacanlı M, Aydos K, Atabekoğlu CS, Golka K, Ickstadt K, Schwerdtle T, Werner M, Bolt HM. Boron-exposed male workers in Turkey: no change in sperm Y:X chromosome ratio and in offspring's sex ratio. Arch Toxicol. 2019 Mar;93(3):743-751
• Duydu Y., Başaran N., Üstündağ A., Aydın S., Ün Değer Ü., Yavuz Ataman O., Aydos K., Düker Y., Ickstadt K., Waltrup B.S., Golka K., Bolt H.M. ''Is Boric Acid Toxic to Reproduction in Humans? Assessment of the Animal Reproductive Toxicity Data and Epidemiological Study Results'', Curr Drug Deliv., 13(3), 324-329 (2016).
• Duydu, Y., Başaran, N., Aydın, S., Üstündağ, A., Yalçın, C.Ö., Anlar, HG, Bacanlı, M., Aydos, K., Atabekoğlu, CS, Golka, K. , Ickstadt, K., Schwerdtle, T., Werner, M., Meyer, S., Bolt, HM Evaluation of FSH, LH, testosterone levels and semen parameters in male boron workers under extreme exposure conditions. Archives of Toxicology, 92(10),3051-3059 (2018).
• Gatz, SA, Salles, D., Jacobsen, EM, Dörk, T., Rausch, T., Aydin, S., Surowy, H., Volcic, M., Vogel, W., Debatin, KM, Stutz, AM, Pannicke, U., Hess, T., Korbel, JO, Schulz, AS, Schumacher, J., Wiesmüller, L. MCM3AP and POMP mutations cause DNA-repair/damage-signaling defect in immunodeficient child. Human Mutation, 37(3):257-68 (2016).
• Goktas H.G., Bacanlı M., Kutluk B., Başaran AA., Başaran N. Cytotoxic Activity of Resveratrol in Different Cell Lines Evaluated by MTT and NRU Assays. Turkish Journal of Pharmaceutical Sciences 13(1): 27-34 (2016)
• Gulru Gurdemir, Pınar Erkekoglu, Aylin Balci, Unzile Sur, Gizem Ozkemahli, Engin Tutkun, Hinc Yilmaz, Ali Asci, &Belma Kocer Gumusel. “Oxidative Stress Parameters, Selenium Levels, DNA damage and Phthalate Levels in Plastic Workers” J Environ Pathol Toxicol Oncol, 38(3):253-270 (2019).
•    Gülin Renda, Ufuk Özgen, Zeynep Ünal, Suna Sabuncuoğlu, Erhan Palaska, İlkay Erdoğan Orhan. Flavonoid Derivatives From The Aerial Parts Of Trifolium Trichocephalum M. Bieb. And Their Antioxidant And Cytotoxic Activity. Rec. Nat. Prod. 11:5 (2017) 479-484.
•    Gürcü S, Girgin G, Yorulmaz G, Kılıçarslan B, Efe B, Baydar T, “Neopterin and Biopterin Levels and Tryptophan Degradation in Patients with Diabetes” Scientific Reports 10: 17025, 2020. DOI: https://doi.org/10.1038/s41598-020-74183-wGürcü, S., Girgin, G., Yorulmaz, G., Kılıçarslan, B., Efe, B., Baydar T. Neopterin and biopterin levels and tryptophan degradation in patients with diabetes. Sci Rep. 10: 17025 (2020).
•    Hameed H., Aydın S., Başaran AA., Başaran N. Assessment Of Cytotoxic Properties Of Sinapic Acid In Vitro. Turkish Journal of Pharmaceutical Sciences, 13(2):129-132, (2016)
•    Hermann M.B., Duydu, Y., Başaran, N., Golka, K. Boron and its compounds: current biological research activities. Archieves of Toxicology, 91: 2719-2722 (2017)
•    Isci Bostanci E, Ugras Dikmen A, Girgin G, Gungor T, Baydar T, Danisman NA, “A new diagnostic and prognostic marker in endometrial cancer: neopterin” International Journal of Gynecological Cancer, 27 (4), 754-758, 2017.
•    İnce T, Balcı A, Yalçın SS, Özkemahlı G, Erkekoglu P, Kocer-Gumusel B, Yurdakök K. Urinary bisphenol-A levels in children with type 1 diabetes mellitus. J Pediatr Endocrinol Metab. 2018 Aug 28;31(8):829-836.
•    Karacaoglu E, Girgin G, Selmanoğlu G, Baydar T, “Antioxidant Effects of Epigallocatechin Gallate in Cerulein-Induced Pancreatitis”, IUFS Journal of Biology, 2019, 78 (2), 125-133. DOI: 10.26650/EurJBiol.2019.0035
•    Kılıç Süloğlu, A., Selmanoğlu, G., Gundogdu, O., Kishalı, N., Girgin, G., Palabiyik, S., Kara, Y., Baydar, T. Evaluation of isoindole derivatives: Antioxidant potential and cytotoxicity in the HT-29 colon cancer cells. Arch Pharm (Weinheim) 2020;e2000065. doi: 10.1002/ardp.202000065.
•    Kilicarslan B, Cardak A, Girgin, Kemer Evren O, Baydar T, “An exploratory study of neopterin and kynurenine pathway in pterygium”, Pteridines, 2019, 30 (1), 153-157. [doi:10.1515/pteridines-2019-0019].
•    Kizilgun M, Takci S, Erkekoglu P, Asci A, Balci A, Yigit S, Kocer-Gumusel B. ‘Copper, zinc and iron levels in premature infants following red blood cell transfusion.’ J Trace Elem Med Biol. 2016 Dec;38:126-130.
•    Kurt OK, Basaran N. Occupational Exposure to Metals and Solvents: Allergy and Airway Diseases. Curr Allergy Asthma Rep. 2020 Jun 6;20(8):38.
•    Kurt, Ö., Ergun, D., Başaran, N. “Can the ceramic industry be a new and hazardous sector for work-related asthma?”, Respiratory Medicine, 137, 176-180, 2018
•    Møller P, Azqueta A, Boutet-Robinet E, Koppen G, Bonassi S, Milić M, Gajski G, Costa S, Teixeira JP, Costa Pereira C, Dusinska M, Godschalk R, Brunborg G, Gutzkow KB, Giovannelli L, Cooke MS, Richling E, Laffon B, Valdiglesias V, Basaran N, Del Bo' C, Zegura B, Novak M, Stopper H, Vodicka P, Vodenkova S, de Andrade VM, Sramkova M, Gabelova A, Collins A, Langie SAS. Minimum Information for Reporting on the Comet Assay (MIRCA): recommendations for describing comet assay procedures and results. Nat Protoc. 2020;15(12):3817-26.
•    Ozkan Vardar, D., Aydin, S., Hocaoglu, İ., Yagci Acar, F.H., Basaran, N: Effects of silver sulfide quantum dots coated with 2-mercaptopropionic acid on genotoxic and apoptotic pathways in vitro. Chemico-Biological Interactions, 291:212–219, (2018).
•    P. Erkekoglu, Y. Üçkardeş, E.N. Özmert, B. Kocer-Gumusel, K. Yurdakök. The effect of zinc supplementation on salivary cortisol levels and salivary amylase activity in primary school children with low socioeconomic status. MOJ Toxicology. 2016, 2(2): 00032.
•    Palabiyik SS, Keles S, Girgin G, Arpali-Tanas E, Topdagi E, Baydar T, “Neopterin release and tryptophan degradation in patients with uveitis” Current Eye Research, 41 (11), 1513-1517, 2016.
•    Palabiyik, Girgin G, Aşçı A, Demirelli S, Uslu A, Karakelleoglu S, Akcay F, Aksakal E, Şahin G, Baydar T, “Folate, neopterin and kynurenine pathway in patients with statin therapy” Pteridines, 27 (1-2), 7-12, 2016.
