• Biopac Student Lab Pro 3.7 (Commat LTD, Turkey) Software
• Ice Machine
• A refrigerator
• “Buxco RC Finepointe Resistance And Compliance” Respiratory Function Meter for Rodents
• CO2 Incubator
• Shaking Water Bath
• Shaker Orbital (Core SL350)
• Deionized Water Device (Mp MINI Pure Dest Up)
• Deep freeze
• Digital Precision Balance (Mettler Toledo)
• Distilled Water Device (Nüve NS104)
• Dril
• Electrophoresis Device
• Oven
• Precision Isometric Force Transducer Swema, Sweden
• Hemothermic Heater
• Hot Plate
• Cell Counter
• Carbon Dioxide Incubator
• Dry Air Sterilizer
• Laminar Flow Cabinet
• Locomotor Activity Cages (Commat)
• Microplate Reader (Biotek Power Wave XS2)
• Microscope
• Mini-Protean Tetra Cell Electrophoresis Device
• MP150WSW Data Acquisition System
• Autoclave (Core OT 032)
• Phmeter (HANNA Instruments HI 9321 Microprocesser Ph Meter)
• Powerpac Basic Power Supply
• Rotarod (For Rat) (Commat)
• Centrifuge (Core CN180)
• Liquid Nitrogen Tank
• Refrigerated Microcentrifuge (Kubota)
• Sonic Homogenizer
• Stereotaxic Apparatus (Kopf)
• Water Bath and Circulator
• Synergy HT Luminometric Microplate Reader
• Ultrasonic Homogenizer (OMNI International)
• Video Tracking System (TSE, Videomot2)
• Vortex (Heidolph)
• Prof. Dr. Serdar UMA
• Prof. Dr. Pelin KELİCEN UĞUR
• Prof. Dr. Nezahat Tuğba KANDİLCİ
• Doç. Dr. Turgut Emrah BOZKURT
• Dr. Öğr. Üyesi Banu Cahide TEL
• Dr. Öğr. Üyesi Melike Hacer ÖZKAN
• Dr. Öğr. Üyesi Merve DENİZALTI
• Ar. Gör. Dr. Ecz. İnci KAZKAYASI
• Ar. Gör. Dr. Ecz. Gökçen TELLİ
• Öğretim Görevlisi Dr. Ecz. Yasemin KARAMAN
• Abdelrahman Abdelghafar Salhin ABDELBARY
• Reshed ABOHALAKA
• Burcu Nur AKGÜNER
• Hilal AKYEL
• Selma KÖSE
• Nasim TOFİGHİ
• Ahmed Algali Sedahmed MUSA
• Bartu ALTIPARMAK
• Turgut Emrah Bozkurt (Project Manager), Zeliha Günnur Dikmen, Ayşen Özcan, Erkan Dikmen, Emirhan Nemutlu, Sevgen Çelik Önder, Yasemin Karaman Kutluay, Reshed Abohalaka, Esra Büber, Başak Çeltikçi, Merve Yılmaz, Özge Burcu Şahan, Müsteba Bayramzadeh, Serkan Docile. Development of New Treatment Methods for Idiopathic Pulmonary Fibrosis. Presidency of Turkish Health Institutes (Tüseb), Strategic Research and Development Projects Support Program, Innovative Drug Development Strategic R&D Project Call 2020-Yi-02. (Project No: 4569) (August 2020-)
• Turgut Emrah Bozkurt (Project Manager), Yasemin Karaman Kutluay, Reshed Abohalaka, Emirhan Nemutlu, Sevgen Çelik Önder. Investigation of Inhibition of Endocannabinoid Metabolism as a New Treatment Strategy in Allergic Respiratory Inflammation. (Tubitak, 1002 Rapid Support Program, Project No: 220s012) (October 2020-).
