Pharmacognosy Department Research Laboratory

About

Research Infrastructure

• Refrigerator (-20°C)
• Refrigerator(-80°C)
• Large Volume Extractor
• Fume Hood
• Oven
• Precision Balance
• Heated Shaker (Plate)
• Air Conditioning Cabinet
• Camera Microscope
• Lyophilizer
• Mono Distilled Pure Water Device
• Mplc
• Rotavopor
• Centrifuge
• Refrigerated Microcentrifuge
• Water bath
• Ultra Pure Water Producer
• Ultrasonic Water Bath
• UV Cabinet
• Vacuum Pump
• Vortex
• Nitrogen Tank
• CO2 Incubator
• Shaking Water Bath
• Extractor
• Oven
• HPLC
• Incubator
• Gel Electrophoresis
• Gel Imaging System
• Laminar Flow Cabinet
• Microplate Reader
• Autoclave
• Herb Mill
• Fume Hood
• Oven
• Microscope
• Rotavopor

Researchers

•    Prof. Dr. Funda Nuray YALÇIN
•    Prof. Dr. İclal SARAÇOĞLU
•    Prof. Dr. Lütfiye Ömür DEMİREZER
•    Prof. Dr. Zeliha Şükran AKDEMİR
•    Prof. Dr. Ayşe KURUÜZÜM UZ
•    Doç. Dr. Dilek ERCİL
•    Doç. Dr. Didem ŞÖHRETOĞLU
•    Dr. Öğr. Üyesi Çiğdem KAHRAMAN
•    Dr. Öğr. Üyesi Yasin GENÇ
•    Dr. Ecz. Vahap Murat KUTLUAY
•    Dr. Ecz. Mine UZUN
•    Dr. Ecz. Zeynep DOĞAN
•    Dr. Ecz. Nadire ÖZENVER
•    Ecz. Nuriye Hilal TAŞTEkin
•    Filiz BOYALI
•    Hande Büşra KELEŞ
•    Hilal ERDEM
•    Kübra UZUN
•    Mehmet UZUN
•    Melike UTLU
•    Merve ŞENSOY
•    Nida KÖKLÜYURT
•    Pınar İKİZ
•    Saliha Meryem ZENBİLCİ
•    Seren GÜNDOĞDU
•    Sevda Deniz DALĞIN
•    Sümeyye ÇOBAN
•    Rabia Sena GÜNEŞER
•    Ahmet Yasin AKCAN
•    Sevda KARABEYESER
•    Bilge SALAR
•    Eliz UYANIR
•    Halime Eda YALÇIN

Ongoing Projects

• 118z708; Taxonomy, phylogeny and phylogeny of Turkey Polygala L. (Polygalaceae) Genus with Biosystematic and Chemosystematic Approach; Ali Donmez; Esra Martin, Funda N. Yalçın, Emel Dönmez, Hatice Nurhan Büyükkartal, Metin Tuna, Zübeyde Uğurlu Aydın, İhsan Çalış, Ömer Bayazeid; 720,000 TL; 2019-
• Thd-2019-18123; Isolation of Antioxidant, Cytotoxic and Anti-inflammatory Compounds From Acanthus Spinosus L.; Zeynep Dogan; İclal Saraçoğlu, Seçil Sarıkaya Aydın; 29,987 TL; 2019-
• Thd-2019-17884; Potential Drug Research on Peganum Harmala L. Seeds Used as a Folk Medicine; Vahap Murat Kutluay; A. Ahmet Basaran, Nuriye Hilal Tastekin; 29,992 TL
• 1001-Phytochemical Analysis of Some Gentianella Species and Effects of Xanthones on Bdnf (Brain-Derived Neurotrophic Factor) Pathway; prof. Dr. Funda N. Yalçın, Duygu Kaya, Pelin Kelicen; Omer Bayazeid, Pinar Ikiz; 451,570 TL; 2017-

Completed Projects

• 119s020; Endemic Scutellaria Rubicunda Hornem. Subsp. Brevibracteata J.R.Edm. Investigating the Anti-Inflammatory Effect of the Plant and Explaining the Possible Effect Mechanism; Zeynep Dogan; İclal Saraçoğlu, Gökçen Telli, Banu Cahide Tel; 44,990 TL
• Acanthus Dioscoridis L. Var. Isolation of Compounds with Antioxidant, Cytotoxic and Anti-inflammatory Effects from Dioscoridis L. Tdk-2017-14444; prof. Dr. İclal Saracoglu; 29,756.10 TL
• Isolation of Antioxidant, Cytotoxic and Anti-inflammatory Compounds from Acanthus Spinosus L. (2019). (Researcher in Project No. Hü-Bab Thd-2019-18123. Director: Dr. Pharm. Seçil Sarikaya Aydın, Other Researchers: Dr. Pharmacist. Zeynep Doğan
• Bab Rapid Support: “In Vitro Antidiabetic Studies in Prunus Mahaleb L. Seeds and Fruit Peels Used as Folk Medicine and Food” Researchers: Zühal Güven, Director: Dr. Zeynep Doğan, Budget: 29959.02 TL
• Fhd-2018- 17122, Biology, Biodiversity and Conservation of Flag Species Polygala Azizsancarii; Ali Donmez; Funda N. Yalcin; 30.000 TL
• Pharmacognostic Studies on Some Scutellaria L. Species, Sources of Pharmaceutical Raw Material Tdk-2017-14236; prof. Dr. İclal Saracoglu; 24,914,50 TL
• Mev-2017-155; Investigation of Biological Effects and Effect Mechanisms of Some Medicinal Plants Grown in Turkey at Molecular Level; Yasin Young; Kübra Uzun; 29,922.00 TL
• Mev-2017-204, Project Name: Investigation of Biological Effects and Effect Mechanisms of Plants Belonging to the Families of Scrophulariaceae and Plantaginaceae at the Molecular Level; Project Coordinator: Çiğdem Kahraman; Project Researchers: Melike Utlu, Ken-Ichi Nakashima; Project Budget: 29,922.00 TL
• Mev-2017-204; Investigation of Biological Effects and Effect Mechanisms of Plants Belonging to Scrophulariaceae and Plantaginaceae Families at Molecular Level; Cigdem Hero; Melike Utlu, Ken-Ichi Nakashima; 29,922.00 TL
• Plantago Holosteum Scop. Pharmacognosic Studies on Tdk-2017-13724 Prof. Dr. İclal Saracoğlu 1466.15 TL
• Polygonum Equisetiforme Sibth. Et Sm. Phytochemical and Biological Activity Studies on Thd-2017-11469 Prof. Dr. Ayşe Kuruüzüm Long 29,982.27 TL
• Determination of the Chemical Profile of Rosa Damascena and Investigation of Its Skin Aging Delaying Effects Thd-2017-15631; Prof. dr. L. Omur Demirezer; 29,990.49 TL
• Tdk-2018-17578; Lavandula Stoechas L. Subsp. Biological Activity Guided Studies on Stoechas; prof. Dr. Ayşe Uz; Merve Yüzbaşıoğlu Baran; Sümeyye Çoban, Omer Bayazeid; prof. Dr. Funda N. Yalcin; 29999.30 TL
• Thd-2017-11469; Polygonum Equisetiforme Sibth. Et Sm. Phytochemical and Biological Activity Studies; prof. Dr. Ayşe Uz; Merve Yüzbaşıoğlu Baran, Mehmet Uzun; 29982.27 TL
• Thd-2017-15620; Pharmacognosic Research on Fruit Shells of Prunus Mahaleb L. Seeds Used as Folk Medicine and Food; prof. Dr. A. Ahmet Basaran; pharmacist. Zühal Güven; 29,886.70 TL
• Thd-2017-15631; Determination of the Chemical Profile of Rosa Damascena and Investigation of Its Anti-Aging Effects; prof. Dr. L. Omur Demirezer; Tuncay Agar; 29 000TL
• Thd-2018-16945; In Vitro and In Silico Investigation of Alpha-Glucosidase and Tyrosinase Enzyme Inhibitor Effect Mechanisms of Some Flavonoids by Kinetic and Computer Modeling Methods; Director: Didem Şöhretoğlu; Researchers: Suat Sarı, Burak Barut, Arzu Özel. Budget: 22607.95 TL
• Thd-2018-17448; In Vitro and In Silico Investigation of Topoisomerase Enzyme Inhibitor Effects on DNA Binding Modes of Polydatin and Kirsosplenetin; Didem Sohretoglu; Suat Sari, Burak Barut, Arzu Ozel; 35999.30 TL
• Thd-2019-18076; In Vitro Antidiabetic Studies on Prunus Mahaleb L. Seeds and Fruit Peels Used as Folk Medicine and Food; Zeynep Dogan; Arif Ahmet Basaran, Zühal Güven; 29,959 TL
• Tubitak 3001 Project Project No: 217s206; Project Name: Bioactivity-Guided Isolation and Characterization of Responsible Substances from Eleagnus Angustifolia L. and Paliurus Spina-Christi Miller Plants with Traditional Use for Antidiabetic Purposes. Dr. Zühal Güvenalp Project Researchers: Prof. Dr. L. Omur Demirezer, Assoc. Dr. Hilal Özbek Project Budget: 59,050 TL