•    Palabiyik, S.S., Keles, S., Girgin, G., Arpali-Tanas, E., Topdagi, E., Baydar, T. “Neopterin Release and Tryptophan Degradation in Patients with Uveitis” Current Eye Res, 41 (11), 1513-1517 (2016).
•    Sabuncuoglu, S., Erkekoglu, P., Aydin, S., Sahin, G., Kocer-Gumusel, B. The effects of season and gender on the serum aflatoxins and ochratoxin A levels of healthy adult subjects from the Central Anatolia Region, Turkey. European Journal of Nutrition, 2015, 54(4): 629-38 (2015).
•    Sabuncuoğlu S, Öztaş Y, Yalcinkaya A, Ünal S, Baydar T, Girgin G. The increased neopterin content in turkish pediatric patients with sickle cell anemia. Ann Hematol. 2020 Jan;99(1):41-47.
•    Samadi A, Isikhan SY, Ansari MHK, Samadi M, Sabuncuoglu S. Effects of clozapine and haloperidol treatment on plasma concentrations of androgen hormones and androgendependent organ changes in rats. Indian J Pharmacol. 2019 Jul-Aug;51(4):269-275.
•    Sarıgöl Kılıç Z.,  Çal T., Ündeğer Bucurgat Ü. "Evaluation of Methylation and Acetylation Profiles of Dinitroaniline Herbicides and Resveratrol on V79 Cell Line", Turk J Pharm Sci., 17 (6), 631-637, (2020).
•    Sarıgöl Kılıç Z., Aydın S., Ündeğer Ü., Başaran N. "In Vitro Genotoxicity Assessment of Dinitroaniline Herbicides Pendimethalin and Trifluralin", Food Chem. Tox., 113, 90-98 (2018).
•    Sarıgöl Kılıç Z., Ündeğer Bucurgat Ü. "Pendimetalin ve Trifluralinin Apopitotik ve Anti-apopitotik Etkilerinin A549 Hücrelerinde İn Vitro Değerlendirilmesi", Turk J.Pharm.Sci., 15 (3), 364-369, (2018).
•    Sipahi, H., Girgin, G., Palabiyik, S.S., Tutkun, E., Yilmaz, O.H., Baydar, T. “Possible changes of New-Generation inflammation markers with occupational lead exposure” J Occup Health, 59 (4), 345-351 (2017).
•    Suna Sabuncuoğlu, Solmaz Mohammadi Nejad, Didem Şöhretoğlu. Geranium Psilostemon Ledeb. Bitkisinden Elde Edilen Fenolik Bileşikler Ve Hidrolizlenebilir Tanenlerin Sitotoksik Ve Genotoksik Özelliklerinin Değerlendirilmesi. Hujpharm, 2017 No:2
•    Sunman B, Yurdakök K, Gümüşel BK, Özyüncü Ö, Akbıyık F, Balcı A, Özkemahlı G, Erkekoğlu P, Yurdakök M. Prenatal bisphenol A and phthalate exposure are risk factors for male reproductive system development and cord blood sex hormone levels. Reprod Toxicol. 2019. pii: S0890-6238(18)30423-4.
•    Süloglu AK, Selmanoglu G, Gündoğdu Ö, Kishalı NH, Girgin G, Palabıyık ŞS, Kanat ÖN, Tan A, Kara Y, Baydar T, “Evaluation of Isoindole Derivatives: Antioxidant Potential and Cytotoxicity in the HT-29 Colon Cancer Cells” Archiv der Pharmazie 2020; 353: (e200006) DOI: 10.1002/ardp.202000065
•    Taner, G., Özkan Vardar, D., Aydın, S., Aytaç, Z., Basaran, A., Basaran, N.: Use of in vitro assays to assess the potential cytotoxic, genotoxic and antigenotoxic effects of Vanillic and cinnamic acid. Drug and Chemical Toxicology, 40(2):183-190 (2017).
•    Teksam O, Sabuncuoğlu S, Girgin G, Özgüneş H. Evaluation of oxidative stress and antioxidant parameters in children with carbon monoxide poisoning. Hum Exp Toxicol. 2019 Nov;38(11):1235-1243.
•    Tokaç, D., Anlar, H., Bacanlı, M., Aydın Dilsiz, S., İritaş, S.B. Başaran, N.: Oxidative stress status of Turkish welders. Toxicology and Industrial Health, 36(4):263-271(2020)
•    Tokaç, M., Aydın, S., Taner, G., Özkardeş, A.B., Taşlıpınar, M.Y., Doğan, M. Dündar, H.Z., Kılıç, M., Başaran, A.A., Basaran, N.: Hepatoprotective and antioxidant effects of lycopene in acute cholestasis. Turkish Journal of Medical Science, 45 (4): 857-64 (2015).
•    Tokaç, M., Bacanlı, M., Dumlu, E.G., Aydın, S., Engin, M., Bozkurt, B., Yalçın, A., Erel, Ö., Kılıç, M. ve Başaran, N. “The ameliorative effects of pycnogenol® on liver ischemia-reperfusion injury in rats”, Turkish Journal of Pharmaceutical Sciences, 14(3):257-263, 2017
•    Unuvar S, Girgin G, Sahin TT, Kilicarslan B, Taneri F, Yuksel O, Baydar T, “Tryptophan degradation and antioxidant status in patients with thyroid disorders”, Archives of Iranian Medicine, 21 (9), 399-405, 2018.
•    Unuvar, S., Erge, D., Kilicarslan, B, Bag, H.G.G., Catal, F., Girgin, G., Baydar, T. “Neopterin Levels and Indoleamine 2,3-Dioxygenase Activity as Biomarkers of Immune System Activation and Childhood Allergic Diseases” Annals Lab Med, 39 (3), 284-290 (2019).
•    Yalcinkaya A, Samadi A, Lay I, Unal S, Sabuncuoglu S, Oztas Y. Oxysterol concentrations are associated with cholesterol concentrations and anemia in pediatric patients with sickle cell disease. Scand J Clin Lab Invest. 2019 Oct;79(6):381-387.
•    Zeybek D. N., Sur Ü., Oflaz O., Erkekoglu P., Balci A., Ozkemahli G, Aşçı A., Kızılgün M., Edebal O., Koçer-Gümüşel B. Renal changes and apoptosis caused by subacute exposure to Aroclor 1254 in selenium-deficient and seleniumsupplemented rats. Arh Hig Rada Toxicol. 71:2,110-120 2020
•    Zor, M., Aydın, S.,  Güner, N.D., Basaran, A.A., Basaran, N. Antigenotoxic properties of Paliurus spina-christi Mill fruits and their active compounds. BMC Complement Altern Med. 17: 229-239 (2017).

Links

About

Research Infrastructure

• Acid purification device
• (ICP-MS preliminary)
• Acid etching device
• (ICP-MS preliminary)
• Biosafety Cabinet, 3 units
• Refrigerator (+4°C), 10 units
• Comet Computerized Imaging System (Comet Analysis Software, version 3.0, Kinetic Imaging)
• Fume Hood, 4 pcs.
• Deionized water device
• Deep Freezer (-20°C), 7 pcs.
• Deep Freezer (-80 °C), 2 pcs.
• Distilled Water Device (MES ultrapure )
• Tissue homogenizer
• Electrophoresis (Biometra Analytical)
• Electrophoresis Power Supply
• (Power Pack P 25)
• Fluorescent Microscope (Leica)
• Fraction Collector
• Precision Balance, 2 pcs.
• ICP-MS
• Inverted Microscope, Leica
• Heater, Multi-Block (Lab-Line)
• Incubator
• Incubator (with CO2), 2 pcs.
• Incubator (Oven), 3 pcs.
• Mixer-Heater
• (Jankel&Kunkel, Ikamag)
• Cracked Ice Machine
• (Scotsman AF100)
• Air conditioner, 5 units
• Labware Washing Machine
• Lyophilizer
• Magnetic Stirrer
• (Stuart Scientific)
• Membrane Filter (0.2 µm pore diameter) Brand
• Microwave Oven (Vestel)
• Microcentrifuge, 2 pcs.