• Evaluation of the Efficacy of Fast and Slow Hydrogen Sulfide (H2s) Donors in the Treatment of Contractility Disorder in Mouse Bladder Detrusor Smooth Muscle in Acute and Chronic Interstitial Cystitis Model” Hacettepe University Scientific Research Projects Coordination Unit, 2018-, Project No: Tsa-2018-17057
• Tubitak 1002 Project, 119s020, Endemic Scutellaria Rubicunda Hornem. Subsp. Brevibracteata J.R.Edm. Investigation of the Anti-Inflammatory Effect of the Plant and Explaining the Possible Effect Mechanism, Dr. pharmacist. Zeynep Dogan, Dr. pharmacist. Gokcen Telli, Dr. Faculty Member Banu C. Tel, Prof. Dr. İclal Saraçoğlu, 45000,00(Tl), 2019- Ongoing.
• Tubitak 1002 Project, 319s005, Intranasal Metformin Treatment in Mice With Alzheimer's Disease Caused by Intracerebroventricular Streptozotocin Administration, Dr. pharmacist. İnci Kazkayasi, Dr. pharmacist. Gokcen Telli, Prof. Dr. Emirhan Nemutlu, Prof. Dr. Serdar Uma, 2019-Ongoing
• Tubitak 2219 Project, 1059b19; Role of Kcne4 Gene in Pulmonary Vascular Tone and Pulmonary Hypertension in Female and Male Rats; Gökçen Telli-Scholarship; 2019-
• H.U. Scientific Research Projects Coordination Unit, Rapid Support Project, Thd-2020-18868; Effect of Allopurinol Treatment in Monocrotalin-Induced Rat Pulmonary Hypertension Model; M. Serdar Uma; Gökçen Telli, İnci Kazkayası, E.İnci Somuncuoğlu, Sevgen Çelik Önder; 29902.56 TL; 2019-Continuing.
• Project No. Bap Id 18020; Project Name Effects of Orphan Drugs Used in Some Lysosomal Storage Diseases on Neuronal Cell Culture and Amyloid-Beta Peptide Decreased Sirtuin-1 and Autophagy-Related Pathways in Transgenic Animal Model of Alzheimer's; Project Manager Prof. Dr. E. Pelin Kelicen-Ugur; Project Researchers Prof. Dr. Hülya Karataş-Kurşun, Dr. Instructor member Banu Cahide Tel, Res.Assist. Dr. Elif Cinar, Hial Akyel, Selma Kose; Project Budget 357,612.11 TL; Start Year 2019- Ongoing.
• Project Code: 17598; Effect of Taliglucerase Alpha and Cysteamine on Amyloidbeta Peptide-Induced Sestrin-2 Increase and Autophagy-Related Pathways in Neuronal Cell Culture. Project Coordinator: Pelin Kelicen-Uğur, Project Researchers; Selma Kose; Project budget; 42,986.72 TL; 2019-Continuing.
• Yasemin Karaman, Yeşim Kaya, Turgut Emrah Bozkurt, İnci Şahin-Erdemli (Project Manager). Investigation of the Mechanism of 5-Hydroxytryptamine (5-Ht) Hyperreactivity in Lipopolysaccharide-Induced Respiratory Inflammation. (Hacettepe University Scientific Research Projects Coordination Unit, Project No: Thd-2016-9383). (2016-2016).
• Yasemin Karaman, Sevgen Önder, İnci Şahin-Erdemli, Turgut Emrah Bozkurt (Project Manager). Effects of Hydrogen Sulfide on Lipopolysaccharide-induced Experimental Airway Inflammation in Mice. (Tubitak, 3001 Initial R&D Projects Support Program, Project No: 315s289) (2016 June-2018 June).
• Turgut Emrah Bozkurt (Project Manager), İnci Şahin-Erdemli, Emirhan Nemutlu, Sevgen Önder, Reshed Abohalaka. The Effects of Fatty Acid Amide Hydrolase (Faah) and Monoacyl Glycerol Lipase (Magl) Inhibitors on Experimental Airway Inflammation in Mice (Hacettepe University Scientific Research Projects Coordination Unit, Project No: Thd-2017-16101 (2017-2019 ).
• Turgut Emrah Bozkurt (Project Manager), İnci Şahin-Erdemli, Yasemin Karaman, Yeşim Kaya-Yaşar, Emirhan Nemutlu, Sevgen Önder. Investigation of the Role of Asymmetric Dimethyl Arginine (Adma) and the Effects of In Vivo Hydrogen Sulfide Treatment in Lipopolysaccharide-Induced Airway Inflammation in Mice. (Hacettepe University Scientific Research Projects Coordination Unit, Comprehensive Project, Project No: Tsa-2017-14475 (2017 July-2020 April).