Publications

• Akkol Ek, Genc Y, Watermelon B, Sobarzo-Sanchez E, Capasso R. Coumarins And Coumarin-Related Compounds In Pharmacotherapy Of Cancer. Cancers. 2020;12(7):1959.
• Akkol Ek, Ilhan M, Karpuz B, Genc Y, Sobarzo-Sanchez E. Sedative And Anxiolytic Activities Of Opuntia Ficus Indica (L.) Mill.: An Experimental Assessment In Mice. molecules 2020;25(8):1844.
• Anlar Hg, Bacanli M, Cal T, Aydin S, Ari N, Undeger Bucurgat U, Et Al. Effects Of Cinnamic Acid On Complications Of Diabetes. Turk J Med Sci. 2018;48(1):168-77.
• Anlar Hg, Bacanli M, Kutluk B, Basaran Aa, Basaran An. Cytotoxic Activity Of Resveratrol In Different Cell Lines Evaluated By Mtt And Nru Assays. Turk J Pharm Sci. 2016;13(1), 27-34.
• Anlas C, Bakirel T, Ustun-Alkan F, Celik B, Baran My, Ustuner O, Et al. In Vitro Evaluation Of The Therapeutic Potential Of Anatolian Kermes Oak (Quercus Coccifera L.) As An Alternative Wound Healing Agent. Ind Crop Prod. 2019;137:24-32.
• Arroo Rrj, Sari S, Barut B, Özel A, Ruparelia Kc, Şöhretoğlu D. Flavones As Tyrosinase Inhibitors: Kinetic Studies In Vitro And In Silico. Phytochem Anal. 2020;31(3):314-21.
• Aydin S, Bacanli M, Anlar Hg, Cal T, Ari N, Bucurgat Uu, Et al. Preventive Role Of Pycnogenol (R) Against The Hyperglycemia-Induced Oxidative Stress And Dna Damage In Diabetic Rats. FoodChem. 2019;124:54-63.
• Aydin S, Sahin Tt, Bacanli M, Taner G, Basaran Aa, Aydin M, Basaran An. Resveratrol Treatment Protects Rat Kidney And Liver From Sepsis Induced Oxidative Damage. Balkan Med J 2016; 33(6) 594-601. (Sci Exp)
• Bacanlı, M., Anlar, H.G., Arı, N., Başaran, A.A., Başaran, N., The Effects of Herbal Extract Pycnogenol® on Diabetes Mellitus Treatment. Turkiye Klinikleri J Pharm Sci, 2017. 6: P. 25-31.
• Bacanlı M., Anlar H.G. Food Chem Toxicol, 2017. In Edition: Doi: 10.1016/J.Fct.2017.09.020.
• Bacanlı, M., Anlar, H.G., Başaran, A.A., Başaran, N., Assessment Of Cytotoxicity Profiles Of Different Phytochemicals: Comparison Of Neutral Red And Mtt Assays In Different Cells In Different Time Periods. Turk J Pharm Sci, 2017. 14: P. 95-107.
• Bacanlı, M., Aydın S., Anlar, H.G., Çal, T., Bucurgat Ündeger, Ü., Başaran, A.A., Başaran, N. Protective Effects Of Ursolic Acid In The Kidneys Of Diabetic Rats. Turk J Pharm Sci, 2017. In ed.
• Bacanlı, M., Aydın, S., Başaran, A.A., Başaran, N. Are All Phytochemicals Useful In The Prevention Of DNA Damage. Food Chem Toxicol, 2017. 109: P. 210-17.
• Bacanlı, M., Başaran, A.A., Başaran, N., The Antioxidant, Cytotoxic And Antigenotoxic Effects Of Galangin, Puerarin And Ursolic Acid In Mammalian Cells. Drug Chem Toxicol, 2017. 40: P. 256-62.
• Bacanlı, M., Başaran, N. , Başaran, A.A., Galangin And Its Antiinflammatory Properties. Medicinal & Analytical Chemistry International Journal, 2017, 1: In Press
• Bacanli M, Anlar Hg, Basaran An, Ari N, Basaran Aa. Beneficial Effects Of Commonly Used Phytochemicals In Diabetes Mellitus. Acta Pharm Sci 2016; 54(1), 9-20.
• Bacanli M, Aydin S, Anlar Hg, Cal T, Ari N, Bucurgat Uu, Et al. Can Ursolic Acid Be Beneficial Against Diabetes In Rats? Turk J Biochem. 2018;43(5):520-9.
• Bacanli M, Aydin S, Anlar Hg, Cal T, Bucurgat Uu, Ari N, Et al. Protective Effects Of Ursolic Acid In The Kidneys O Diabetic Rats. Turk J Pharm Sci. 2018;15(2):166-70.
• Baran My, Şöhretoğlu D, Uz Ak. Quantitative Analysis Of Polydatin In A Turkish Oak: Quercus Coccifera L. With Hplc-Dad. Ijsm. 2019;6(3):233-40
• Barut B, Şöhretoğlu D. Total Phenolic Content, Cyclooxygenases, Α-Glucosidase, Acetylcholinesterase, Tyrosinase Inhibitory And Dpph Radical Scavenging Effects Of Cornus Sanguinea Leaves And Fruits. JRes Pharm. 2020;24(5):623-31.
• Bayazeid O And Yalçın Fn. Biological Targets Of 92 Alkaloids Isolated From Papaver Genus: A Perspective Based On In Silico Predictions. MedChem Res. 2020;1-12.
• Bayazeid O, Bedir E, Yalcin Fn. Ligand-Based Virtual Screening And Molecular Docking Of Two Cytotoxic Compounds Isolated From Papaver Lacerum. Phytochem Lett. 2019;30:26-30.
• Bayazeid O, Eylem Cc, Recber T, Yalcin Fn, Kir S, Nemutlu E. An Lc-Esı-Ms/Ms Method For The Simultaneous Determination Of Pronuciferine Arid Roemerine In Some Papaver Species. J Chromatogr B. 2018;1096:223-7.
• Bayazeid O, Nemutlu E, Eylem Cc, İlhan M, Kupeli Akkol E, Karahan H Ve Ark. Neuroactivity Of The Naturally Occurring Aporphine Alkaloid, Roemerine. Nat Prod Res. 2020;1-6.
• Bayazeid O, Nemutlu E, Eylem Cc, Yalçın Fn. Neuroactivity Of Naturally Occurring Proaporphine Alkaloid, Pronuciferine. J Biochem Mol Toxicol. 2020;E22601.
• Chowdhury Hm, Sharmin N, Baran My, Long L, Morrell Nw, Trembath Rc, Et al. Bmprii Deficiency Impairs Apoptosis Via The Bmprii-Alk1-Bclx-Mediated Pathway In Pulmonary Arterial Hypertension. Hum Mol Genet. 2019;28(13):2161-73.
• Demirezer Lö, Uzun M, Ozenver N, Güvenalp Z. Determination Of Phytoestrogenic Potential Of Anthranoids By Molecular Docking Studies, Fabad, J. Pharm. sci. 2018;43(3):129-41.
• Diker Ny, Kahraman C, Akkol Ek, Karaoglu Mt, Comoglu T, Akdemir Zs, Et Al. The Evaluation Of Sterile Solutions Of Ilwensisaponin A And C From Verbascum Pterocalycinum Var. Mutense Hub.-Purple. On Antiviral, Antinociceptive And Anti-Inflammatory Activities. Saudi Pharm J. 2019;27(3):432-6.
• Dogan Z, Ishiuchi Ki, Makino T, Saracoglu I. New Acylated Iridoid Glucosides From Scutellaria Glaphyrostachys Rech. F. And Chemotaxonomic Importance For The Genus Scutellaria. Phytochem Lett. 2019;32:157-61.
• Doğan Z, Ishiuchi Kı, Makino T, Saraçoğlu İ. Alpha-Pyrone Glycosides From Scutellaria Salviifolia Benth. Turk J Chem. 2019;43(3):972-81.
• Dönmez C, Yalçın Fn, Boyacıoğlu Ö, Korkusuz P, Akkol Ek, Nemutlu E Ve Ark. From Nutrition To Medicine: Assessing Hemorrhoid Healing Activity Of Solanum Melongena L. Via In Vivo Experimental Models And Its Major Chemicals. J Ethnopharmacol. 2020;261:113143.
• Efferth T, Banerjee M, Abu-Darwish Ms, Abdelfatah S, Bockers M, Bhakta-Guha D, Et Al. Biopiracy Versus One-World Medicine-From Colonial Relicts To Global Collaborative Concepts. phytomedicine 2019;53:319-31.
• Genc Y, Bardakci H, Yucel C, Karatoprak Gs, Akkol Ek, Barak Th Ve Ark. Oxidative Stress And Marine Carotenoids: Application By Using Nanoformulations. Mar Drugs. 2020;18(8):423.
• Genc Y, Dereli Ftg, Saracoglu I, Akkol Ek. The Inhibitory Effects Of Isolated Constituents From Plantago Major Subsp. Major L. On Collagenase, Elastase And Hyaluronidase Enzymes: Potential Wound Healer. Saudi Pharm J. 2019.
• Genc Y, Guragac Dereli Ft, Saracoglu I, Kupeli Akkol E. The Inhibitory Effects Of Isolated Constituents From Plantago Major Subsp. Major L. On Collagenase, Elastase And Hyaluronidase Enzymes: Potential Wound Healer. Saudi Pharm J. 2020;28(1):101-6.