• Nanodrop
• Autoclave Rodwell (Monarch MP)
• pH meter (Cyberscan)
• Real Time PCR Device and Software
• Pure water device
• Centrifuge, 2 units
• Refrigerated centrifuge
• Spectrophotometer, 2 pcs.
• Spectrophotometer (Plate reader)
• Spectrophotometer / Spectrofluorometer (Plate reader)
• Water Bath (2 units)
• Libra (Schimadzu Libror)
• Ultrasonic Bath
• (Transsonic 460/H)
• Ultrasonic Probe (Bandelin Sonoplus)
• Top-loading scales (2 pcs.)
• Vacuum pump
• Vortex (7 pieces)
• Horizontal shaker (Edmund Bühler)
• High Pressure Liquid Chromatography (2 units)

Researchers

•    Prof. Dr. Ayşe Nurşen BAŞARAN
•    Prof. Dr. Terken BAYDAR
•    Prof. Dr. Ülkü ÜNDEĞER BUCURGAT
•    Prof. Dr. Aylin GÜRBAY
•    Prof. Dr. Pınar ERKEKOĞLU
•    Prof. Dr. Sevtap AYDIN DİLSİZ
•    Doç. Dr. Gözde GİRGİN
•    Doç. Dr. Suna SABUNCUOĞLU
•    Dr. Aydan ÇAĞLAYAN
•    Dr. Duygu PASLI
•    Dr. Aylin BALCI ÖZYURT
•    Uzm. Ecz. Tuğbagül ÇAL
•    Uzm. Ecz. Ünzile SUR
•    Uzm. Ecz. Anıl YİRÜN
•    Selinay Başak ERDEMLİ KÖSE
•    Uzm. Ecz. Can BABACANOĞLU
•    Uzm. Ecz. Merve BECİT
•    Uzm. Ecz. Aysun ÖKÇESİZ
•    Zeynep BAYDAŞ
•    Yücel YÜZBAŞIOĞLU
•    Sultan Pınar ÇETİNTEPE
•    Özlem KAR KURT
•    Hediye Gamze Nur ÇELEBİOĞLU
•    Fundanur YAZICI

Ongoing Projects

• “Evaluation of Oxidative Stress Parameters and Genotoxic Effects in Patients Diagnosed with Work-Related Asthma and Silicosis” Hacettepe University BAP Unit, PhD Thesis Project, TDK-2020-18450 (Project Coordinator: Prof. Dr. Nurşen Başaran, Researcher: Özlem Kar Kurt, Dilek Ergün , Mevlüt Karataş, Merve Bacanlı, Merve Hazar) (14.02.2020-) Budget: 30.000 TL.
• “Evaluation of the Effects of Different Storage Conditions and Durations on Genotoxic Damage” Hacettepe University BAP Unit, Yüksel Undergraduate Thesis Project, TYL-2019-17701 (Project Coordinator: Prof. Dr. Nurşen Başaran, Researcher: Merve Bacanlı, Zeynep Baydaş) (12.02. 2019-) 27.999.48 TL
• “Evaluation of Oxidative Stress Immune System Indicators Genotoxicity and Heavy Metal Levels in Mothers and Babies with Diabetes and Preeclampsia” Hacettepe University BAP Unit, Comprehensive Research Project, TSA-2017-14441 (Project Coordinator: Prof. Dr. Nurşen Başaran, Researcher: Merih Bayram, Merve Bacanlı, Hatice Gül Anlar, Pınar Çalış) (25.12.2017-) 18,8423,84 TL.
• "Evaluation of the Effects of Genistein on DNA Damage in Colon Cancer Cells by Single Cell Gel Electrophoresis Comet Method", (Executive) Hacettepe University Scientific Research Thesis Project (TDK-2019-18077), 2021.
• "In Vitro Evaluation of Possible Genotoxic Effects of Acrylamide and 5-Hydroxymethylfurfural by Single Cell Gel Electrophoresis Method", (Executive) Hacettepe University Scientific Research Thesis Project (TDK-2019-17708) 2021.
• Evaluation of Possible Cytotoxic, Genotoxic and Epigenotoxic Effects of Titanium Dioxide Nanoparticles with 3T3 Fibroblast Cells Compared to Normal Size Titanium Dioxide and Possible Protective Effect of Melatonin, Hacettepe University Scientific Research Unit Research Project, Project ID: THD-2019-18423. Project Manager: Dr. Aylin Balci. Researcher: Prof.Dr. Pınar Erkekoğlu Budget: 29.999.99 TL (20.11.2019-…)
• Comparative Evaluation of Methyl Mercury and Thiomersalin Toxicity in Human Neuroblastoma Cells for Gender Differences. Hacettepe University Executive: Prof.Dr. Pınar Erkekoğlu, Researcher Dr. Aylin Balcı Budget: 36.000 TL (29.01.2020-…)
• Evaluation of Possible Cytotoxic, Genotoxic and Immunotoxic Effects of Bisphenol Derivatives in HepG2 Cells. Executive Prof.Dr. Pınar Erkekoğlu, Researcher Dr.Aylin Balcı. Hacettepe University Budget: 36.000 TL (29.01.2020-…)
• The Relationship Between Bisphenol A and Vitamin D Levels in Cord Blood. Researcher/Specialist Assoc. Dr. Pınar Erkekoğlu, Dr.Aylin Balcı. Budget: 30.000 TL Hacettepe University 16.03.2020-16.06.2021
• Evaluation of the Effect of Smoking on Possible Oxidative Damage and Serum Heavy Metal Levels in Silicosis Patients. Researcher/Specialist Prof.Dr. Pinar Erkekoglu. Hacettepe University Budget: 30.000 TL (21.05.2020-…)
• Synthesis and Characterization of New Hexahydroquinoline Derivatives. In Vitro and In Silico Investigation of Inhibitory Effects on Transforming Growth Factor-Beta (TGF-beta) and Inflammation Mediators. Researcher/Specialist Assoc. Dr. Pınar Erkekoğlu, Dr.Aylin Balcı. Hacettepe University Budget: 30.000 TL (21.05.2020-…)
• Evaluation of Possible Toxic Effects of Protective and Adjuvant Substances Used in Vaccines. Executive Assoc. Dr. Pinar Erkekoglu. Hacettepe University Budget: 30.000 TL (21.06.2020-…)
• Peptide Based Vaccine Research and Development Studies against COVID-19. Researcher/Specialist Prof. Dr. Pinar Erkekoglu. National TUSEB Project Budget: 842,600 TL (10.06.2020-…)
• Discovery of new antifungal compounds by ligand and structure-based virtual activity screening method. Hacettepe University Scientific Research Unit Project, Assistant Researcher Assoc. Dr. Suna Sabuncuoglu
• The Roles of Changes in Respiratory Function, Exercise Capacity and Quality of Life in Oxidant and Antioxidant Response in Patients with Primary Ciliary Dyskinesia. Hacettepe University Scientific Research Unit Project, Assistant Researcher Assoc. Dr. Suna Sabuncuoglu

Completed Projects

• H.U. Faculty of Pharmacy, Department of Pharmaceutical Toxicology, Department of Pharmaceutical Toxicology Laboratory "In Vitro Investigation of Genotoxicity of Nandrolone by Single Cell Gel Electrophoresis Technique" Hacettepe University BAP Unit Master's Project, TYL-2019-17945. (Project Coordinator: Associate Professor Sevtap Aydın Dilsiz, Researcher: Pharmacist Emre Korkmaz). (28.05.2019-07.02.2020) Budget: 27,868,13 TL
• “In vitro evaluation of the effects of sinapic acid on cytotoxic, genotoxic and apoptosis” Hacettepe University BAP Unit, Support Project, 014 D11 301 002-775 (Project coordinator, Associate Professor Sevtap Aydın; Researcher, Prof.Dr.A.Nurşen Başaran ). (13.11.2014-24.10.2016). Budget: 19,766 TL
• "In Vitro Epigenetic Evaluation of Dinitroaniline Herbicide Compound Trifluralin and Pendimethalin" (Executive), Hacettepe University Scientific Research Rapid Support Project, 2015.
