Toxicology Laboratory

About

Research Infrastructure

• Olympus BX51 Light Microscope
• SHIMADZU CL-770 Clinical Spectrophotometer
• MELET SCHLOESING MS59 Blood Counter
• Vacuum oven 28L
• Leica CM1900 Cryostat
• Leica RM2125 Microtome
• Protherm Muffle Furnace
• SHIMADZU PharmaSpec UV-1700 UV-Visible Spectrophotometer
• Vacuum Oven
• MICCRA Tissue Homogenizer
• Leica Microscope

Researchers

•    Prof. Dr. Nurhayat Barlas
•    Prof. Dr. Güldeniz Selmanoğlu
•    Doç.Dr. Aysun Kılıç Süloğlu
•    Dr. Elif Karacaoğlu
PhD Students
•    Eda Nur İnkaya
•    Nilüfer Coşkun
Master Students
•    Mevlahan Özkan,
•    Mehmet Emre Erol
•    Ceren Kayi
•    Ekin Tokgöz

Ongoing Projects

• Barlas, N, Semra İde, Aysun Kılıç Süloğlu, Tuncay Türkeş, Seçil Karahisar Turan, Tayfun İde, In vitro and In Vivo Investigation of the Fine Structure, Cytotoxic Effect and Medical Use of Argiope bruennichi Spider Silk-Based New Design Biomaterial, H. Ü . Scientific Research Unit, FBA-2018-16615 Project (Project Manager) 27.03.2018 - 27.03.2020, 128,838.95 (TL).

Completed Projects

• Barlas, N., Karabulut, G., Kaçamak, P., Investigation of the Cytotoxic and Genotoxic Effects of Tetrabromobisphenol A on the Hs 578Bst Human Breast Cell Line H. Ü. Scientific Research Unit FHD-2015-6025 Project (Project Manager) 2015.
• Barlas, N., Burcu Öztaşçı., Investigation of the genotoxic, histological and biochemical effects of butylparaben (Butyl 4-hydroxybenzoate) in pubertal male rats. H. U. Scientific Research Unit FHD-2015-6025 Project (Project Manager) 2015-1016.
• Barlas, N., Özdemir, E., Investigation of Antiandrogenic Effects of Propyl Paraben in Immature Male Rats, H. Ü. Scientific Research Unit, FHD-2017-13477 Project (Project Manager) 2017-1017,
• Barlas, N; Eda Nur İNKAYA; Nilüfer COŞKUN Investigation of the Combined Effect of Methyl Paraben and Propyl Paraben on Pituitary Adrenal Axis in Male Rats. H. U. Scientific Research Unit, Project No: FHD-2018-17085, 25.12.2019.
• Barlas, N; Nilüfer COŞKUN; Eda Nur İNKAYA Investigation of the Protective Effects of Fluoretin Against Bisphenol A-Induced Polycystic Ovary Syndrome in Rats, H. Ü. Scientific Research Unit, FHD-2019-17619