• Genc Y, Harput Us, Saracoglu I. Active Compounds Isolated From Plantago Subulata L. Via Wound Healing And Antiinflammatory Activity Guided Studies. J Ethnopharmacol. 2019;241.
• Genc Y, Sohretoglu D, Harput Us, Ishiuchi K, Makino T, Saracoglu I. Chemical Constituents From Plantago Holosteum Scop. And Evaluation Of Their Chemotaxonomical Significance. ChemNat Comp. 2020;56(3):566-8.
• Gonulalan Em, Bayazeid O, Yalcin Fn, Demirezer Lo. The Roles Of Valerenic Acid On Bdnf Expression In The Sh-Sy5y Cell. Saudi Pharm J. 2018;26(7):960-4.
• Gonulalan Em, Nemutlu E, Bayazeid O, Koçak E, Yalçın Fn, Demirezer Lo. Metabolomics And Proteomics Profiles Of Some Medicinal Plants And Correlation With Bdnf Activity. phytomedicine 2019:152920.
• Gonulalan Em, Nemutlu E, Bayazeid O, Koçak E, Yalçın Fn, Demirezer Lo. Metabolomics And Proteomics Profiles Of Some Medicinal Plants And Correlation With Bdnf Activity. phytomedicine 2020; 74:152920.
• Gonulalan Em, Nemutlu E, Demirezer Lo. A New Perspective On Evaluation Of Medicinal Plant Biological Activities: The Correlation Between Phytomics And Matrix Metalloproteinases Activities Of Some Medicinal Plants. Saudi Pharm J. 2019;27(3):446-52.
• Gönülalan Em, Nemutlu E, Demirezer Lo. Metabolomics (Phytomics) Studies and Its Importance in Phytotherapy, Metabolomics (Phytomics) Studies and Its Importance In Phytotherapy. Turkey Clinics Traditional and Complementary Medicine-Special Topics.2020:68-74.
• Guragac Dereli Ft, Genc Y, Saracoglu I, Kupeli Akkol E. Enzyme Inhibitory Assessment Of Isolated Constituents From Plantago Holosteum Scop. Z Naturforch C. 2020;75(3-4):121-8.
• Gurbuz P, Baran My, Demirezer Lo, Guvenalp Z, Kuruuzum-Uz A. Phenylacylated-Flavonoids From Peucedanum Chryseum. Rev Bras Pharmacogn. 2018;28(2):228-30.
• Gurbuz P, Kosar M, Guvenalp Z, Uz Ak, Demirezer Lo. Simultaneous Determination Of Selected Flavonoids From Different Cistus Species By Hplc-Pda. JRes Pharm. 2018;22(3):405-10.
• Guvenalp, Z., Et Al., Cholinesterase Inhibition And Molecular Docking Studies Of Sesquiterpene Coumarin Ethers From Heptaptera Cilicica, Rec. Nat. Prod., 2017. 11(5): P. 462-467.
• Gündoğdu S, Ayhan S, Raisin-Uz A. A Review on Herbal Source Studies for the Treatment of Substance Addiction. Literature Journal of Pharmaceutical Sciences. 2020; Doi: 10.5336/Pharmsci.2019-72972.
• Hameed H, Aydin S, Basaran Aa, Basaran An. Assessment Of Cytotoxic Properties Of Sinapic Acid In Vitro. Turk J Pharm Sci. 2016;13(2), 129-132. (International Referee)
• Ihtesham Y, Khan U, Dogan Z, Kutluay Vm, Saracoglu I. Evaluation Of Some Biological Effects Of Incarvillea Emodi (Royle Ex Lindl.) Chatterjee And Determination Of Its Active Constituents. Kafkas Univ Vet Fak. 2019;25(2):171-8.
• Kahraman C, Tatli II, Card D, Ekizoglu M, Akdemir Zs. Structure Elucidation And Antimicrobial Activities Of Secondary Metabolites From The Flowery Parts Of Verbascum Mucronatum Lam. Turk J Pharm Sci. 2018;15(3):231-7.
• Kahraman C, Topcu G, Bedir E, Tatli II, Ekizoglu M, Akdemir Zs. Phytochemical Screening And Evaluation Of The Antimicrobial And Antioxidant Activities Of Ferula Caspica M. Bieb. Extracts. Saudi Pharm J. 2019;27(4):525-31.
• Kahraman C, Zare G, Arabaci S, Kupeli Akkol E, Tatli Cankaya II. Evaluation Of Cucurbita Pepo L. Seeds Used In Folk Medicine For Their Anti-Inflammatory And Wound Healing Activity. MedScience. 2020;9(2):381-4.
• Kahraman Ç, Baysal İ, Çankaya İ, Göger F, Kırıker N, Akdemir Zş. Acetylcholinesterase Inhibitory Activities And Lc-Ms Analysis Of The Antioxidant Ferula Caspica M. Bieb. And F. Halophila Peşmen Extracts. J Pharm Res. 2019; 23(3):543-551.
• Karatoprak Gs, Akkol Ek, Genc Y, Bardakci H, Yucel C, Sobarzo-Sanchez E. Combretastatins: An Overview Of Structure, Probable Mechanisms Of Action And Potential Applications. Molecules 2020;25 (11):2560.
• Koca-Caliskan U, Yilmaz I, Taslidere A, Yalcin Fn, Aka C, Sekeroglu N. Cuscuta Arvensis Beyr "Dodder": In Vivo Hepatoprotective Effects Against Acetaminophen-Induced Hepatotoxicity In Rats. J Med Food. 2018;21(6):625-31.
• Kutluay Vm, Diker Ny. Constitution Of A Comprehensive Phytochemical Profile And Network Pharmacology Based Investigation To Decipher Molecular Mechanisms Of Teucrium Polium L. In The Treatment Of Type 2 Diabetes Mellitus. Peerge. 2020;8:E10111.
• Kutluay Vm, Inoue M, Saracoglu I. Assessment Of Lxrα Agonist Activity And Selective Antiproliferative Efficacy: A Study On Different Parts Of Digitalis Species. Turk J Biochem. 2019;44(6):745-51.
• Kutluay Vm, Ishiuchi K, Makino T, Saracoglu I. Cytotoxic Phenylethanoid Glycosides From Digitalis Davisiana Heywood: Evaluation Of Structure Activity Relationships And Chemotaxonomical Significance Of Isolated Compounds. phytotherapy 2019;135:90-8.
• Kutluay Vm, Makino T, Inoue M, Saracoglu I. New Knowledge About Old Drugs; A Cardenolide Type Glycoside With Cytotoxic Effect And Unusual Secondary Metabolites From Digitalis Grandiflora Miller. phytotherapy 2019;134:73-80.
• Kutluay Vm, Saracoglu I. Cytotoxic Effect Of Some Digitalis Species; A Study Of Selectivity. Fabad J Pharm Sci. 2018; 43(1):25-29.
• Orhan E, Aka İö, Yüzbaşıoğlu M, Yavuz B, Bilensoy E, Uz Ak. The Effect Of Quercus Coccifera L. Extract On The Necrosis Of Random-Pattern Skin Flaps In Rats. Med Bull Haseki, 2019;57(3):249-254.
• Orhan E, Yüzbaşıoğlu M, Erol Yr, Bilensoy E, Erdoğar N, Demirezer Lö, Et Al. The Effect Of Arnebia Purpurea Extract On The Survival Of Random Pattern Skin Flaps In Rats. The European Research Journal. 2018;4(3):152-6.
• Osmanlıoğlu Dağ, R., Kuruüzüm-Uz, A., The Role of Ginger in Pharmacy and Its Antitumor Effect, Hacettepe University Faculty of Pharmacy Journal. 38(2) 76-84 (2018).
• Ozbek H, Guvenalp Z, Yilmaz G, Yerdelen Ko, Kazaz C, Demirezer Ol. In Vitro Anticholinesterase Activity And Molecular Docking Studies Of Coumarin Derivatives Isolated From Roots Of Heptaptera Cilicica. MedChem Res. 2018;27(2):538-45.
• Ozbek, H., Et Al., Chemical Composition, Antioxidant And Anticholinesterase Activities Of The Essential Oil Of Origanum Rotundifolium Boiss. From Turkey, Rec. Nat. Prod., 2017. 11(5): P. 485-490.
• Özbek H, Yuca H, Gözcü S, Dursunoğlu B, Özenver N, Güvenalp Z Ve Ark. Phenolic Compounds From Cotinus Coggygria Scop. With Alpha Glucosidase Inhibition. Fabad Jpharm Sci. 2019; 44(2): 119-125.
• Özbek Hı, Güvenalp Z, Uz A, Demirezer Lö, Kazaz C. Hydroxydihydrochalcone And Flavonoid Glycosides Along With Triterpene Saponin And Sesquiterpene From The Herbs Of Pimpinella Rhodantha Boiss. Nat Prod Res 2016;30(7):750-754. (Sci Exp)
• Ö̈Zbek Hı, Güvenalp Z, Uz A, Demirezer Lö, Kazaz C. Phenylpropanoids Sesquiterpenoids And Flavonoids From Pimpinella Tragium Vill Subsp Lithophila Schischkin Tutin. Rec Nat Prod 2016;10(2):207-213. (Sci Exp)