• "Determination of Heavy Metal Levels in Drinking Water of Provinces in the Central Anatolia Region" (Researcher), Hacettepe University Scientific Research Rapid Support Project (THD-15735), 2017.
• "Evaluation of Possible Apoptotic Effects of Genistein, TNF-Related Apoptosis Inducing Ligand (TRAIL) and 5-Fluorouracil in Colon Cancer Cells", (Executive) TÜBİTAK Rapid Support Project (219S200), 2020.
• "In Vitro Evaluation of Oxidative DNA Damage and Repair in Stem Cells by Single Cell Gel Electrophoresis" (Executive), Hacettepe University Scientific Research Rapid Support Project, 2015.
• "In Vitro Evaluation of the Cytotoxic, Apoptotic and Genotoxic Effects of Metformin" (Executive), Hacettepe University Scientific Research Rapid Support Project (THD-13153), 2017.
• "Hela Evaluation of Possible Apoptotic Antioxidant and Genotoxic Effects of Pitavastatin in Human Cervical Cancer Cell Line", (Executive) Hacettepe University Scientific Research Rapid Support Project (THD-2019-17809), 2020.
• “Determination of Heavy Metal Levels in Drinking Waters of Ankara Province” Hacettepe University BAP Unit, Rapid Support Project, THD-2016-9360, (Project Coordinator: Merve Bacanlı; Researcher: Prof.Dr.Nurşen Başaran, Hatice Gül Anlar (21.03.2016- 24.07.2017) 27,377.67 TL.
• “Investigation of the toxic effects of boron exposure on reproductive function of humans-II” ETİ Mining General Directorate Research Project (Project coordinator, Prof.Dr.A.Nurşen Başaran, Prof.Dr.Yalçın Duydu; Researcher, Merve Bacanlı, Hatice Gül Göktaş, Zehra Sarıgöl, Can Özgür Yalçın, Kaan Aydos, Cem Somer Atabekoğlu, Sevtap Aydın,) (28.08.2014-28.08.2017)
• “Effects of Pycnogenol, Cinnamic Acid, Ursolic Acid and Limonene on Oxidative Stress and Genotoxicity in Wistar Albino Rats with Experimental Diabetes” 3001-TUBITAK Initial R&D Projects Support Program, 114S919. (Project Coordinator: Dr. Merve BACANLI, Assistant Researcher: Associate Professor Sevtap Aydın, Prof. Dr. Ülkü Ün Değer Bucurgat, Prof. Dr. Nurşen Başaran). (01.12.2014-11.05.2017) 81.000 TL
• “Evaluation of Toxic Effects of Aroclor 1254 in HEPG2 Cells and Possible Protective Effect of Curcumin” Hacettepe University BAP Unit, Rapid Support Project, 013 D01 301 002 (Project Coordinator: Prof.Dr.A. Nurşen Başaran Researcher: Merve Bacanlı, Hatice Gül Anlar (16.01.2013 - 11.08.2017) 11.400 TL
• “Determination of Blood Metal Levels in Welding Workers” Hacettepe University BAP Unit, Rapid Support Project, THD-2017-15736 (Project Coordinator: Prof.Dr.A. Nurşen Başaran Researcher: Merve Bacanlı, Hatice Gül Anlar (07.09.2017 - 07.08. 2018) 27,909.36 TL
• “Evaluation of the Effects of Quantum Dot Nanoparticles on Cytotoxicity and Apoptosis in V79 Fibroblast Cells” 3001-TUBITAK Initial R&D Projects Support Program, 114S861 (Project coordinator, Associate Professor Sevtap Aydın; Researcher, Prof.Dr.A.Nurşen Başaran, Deniz Ozkan Vardar). (01.10.2014-21.02.2017).
• “Examination of the combined effects of cisplatin and pycnogenol in cervical cancer cell lines” Hacettepe University BAP Unit, Rapid Support Project, THD-2016-11838 (Project coordinator, Associate Professor Sevtap Aydın). (30.11.2016-28.02.2018). 22,107 TL
• Investigation of cytotoxic action mechanisms of zinc oxide and copper oxide nanoparticles in vitro (Project Coordinator: Prof. Dr. Aylin Gürbay, Researcher: Dr. Pharmacist Duygu Paslı), Hacettepe University Scientific Research Support Project 6080, Project no: THD-2017- 14012. (03.05.2017-06.11.2018, Budget: 29.991.78 TL.
• Evaluation of the cytotoxic effects of zinc oxide and copper oxide nanoparticles (Project Coordinator: Prof. Dr. Aylin Gürbay, Researcher: Pharmacist Duygu Paslı), Hacettepe University Scientific Research Support Project 6080, Project no: 014 D12 301 001-830. (15.01.2015-09.12.2016), Budget: 19.799.23 TL.
• Evaluation of respiratory CO and urinary cotinine levels of electronic cigarette (e-cigarette) users (Project Leader: Prof. Dr. Dilek Aslan, Researchers: Lecturer Meltem Şengelen, Dr. Pharm Duygu Paslı, Dr. Beril Chousein, Prof. Dr. Aylin Gurbay, Prof. Dr. Kadir Mutlu Fan). Hacettepe University Scientific Research Infrastructure Project, Project no: TAY-2016-9469 (19.04.2016-29.12.2017) Budget: 15,957.64 TL.
• Vaccine Development and Analysis Studies. Researcher/Specialist (National) (Prof.Dr. Pınar Erkekoğlu) Hacettepe University Budget: 1.387.207 TL (01.08.2014-01.08.2016)
• Domestic Vaccine Research and Development Studies. Researcher/Specialist Industry/Private Sector (Prof.Dr. Pınar Erkekoğlu) Ministry of Industry and Trade. Budget: 2.132.000 TL (01.02.2015-01.02.2017)
• Investigation of Bisphenol A and Phthalate Levels in Adolescent Cases with Polycystic Ovary Syndrome, Hacettepe University Scientific Research Unit Research Project, Project Id: 13147 Project Manager: Prof.Dr. Nuray Kanbur (Associate Researcher: Dr. Aylin Balcı, Prof. Dr. Pınar Erkekoğlu, Specialist Pharmacist Ünzile Sur) THD-2017-13147. Budget 20,699.84, (23.03.2017-23.07.2018)
• Investigation of the Effects of Bisphenol A and Di-2-ethyl Hexyl Phthalate Exposure on Male Reproductive System during Prenatal and Lactation Period, Hacettepe University Scientific Research Unit Research Project, Project Manager: Prof.Dr. Belma Gümüşel Project ID:12150 (Assistant Researcher: Dr. Aylin Balcı, Prof.Dr. Pınar Erkekoğlu, Budget 21,831.80 TL (17.01.2017-22.01.2018)
• Evaluation of the Effects of Prenatal Bisphenol A and Phthalate Exposure on Reproductive System and Thyroid Hormones in Newborns, TÜBİTAK 1001, 115S477, Associate Researcher: Prof.Dr. Pınar Erkekoğlu, Scholar Dr. Aylin Balcı, Budget 301,142,96 TL (15.09.2015-15.09.2017)
• Domestic Vaccine Research and Development Studies SAN-TEZ Project (0687.STZ.2014). 2014-2019 Researcher/Specialist Prof.Dr. Pınar Erkekoğlu (National) SAN-TEZ project Budget: 2.500.000 TL
• Metabolomics Studies in Children with Central and Peripheral Precocious Puberty, Hacettepe University Scientific Research Unit Research Project, Project Id: THD-2017-14278 Project Manager: Assoc. Pınar Erkekoğlu Assistant Researcher Dr. Aylin Balci. Budget: 29.999.97 TL (31.07.2017-25.06.2018)
• Toxic Effects of Bisphenol A in Thyroid Cells and Evaluation of the Protective Role of Selenium Compounds. Executive Prof.Dr. Pınar Erkekoğlu (National) Hacettepe University Budget: 20.700 TL (02.07.2018-07.01.2020)
