Radiopharmacy Department Research Laboratory

About

Research Infrastructure

• Rotavapor
• Climate Cabinet
• A refrigerator
• Deep Freeze (-20°C)
• Precision Balance-Mettler
• Precision Balance-Computer Connection
• UV Spectrophotometer
• Viscometer
• Vacuum Oven
• Heat Block
• Refrigerated High Speed ​​Centrifuge
• Microcentrifuge
• Polarized Microscope
• Gamma Counter
• Liquid Scintillation Counter
• Dose Calibrator
• Geiger-Müller Counter
• Lead Armored Laminar Flow Cabin
• Lead Armored Refrigerator
• Lead Armored Deep Freezer
• L-Shielding
• Survey-Meter
• Pb Shielding in Various Sizes

Researchers

• Prof. Dr. Suna ERDOĞAN
• Dr. Instructor Member Mine SİLİNDİR GÜNAY
• Research Assistant Pharm. Elif Tuğçe SARCAN
• Res. Assistant Pharmac. Hümeyra BATTAL

Ongoing Projects

• Studies on Creating a Bone Metastasis Model to be Used in the Evaluation of the Efficacy of Radiopharmaceuticals to be Developed for Use in the Imaging of Bone Metastases, Project Coordinator: Prof.Dr.Suna Erdoğan; Researchers: Prof.Dr. Murat Tuncel, Prof.Dr. Kemal Kösemehmetoğlu, Hü-Bap Project, Project No: Thd-2019-17653; February 2019-February 2021.
• Development of Ga-68 Labeled Multifunctional Theranostic Liposomes Containing Ir 780 for Imaging and Photodynamic Therapy of Glioblastoma, Project Leader: Dr. Instructor Member Mine Cylinder Gunay; Researchers: Prof.Dr. Samiye Wildoglu Ciftci, Dr. Instructor Member İpek Baysal, Dr. Instructor Member Süleyman Can Öztürk, Tübitak-1001 Project No: 219s986; July 2020-Continuing.

Completed Projects

• Development of Tumor-Specific Targeted Nanosized Liposomes Containing Quantum Dots and Photosensitizer for Use in Radiotherapy, Project Coordinator: Prof.Dr. Suna Erdogan; Researchers: Prof.Dr. Murat Tuncel, Prof.Dr. Mustafa Cengiz, Prof.Dr. Rıfkı Hızıroğlu, Tübitak-1001, Project No: 116s323, 2017-2020.
• Development of Gallium-68 (Ga-68) Labeled Nanosized Tumor-targeted Liposomal Drug Delivery Systems for Tumor Imaging by Pet Method, Project Coordinator: Prof.Dr. Suna Erdogan; Researchers: Prof.Dr. Omer Ugur, Prof.Dr. Murat Tuncel, Prof.Dr. A. Yekta Ozer, Assoc. Dr. E. Meltem Ocak Demirci, Tübitak-1001, Project No: 115s416; 2015- 2019.
• Sterilization of Dermal Grafts, Bone Grafts and Cortical Laminas Used in Periodontology by Gamma Radiation; Project Manager: Dr. Instructor Member Mine Cylinder Gunay; Researchers: Prof.Dr. A. Yekta Ozer, Prof.Dr. Semra İde, Prof.Dr. Rahime Meral Nohutçu, Prof.Dr. Şeyda Colak, Assoc. Melike Ekizoğlu, Associate Professor Hüseyin Burak Kutlu; Hü-Bap Project, Project No: 12866; 2017- 2020.