• Özenver N, Abdelfatah S, Fleischer E, Klinger A, Efferth T. Chemometric And Transcriptomic Profiling, Microtubule Disruption And Cell Death Induction By Secalonic Acid In Tumor Cells. molecules 2020; 25(14):3224.
• Özenver N, Abdelfatah S, Klinger A, Fleischer E, Efferth T. Identification And Characterization Of Deschloro-Chlorothricin Obtained From A Large Natural Product Library Targeting Aurora A Kinase In Multiple Myeloma. Invest New Drug. 2020.
• Özenver N, Efferth T. Immunotoxicity Of Therapeutic Antibodies And Nanoparticles. Crit Rev. Immunol. 2020;40(1):53-74.
• Özenver N, Efferth T. Small Molecule Inhibitors And Stimulators Of Inducible Nitric Oxide Synthase In Cancer Cells From Natural Origin (Phytochemicals, Marine Compounds, Antibiotics). Biochem Pharmacol. 2020;176:113792.
• Özenver N, Güvenalp Z, Kuruüzüm-Uz A, Demirezer Lö. Inhibitory Potential On Key Enzymes Relevant To Type İi Diabetes Mellitus And Antioxidant Properties Of The Various Extracts And Phytochemical Constituents From Rumex Acetosella L. J Food Biochem. 2020;44(10):E13415.
• Özenver N, Saeed M, Demirezer Lö, Efferth T. Aloe-Emodin As Drug Candidate For Cancer Therapy. oncotarget. 2018;9(25):17770.
• Renda G, Sari S, Barut B, Soral M, Liptaj T, Korkmaz B, Et al. Alpha-Glucosidase Inhibitory Effects Of Polyphenols From Geranium Asphodeloides: Inhibition Kinetics And Mechanistic Insights Through In Vitro And In Silico Studies. Bioorg Chem. 2018;81:545-52.
• Saracoglu I, Suleimanov T, Pashaeva N, Dogan Z, Inoue M, Nakashima K. Iridoids From Veronica Crista-Galli From The Flora Of Azerbaijan. ChemNat Comp. 2020;56(4):751-3.
• Saracoglu, I., Et Al., Iridoids And Phenylethanoid Glycosides In Phlomis Pungens Willd. Of Thflora Of Azerbaijan, Chem Nat Compd, 2017. 53(3). Doi 10.1007/S10600-017-2055-7."
• Saraçoğlu İ., Suleymanov T., Shukurova A., Doğan Z. Iridoid And Phenylethanoid Glycosides Of Phlomis Pungens Willd From Azerbaijan. Chemistry Of Natural Compounds (In Press) 2016. (Sci Exp)
• Sari S, Barut B, Ozel A, Kuruuzum-Uz A, Sohretoglu D. Tyrosinase And Alpha-Glucosidase Inhibitory Potential Of Compounds Isolated From Quercus Coccifera Bark: In Vitro And In Silico Perspectives. Bioorg Chem. 2019;86:296-304.
• Sari S, Barut B, Ozel A, Kuruuzum-Uz A, Sohretoglu D. Tyrosinase And Alpha-Glucosidase Inhibitory Potential Of Compounds Isolated From Quercus Coccifera Bark: In Vitro And In Silico Perspectives. Bioorg Chem. 2019;86:296-304.
• Sari S, Barut B, Ozel A, Sohretoglu D. Tyrosinase Inhibitory Effects Of Vinca Major And Its Secondary Metabolites: Enzyme Kinetics And In Silico Inhibition Model Of The Metabolites Validated By Pharmacophore Modeling. Bioorg Chem. 2019;92.
• Selbes Y, Caglayan Mg, Eryılmaz M, Boyaci Ih, Saglam N, Basaran Aa, Tamer U. Surface Enhanced Raman Probe For Rapid Nanoextraction And Detection Of Erythropoietin In Urine. Anal. bioanal. chem. 2016; 408(29), 8447-8456. (Sci)
• Sevindik Hg, ÖZek T, Yerdelen Kö, ÖNal M, ÖZbek H, Güvenalp Z, Demiezer Lö. Chemical Composition Antioxidant Capacity Acetyl And Butyrylcholinesterase Inhibitory Activities Of The Essential Oil Of Thymus Haussknechtii Velen. Rec Nat Prod 2016;10(4):503-507. (Sci Exp)
• Sohretoglu D, Baran My, Arroo R, Kuruuzum-Uz A. Recent Advances In Chemistry, Therapeutic Properties And Sources Of Polydatin. Phytochem Rev. 2018;17(5):973-1005.
• Sohretoglu D, Huang Sl. Ganoderma Lucidum Polysaccharides As An Anti-Cancer Agent. Anti-Cancer Agents In Med Chem. 2018;18(5):667-74.
• Sohretoglu D, Sari S, Barut B, Ozel A. Discovery Of Potent Alpha-Glucosidase Inhibitor Flavonols: Insights Into Mechanism Of Action Through Inhibition Kinetics And Docking Simulations. Bioorg Chem. 2018;79:257-64.
• Sohretoglu D, Sari S, Barut B, Ozel A. Tyrosinase Inhibition By A Rare Neolignan: Inhibition Kinetics And Mechanistic Insights Through In Vitro And In Silico Studies. Comput Biol Chem. 2018;76:61-7.
• Sohretoglu D, Sari S, Barut B, Ozel A. Tyrosinase Inhibition By Some Flavonoids: Inhibitory Activity, Mechanism By In Vitro And In Silico Studies. Bioorg Chem. 2018;81:168-74.
• Sohretoglu D, Sari S, Soral M, Barut B, Ozel A, Liptaj T. Potential Of Potentilla Inclinata And Its Polyphenolic Compounds In Alpha-Glucosidase Inhibition: Kinetics And Interaction Mechanism Merged With Docking Simulations. Int J Biol Macromol. 2018;108:81-7.
• Sohretoglu D, Zhang C, Luo J, Huang Sl. Reishimax Inhibits Mtorc1/2 By Activating Ampk And Inhibiting Igfr/Pı3k/Rheb In Tumor Cells. Signal Transduct Tar. 2019;4.
• Şöhretoğlu D, Barut B, Sari S, Özel A, Arroo Rrj. In Vitro And In Silico Assessment Of Dna Interaction, Topoisomerase I And II Inhibition Properties Of Chrysosplenetin. Int J Biol Macromol. 2020;163:1053-59.
• Şöhretoğlu D, Renda G. The Polyphenolic Profile Of Oak (Quercus) Species: A Phytochemical And Pharmacological Overview. Phytochem Rev. 2020;19(6):1379-1426.
• Şöhretoğlu D, Sari S. Flavonoids As Alpha-Glucosidase Inhibitors: Mechanistic Approaches Merged With Enzyme Kinetics And Molecular Modeling. Phytochem Rev.1-12.
• Şöhretoğlu D, Sari S. Flavonoids As Alpha-Glucosidase Inhibitors: Mechanistic Approaches Merged With Enzyme Kinetics And Molecular Modeling. Phytochem Rev. 2020;19:1081–92.
• Şöhretoğlu, D., Et Al., Comparative Evaluation Of Phenolic Profile, Antioxidative And Cytotoxic Activities Of Different Geranium Species, Iran J Pharm Res, 2017. 16: P. 178-187.
• Şöhretoğlu, D., Et Al., Α-Glucosidase Inhibitory Effect Of Potentilla Astracanica And Someisoflavones: Inhibition Kinetics And Mechanistic Insights Through In Vitro And In Silico Studies. int. J. Biol. Macromol., 2017.
• Uzun M, Demirezer Lo. Anti-Aging Power Of Rumex Crispus L.: Matrixmetalloproteinases Inhibitor, Sun Protective And Antioxidant. S Afr J Bot. 2019;124:364-71.
• Uzun M, Guvenalp Z, Kazaz C, Demirezer Lo. Matrix Metalloproteinase Inhibitor And Sunscreen Effective Compounds From Rumex Crispus L.: Isolation, Identification, Bioactivity And Molecular Docking Study. Phytochem Analysis. 2020;31:818-34.
• Yuzbasioglu Baran M, Emecen G, Simon A, Tóth G, Kuruuzum-Uz A. Assessment Of The Antioxidant Activity And Genotoxicity Of The Extracts And Isolated Glycosides With A New Flavonoid From Lotus Aegaeus (Gris.) Boiss. Ind Crops Prod. 2020;153:112590.
• Yuzbasioglu Baran M, Guvenalp Z, Saracoglu I, Kazaz C, Salih B, Demirezer Lo Ve Ark. Cytotoxic Naphthoquinones From Arnebia Densiflora (Nordm.) Ledeb And Determining New Apoptosis Inducers. Nat Prod Res. 2020;34(12):1669-77.
• Zor, M., Aydın, S., Güner, N.D., Başaran, N., Başaran, A.A., Antigenotoxic Properties Of Paliurus Spina-Christi Mill Fruits And Their Active Compounds. Bmc Complement Altern Med, 2017. 17: P. 229-239. Doi: 10.1186/S12906-017-1732-1