• Evaluation of Neuroendocrine Disruptive Effects of Prenatal Bisphenol A And/or Di-2-EthyL Hexyl Phthalate Exposure, Hacettepe University Scientific Research Unit Research Project, Project Id: TYL-2018 17006 Project Manager: Assoc. Pınar Erkekoğlu Assistant Researcher Dr. Aylin Balcı Budget: 29.999.52 TL (09.07.2018-04.03.2019)
• Evaluation of Toxic Effects of Dibutyl Phthalate on Human Lung Cell Line and Possible Protective Effects of Ascorbic Acid and N Acetylcysteine ​​Hacettepe University BAB Director: Prof.Dr.Pınar Erkekoğlu, Associate Researcher: Dr.Aylin Balcı. Budget: 20700 12.06.2018-12.05.2020
• Evaluation of Toxic Effects of Combined Exposure to Endocrine Disrupting Chemicals in Different Cell Lines: Endoplasmic Reticulum Stress and Oxidative Stress, Hacettepe University Scientific Research Unit Research Project, Project Id: 12882 Project Manager: Assoc.Prof.Dr. Pınar Erkekoğlu Associate Researcher: Dr. Aylin Balcı Budget: 111,875.50 TL (07.06.2017-18.02.2020)
• Examining the relationship between speech delay and plasma phthalate level in children aged 2-6 years Hacettepe University Researcher: Prof.Dr. Pinar Erkekoglu. BAB Budget: 30.000 TL (20.12.2019-20.12.2020)
• Bringing Erzincan Medicinal and Aromatic Plants to the Local Economy. TANAP project Researcher/Specialist Prof.Dr. Pınar Erkekoğlu, Budget: 1.500.000 TL (2017-2019)
• Geranium Psilostemon Ledeb. Evaluation of Possible Cytotoxic and Genotoxic Activity of Some Pure Substances Extracted from the Plant, Hacettepe University Scientific Research Unit Project, Executive Assoc. Suna Sabuncuoglu
• Establishment of Pharmaceuticals and Cosmetics Research, Development and Quality Control Laboratory affiliated to Hacettepe University Faculty of Pharmacy, Ankara Development Agency, Hacettepe University Scientific Research Unit Project, Assistant Researcher Assoc. Suna Sabuncuoglu
• Investigation of Cytotoxic Potentials of Some Tannin and Tannin Precursors, Hacettepe University Scientific Research Unit Project, Assistant Researcher Assoc. Suna Sabuncuoglu
• Investigation of in vitro radical scavenging effects of some 1,4 dihydropyridine derivative calcium channel blocker substances, Hacettepe University Scientific Research Unit Project, Executive Assoc. Suna Sabuncuoglu
• The Effect of HBO Treatment on Kidney Damage Due to Muscle Waste: The Role of Heme Oxygenase 1, 3001 TÜBİTAK Initial Project, Assistant Researcher Assoc. Suna Sabuncuoglu
• Accreditation Project of Hacettepe University Faculty of Pharmacy Pharmaceuticals and Cosmetics R&D and Quality Control Laboratory (HÜNİKAL) within the scope of TS EN ISO/IEC 17025 Standard, Hacettepe University Scientific Research Unit Project, Assistant Researcher Assoc. Suna Sabuncuoglu
• Anti-cancer drug activity prediction with cell line susceptibility signatures and collective machine learning methods, TÜBİTAK 3501, Assistant Researcher Doç.Dr. Suna Sabuncuoglu
• In vitro evaluation of the interaction of metformin with some chemotherapeutic drugs, Hacettepe University Scientific Research Unit Project, Executive Assoc. Suna Sabuncuoglu
• Investigation of changes in lipid metabolism in sickle cell disease and associating it with the pathogenesis of the disease, Assistant Researcher Doç.Dr. Suna Sabuncuoglu
• Evaluation of Oxidant and Antioxidant Parameters in Children with Carbon Monoxide Poisoning, Hacettepe University Scientific Research Unit Project, Assistant Researcher Assoc. Suna Sabuncuoglu
• Investigation of in vitro radical scavenging effects of some 1,4 dihydropyridine derivative calcium channel blocker substances, Hacettepe University Scientific Research Unit Project, Assistant Researcher, Assoc. Gozde Girgin
• Evaluation of Oxidant and Antioxidant Parameters in Children with Carbon Monoxide Poisoning, Hacettepe University Scientific Research Unit Project, Assistant Researcher Assoc. Gozde Girgin
• Evaluation of Pteridine and Related Pathways in Pterygium Patients, Hacettepe University Scientific Research Unit Project, Assistant Researcher Assoc. Gozde Girgin
• The Effect of Lead Exposure and Chelation Therapy on Some Parameters Affecting Toxicity, Hacettepe University Scientific Research Unit Project, Assistant Researcher Assoc. Gozde Girgin
• Determination of Various Mycotoxin Levels in Animal Feeds and Milk, Hacettepe University Scientific Research Unit Project, Executive Assoc. Gozde Girgin
• Evaluation of Pteridine and Related Pathways in Pterygium Patients, Hacettepe University Scientific Research Unit Project, Executive Prof.Dr. Terken Baydar, Bilge Kılıçarslan (2016-2018)

Publications

• Abdallah, M.F., Girgin, G., Baydar, T., “Mycotoxin Detection in Maize, Commercial Feed, and Raw Dairy Milk Samples from Assiut City, Egypt” Vet Sci, 6 (2), 57 (2019).
• Adak T, Samadi A, Ünal AZ, Sabuncuoğlu S. A reappraisal on metformin. Regul Toxicol Pharmacol. 2018 Feb;92:324-332.
• Akgül S, Sur Ü, Düzçeker Y, Balcı A, Kızılkan MP, Kanbur N, Bozdağ G, Erkekoğlu P, Gümüş E, Kocer-Gumusel B, Derman O. “Bisphenol A and phthalate levels in adolescents with polycystic ovary syndrome.” Gynecol Endocrinol. 2019 Jun 20:1-4.
• Aksu N, Samadi A, Yalçınkaya A, Çetin T, Eser B, Lay İ, Öziş TN, Öztaş Y, Sabuncuoğlu S. Evaluation of oxysterol levels of patients with silicosis by LC-MS/MS method. MolCell Biochem. 2020;467:117-125.
• Aksu, İ., Anlar, HG, Taner, G., Bacanlı, M., İritaş, S., Tutkun, E., Başaran, N. “Assessment of DNA damage in welders using comet and micronucleus assays”, Mutation Research /Genetic Toxicology and Environmental Mutagenesis, 2018, Accepted (doi: 10.1016/j.mrgentox.2018.11.006)
• Anlar H.G., Bacanlı M., Çal T., Aydın S., Arı N., Ün Değer Bucurgat Ü., Başaran A.A., Başaran A. N., "Effects of Cinnamic acid on complications of diabetes", Turk J. Med. sci. 47, (2018).
• Anlar HG, Galbiati V, Corsini E, Basaran N. Evaluation of the Possible Role of miRNAs in Chemical Allergen Potency. Turk J Pharm Sci. 2020; 17(4):452-456.
• Anlar, HG, Bacanlı, M., Gündüzöz, M., İritaş, S., Tutkun, E., Yılmaz, Ö.H., Başaran, N. “Evaluation of health status of Turkish ceramic workers”, Clinical and Experimental Health Sciences, 2018, 8(3), 202-206
• Anlar, HG, Bacanlı, M., İritaş, SB, Bal, C., Kurt, T., Tutkun, E., Yılmaz, Ö.H., Başaran N. Effects of Occupational Silica Exposure on Oxidative Stress and Immune System Parameters in Ceramic Workers in Turkey. Journal of Toxicology and Environmental Health (JTEH) Portugal Symposium volume, 80(13-15): 688-696 (2017).