• “Investigation of Intracellular Mechanisms of Sphingosine-1-Phosphate (S1p)-Induced Contractions in Detrusor Smooth Muscle of Rats Caused Cystitis by Cyclophosphamide” Hacettepe University Scientific Research Projects Coordination Unit, 2014-2016, Project No: 014 D08 301 002.
• “Investigation of the Role of Protease-Activated Receptors (Par) in Contractile Mechanisms in Bladder Smooth Muscle in Interstitial Cystitis Model” Hacettepe University Scientific Research Projects Coordination Unit, 2016-2017, Project No: Thd-2016-10225.
• “Investigation of the Effect of Cyclic Adenosine Diphosphate Ribose and Nicotinic Acid Adenine Dinucleotide Phosphate on Sphingosine-1-Phosphate (S1p)-Induced Contraction Responses in Detrusor Smooth Muscle of Rats Caused by Cyclophosphamide” Hacettepe University Scientific Research Projects, 2017-2019 Coordination Unit No: Thd-2017-13342.
• Behavioral and Pathological Evaluation of Parkinson's Disease Model Established by Unilateral Aav-Mediated Alpha-Synuclein Injection to Basal Ganglia and Hippocampus. Hacettepe University Scientific Research Projects Coordination Unit-Quick Support Project; Researcher, 2014-2017.
• Mao Inhibitory and Antidepressant Activities of New 2-Pyrazoline Derivatives, Hacettepe University Scientific Research Projects Coordination Unit-Scientific Success Support Project, Researcher, 2015-2016
• Investigation of the Mechanism of Action of Intermedin (Imd/Am2) in the Rat Major Pulmonary Artery; Hacettepe University Scientific Research Projects Coordination Unit Rapid Support Project, Researcher, 2016-2017
• Comparative Analysis of Motor and Behavioral Changes with Pathology in a Model of Parkinson's Disease Based on Viral Vector-mediated Alpha-Synuclein Overexpression in Basal Ganglia and Limbic Cortex and Investigation of the Effect of Rapamycin Administration in This Model. Hacettepe University Scientific Research Projects Coordination Unit-Quick Support Project; Researcher, 2015-2019
• Investigation of the Effect of Intestinal Microbiota-Derived Metabolite Trimethylamine-N-Oxide on Rat Isolated Mesenteric Artery Endothelial Reactivity
• Melike Hacer Özkan, İnci Kazkayası, Mehmet Serdar Uma, H. Ü. Scientific Research Unit, Rapid Support Project, Project Code: Thd-2018-17510
• The Role of Saladin and Cholesterol in the Relationship Between Diabetes and Alzheimer's Disease, İnci Kazkayası, H. Ü. Scientific Research Unit, Scientific Cooperation Development Project, Project Code: TBI-2015-6639
• Possible Role of Insulin Degrading Enzyme in the Relationship between Diabetes and Alzheimer's Disease, İnci Kazkayası, H. Ü. Scientific Research Unit, Scientific Achievement Support, Project Code: Tbb-2015-5401
• Project No: Thd-2017-13478, Effect of Atorvastatin on Amyloid-Beta Peptide-Induced Sestrin-2 Induction in Human Neuroblastoma Cell Culture. Project Coordinator: Prof.Dr. Emine Pelin Kelicen; Researcher(s): Bio. Hande Celik, Res.Assist. Hande Karahan; Project Budget: 25.000 TL; (25.01.2017-09.10.2018).
• Project No. 7655; Investigation of the Mechanism of Acetylcholine Releases Potentiated by Ici 118,551 in Rat Isolated Mesenteric Artery; Project Coordinator S.Uma; Project Researchers E.İ. Somuncuoğlu (Resigned Staff), M.H. Özkan (Staff Researcher), S. Erdoğan (External Researcher); 20,000 TL; 2015-2018.
• Abohalaka A, Reçber T, Nemutlu E, Bozkurt Te, Kır S, Erdemli İ. Inflammation-Induced Adaptive Transitions In The Metabolomic Profile Of Mouse Lung And Plasma. Fabad J. Pharm. sci. 2019; 44(1):27-34.