Publications

• Bargh S, Cylinder-Gunay M, Ozer Ay, Palaska E, Karaarslan D, Ide S, Ve Ark. Physicochemical Evaluation Of Gamma And Microwave Irradiated Dental Grafts. Radiat Phys Chem. 2020; 170:108627.
• Erdogan S, Torchilin Vp. Gadolinium-Loaded Polychelating Polymer-Containing Tumor-Targeted Liposomes. Methods in Molecular Biology. 2017;1522:179-92.
• Gunay M.S, Ozer Ay, Erdogan S, Bodard S, Baysal I, Gulhan Z, Guilloteau D, Chalon S. Development Of Nanosized, Pramipexole-Encapsulated Liposomes And Niosomes For The Treatment Of Parkinson's Disease. J. Nanosci. nanotechnol. Development Of Nanosized, Pramipexole-Encapsulated Liposomes And Niosomes For The Treatment Of Parkinson's Disease. 2017;17:5155-67.
• Karpuz M, Cylinder Gunay M, Ozer Ay. Advances And Avenues In Development Of Novel Carriers For Bioactives And Biological Agents, Elsevier, Academic Press; 2020.
• Karpuz M, Cylinder-Gunay M, Kursunel Ma, Esendagli G, Dogan A, Ozer Ay. Design And In Vitro Evaluation Of Folate-Targeted, Co-Drug Encapsulated Theranostic Liposomes For Diagnosis And Therapy Of Non-Small Cell Lung Cancer. J Drug Deliv Sci Tec. 2020;57:101707.
• Karpuz M, Cylinder-Gunay M, Ozer Ay. Current And Future Approaches For Effective Cancer Imaging And Treatment. Cancer Biotherapy And Radiopharmaceuticals. 2018;33:39-51.
• Sakar F, Özer, Ay, Erdogan S, Ekizoglu M, Kart D, Özalp M, Colak S, Zencir Y. Nano Drug Delivery Systems And Gamma Radiation Sterilization. Pharm. Giant. Technol. 2017;22:775-84.
• Sarcan Et, Ozer Ay. Ionizing Radiation And Its Effects On Pharmaceuticals. J Radioanal And Nucl Ch. 2020;323:1-11.
• Sarcan Et, Cylinder-Gunay M, Ozer Ay. Theranostic Polymeric Nanoparticles For Nır Imaging And Photodynamic Therapy. int. J. Pharm. 2018;551:329-31.
• Sarcan Et, Tas A, Cylinder-Gunay M, Ozer Ay, Colak S, Hekimoglu B. Esr Investigations Of X-Ray Exposed Drugs. J Pharmceud Biomed. 2020;188:113311.
• Sarcan Et, Tas A, Cylinder-Gunay M, Ozer Ay, Palaska E, Hekimoglu B. Effect Of X-Ray Irradiation On Some Analgesics, Anti-Diabetics, PPI's, Anti-Hypertensives, Heart Failure Drugs In Tablet And Capsule Forms. J Pharm Sci. 2020;109(12);3653-3659.
• Cylinder Gunay M, Ozer Ay. Liposomes And Micelles As Nanocarriers For Diagnostic And Imaging Purposes.Design Of Nanostructures For Theranostics Applications. 2018:305-40.
• Cylinder Gunay M, Ozer Ay. Nanosized Drug Delivery Systems As Radiopharmaceuticals. Nanostructures For Cancer Therapy. 2017:563-92.
• Cylinder Gunay M, Ozer Ay. Nanocarriers For Diagnosis And Imaging Of Neurodegenerative Diseases. In: Pathology, Prevention And Therapeutics Of Neurodegenerative Diseases. Singapore: Springer Nature; 2019.
• Cylinder-Gunay M, Karpuz M, Ozturk N, Ozer Ay, Erdogan S, Tuncel M. Radiolabeled, Folate-Conjugated Liposomes As Tumor Imaging Agents: Formulation And In Vitro Evaluation. J Drug Deliv Sci Technol. 2019;50:321-328.
• Cylinder-Gunay M, Ozer Ay. 99mtc-Radiolabeled Levofloxacin And Micelles As Infection And Inflammation Imaging Agents. J Drug Deliv Sci Tec. 2020; 56:101571.
• Cylinder-Gunay M, Sarcan Et, Ozer Ay. Near-Infrared Imaging Of Diseases: A Nanocarrier Approach. Drug Dev Res. 2019;80(5):1-14.
• Cylinder-Gunay M. Glioma Imaging And Novel Agents. Frontiers In Clinical Drug Research-Cns And Neurological Disorders. Bentham Science Publishers Pte. Ltd., 2020.
Cylinder-Gunay M. The Formulation Of Methylene Blue Encapsulated, Tc-99m Labeled Multifunctional Liposomes For Sentinel Lymph Node Imaging And Therapy. Turk J Pharm Sci. 2020;17(4):381-387.