• Anlar, H.G., Bacanlı, M., Tuğbagül, Ç., Aydın, S., Arı, N., Ün Değer Bucurgat, Ü., Başaran, A.A., Başaran, N.: Effects of cinnamic acid on complications of diabetes. Turkish J Med Sci, 48: 168-177 (2018).
• Anlar, H.G., Taner, G., Bacanlı, M., İritaş, S., Kurt, T., Tutkun, E., Yılmaz, Ö.H. ve Başaran, N. “Assessment of DNA damage in ceramic workers”, Mutagenesis, 24;33(1):97-104, 2018
• Aydın, S., Bacanlı, M., Anlar, HG, Çal, T., Arı, N., Ün Değer Bucurgat, Ü., Başaran, AA, Başaran, N.: Preventive role of Pycnogenol® against the hyperglycemia-induced oxidative stress and DNA damage in diabetic rats. Food and Chemical Toxicology, 124: 54-63 (2019).
• Aydın, S., Erkekoglu, P., Başaran, N., Kocer-Gumusel, B.: Impact of selenium status on Aroclor 1254-induced DNA damage in sperm and different tissues of rats. Toxicol Mech Methods, 12:1-10 (2017).
• Aydın, S., Şahin, T.T., Bacanlı, M., Taner, G., Basaran, A.A., Aydın, M., Basaran, N.: Resveratrol treatment protects rat kidney and liver from sepsis induced oxidative damage. Balkan Medical Journal, 33(6): 594-601 (2016).
• Aydın, S., Tokaç, D., Başaran, N., Başaran, A.A. Effect of Epigallocatechin Gallate on Oxidative DNA Damage in Human Lymphocytes. Turkish Journal of Pharmaceutical Sciences. 12 (1), 19-28, (2015)
• Aydin, M., Aydin, S., Bacanlı, M., Basaran, N. Aflatoxin levels in chronic hepatitis B patients with cirrhosis or hepatocellular carcinoma in Balıkesir, Turkey. Journal of Viral Hepatitis, 22(11):926-935 (2015).
• Bacanlı M, Anlar HG, Aydın S, Çal T, Arı N, Ün Değer Bucurgat Ü, Başaran AA, Başaran N. d-limonene ameliorates diabetes and its complications in streptozotocin-induced diabetic rats. Food and Chemical Toxicology, 110: 434-441 (2017).
• Bacanlı M., Aydın S., Anlar HG, Çal T., Arı N., Ün Değer Bucurgat Ü., Başaran AA, Başaran, N. "Protective Effects of Ursolic Acid in The Kidneys of Diabetic Rats", Turk, J. Pharm. Sci., 15 (2), 166-170, (2018).
• Bacanlı M., Başaran AA., Başaran N. Cytotoxicity Evaluation of Some Phenolic Compounds in V79 Cells. Turkish Journal of Pharmaceutical Sciences, 12(3):53-61, (2015)
• Bacanlı, M., Anlar, HG, Başaran, AA, Başaran, N. Assessment of Cytotoxicity Profiles of Different Phenolics: Comparison of Neutral Red and MTT Assays in Different Cells in Different Time Periods, Turkish Journal of Pharmaceutical Sciences, 14(2 ), 95-107, 2017
• Bacanlı, M., Aydın, S., Anlar, H.G., Çal, T., Ari, N., Bucurgat Ündeger, Ü., Başaran, A.A. ve Başaran, N., “Can ursolic acid be beneficial against diabetes in rats?”, Turkish Journal of Biochemistry, 2018, 43(5), 520-529
• Bacanlı, M., Aydın, S., Taner, G., Göktaş, H.G., Sahin, T., Başaran, A.A., Başaran, N. Does rosmarinic acid treatment have protective role against sepsis-induced damage in Wistar albino rats? Human & Experimental Toxicology, 35(8):877-86 (2015).
• Bacanli, M., Basaran, A.A. ve Başaran, N., “The antioxidant, cytotoxic and antigenotoxic effects of galangin, puerarin and ursolic acid in mammalian cells”, Drug and Chemical Toxicology, 40(3): 256-262, (2017)
• Balcı A, Özkemahlı G, Erkekoglu P, Zeybek D, Yersal N, Kocer-Gumusel B. Effects of prenatal and lactational bisphenol a and/or di(2-ethylhexyl) phthalate exposure on male reproductive system. Int J Environ Health Res. 2020;1-14.
• Balci A, Ozkemahli G, Erkekoglu P, Zeybek ND, Yersal N, Kocer-Gumusel B. “Histopathologic, apoptotic and autophagic, effects of prenatal bisphenol A and/or di(2-ethylhexyl) phthalate exposure on prepubertal rat testis.” Environ Sci Pollut Res Int. 2020 Apr 1
• Başaran, N., Duydu, Y., Bacanlı, M., Anlar, H.G., Aydın Dilsiz, S., Üstündağ, A., Yalçın, C.Ö., Schwerdtle, T., Bolt, H.M. Evaluation of oxidative stress and immune parameters of boron exposed males and females. Food and Chemical Toxicology, 142, 1114888 (2020)
• Başaran, N., Duydu, Y., Üstündağ, A., Taner G., Aydın, S., Anlar, HG, Yalçın, C.Ö., Bacanlı, M., Aydos, K., Atabekoğlu, CS, Golka, K., Ickstadt, K., Schwerdtle, T., Werner, M., Meyer, S., Bolt, HM Evaluation of the DNA damage in lymphocytes, sperm and buccal cells of workers under environmental and occupational boron exposure conditions. Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 843:33-39 (2019)
• Başaran, N., Duydu, Y., Üstündağ, A., Taner, G., Aydın Dilsiz, S., Anlar, HG, Yalçın, C.Ö., Bacanlı, M., Golka, K., Schwerdtle, T., Bolt, HM: Environmental boron exposure does not induce DNA damage in lymphocytes and buccal cells of females: DNA damage in lymphocytes and buccal cells of boron exposed females. Journal of Trace Elements in Medicine and Biology, 53: 150-153 (2019).
• Baydar T, Kemer Evren Ö, Çakmak A, Kılıçarslan B, Girgin G, “Detection of neopterin in tear samples” Pteridines, 27 (1-2), 13-16, 2016.
• Bostanci, E.I., Dikmen, A.U., Girgin, G., Gungor, T., Baydar, T., Consultant, A.N. “A New Diagnostic and Prognostic Marker in Endometrial Cancer: Neopterin” Int J Gynecol Cancer, 27 (4), 754-758 (2017).
• Buyuktiryaki B, Sahiner UM, Girgin G, Birben E, Soyer OU, Cavkaytar O, Cetin C, Arik Yilmaz E, Yavuz ST, Kalayci O, Baydar T, Sackesen C, “Low indoleamine 2,3-dioxygenase activity in persistent food allergy in children” Allergy: European Journal of Allergy and Clinical Immunology, 71 (2), 258-266, 2016.
• Cebi G, Yildiz S, Uzun G, Oztas Y, Sabuncuoglu S, Kutlu A, Ilgaz Y, Karatop-Cesur I, Dogan E, Oztas E. The effect of hyperbaric oxygen therapy on rhabdomyolysis-induced myoglobinuric acute renal failure in rats. Ren Fail. 2016 Oct;38(9):1554-1559.
• Charehsaz M., Hougaard KS, Sipahi H., Doğan Ekici AI, Kapsar Ç., Culha M., Ün Değer Bucurgat Ü., Aydın A. "Effects of developmental exposure to silver in ionic and nanoparticle form: A study in rats" , DARU J.Pharm. Sci., 24:24 (DOI 10.1186/s40199-016-0162-9) (2016).
• Çal T, Ün Değer Bucurgat Ü. "In vitro investigation of the effects of boron nitride nanotubes and curcumin on DNA damage", DARU J. Pharm. Sci., 27(1):203-218 (2019).
• Demir N., Aydın S., Ün Değer Bucurgat Ü. "Assessment of Genotoxic Effects of Pendimethaline in Chinese Hamster Over (CHO) Cells by The Single Cell Gel Electrophoresis (Comet) Assay", Turk J.Pharm.Sci., 14(2), 185-190, (2017).