• Abohalaka R., Bozkurt T.E., Nemutlu E., Onder S.C. Sahin-Erdemli I. The Effects Of Fatty Acid Amide Hydrolase And Monoacylglycerol Lipase Inhibitor Treatments On Lipopolysaccharide-Induced Airway Inflammation In Mice. Pulm. Pharmacol. ther. 62: 101920, 2020.
• Anjum I., Denizaltı M., Kandilci H.B., Durlu-Kandilci N.T., Sahin-Erdemli I. Enhancement Of S1p-Induced Contractile Response In Detrusor Smooth Muscle Of Rats Having Cystitis. EurJ Pharmacol. 814:343-351, 2017.
• Bozkurt T.E. Endocannabinoid System In The Airways. molecules Dec 17;24(24). Pii: E4626. Doi: 10.3390/Molecules24244626.2019, 2019.
• Bozkurt T.E., Kaya Y., Durlu-Kandilci N.T., Onder S., Sahin-Erdemli I. The Effect Of Cannabinoids On Dinitrofluorobenzene-Induced Experimental Asthma In Mice. Respir Physiol Neurobiol. Sep, 231:7-13, 2016.
• Bozkurt T.E., Larsson O., Adner M. Stimulation Of Cannabinoid Cb1 Receptors Prevents Nerve-Mediated Airway Hyperreactivity In Ngf-Induced Inflammation In Mouse Airways. EUR. J. Pharmacol. Apr 5;776:132-8, 2016.
• Cinar, E., Yalcin-Cakmakli, G., Saka, E., Ulusoy, A., Yuruker, S., Elibol, B., Tel, BC, (2020) Modeling Cognitive Deficits In Parkinson's Disease: Is Ca2 A Gateway For Hippocampal Synucleinopathy? Experimental Neurology (330) 113357:1-16.
• Çınar, E., Yalçın- Çakmaklı, G., Tel, B.C. (2019) Neuroprotective Treatments In Parkinson's Disease. Turkish Journal Of Neurology 25 (4): 25: 189-197.
• Çınar, E., Yalçın- Çakmaklı, G., Tel, B.C. (2020) Motor Dysfunction And Related Synaptic Organization In Avv-Mediated Alpha-Synuclein Overexpression Model Of Parkinson's Disease. Hacettepe University Journal of the Faculty of Pharmacy/ Hacettepe University Journal Of The Faculty Of Pharmacy 40(2):74-82.
• Denizaltı M, Durlu-Kandilci N.T., Simsek G., Bozkurt T.E., Sahin-Erdemli I. Rho Kinase And Protein Kinase C Pathways Are Responsible For Enhanced Carbachol Contraction İn
• Denizalti M., Durlu-Kandilci N.T., Simsek G., Bozkurt T.E., Sahin-Erdemli I. Rho Kinase And Protein Kinase C Pathways Are Responsible For Enhanced Carbachol Contraction In Permeabilized Detrusor In A Rat Model Of Cystitis. Basic Clin Pharmacol Toxicol. Nov;123(5):567-576, 2018.
• Durlu-Kandilci N.T., Denizaltı M., Sahin-Erdemli I. Aging Changes Agonist Induced Contractile Responses In Permeabilized Rat Bladder. Age (Dordr). 37(4):9807, 2015.
• Karahan H, Lüle S, Kelicen-Uğur P. Aromatase/Seladin-1 Interactions In Human Neuronal Cell Culture, The Hippocampus Of Healthy Rats And Transgenic Alzheimer's Disease Mice. pharmacology. 2018; 102(1-2):42-52.
• Kaya-Yasar Y., Karaman Y., Bozkurt T.E., Onder Sc, Sahin-Erdemli I. Effects Of Intranasal Treatment With Slow (Gyy4137) And Rapid (Nahs) Donors Of Hydrogen Sulfide In Lipopolysaccharide-Induced Airway Inflammation In Mice. Pulm Pharmacol Ther. 45: 170-180, 2017.
