Prof. Dr. Altan Günalp Research Laboratory

About

General Overview

In the context of genomic sciences, the Medical Biology department conducts research in identification of rare disease genes and the molecular fundamentals of genetic diseases by using “omics” technologies. Department also performs research on biomarker identification and investigation of new therapeutic approaches. Several collaborations are held with basic and medical science divisions of Hacettepe University Faculty of Medicine and also with Faculty of Pharmacy and Faculty of Science

National Collaborations;

  • Sabancı University, Faculty of Engineering and Natural Sciences
  • Ankara University Biotechnology Institute
  • Bilkent University, Molecular Biology and Genetic Department
  • Middle East Technical University, Department of Chemistry, Computer Engineering and Biostatistics
  • Kadir Has University ,Faculty of Engineering and Natural Sciences, Bioinformatics and Genetics

International Collaborations;

  • Hannover Medical School Institute of Neuroanatomy
  • University of Luxembourg-Centre for Systems Biomedicine
  • King's College London-Randall Division for Cell & Molecular Biophysics and MRC Centre for Developmental Neurobiology Muscle Signalling Section
  • Imperial Collage Faculty of Medicine-Neuromuscular Unit
  • University of Michigan, Department of Cell and Development Biology

Patents

  • HDAC inhibition activities and gene expression inducing effects of arylbutanoic acid derivatives. (National patent, TR2011 03844 A2)
  • Molecular genetic diagnosis kit for phenylketonuria and hyperphenylalaninemia (National patent 2009 04011)

Awards

  • Presentation Award (2016): “Autophagy Mechanism in Gaucher Disease Pathology”. V. National Conference of Lysosomal Diseases, 14-17th April 2016, Bodrum, Muğla
  • Poster Award (2015): The effect of anti-inflammatory drugs on ASC gene level and cellular viability” 8th International Congress of Familial Mediterranean Fever and Systemic Autoinflammatory Diseases (ISSAID), 30th September- 3rd October 2015, Dresden,Germany
  • Hacettepe Technopolis Project Award (2009): The development of a genetic diagnostic kit for phenylketonuria disease in Turkish population, 1501 R&D support project.
  • Prof. Dr. Altan Günalp Scientific Award (2009): Histone Deacetylase Inhibition Activity and Molecular Docking of (e)-Resveratrol: Its Therapeutic Potential In Spinal Muscular Atrophy. XI. National Congress of Medical Biology and Genetics, 28-31 October 2009, Bodrum, Muğla, Turkey
  • Prof. Dr. Altan Günalp Scientific Award (2007): The expression of ASC in renal tissues of FMF patients with amyloidosis a potential role for ASC in AA type amyloid deposition.  X. National Congress of Medical Biology and Genetics. 6-9 September 2007, Antalya, Turkey
  • Prof. Dr. Altan Günalp Scientific Award (1998): Deletion and CA repeat analysis on Spinal Muscular Atrophy candidate genes. V. National Congress of Medical Biology and Genetics,  21-24 September 1998, İzmir, Turkey
  • HUGEV Young Scientist Publication Encouragement (1997): A Biochemical and Clinical Survey of Autosomal Recessive Limb Girdle Muscular Dystrophies in Turkey