• Didem Şöhretoğlu, Yasin Genç, Ü. Sebnem Harput, Suna Sabuncuoğlu, Michal Šoral, Gülin Renda, Tibor Liptaj. Phytochemical Content, Antioxidant and cytotoxic Activities of Sedum spurium. Nat Prod Com 2016, 11 (11).
• Duydu Y, Başaran N, Üstündağ A, Aydın S, Ün Değer Ü, YavuzAtaman O, Aydos K, Düker Y, Ickstadt K, Waltrup BS, Golka K, Bolt HM. Is Boric Acid Toxic to Reproduction in Humans? Assessment of the Animal Reproductive Toxicity Data and Epidemiological Study Results. Current Drug Delivery, 13(3):324-9 (2016).
• Duydu Y, Başaran N, Üstündağ A, Aydın S, Yalçın CÖ, Anlar HG, Bacanlı M, Aydos K, Atabekoğlu CS, Golka K, Ickstadt K, Schwerdtle T, Werner M, Meyer S, Bolt HM. Birth weights of newborns and pregnancy outcomes of environmentally boron-exposed females in Turkey. Arch Toxicol. 92(8):2475-2485 (2018).
• Duydu Y, Başaran N, Yalçın CÖ, Üstündağ A, Aydın S, Anlar HG, Bacanlı M, Aydos K, Atabekoğlu CS, Golka K, Ickstadt K, Schwerdtle T, Werner M, Bolt HM. Boron-exposed male workers in Turkey: no change in sperm Y:X chromosome ratio and in offspring's sex ratio. Arch Toxicol. 2019 Mar;93(3):743-751
• Duydu Y., Başaran N., Üstündağ A., Aydın S., Ün Değer Ü., Yavuz Ataman O., Aydos K., Düker Y., Ickstadt K., Waltrup B.S., Golka K., Bolt H.M. ''Is Boric Acid Toxic to Reproduction in Humans? Assessment of the Animal Reproductive Toxicity Data and Epidemiological Study Results'', Curr Drug Deliv., 13(3), 324-329 (2016).
• Duydu, Y., Başaran, N., Aydın, S., Üstündağ, A., Yalçın, C.Ö., Anlar, HG, Bacanlı, M., Aydos, K., Atabekoğlu, CS, Golka, K. , Ickstadt, K., Schwerdtle, T., Werner, M., Meyer, S., Bolt, HM Evaluation of FSH, LH, testosterone levels and semen parameters in male boron workers under extreme exposure conditions. Archives of Toxicology, 92(10),3051-3059 (2018).
• Gatz, SA, Salles, D., Jacobsen, EM, Dörk, T., Rausch, T., Aydin, S., Surowy, H., Volcic, M., Vogel, W., Debatin, KM, Stutz, AM, Pannicke, U., Hess, T., Korbel, JO, Schulz, AS, Schumacher, J., Wiesmüller, L. MCM3AP and POMP mutations cause DNA-repair/damage-signaling defect in immunodeficient child. Human Mutation, 37(3):257-68 (2016).
• Goktas H.G., Bacanlı M., Kutluk B., Başaran AA., Başaran N. Cytotoxic Activity of Resveratrol in Different Cell Lines Evaluated by MTT and NRU Assays. Turkish Journal of Pharmaceutical Sciences 13(1): 27-34 (2016)
• Gulru Gurdemir, Pınar Erkekoglu, Aylin Balci, Unzile Sur, Gizem Ozkemahli, Engin Tutkun, Hinc Yilmaz, Ali Asci, &Belma Kocer Gumusel. “Oxidative Stress Parameters, Selenium Levels, DNA damage and Phthalate Levels in Plastic Workers” J Environ Pathol Toxicol Oncol, 38(3):253-270 (2019).
•    Gülin Renda, Ufuk Özgen, Zeynep Ünal, Suna Sabuncuoğlu, Erhan Palaska, İlkay Erdoğan Orhan. Flavonoid Derivatives From The Aerial Parts Of Trifolium Trichocephalum M. Bieb. And Their Antioxidant And Cytotoxic Activity. Rec. Nat. Prod. 11:5 (2017) 479-484.
•    Gürcü S, Girgin G, Yorulmaz G, Kılıçarslan B, Efe B, Baydar T, “Neopterin and Biopterin Levels and Tryptophan Degradation in Patients with Diabetes” Scientific Reports 10: 17025, 2020. DOI: https://doi.org/10.1038/s41598-020-74183-wGürcü, S., Girgin, G., Yorulmaz, G., Kılıçarslan, B., Efe, B., Baydar T. Neopterin and biopterin levels and tryptophan degradation in patients with diabetes. Sci Rep. 10: 17025 (2020).
•    Hameed H., Aydın S., Başaran AA., Başaran N. Assessment Of Cytotoxic Properties Of Sinapic Acid In Vitro. Turkish Journal of Pharmaceutical Sciences, 13(2):129-132, (2016)
•    Hermann M.B., Duydu, Y., Başaran, N., Golka, K. Boron and its compounds: current biological research activities. Archieves of Toxicology, 91: 2719-2722 (2017)
•    Isci Bostanci E, Ugras Dikmen A, Girgin G, Gungor T, Baydar T, Danisman NA, “A new diagnostic and prognostic marker in endometrial cancer: neopterin” International Journal of Gynecological Cancer, 27 (4), 754-758, 2017.
•    İnce T, Balcı A, Yalçın SS, Özkemahlı G, Erkekoglu P, Kocer-Gumusel B, Yurdakök K. Urinary bisphenol-A levels in children with type 1 diabetes mellitus. J Pediatr Endocrinol Metab. 2018 Aug 28;31(8):829-836.
•    Karacaoglu E, Girgin G, Selmanoğlu G, Baydar T, “Antioxidant Effects of Epigallocatechin Gallate in Cerulein-Induced Pancreatitis”, IUFS Journal of Biology, 2019, 78 (2), 125-133. DOI: 10.26650/EurJBiol.2019.0035
•    Kılıç Süloğlu, A., Selmanoğlu, G., Gundogdu, O., Kishalı, N., Girgin, G., Palabiyik, S., Kara, Y., Baydar, T. Evaluation of isoindole derivatives: Antioxidant potential and cytotoxicity in the HT-29 colon cancer cells. Arch Pharm (Weinheim) 2020;e2000065. doi: 10.1002/ardp.202000065.
•    Kilicarslan B, Cardak A, Girgin, Kemer Evren O, Baydar T, “An exploratory study of neopterin and kynurenine pathway in pterygium”, Pteridines, 2019, 30 (1), 153-157. [doi:10.1515/pteridines-2019-0019].
•    Kizilgun M, Takci S, Erkekoglu P, Asci A, Balci A, Yigit S, Kocer-Gumusel B. ‘Copper, zinc and iron levels in premature infants following red blood cell transfusion.’ J Trace Elem Med Biol. 2016 Dec;38:126-130.
•    Kurt OK, Basaran N. Occupational Exposure to Metals and Solvents: Allergy and Airway Diseases. Curr Allergy Asthma Rep. 2020 Jun 6;20(8):38.
•    Kurt, Ö., Ergun, D., Başaran, N. “Can the ceramic industry be a new and hazardous sector for work-related asthma?”, Respiratory Medicine, 137, 176-180, 2018
•    Møller P, Azqueta A, Boutet-Robinet E, Koppen G, Bonassi S, Milić M, Gajski G, Costa S, Teixeira JP, Costa Pereira C, Dusinska M, Godschalk R, Brunborg G, Gutzkow KB, Giovannelli L, Cooke MS, Richling E, Laffon B, Valdiglesias V, Basaran N, Del Bo' C, Zegura B, Novak M, Stopper H, Vodicka P, Vodenkova S, de Andrade VM, Sramkova M, Gabelova A, Collins A, Langie SAS. Minimum Information for Reporting on the Comet Assay (MIRCA): recommendations for describing comet assay procedures and results. Nat Protoc. 2020;15(12):3817-26.