• Kazkayası I., Burul-Bozkurt N., Uma S. The Relationship Between Diabetes and Alzheimer's Disease (J Lit Pharm Sci 2018;7(2):110-7) Doi: 10.5336/Pharmsci.2017-58894
• Kazkayasi I., Burul-Bozkurt N., Ismail Ma., Merino-Serrais P., Pekiner C., Cedazo-Minguez A., Uma S. Insulin Deprivation Decreases Insulin Degrading Enzyme Levels In Primary Cultured Cortical Neurons And In The Cerebral Cortex Of Rats With Streptozotocin-Induced Diabetes, Pharmacological Reports, 2018, Vol 70, Issue 4, Pages 677-683) Doi: 10.1016/J.Pharep.2018.01.008
• Kazkayasi I., Ismail Ma., Parrado-Fernandez C., Björkhem I., Pekiner C., Uma S., Cedazo-Minguez A., Burul-Bozkurt N. Lack Of Insulin Results In Reduced Seladin-1 Expression In Primary Cultured Neurons And In Cerebral Cortex Of Stz-Induced Diabetic Rats, 2016, Neurosci. Lett., Vol 633, Pages 174-181
• Kelicen-Ugur P, Cincioğlu-Palabıyık M, Çelik H, Karahan H. Interactions Of Aromatase And Seladin-1: A Neurosteroidogenic And Gender Perspective. Transl Neurosci. 2019 Nov 6;10:264-279.
• Ozkan Mh And Uma S. Beta-Adrenergic Receptor Blocker Icı 118,551 Selectively Increases Intermediate-Conductance Calcium-Activated Potassium Hannel (Ikca)-Mediated Relaxations In Rat Main Mesenteric Artery. Basic Clin Pharmacol Toxicol. 2018; 122(6):570-6.
• Permeabilized Detrusor In A Rat Model Of Cystitis. Basic Clin Pharmacol Toxicol. 123(5):567-576, 2018.
• Sarigol, D., Uzgoren-Baran, A., Tel, BC, Somuncuoglu, EI, Kazkayasi I., Ozadali-Sari K., Unsal-Tan O., Okay, G., Ertan, M., Tozkoparan, B. ., (2015). Novel Thiazolo[3,2-B]-1,2,4-Triazoles Derived From Naproxen With Analgesic/Anti-Inflammatory Properties: Synthesis, Biological Evaluation And Molecular Modeling Studies. Bioorganic & Medicinal Chemistry. 23(10):2518-28.
• Sert-Ozgur, S., Tel, BC, Somuncuoglu, EI, Kazkayasi, I., Ertan, M., Tozkoparan, B., (2017) Design And Synthesis Of 1,2,4-Triazolo[3,2- B]-1,3,5-Thiadiazine Derivatives As A Novel Template For Analgesic/Anti-Inflammatory Activity. arch. Pharm. (Weinheim). 350(7) E1700052.
• Tel, B.C., Telli, G., Onder, S., Nemutlu, E., Bozkurt, T.E., (2021) Investigation Of The Relationship Between Chronic Montelukast Treatment, Asthma And Depression-Like Behavior In Mice. Experimental And Therapeutic Medicine 21 (1): 27:1-9.
• Telli, G., Erac, Y., Tel, B.C., Gumusel, B., (2018) Mechanism Of Adrenomedullin 2/Intermedin Mediated Vasorelaxation In Rat Main Pulmonary Artery. Peptides 103: 65–71.
• Telli, G., Tel, B.C., Buyukafsar, K., Gumusel, B., (2018) Effects Of Gper-1 Receptor Activation On The Reactivity Of Pulmonary Vascular Bed And Its Possible Protective Role On Ischemia/Reperfusion Injury. Journal Of Research In Pharmacy 22 (3):422-428.
• Telli, G., Tel, B.C., Gumusel, B. (2020) The Cardiopulmonary Effects Of The Calcitonin Gene-Related Peptide Family. Turkish Journal Of Pharmaceutical Sciences 17(2):349-356.
• Telli, G., Tel, B.C., Yersal, N., Korkusuz, P., Gumusel, B., (2018) Effect Of Intermedin/Adrenomedullin2 On The Pulmonary Vascular Bed In Hypoxia-Induced Pulmonary Hypertensive Rats. LifeSci. 192:62-67.