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About

Research Infrastructure

• Refrigerator (-20°C)
• Refrigerator(-80°C)
• Large Volume Extractor
• Fume Hood
• Oven
• Precision Balance
• Heated Shaker (Plate)
• Air Conditioning Cabinet
• Camera Microscope
• Lyophilizer
• Mono Distilled Pure Water Device
• Mplc
• Rotavopor
• Centrifuge
• Refrigerated Microcentrifuge
• Water bath
• Ultra Pure Water Producer
• Ultrasonic Water Bath
• UV Cabinet
• Vacuum Pump
• Vortex
• Nitrogen Tank
• CO2 Incubator
• Shaking Water Bath
• Extractor
• Oven
• HPLC
• Incubator
• Gel Electrophoresis
• Gel Imaging System
• Laminar Flow Cabinet
• Microplate Reader
• Autoclave
• Herb Mill
• Fume Hood
• Oven
• Microscope
• Rotavopor

Researchers

•    Prof. Dr. Funda Nuray YALÇIN
•    Prof. Dr. İclal SARAÇOĞLU
•    Prof. Dr. Lütfiye Ömür DEMİREZER
•    Prof. Dr. Zeliha Şükran AKDEMİR
•    Prof. Dr. Ayşe KURUÜZÜM UZ
•    Doç. Dr. Dilek ERCİL
•    Doç. Dr. Didem ŞÖHRETOĞLU
•    Dr. Öğr. Üyesi Çiğdem KAHRAMAN
•    Dr. Öğr. Üyesi Yasin GENÇ
•    Dr. Ecz. Vahap Murat KUTLUAY
•    Dr. Ecz. Mine UZUN
•    Dr. Ecz. Zeynep DOĞAN
•    Dr. Ecz. Nadire ÖZENVER
•    Ecz. Nuriye Hilal TAŞTEkin
•    Filiz BOYALI
•    Hande Büşra KELEŞ
•    Hilal ERDEM
•    Kübra UZUN
•    Mehmet UZUN
•    Melike UTLU
•    Merve ŞENSOY
•    Nida KÖKLÜYURT
•    Pınar İKİZ
•    Saliha Meryem ZENBİLCİ
•    Seren GÜNDOĞDU
•    Sevda Deniz DALĞIN
•    Sümeyye ÇOBAN
•    Rabia Sena GÜNEŞER
•    Ahmet Yasin AKCAN
•    Sevda KARABEYESER
•    Bilge SALAR
•    Eliz UYANIR
•    Halime Eda YALÇIN

Ongoing Projects

• 118z708; Taxonomy, phylogeny and phylogeny of Turkey Polygala L. (Polygalaceae) Genus with Biosystematic and Chemosystematic Approach; Ali Donmez; Esra Martin, Funda N. Yalçın, Emel Dönmez, Hatice Nurhan Büyükkartal, Metin Tuna, Zübeyde Uğurlu Aydın, İhsan Çalış, Ömer Bayazeid; 720,000 TL; 2019-
• Thd-2019-18123; Isolation of Antioxidant, Cytotoxic and Anti-inflammatory Compounds From Acanthus Spinosus L.; Zeynep Dogan; İclal Saraçoğlu, Seçil Sarıkaya Aydın; 29,987 TL; 2019-
• Thd-2019-17884; Potential Drug Research on Peganum Harmala L. Seeds Used as a Folk Medicine; Vahap Murat Kutluay; A. Ahmet Basaran, Nuriye Hilal Tastekin; 29,992 TL
• 1001-Phytochemical Analysis of Some Gentianella Species and Effects of Xanthones on Bdnf (Brain-Derived Neurotrophic Factor) Pathway; prof. Dr. Funda N. Yalçın, Duygu Kaya, Pelin Kelicen; Omer Bayazeid, Pinar Ikiz; 451,570 TL; 2017-