•    Ozkan Vardar, D., Aydin, S., Hocaoglu, İ., Yagci Acar, F.H., Basaran, N: Effects of silver sulfide quantum dots coated with 2-mercaptopropionic acid on genotoxic and apoptotic pathways in vitro. Chemico-Biological Interactions, 291:212–219, (2018).
•    P. Erkekoglu, Y. Üçkardeş, E.N. Özmert, B. Kocer-Gumusel, K. Yurdakök. The effect of zinc supplementation on salivary cortisol levels and salivary amylase activity in primary school children with low socioeconomic status. MOJ Toxicology. 2016, 2(2): 00032.
•    Palabiyik SS, Keles S, Girgin G, Arpali-Tanas E, Topdagi E, Baydar T, “Neopterin release and tryptophan degradation in patients with uveitis” Current Eye Research, 41 (11), 1513-1517, 2016.
•    Palabiyik, Girgin G, Aşçı A, Demirelli S, Uslu A, Karakelleoglu S, Akcay F, Aksakal E, Şahin G, Baydar T, “Folate, neopterin and kynurenine pathway in patients with statin therapy” Pteridines, 27 (1-2), 7-12, 2016.
•    Palabiyik, S.S., Keles, S., Girgin, G., Arpali-Tanas, E., Topdagi, E., Baydar, T. “Neopterin Release and Tryptophan Degradation in Patients with Uveitis” Current Eye Res, 41 (11), 1513-1517 (2016).
•    Sabuncuoglu, S., Erkekoglu, P., Aydin, S., Sahin, G., Kocer-Gumusel, B. The effects of season and gender on the serum aflatoxins and ochratoxin A levels of healthy adult subjects from the Central Anatolia Region, Turkey. European Journal of Nutrition, 2015, 54(4): 629-38 (2015).
•    Sabuncuoğlu S, Öztaş Y, Yalcinkaya A, Ünal S, Baydar T, Girgin G. The increased neopterin content in turkish pediatric patients with sickle cell anemia. Ann Hematol. 2020 Jan;99(1):41-47.
•    Samadi A, Isikhan SY, Ansari MHK, Samadi M, Sabuncuoglu S. Effects of clozapine and haloperidol treatment on plasma concentrations of androgen hormones and androgendependent organ changes in rats. Indian J Pharmacol. 2019 Jul-Aug;51(4):269-275.
•    Sarıgöl Kılıç Z.,  Çal T., Ündeğer Bucurgat Ü. "Evaluation of Methylation and Acetylation Profiles of Dinitroaniline Herbicides and Resveratrol on V79 Cell Line", Turk J Pharm Sci., 17 (6), 631-637, (2020).
•    Sarıgöl Kılıç Z., Aydın S., Ündeğer Ü., Başaran N. "In Vitro Genotoxicity Assessment of Dinitroaniline Herbicides Pendimethalin and Trifluralin", Food Chem. Tox., 113, 90-98 (2018).
•    Sarıgöl Kılıç Z., Ündeğer Bucurgat Ü. "Pendimetalin ve Trifluralinin Apopitotik ve Anti-apopitotik Etkilerinin A549 Hücrelerinde İn Vitro Değerlendirilmesi", Turk J.Pharm.Sci., 15 (3), 364-369, (2018).
•    Sipahi, H., Girgin, G., Palabiyik, S.S., Tutkun, E., Yilmaz, O.H., Baydar, T. “Possible changes of New-Generation inflammation markers with occupational lead exposure” J Occup Health, 59 (4), 345-351 (2017).
•    Suna Sabuncuoğlu, Solmaz Mohammadi Nejad, Didem Şöhretoğlu. Geranium Psilostemon Ledeb. Bitkisinden Elde Edilen Fenolik Bileşikler Ve Hidrolizlenebilir Tanenlerin Sitotoksik Ve Genotoksik Özelliklerinin Değerlendirilmesi. Hujpharm, 2017 No:2
•    Sunman B, Yurdakök K, Gümüşel BK, Özyüncü Ö, Akbıyık F, Balcı A, Özkemahlı G, Erkekoğlu P, Yurdakök M. Prenatal bisphenol A and phthalate exposure are risk factors for male reproductive system development and cord blood sex hormone levels. Reprod Toxicol. 2019. pii: S0890-6238(18)30423-4.
•    Süloglu AK, Selmanoglu G, Gündoğdu Ö, Kishalı NH, Girgin G, Palabıyık ŞS, Kanat ÖN, Tan A, Kara Y, Baydar T, “Evaluation of Isoindole Derivatives: Antioxidant Potential and Cytotoxicity in the HT-29 Colon Cancer Cells” Archiv der Pharmazie 2020; 353: (e200006) DOI: 10.1002/ardp.202000065
•    Taner, G., Özkan Vardar, D., Aydın, S., Aytaç, Z., Basaran, A., Basaran, N.: Use of in vitro assays to assess the potential cytotoxic, genotoxic and antigenotoxic effects of Vanillic and cinnamic acid. Drug and Chemical Toxicology, 40(2):183-190 (2017).
•    Teksam O, Sabuncuoğlu S, Girgin G, Özgüneş H. Evaluation of oxidative stress and antioxidant parameters in children with carbon monoxide poisoning. Hum Exp Toxicol. 2019 Nov;38(11):1235-1243.
•    Tokaç, D., Anlar, H., Bacanlı, M., Aydın Dilsiz, S., İritaş, S.B. Başaran, N.: Oxidative stress status of Turkish welders. Toxicology and Industrial Health, 36(4):263-271(2020)
•    Tokaç, M., Aydın, S., Taner, G., Özkardeş, A.B., Taşlıpınar, M.Y., Doğan, M. Dündar, H.Z., Kılıç, M., Başaran, A.A., Basaran, N.: Hepatoprotective and antioxidant effects of lycopene in acute cholestasis. Turkish Journal of Medical Science, 45 (4): 857-64 (2015).
•    Tokaç, M., Bacanlı, M., Dumlu, E.G., Aydın, S., Engin, M., Bozkurt, B., Yalçın, A., Erel, Ö., Kılıç, M. ve Başaran, N. “The ameliorative effects of pycnogenol® on liver ischemia-reperfusion injury in rats”, Turkish Journal of Pharmaceutical Sciences, 14(3):257-263, 2017
•    Unuvar S, Girgin G, Sahin TT, Kilicarslan B, Taneri F, Yuksel O, Baydar T, “Tryptophan degradation and antioxidant status in patients with thyroid disorders”, Archives of Iranian Medicine, 21 (9), 399-405, 2018.
•    Unuvar, S., Erge, D., Kilicarslan, B, Bag, H.G.G., Catal, F., Girgin, G., Baydar, T. “Neopterin Levels and Indoleamine 2,3-Dioxygenase Activity as Biomarkers of Immune System Activation and Childhood Allergic Diseases” Annals Lab Med, 39 (3), 284-290 (2019).
•    Yalcinkaya A, Samadi A, Lay I, Unal S, Sabuncuoglu S, Oztas Y. Oxysterol concentrations are associated with cholesterol concentrations and anemia in pediatric patients with sickle cell disease. Scand J Clin Lab Invest. 2019 Oct;79(6):381-387.
•    Zeybek D. N., Sur Ü., Oflaz O., Erkekoglu P., Balci A., Ozkemahli G, Aşçı A., Kızılgün M., Edebal O., Koçer-Gümüşel B. Renal changes and apoptosis caused by subacute exposure to Aroclor 1254 in selenium-deficient and seleniumsupplemented rats. Arh Hig Rada Toxicol. 71:2,110-120 2020
•    Zor, M., Aydın, S.,  Güner, N.D., Basaran, A.A., Basaran, N. Antigenotoxic properties of Paliurus spina-christi Mill fruits and their active compounds. BMC Complement Altern Med. 17: 229-239 (2017).

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