Links

About

Research Infrastructure

• Rotavapor
• Climate Cabinet
• A refrigerator
• Deep Freeze (-20°C)
• Precision Balance-Mettler
• Precision Balance-Computer Connection
• UV Spectrophotometer
• Viscometer
• Vacuum Oven
• Heat Block
• Refrigerated High Speed ​​Centrifuge
• Microcentrifuge
• Polarized Microscope
• Gamma Counter
• Liquid Scintillation Counter
• Dose Calibrator
• Geiger-Müller Counter
• Lead Armored Laminar Flow Cabin
• Lead Armored Refrigerator
• Lead Armored Deep Freezer
• L-Shielding
• Survey-Meter
• Pb Shielding in Various Sizes

Researchers

• Prof. Dr. Suna ERDOĞAN
• Dr. Instructor Member Mine SİLİNDİR GÜNAY
• Research Assistant Pharm. Elif Tuğçe SARCAN
• Res. Assistant Pharmac. Hümeyra BATTAL

Ongoing Projects

• Studies on Creating a Bone Metastasis Model to be Used in the Evaluation of the Efficacy of Radiopharmaceuticals to be Developed for Use in the Imaging of Bone Metastases, Project Coordinator: Prof.Dr.Suna Erdoğan; Researchers: Prof.Dr. Murat Tuncel, Prof.Dr. Kemal Kösemehmetoğlu, Hü-Bap Project, Project No: Thd-2019-17653; February 2019-February 2021.
• Development of Ga-68 Labeled Multifunctional Theranostic Liposomes Containing Ir 780 for Imaging and Photodynamic Therapy of Glioblastoma, Project Leader: Dr. Instructor Member Mine Cylinder Gunay; Researchers: Prof.Dr. Samiye Wildoglu Ciftci, Dr. Instructor Member İpek Baysal, Dr. Instructor Member Süleyman Can Öztürk, Tübitak-1001 Project No: 219s986; July 2020-Continuing.

Completed Projects

• Development of Tumor-Specific Targeted Nanosized Liposomes Containing Quantum Dots and Photosensitizer for Use in Radiotherapy, Project Coordinator: Prof.Dr. Suna Erdogan; Researchers: Prof.Dr. Murat Tuncel, Prof.Dr. Mustafa Cengiz, Prof.Dr. Rıfkı Hızıroğlu, Tübitak-1001, Project No: 116s323, 2017-2020.
• Development of Gallium-68 (Ga-68) Labeled Nanosized Tumor-targeted Liposomal Drug Delivery Systems for Tumor Imaging by Pet Method, Project Coordinator: Prof.Dr. Suna Erdogan; Researchers: Prof.Dr. Omer Ugur, Prof.Dr. Murat Tuncel, Prof.Dr. A. Yekta Ozer, Assoc. Dr. E. Meltem Ocak Demirci, Tübitak-1001, Project No: 115s416; 2015- 2019.
• Sterilization of Dermal Grafts, Bone Grafts and Cortical Laminas Used in Periodontology by Gamma Radiation; Project Manager: Dr. Instructor Member Mine Cylinder Gunay; Researchers: Prof.Dr. A. Yekta Ozer, Prof.Dr. Semra İde, Prof.Dr. Rahime Meral Nohutçu, Prof.Dr. Şeyda Colak, Assoc. Melike Ekizoğlu, Associate Professor Hüseyin Burak Kutlu; Hü-Bap Project, Project No: 12866; 2017- 2020.