Completed Projects

• 119s020; Endemic Scutellaria Rubicunda Hornem. Subsp. Brevibracteata J.R.Edm. Investigating the Anti-Inflammatory Effect of the Plant and Explaining the Possible Effect Mechanism; Zeynep Dogan; İclal Saraçoğlu, Gökçen Telli, Banu Cahide Tel; 44,990 TL
• Acanthus Dioscoridis L. Var. Isolation of Compounds with Antioxidant, Cytotoxic and Anti-inflammatory Effects from Dioscoridis L. Tdk-2017-14444; prof. Dr. İclal Saracoglu; 29,756.10 TL
• Isolation of Antioxidant, Cytotoxic and Anti-inflammatory Compounds from Acanthus Spinosus L. (2019). (Researcher in Project No. Hü-Bab Thd-2019-18123. Director: Dr. Pharm. Seçil Sarikaya Aydın, Other Researchers: Dr. Pharmacist. Zeynep Doğan
• Bab Rapid Support: “In Vitro Antidiabetic Studies in Prunus Mahaleb L. Seeds and Fruit Peels Used as Folk Medicine and Food” Researchers: Zühal Güven, Director: Dr. Zeynep Doğan, Budget: 29959.02 TL
• Fhd-2018- 17122, Biology, Biodiversity and Conservation of Flag Species Polygala Azizsancarii; Ali Donmez; Funda N. Yalcin; 30.000 TL
• Pharmacognostic Studies on Some Scutellaria L. Species, Sources of Pharmaceutical Raw Material Tdk-2017-14236; prof. Dr. İclal Saracoglu; 24,914,50 TL
• Mev-2017-155; Investigation of Biological Effects and Effect Mechanisms of Some Medicinal Plants Grown in Turkey at Molecular Level; Yasin Young; Kübra Uzun; 29,922.00 TL
• Mev-2017-204, Project Name: Investigation of Biological Effects and Effect Mechanisms of Plants Belonging to the Families of Scrophulariaceae and Plantaginaceae at the Molecular Level; Project Coordinator: Çiğdem Kahraman; Project Researchers: Melike Utlu, Ken-Ichi Nakashima; Project Budget: 29,922.00 TL
• Mev-2017-204; Investigation of Biological Effects and Effect Mechanisms of Plants Belonging to Scrophulariaceae and Plantaginaceae Families at Molecular Level; Cigdem Hero; Melike Utlu, Ken-Ichi Nakashima; 29,922.00 TL
• Plantago Holosteum Scop. Pharmacognosic Studies on Tdk-2017-13724 Prof. Dr. İclal Saracoğlu 1466.15 TL
• Polygonum Equisetiforme Sibth. Et Sm. Phytochemical and Biological Activity Studies on Thd-2017-11469 Prof. Dr. Ayşe Kuruüzüm Long 29,982.27 TL
• Determination of the Chemical Profile of Rosa Damascena and Investigation of Its Skin Aging Delaying Effects Thd-2017-15631; Prof. dr. L. Omur Demirezer; 29,990.49 TL
• Tdk-2018-17578; Lavandula Stoechas L. Subsp. Biological Activity Guided Studies on Stoechas; prof. Dr. Ayşe Uz; Merve Yüzbaşıoğlu Baran; Sümeyye Çoban, Omer Bayazeid; prof. Dr. Funda N. Yalcin; 29999.30 TL
• Thd-2017-11469; Polygonum Equisetiforme Sibth. Et Sm. Phytochemical and Biological Activity Studies; prof. Dr. Ayşe Uz; Merve Yüzbaşıoğlu Baran, Mehmet Uzun; 29982.27 TL
• Thd-2017-15620; Pharmacognosic Research on Fruit Shells of Prunus Mahaleb L. Seeds Used as Folk Medicine and Food; prof. Dr. A. Ahmet Basaran; pharmacist. Zühal Güven; 29,886.70 TL
• Thd-2017-15631; Determination of the Chemical Profile of Rosa Damascena and Investigation of Its Anti-Aging Effects; prof. Dr. L. Omur Demirezer; Tuncay Agar; 29 000TL
• Thd-2018-16945; In Vitro and In Silico Investigation of Alpha-Glucosidase and Tyrosinase Enzyme Inhibitor Effect Mechanisms of Some Flavonoids by Kinetic and Computer Modeling Methods; Director: Didem Şöhretoğlu; Researchers: Suat Sarı, Burak Barut, Arzu Özel. Budget: 22607.95 TL
• Thd-2018-17448; In Vitro and In Silico Investigation of Topoisomerase Enzyme Inhibitor Effects on DNA Binding Modes of Polydatin and Kirsosplenetin; Didem Sohretoglu; Suat Sari, Burak Barut, Arzu Ozel; 35999.30 TL
• Thd-2019-18076; In Vitro Antidiabetic Studies on Prunus Mahaleb L. Seeds and Fruit Peels Used as Folk Medicine and Food; Zeynep Dogan; Arif Ahmet Basaran, Zühal Güven; 29,959 TL
• Tubitak 3001 Project Project No: 217s206; Project Name: Bioactivity-Guided Isolation and Characterization of Responsible Substances from Eleagnus Angustifolia L. and Paliurus Spina-Christi Miller Plants with Traditional Use for Antidiabetic Purposes. Dr. Zühal Güvenalp Project Researchers: Prof. Dr. L. Omur Demirezer, Assoc. Dr. Hilal Özbek Project Budget: 59,050 TL