Research Infrastructure

• PCR Biometra (T-Gradient)
• PCR
• PCR Thermo Scientific (SimpliAmp)
• Real Time-PCR Biorad (IQ5)
• DNA Sequence Analyzer AB Applied Biosystem (Science 3130 Genetic Analyzer)
• Microscope (Inverted, with Fluorescent attachment) Leica (DMIL)
• Fluorescent light source (shutter) and camera Leica (Kübler Codix), Leica (DFC320)
• Live Imaging, CO2 Controller and Tempcontrol Device Set PECON GmBH
• Microscope (Inverted) Leica (DFC320)
• Microscope (Dissection) CETI (Twisterz 7400)
• Capillary Western Blot device ProteinSimple (WES)
• Spectrophotometer Molecular Devices (SpektraMax M2)
• Spectrophotometer NanoDrop (ND-1000)
• Fluorometer
• Quantus (E6150)
• Tissue Shredder Thermo Fastprep (FP120)
• Sonicator Sonics Vibracell (BCX130)
• Shaker FALC
• Shaking American optical corporation (2156)
• Magnetic stirrer InterMed (QuickMag)
• Magnetic stirrer Thermolyne Vorymix (Nuova)
• Mini-rotator GrantBio (PTR-25)
• Falkon mixer IsoLab (MX-T6-S)
• Vortex Biosan (V1)
• Vortex Boeco (V1 Plus)
• Vortex Boeco (Biovortex v1)
• Precision balance KERN (ALJ220-4)
• Balance KERN (EW820-2-NM)
• pH meter Hanna Instruments (H12211)
• Centrifugal MPV (MPV-320R)
• Centrifuge Boeco (U-320R)
• Centrifuge IEC (SIZE:2, Model K,
• No: AA0743)
• Mini Centrifuge Biosan (Multispin MSC3000)
• Micro Centrifuge Hettich (EBA21)
• Heating block Eppendorf (ThermoMixer C)
• Multi Block Heater Thermo Lyne (Dri-bath 17600)
• Fume Hood
• Biosafety Cabinet Faster (BH-EN 2004)
• CO2 Oven Thermo Electron Corporation (Hera Cell 150)
• Panasonic CO2 Oven (MCO-18ACUV-PE)
• Oven Heraeus (Functionline)
• Shaking oven Shellab (SI4-2)
• Dry Oven Core (EN025)
• Beaded Heat Bath Grant
• Water bath Neslab (GP200)
• Electroporation device BTX Harvad (ECM830)
• Cell counter Roche Innovatis (Cedex XS)
• Liquid Aspirator Üzümcü (PA-2)
• UV Transilluminator Spectroline (TS-312E/F)
• Gel Imaging System Biodoc Analyze (Biometra)
• Chemiluminescent Imaging Device GeneGnome (75000)
• Western blot Semi-dry Transfer Device Biorad (Transblot SD cell)
• Autoclave Hirayama (HiClave HV-50L HMC)
• Autoclave (table top) Nuve (OT O32)
• Ice Machine SCOTSMANN (AF-100)
• Water Distiller Mes (Mp MINIpure)
• Microwave Oven Newtech
• Vertical Electrophoresis BioRad (Protean IIxi cell)
• Horizontal Electrophoresis Biorad (Mini sub cell GT), Biolab (SCIE-PLUS), Hybaid, Consort
• Power Supply (3 x) Biorad (PAC Universal and 200/2.0), Thermo (EC105)
• Uninterruptible Power Supply (UPS) (2 units) Inform
• Air Purifier (2 pcs.) Lovier
• Pasteur Oven Horo
• Vertical Freezers (-80 ºC) New BrunswickScientific and Hettich
• Deep Freezers (-20°C) Different brands
• Refrigerators Different brands
• Liquid nitrogen tank Statebourne (Biorack 3000)

Researchers

• 8 Faculty Members
• 1 Dr. Instructor
• 7 Research Assistants (2 post-doctoral, 5 doctorate)
• 9 Thesis Term Students (excluding research assistants)

Ongoing Projects

• 10 BAP
• 4 Tubitak
• 1 Infrastructure
• 1 Horizon 2020 (partner)

Completed Projects

• 19 BAP
• 7 Tubitak
• 1 Infrastructure
• 2 International (partner)

Publications

• 50 publications scanned in the Web of Science index

Links

About

General Overview

In the context of genomic sciences, the Medical Biology department conducts research in identification of rare disease genes and the molecular fundamentals of genetic diseases by using “omics” technologies. Department also performs research on biomarker identification and investigation of new therapeutic approaches. Several collaborations are held with basic and medical science divisions of Hacettepe University Faculty of Medicine and also with Faculty of Pharmacy and Faculty of Science

National Collaborations;

  • Sabancı University, Faculty of Engineering and Natural Sciences
  • Ankara University Biotechnology Institute
  • Bilkent University, Molecular Biology and Genetic Department
  • Middle East Technical University, Department of Chemistry, Computer Engineering and Biostatistics
  • Kadir Has University ,Faculty of Engineering and Natural Sciences, Bioinformatics and Genetics

International Collaborations;

  • Hannover Medical School Institute of Neuroanatomy
  • University of Luxembourg-Centre for Systems Biomedicine
  • King's College London-Randall Division for Cell & Molecular Biophysics and MRC Centre for Developmental Neurobiology Muscle Signalling Section
  • Imperial Collage Faculty of Medicine-Neuromuscular Unit
  • University of Michigan, Department of Cell and Development Biology

Patents

  • HDAC inhibition activities and gene expression inducing effects of arylbutanoic acid derivatives. (National patent, TR2011 03844 A2)
  • Molecular genetic diagnosis kit for phenylketonuria and hyperphenylalaninemia (National patent 2009 04011)

Awards

  • Presentation Award (2016): “Autophagy Mechanism in Gaucher Disease Pathology”. V. National Conference of Lysosomal Diseases, 14-17th April 2016, Bodrum, Muğla
  • Poster Award (2015): The effect of anti-inflammatory drugs on ASC gene level and cellular viability” 8th International Congress of Familial Mediterranean Fever and Systemic Autoinflammatory Diseases (ISSAID), 30th September- 3rd October 2015, Dresden,Germany
  • Hacettepe Technopolis Project Award (2009): The development of a genetic diagnostic kit for phenylketonuria disease in Turkish population, 1501 R&D support project.
  • Prof. Dr. Altan Günalp Scientific Award (2009): Histone Deacetylase Inhibition Activity and Molecular Docking of (e)-Resveratrol: Its Therapeutic Potential In Spinal Muscular Atrophy. XI. National Congress of Medical Biology and Genetics, 28-31 October 2009, Bodrum, Muğla, Turkey
  • Prof. Dr. Altan Günalp Scientific Award (2007): The expression of ASC in renal tissues of FMF patients with amyloidosis a potential role for ASC in AA type amyloid deposition.  X. National Congress of Medical Biology and Genetics. 6-9 September 2007, Antalya, Turkey
  • Prof. Dr. Altan Günalp Scientific Award (1998): Deletion and CA repeat analysis on Spinal Muscular Atrophy candidate genes. V. National Congress of Medical Biology and Genetics,  21-24 September 1998, İzmir, Turkey
  • HUGEV Young Scientist Publication Encouragement (1997): A Biochemical and Clinical Survey of Autosomal Recessive Limb Girdle Muscular Dystrophies in Turkey