Publications

• Bargh S, Cylinder-Gunay M, Ozer Ay, Palaska E, Karaarslan D, Ide S, Ve Ark. Physicochemical Evaluation Of Gamma And Microwave Irradiated Dental Grafts. Radiat Phys Chem. 2020; 170:108627.
• Erdogan S, Torchilin Vp. Gadolinium-Loaded Polychelating Polymer-Containing Tumor-Targeted Liposomes. Methods in Molecular Biology. 2017;1522:179-92.
• Gunay M.S, Ozer Ay, Erdogan S, Bodard S, Baysal I, Gulhan Z, Guilloteau D, Chalon S. Development Of Nanosized, Pramipexole-Encapsulated Liposomes And Niosomes For The Treatment Of Parkinson's Disease. J. Nanosci. nanotechnol. Development Of Nanosized, Pramipexole-Encapsulated Liposomes And Niosomes For The Treatment Of Parkinson's Disease. 2017;17:5155-67.
• Karpuz M, Cylinder Gunay M, Ozer Ay. Advances And Avenues In Development Of Novel Carriers For Bioactives And Biological Agents, Elsevier, Academic Press; 2020.
• Karpuz M, Cylinder-Gunay M, Kursunel Ma, Esendagli G, Dogan A, Ozer Ay. Design And In Vitro Evaluation Of Folate-Targeted, Co-Drug Encapsulated Theranostic Liposomes For Diagnosis And Therapy Of Non-Small Cell Lung Cancer. J Drug Deliv Sci Tec. 2020;57:101707.
• Karpuz M, Cylinder-Gunay M, Ozer Ay. Current And Future Approaches For Effective Cancer Imaging And Treatment. Cancer Biotherapy And Radiopharmaceuticals. 2018;33:39-51.
• Sakar F, Özer, Ay, Erdogan S, Ekizoglu M, Kart D, Özalp M, Colak S, Zencir Y. Nano Drug Delivery Systems And Gamma Radiation Sterilization. Pharm. Giant. Technol. 2017;22:775-84.
• Sarcan Et, Ozer Ay. Ionizing Radiation And Its Effects On Pharmaceuticals. J Radioanal And Nucl Ch. 2020;323:1-11.
• Sarcan Et, Cylinder-Gunay M, Ozer Ay. Theranostic Polymeric Nanoparticles For Nır Imaging And Photodynamic Therapy. int. J. Pharm. 2018;551:329-31.
• Sarcan Et, Tas A, Cylinder-Gunay M, Ozer Ay, Colak S, Hekimoglu B. Esr Investigations Of X-Ray Exposed Drugs. J Pharmceud Biomed. 2020;188:113311.
• Sarcan Et, Tas A, Cylinder-Gunay M, Ozer Ay, Palaska E, Hekimoglu B. Effect Of X-Ray Irradiation On Some Analgesics, Anti-Diabetics, PPI's, Anti-Hypertensives, Heart Failure Drugs In Tablet And Capsule Forms. J Pharm Sci. 2020;109(12);3653-3659.
• Cylinder Gunay M, Ozer Ay. Liposomes And Micelles As Nanocarriers For Diagnostic And Imaging Purposes.Design Of Nanostructures For Theranostics Applications. 2018:305-40.
• Cylinder Gunay M, Ozer Ay. Nanosized Drug Delivery Systems As Radiopharmaceuticals. Nanostructures For Cancer Therapy. 2017:563-92.
• Cylinder Gunay M, Ozer Ay. Nanocarriers For Diagnosis And Imaging Of Neurodegenerative Diseases. In: Pathology, Prevention And Therapeutics Of Neurodegenerative Diseases. Singapore: Springer Nature; 2019.
• Cylinder-Gunay M, Karpuz M, Ozturk N, Ozer Ay, Erdogan S, Tuncel M. Radiolabeled, Folate-Conjugated Liposomes As Tumor Imaging Agents: Formulation And In Vitro Evaluation. J Drug Deliv Sci Technol. 2019;50:321-328.
• Cylinder-Gunay M, Ozer Ay. 99mtc-Radiolabeled Levofloxacin And Micelles As Infection And Inflammation Imaging Agents. J Drug Deliv Sci Tec. 2020; 56:101571.
• Cylinder-Gunay M, Sarcan Et, Ozer Ay. Near-Infrared Imaging Of Diseases: A Nanocarrier Approach. Drug Dev Res. 2019;80(5):1-14.
• Cylinder-Gunay M. Glioma Imaging And Novel Agents. Frontiers In Clinical Drug Research-Cns And Neurological Disorders. Bentham Science Publishers Pte. Ltd., 2020.
Cylinder-Gunay M. The Formulation Of Methylene Blue Encapsulated, Tc-99m Labeled Multifunctional Liposomes For Sentinel Lymph Node Imaging And Therapy. Turk J Pharm Sci. 2020;17(4):381-387.

Links