Publications

• Akkol Ek, Genc Y, Watermelon B, Sobarzo-Sanchez E, Capasso R. Coumarins And Coumarin-Related Compounds In Pharmacotherapy Of Cancer. Cancers. 2020;12(7):1959.
• Akkol Ek, Ilhan M, Karpuz B, Genc Y, Sobarzo-Sanchez E. Sedative And Anxiolytic Activities Of Opuntia Ficus Indica (L.) Mill.: An Experimental Assessment In Mice. molecules 2020;25(8):1844.
• Anlar Hg, Bacanli M, Cal T, Aydin S, Ari N, Undeger Bucurgat U, Et Al. Effects Of Cinnamic Acid On Complications Of Diabetes. Turk J Med Sci. 2018;48(1):168-77.
• Anlar Hg, Bacanli M, Kutluk B, Basaran Aa, Basaran An. Cytotoxic Activity Of Resveratrol In Different Cell Lines Evaluated By Mtt And Nru Assays. Turk J Pharm Sci. 2016;13(1), 27-34.
• Anlas C, Bakirel T, Ustun-Alkan F, Celik B, Baran My, Ustuner O, Et al. In Vitro Evaluation Of The Therapeutic Potential Of Anatolian Kermes Oak (Quercus Coccifera L.) As An Alternative Wound Healing Agent. Ind Crop Prod. 2019;137:24-32.
• Arroo Rrj, Sari S, Barut B, Özel A, Ruparelia Kc, Şöhretoğlu D. Flavones As Tyrosinase Inhibitors: Kinetic Studies In Vitro And In Silico. Phytochem Anal. 2020;31(3):314-21.
• Aydin S, Bacanli M, Anlar Hg, Cal T, Ari N, Bucurgat Uu, Et al. Preventive Role Of Pycnogenol (R) Against The Hyperglycemia-Induced Oxidative Stress And Dna Damage In Diabetic Rats. FoodChem. 2019;124:54-63.
• Aydin S, Sahin Tt, Bacanli M, Taner G, Basaran Aa, Aydin M, Basaran An. Resveratrol Treatment Protects Rat Kidney And Liver From Sepsis Induced Oxidative Damage. Balkan Med J 2016; 33(6) 594-601. (Sci Exp)
• Bacanlı, M., Anlar, H.G., Arı, N., Başaran, A.A., Başaran, N., The Effects of Herbal Extract Pycnogenol® on Diabetes Mellitus Treatment. Turkiye Klinikleri J Pharm Sci, 2017. 6: P. 25-31.
• Bacanlı M., Anlar H.G. Food Chem Toxicol, 2017. In Edition: Doi: 10.1016/J.Fct.2017.09.020.
• Bacanlı, M., Anlar, H.G., Başaran, A.A., Başaran, N., Assessment Of Cytotoxicity Profiles Of Different Phytochemicals: Comparison Of Neutral Red And Mtt Assays In Different Cells In Different Time Periods. Turk J Pharm Sci, 2017. 14: P. 95-107.
• Bacanlı, M., Aydın S., Anlar, H.G., Çal, T., Bucurgat Ündeger, Ü., Başaran, A.A., Başaran, N. Protective Effects Of Ursolic Acid In The Kidneys Of Diabetic Rats. Turk J Pharm Sci, 2017. In ed.
• Bacanlı, M., Aydın, S., Başaran, A.A., Başaran, N. Are All Phytochemicals Useful In The Prevention Of DNA Damage. Food Chem Toxicol, 2017. 109: P. 210-17.
• Bacanlı, M., Başaran, A.A., Başaran, N., The Antioxidant, Cytotoxic And Antigenotoxic Effects Of Galangin, Puerarin And Ursolic Acid In Mammalian Cells. Drug Chem Toxicol, 2017. 40: P. 256-62.
• Bacanlı, M., Başaran, N. , Başaran, A.A., Galangin And Its Antiinflammatory Properties. Medicinal & Analytical Chemistry International Journal, 2017, 1: In Press
• Bacanli M, Anlar Hg, Basaran An, Ari N, Basaran Aa. Beneficial Effects Of Commonly Used Phytochemicals In Diabetes Mellitus. Acta Pharm Sci 2016; 54(1), 9-20.
• Bacanli M, Aydin S, Anlar Hg, Cal T, Ari N, Bucurgat Uu, Et al. Can Ursolic Acid Be Beneficial Against Diabetes In Rats? Turk J Biochem. 2018;43(5):520-9.
• Bacanli M, Aydin S, Anlar Hg, Cal T, Bucurgat Uu, Ari N, Et al. Protective Effects Of Ursolic Acid In The Kidneys O Diabetic Rats. Turk J Pharm Sci. 2018;15(2):166-70.
• Baran My, Şöhretoğlu D, Uz Ak. Quantitative Analysis Of Polydatin In A Turkish Oak: Quercus Coccifera L. With Hplc-Dad. Ijsm. 2019;6(3):233-40
• Barut B, Şöhretoğlu D. Total Phenolic Content, Cyclooxygenases, Α-Glucosidase, Acetylcholinesterase, Tyrosinase Inhibitory And Dpph Radical Scavenging Effects Of Cornus Sanguinea Leaves And Fruits. JRes Pharm. 2020;24(5):623-31.
• Bayazeid O And Yalçın Fn. Biological Targets Of 92 Alkaloids Isolated From Papaver Genus: A Perspective Based On In Silico Predictions. MedChem Res. 2020;1-12.
• Bayazeid O, Bedir E, Yalcin Fn. Ligand-Based Virtual Screening And Molecular Docking Of Two Cytotoxic Compounds Isolated From Papaver Lacerum. Phytochem Lett. 2019;30:26-30.
• Bayazeid O, Eylem Cc, Recber T, Yalcin Fn, Kir S, Nemutlu E. An Lc-Esı-Ms/Ms Method For The Simultaneous Determination Of Pronuciferine Arid Roemerine In Some Papaver Species. J Chromatogr B. 2018;1096:223-7.
• Bayazeid O, Nemutlu E, Eylem Cc, İlhan M, Kupeli Akkol E, Karahan H Ve Ark. Neuroactivity Of The Naturally Occurring Aporphine Alkaloid, Roemerine. Nat Prod Res. 2020;1-6.
• Bayazeid O, Nemutlu E, Eylem Cc, Yalçın Fn. Neuroactivity Of Naturally Occurring Proaporphine Alkaloid, Pronuciferine. J Biochem Mol Toxicol. 2020;E22601.
• Chowdhury Hm, Sharmin N, Baran My, Long L, Morrell Nw, Trembath Rc, Et al. Bmprii Deficiency Impairs Apoptosis Via The Bmprii-Alk1-Bclx-Mediated Pathway In Pulmonary Arterial Hypertension. Hum Mol Genet. 2019;28(13):2161-73.
• Demirezer Lö, Uzun M, Ozenver N, Güvenalp Z. Determination Of Phytoestrogenic Potential Of Anthranoids By Molecular Docking Studies, Fabad, J. Pharm. sci. 2018;43(3):129-41.
• Diker Ny, Kahraman C, Akkol Ek, Karaoglu Mt, Comoglu T, Akdemir Zs, Et Al. The Evaluation Of Sterile Solutions Of Ilwensisaponin A And C From Verbascum Pterocalycinum Var. Mutense Hub.-Purple. On Antiviral, Antinociceptive And Anti-Inflammatory Activities. Saudi Pharm J. 2019;27(3):432-6.
• Dogan Z, Ishiuchi Ki, Makino T, Saracoglu I. New Acylated Iridoid Glucosides From Scutellaria Glaphyrostachys Rech. F. And Chemotaxonomic Importance For The Genus Scutellaria. Phytochem Lett. 2019;32:157-61.
• Doğan Z, Ishiuchi Kı, Makino T, Saraçoğlu İ. Alpha-Pyrone Glycosides From Scutellaria Salviifolia Benth. Turk J Chem. 2019;43(3):972-81.
• Dönmez C, Yalçın Fn, Boyacıoğlu Ö, Korkusuz P, Akkol Ek, Nemutlu E Ve Ark. From Nutrition To Medicine: Assessing Hemorrhoid Healing Activity Of Solanum Melongena L. Via In Vivo Experimental Models And Its Major Chemicals. J Ethnopharmacol. 2020;261:113143.
• Efferth T, Banerjee M, Abu-Darwish Ms, Abdelfatah S, Bockers M, Bhakta-Guha D, Et Al. Biopiracy Versus One-World Medicine-From Colonial Relicts To Global Collaborative Concepts. phytomedicine 2019;53:319-31.
• Genc Y, Bardakci H, Yucel C, Karatoprak Gs, Akkol Ek, Barak Th Ve Ark. Oxidative Stress And Marine Carotenoids: Application By Using Nanoformulations. Mar Drugs. 2020;18(8):423.
• Genc Y, Dereli Ftg, Saracoglu I, Akkol Ek. The Inhibitory Effects Of Isolated Constituents From Plantago Major Subsp. Major L. On Collagenase, Elastase And Hyaluronidase Enzymes: Potential Wound Healer. Saudi Pharm J. 2019.
• Genc Y, Guragac Dereli Ft, Saracoglu I, Kupeli Akkol E. The Inhibitory Effects Of Isolated Constituents From Plantago Major Subsp. Major L. On Collagenase, Elastase And Hyaluronidase Enzymes: Potential Wound Healer. Saudi Pharm J. 2020;28(1):101-6.
• Genc Y, Harput Us, Saracoglu I. Active Compounds Isolated From Plantago Subulata L. Via Wound Healing And Antiinflammatory Activity Guided Studies. J Ethnopharmacol. 2019;241.
• Genc Y, Sohretoglu D, Harput Us, Ishiuchi K, Makino T, Saracoglu I. Chemical Constituents From Plantago Holosteum Scop. And Evaluation Of Their Chemotaxonomical Significance. ChemNat Comp. 2020;56(3):566-8.
• Gonulalan Em, Bayazeid O, Yalcin Fn, Demirezer Lo. The Roles Of Valerenic Acid On Bdnf Expression In The Sh-Sy5y Cell. Saudi Pharm J. 2018;26(7):960-4.
• Gonulalan Em, Nemutlu E, Bayazeid O, Koçak E, Yalçın Fn, Demirezer Lo. Metabolomics And Proteomics Profiles Of Some Medicinal Plants And Correlation With Bdnf Activity. phytomedicine 2019:152920.
• Gonulalan Em, Nemutlu E, Bayazeid O, Koçak E, Yalçın Fn, Demirezer Lo. Metabolomics And Proteomics Profiles Of Some Medicinal Plants And Correlation With Bdnf Activity. phytomedicine 2020; 74:152920.
• Gonulalan Em, Nemutlu E, Demirezer Lo. A New Perspective On Evaluation Of Medicinal Plant Biological Activities: The Correlation Between Phytomics And Matrix Metalloproteinases Activities Of Some Medicinal Plants. Saudi Pharm J. 2019;27(3):446-52.
• Gönülalan Em, Nemutlu E, Demirezer Lo. Metabolomics (Phytomics) Studies and Its Importance in Phytotherapy, Metabolomics (Phytomics) Studies and Its Importance In Phytotherapy. Turkey Clinics Traditional and Complementary Medicine-Special Topics.2020:68-74.