Research Infrastructure

• PCR Biometra (T-Gradient)
• PCR
• PCR Thermo Scientific (SimpliAmp)
• Real Time-PCR Biorad (IQ5)
• DNA Sequence Analyzer AB Applied Biosystem (Science 3130 Genetic Analyzer)
• Microscope (Inverted, with Fluorescent attachment) Leica (DMIL)
• Fluorescent light source (shutter) and camera Leica (Kübler Codix), Leica (DFC320)
• Live Imaging, CO2 Controller and Tempcontrol Device Set PECON GmBH
• Microscope (Inverted) Leica (DFC320)
• Microscope (Dissection) CETI (Twisterz 7400)
• Capillary Western Blot device ProteinSimple (WES)
• Spectrophotometer Molecular Devices (SpektraMax M2)
• Spectrophotometer NanoDrop (ND-1000)
• Fluorometer
• Quantus (E6150)
• Tissue Shredder Thermo Fastprep (FP120)
• Sonicator Sonics Vibracell (BCX130)
• Shaker FALC
• Shaking American optical corporation (2156)
• Magnetic stirrer InterMed (QuickMag)
• Magnetic stirrer Thermolyne Vorymix (Nuova)
• Mini-rotator GrantBio (PTR-25)
• Falkon mixer IsoLab (MX-T6-S)
• Vortex Biosan (V1)
• Vortex Boeco (V1 Plus)
• Vortex Boeco (Biovortex v1)
• Precision balance KERN (ALJ220-4)
• Balance KERN (EW820-2-NM)
• pH meter Hanna Instruments (H12211)
• Centrifugal MPV (MPV-320R)
• Centrifuge Boeco (U-320R)
• Centrifuge IEC (SIZE:2, Model K,
• No: AA0743)
• Mini Centrifuge Biosan (Multispin MSC3000)
• Micro Centrifuge Hettich (EBA21)
• Heating block Eppendorf (ThermoMixer C)
• Multi Block Heater Thermo Lyne (Dri-bath 17600)
• Fume Hood
• Biosafety Cabinet Faster (BH-EN 2004)
• CO2 Oven Thermo Electron Corporation (Hera Cell 150)
• Panasonic CO2 Oven (MCO-18ACUV-PE)
• Oven Heraeus (Functionline)
• Shaking oven Shellab (SI4-2)
• Dry Oven Core (EN025)
• Beaded Heat Bath Grant
• Water bath Neslab (GP200)
• Electroporation device BTX Harvad (ECM830)
• Cell counter Roche Innovatis (Cedex XS)
• Liquid Aspirator Üzümcü (PA-2)
• UV Transilluminator Spectroline (TS-312E/F)
• Gel Imaging System Biodoc Analyze (Biometra)
• Chemiluminescent Imaging Device GeneGnome (75000)
• Western blot Semi-dry Transfer Device Biorad (Transblot SD cell)
• Autoclave Hirayama (HiClave HV-50L HMC)
• Autoclave (table top) Nuve (OT O32)
• Ice Machine SCOTSMANN (AF-100)
• Water Distiller Mes (Mp MINIpure)
• Microwave Oven Newtech
• Vertical Electrophoresis BioRad (Protean IIxi cell)
• Horizontal Electrophoresis Biorad (Mini sub cell GT), Biolab (SCIE-PLUS), Hybaid, Consort
• Power Supply (3 x) Biorad (PAC Universal and 200/2.0), Thermo (EC105)
• Uninterruptible Power Supply (UPS) (2 units) Inform
• Air Purifier (2 pcs.) Lovier
• Pasteur Oven Horo
• Vertical Freezers (-80 ºC) New BrunswickScientific and Hettich
• Deep Freezers (-20°C) Different brands
• Refrigerators Different brands
• Liquid nitrogen tank Statebourne (Biorack 3000)

Researchers

• 8 Faculty Members
• 1 Dr. Instructor
• 7 Research Assistants (2 post-doctoral, 5 doctorate)
• 9 Thesis Term Students (excluding research assistants)

Ongoing Projects

• 10 BAP
• 4 Tubitak
• 1 Infrastructure
• 1 Horizon 2020 (partner)

Completed Projects

• 19 BAP
• 7 Tubitak
• 1 Infrastructure
• 2 International (partner)

Publications

• 50 publications scanned in the Web of Science index

Links