• Guragac Dereli Ft, Genc Y, Saracoglu I, Kupeli Akkol E. Enzyme Inhibitory Assessment Of Isolated Constituents From Plantago Holosteum Scop. Z Naturforch C. 2020;75(3-4):121-8.
• Gurbuz P, Baran My, Demirezer Lo, Guvenalp Z, Kuruuzum-Uz A. Phenylacylated-Flavonoids From Peucedanum Chryseum. Rev Bras Pharmacogn. 2018;28(2):228-30.
• Gurbuz P, Kosar M, Guvenalp Z, Uz Ak, Demirezer Lo. Simultaneous Determination Of Selected Flavonoids From Different Cistus Species By Hplc-Pda. JRes Pharm. 2018;22(3):405-10.
• Guvenalp, Z., Et Al., Cholinesterase Inhibition And Molecular Docking Studies Of Sesquiterpene Coumarin Ethers From Heptaptera Cilicica, Rec. Nat. Prod., 2017. 11(5): P. 462-467.
• Gündoğdu S, Ayhan S, Raisin-Uz A. A Review on Herbal Source Studies for the Treatment of Substance Addiction. Literature Journal of Pharmaceutical Sciences. 2020; Doi: 10.5336/Pharmsci.2019-72972.
• Hameed H, Aydin S, Basaran Aa, Basaran An. Assessment Of Cytotoxic Properties Of Sinapic Acid In Vitro. Turk J Pharm Sci. 2016;13(2), 129-132. (International Referee)
• Ihtesham Y, Khan U, Dogan Z, Kutluay Vm, Saracoglu I. Evaluation Of Some Biological Effects Of Incarvillea Emodi (Royle Ex Lindl.) Chatterjee And Determination Of Its Active Constituents. Kafkas Univ Vet Fak. 2019;25(2):171-8.
• Kahraman C, Tatli II, Card D, Ekizoglu M, Akdemir Zs. Structure Elucidation And Antimicrobial Activities Of Secondary Metabolites From The Flowery Parts Of Verbascum Mucronatum Lam. Turk J Pharm Sci. 2018;15(3):231-7.
• Kahraman C, Topcu G, Bedir E, Tatli II, Ekizoglu M, Akdemir Zs. Phytochemical Screening And Evaluation Of The Antimicrobial And Antioxidant Activities Of Ferula Caspica M. Bieb. Extracts. Saudi Pharm J. 2019;27(4):525-31.
• Kahraman C, Zare G, Arabaci S, Kupeli Akkol E, Tatli Cankaya II. Evaluation Of Cucurbita Pepo L. Seeds Used In Folk Medicine For Their Anti-Inflammatory And Wound Healing Activity. MedScience. 2020;9(2):381-4.
• Kahraman Ç, Baysal İ, Çankaya İ, Göger F, Kırıker N, Akdemir Zş. Acetylcholinesterase Inhibitory Activities And Lc-Ms Analysis Of The Antioxidant Ferula Caspica M. Bieb. And F. Halophila Peşmen Extracts. J Pharm Res. 2019; 23(3):543-551.
• Karatoprak Gs, Akkol Ek, Genc Y, Bardakci H, Yucel C, Sobarzo-Sanchez E. Combretastatins: An Overview Of Structure, Probable Mechanisms Of Action And Potential Applications. Molecules 2020;25 (11):2560.
• Koca-Caliskan U, Yilmaz I, Taslidere A, Yalcin Fn, Aka C, Sekeroglu N. Cuscuta Arvensis Beyr "Dodder": In Vivo Hepatoprotective Effects Against Acetaminophen-Induced Hepatotoxicity In Rats. J Med Food. 2018;21(6):625-31.
• Kutluay Vm, Diker Ny. Constitution Of A Comprehensive Phytochemical Profile And Network Pharmacology Based Investigation To Decipher Molecular Mechanisms Of Teucrium Polium L. In The Treatment Of Type 2 Diabetes Mellitus. Peerge. 2020;8:E10111.
• Kutluay Vm, Inoue M, Saracoglu I. Assessment Of Lxrα Agonist Activity And Selective Antiproliferative Efficacy: A Study On Different Parts Of Digitalis Species. Turk J Biochem. 2019;44(6):745-51.
• Kutluay Vm, Ishiuchi K, Makino T, Saracoglu I. Cytotoxic Phenylethanoid Glycosides From Digitalis Davisiana Heywood: Evaluation Of Structure Activity Relationships And Chemotaxonomical Significance Of Isolated Compounds. phytotherapy 2019;135:90-8.
• Kutluay Vm, Makino T, Inoue M, Saracoglu I. New Knowledge About Old Drugs; A Cardenolide Type Glycoside With Cytotoxic Effect And Unusual Secondary Metabolites From Digitalis Grandiflora Miller. phytotherapy 2019;134:73-80.
• Kutluay Vm, Saracoglu I. Cytotoxic Effect Of Some Digitalis Species; A Study Of Selectivity. Fabad J Pharm Sci. 2018; 43(1):25-29.
• Orhan E, Aka İö, Yüzbaşıoğlu M, Yavuz B, Bilensoy E, Uz Ak. The Effect Of Quercus Coccifera L. Extract On The Necrosis Of Random-Pattern Skin Flaps In Rats. Med Bull Haseki, 2019;57(3):249-254.
• Orhan E, Yüzbaşıoğlu M, Erol Yr, Bilensoy E, Erdoğar N, Demirezer Lö, Et Al. The Effect Of Arnebia Purpurea Extract On The Survival Of Random Pattern Skin Flaps In Rats. The European Research Journal. 2018;4(3):152-6.
• Osmanlıoğlu Dağ, R., Kuruüzüm-Uz, A., The Role of Ginger in Pharmacy and Its Antitumor Effect, Hacettepe University Faculty of Pharmacy Journal. 38(2) 76-84 (2018).
• Ozbek H, Guvenalp Z, Yilmaz G, Yerdelen Ko, Kazaz C, Demirezer Ol. In Vitro Anticholinesterase Activity And Molecular Docking Studies Of Coumarin Derivatives Isolated From Roots Of Heptaptera Cilicica. MedChem Res. 2018;27(2):538-45.
• Ozbek, H., Et Al., Chemical Composition, Antioxidant And Anticholinesterase Activities Of The Essential Oil Of Origanum Rotundifolium Boiss. From Turkey, Rec. Nat. Prod., 2017. 11(5): P. 485-490.
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• Özbek Hı, Güvenalp Z, Uz A, Demirezer Lö, Kazaz C. Hydroxydihydrochalcone And Flavonoid Glycosides Along With Triterpene Saponin And Sesquiterpene From The Herbs Of Pimpinella Rhodantha Boiss. Nat Prod Res 2016;30(7):750-754. (Sci Exp)
• Ö̈Zbek Hı, Güvenalp Z, Uz A, Demirezer Lö, Kazaz C. Phenylpropanoids Sesquiterpenoids And Flavonoids From Pimpinella Tragium Vill Subsp Lithophila Schischkin Tutin. Rec Nat Prod 2016;10(2):207-213. (Sci Exp)
• Özenver N, Abdelfatah S, Fleischer E, Klinger A, Efferth T. Chemometric And Transcriptomic Profiling, Microtubule Disruption And Cell Death Induction By Secalonic Acid In Tumor Cells. molecules 2020; 25(14):3224.
• Özenver N, Abdelfatah S, Klinger A, Fleischer E, Efferth T. Identification And Characterization Of Deschloro-Chlorothricin Obtained From A Large Natural Product Library Targeting Aurora A Kinase In Multiple Myeloma. Invest New Drug. 2020.
• Özenver N, Efferth T. Immunotoxicity Of Therapeutic Antibodies And Nanoparticles. Crit Rev. Immunol. 2020;40(1):53-74.
• Özenver N, Efferth T. Small Molecule Inhibitors And Stimulators Of Inducible Nitric Oxide Synthase In Cancer Cells From Natural Origin (Phytochemicals, Marine Compounds, Antibiotics). Biochem Pharmacol. 2020;176:113792.
• Özenver N, Güvenalp Z, Kuruüzüm-Uz A, Demirezer Lö. Inhibitory Potential On Key Enzymes Relevant To Type İi Diabetes Mellitus And Antioxidant Properties Of The Various Extracts And Phytochemical Constituents From Rumex Acetosella L. J Food Biochem. 2020;44(10):E13415.
• Özenver N, Saeed M, Demirezer Lö, Efferth T. Aloe-Emodin As Drug Candidate For Cancer Therapy. oncotarget. 2018;9(25):17770.
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• Saracoglu I, Suleimanov T, Pashaeva N, Dogan Z, Inoue M, Nakashima K. Iridoids From Veronica Crista-Galli From The Flora Of Azerbaijan. ChemNat Comp. 2020;56(4):751-3.
• Saracoglu, I., Et Al., Iridoids And Phenylethanoid Glycosides In Phlomis Pungens Willd. Of Thflora Of Azerbaijan, Chem Nat Compd, 2017. 53(3). Doi 10.1007/S10600-017-2055-7."
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• Sari S, Barut B, Ozel A, Kuruuzum-Uz A, Sohretoglu D. Tyrosinase And Alpha-Glucosidase Inhibitory Potential Of Compounds Isolated From Quercus Coccifera Bark: In Vitro And In Silico Perspectives. Bioorg Chem. 2019;86:296-304.
• Sari S, Barut B, Ozel A, Kuruuzum-Uz A, Sohretoglu D. Tyrosinase And Alpha-Glucosidase Inhibitory Potential Of Compounds Isolated From Quercus Coccifera Bark: In Vitro And In Silico Perspectives. Bioorg Chem. 2019;86:296-304.
• Sari S, Barut B, Ozel A, Sohretoglu D. Tyrosinase Inhibitory Effects Of Vinca Major And Its Secondary Metabolites: Enzyme Kinetics And In Silico Inhibition Model Of The Metabolites Validated By Pharmacophore Modeling. Bioorg Chem. 2019;92.
• Selbes Y, Caglayan Mg, Eryılmaz M, Boyaci Ih, Saglam N, Basaran Aa, Tamer U. Surface Enhanced Raman Probe For Rapid Nanoextraction And Detection Of Erythropoietin In Urine. Anal. bioanal. chem. 2016; 408(29), 8447-8456. (Sci)
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• Sohretoglu D, Huang Sl. Ganoderma Lucidum Polysaccharides As An Anti-Cancer Agent. Anti-Cancer Agents In Med Chem. 2018;18(5):667-74.
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• Uzun M, Demirezer Lo. Anti-Aging Power Of Rumex Crispus L.: Matrixmetalloproteinases Inhibitor, Sun Protective And Antioxidant. S Afr J Bot. 2019;124:364-71.
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