Publications

• Taslan C, Yaşar S, Tanyolaç MB, Turgut K, Sireli UT, Atak Ç, Haliloğlu K, Benlioğlu K, Taşkın KM, Barlas N, Yıldız G, 2020, CRISPR-Of-Things: Applications and Challenges of the Most Popular Gene Editing Tool in the Fields of Health, Agriculture and Environment, International Journal of Innovative Approaches in Science Research.
• Duygu Aydemir, Burcu Öztaşcı, Nurhayat Barlas, Nuriye Nuray Ulusu, 2021, Influence of the butylparaben administration on the oxidative stress metabolism of liver, kidney and spleen, Turkish Journal of Biochemistry, vol:46 (2021), iss:1. DOI: https://doi.org/10.1515/tjb-2020-0048.
• Nurhayat Barlas, Emre Göktekin, Gözde Karabulut, 2020, Influence of in utero di-n-hexyl phthalate and di-cyclohexyl phthalate exposure on the endocrine glands and T3, T4, TSH hormone levels of male and female rats: Postnatal outcomes, Toxicology and Industrial Health Vol. 36(6) 399–416, © DOI: 10.1177/0748233720931698.
• Duygu Aydemir, Burcu Öztaşcı, Nurhayat Barlas, Nuriye Nuray Ulusu, 2019. Butylparaben effects on antioxidant enzyme activity and histopathological changes in rat tissues, Archives of Industrial Hygiene and Toxicology, 70: 315-324. DOI: 10.2478/aiht-2019-70-3342.
• Nurhayat Barlas, Aslı Okan Oflamaz, 2019, Assessing the Potential Impact on the Liver, Kidney, Spleen and Some Endocrine Glands of Myricetin in Male Rats at Prepubertal Period, Hacettepe J. Biol. & Chem., 47 (3), 317-326.
• Duygu Aydemir, Gözde Karabulut, Muslum Gök, Nurhayat Barlas, Nuray N Ulusu, 2019, Data the DEHP induced changes on the trace element and mineral levels in the brain and testis tissues of rats, Data in Brief, 26, 104526. doi. org/10.1016/j.dib.2019.104526
• Fatma Telli Karakoç and Nurhayat Barlas, 2019, Determination of the healthiness of aquaculture fish by enzymes and histopathological methods. Marine Pollution Bulletin, 149, 110535. https://doi.org/10.1016/j.marpolbul.2019.110535.
• Nurhayat Barlas, Nuray N Nation, 2019, Endocrine Disruptors. Endocrine, Metabolic Diseases and in vitro Diagnostics. Biomarkers from Diagnosis to Treatment, Dokuz Eylul University Press. Editors: Hilal Koçar, Aysun Pabuççuoğlu, Nilgün Yener Publication No: 09.8888.5200.000/DR.018.004.938, ISBN: 978-975-444-513-1.
• Gözde Karabulut, Nurhayat Barlas, 2018, A dose–response study following in vivo exposure to di (2-ethylhexyl)-phthalate (DEHP): Genotoxic, histologic, immunohistochemical, morphometric and hormonal effects on reproductive systems in pre-pubertal male rats , Toxicology Research DOI: 10.1039/c8tx00045j. 7, 859 – 873. Q4
• Duygu Aydemir, Gözde Karabulut, Gülsu Şimsek, Muslum Gök, Nurhayat Barlas, Nuray Ulusu, 2018, Impact of the Di(2-ethylhexyl) phthalate administration on trace element and mineral levels in relation of kidney and liver damage in rats. Biological Trace Element Research. 186:474–488 https://doi.org/10.1007/s12011-018-1331-0.Q3,
• Ecem Özdemir, Nurhayat Barlas and Mehmet Alper Çetinkaya, 2018, Assessing the antiandrogenic properties of propyl paraben using the Hershberger bioassay. DOI:10.1039/c7tx00319f, Toxicology Research, 2018, 7, 235 – 243.Q4
• Emre Göktekin, Nurhayat Barlas, 2017, Biochemical and histopathological effects of in utero di-n-hexyl phthalate and di-cyclohexyl phthalate exposure on the thyroid gland and T3, T4, TSH hormone levels of male rats: at adulthood. Erciyes Medical Journal 39 (4) 176-182, DOİ:10.5152/etd.2017.17069
• Müfide Aydogan Ahbab; Celal Guven; Evrim Arzu Koçkaya; Nurhayat Barlas, 2017, Comparative developmental toxicity evaluation of Di-n-hexyl phthalate and Dicyclohexyl phthalate in rats. Toxicology and Industrial Health. WOS:000410998600004 Vol. 33(9) 696–716. DOI: 10.1177/074823371711868. Q4
• Müfide Aydoğan Ahbab, Nurhayat Barlas*, Gözde Karabulut, 2017, Toxicity studies of bisphenol A and octylphenol: hormonal, histopathologic and immunohistochemical effects on the reproductive system of prepubertal male rats, Toxicology and Industrial Health Volume 33, Issue 2, 1 February 2017 , WOS:000397442200004 Pages 133-146, DOI: 10.1177/0748233715603847.Q4
• Müfide Aydoğan Ahbab, Nurhayat Barlas., 2015, Influence of in utero Di-n-hexyl phthalate and Dicyclohexyl phthalate on fetal testicular development in rats. Toxicology Letters., 233, 125-137, doi.org/10.1016/j.toxlet.2015.01.015,
• Aslı Okan, Nurhayat Barlas, Gözde Karabulut, 2015, Investigation of effects of myricetin on thyroid-gonadal axis of male rats at prepubertal period, Environmental Toxicology and Pharmacology 40, 268-279. //dx.doi.org/doi: 10.1016/j.etap.2015.04.015.
• Nurhayat Barlas, Gözde Karabulut, 2015, Hematological and histopathological effects of apigenin, phloretin and myricetin based on uterotrophic assay in immature Wistar female albino rats, Human Experimental Toxicology Vol. 34(7) 755–768 DOI: 10.1177/0960327114557903.

Links

About

Research Infrastructure

• Olympus BX51 Light Microscope
• SHIMADZU CL-770 Clinical Spectrophotometer
• MELET SCHLOESING MS59 Blood Counter
• Vacuum oven 28L
• Leica CM1900 Cryostat
• Leica RM2125 Microtome
• Protherm Muffle Furnace
• SHIMADZU PharmaSpec UV-1700 UV-Visible Spectrophotometer
• Vacuum Oven
• MICCRA Tissue Homogenizer
• Leica Microscope

Researchers

•    Prof. Dr. Nurhayat Barlas
•    Prof. Dr. Güldeniz Selmanoğlu
•    Doç.Dr. Aysun Kılıç Süloğlu
•    Dr. Elif Karacaoğlu
PhD Students
•    Eda Nur İnkaya
•    Nilüfer Coşkun
Master Students
•    Mevlahan Özkan,
•    Mehmet Emre Erol
•    Ceren Kayi
•    Ekin Tokgöz

Ongoing Projects

• Barlas, N, Semra İde, Aysun Kılıç Süloğlu, Tuncay Türkeş, Seçil Karahisar Turan, Tayfun İde, In vitro and In Vivo Investigation of the Fine Structure, Cytotoxic Effect and Medical Use of Argiope bruennichi Spider Silk-Based New Design Biomaterial, H. Ü . Scientific Research Unit, FBA-2018-16615 Project (Project Manager) 27.03.2018 - 27.03.2020, 128,838.95 (TL).

Completed Projects

• Barlas, N., Karabulut, G., Kaçamak, P., Investigation of the Cytotoxic and Genotoxic Effects of Tetrabromobisphenol A on the Hs 578Bst Human Breast Cell Line H. Ü. Scientific Research Unit FHD-2015-6025 Project (Project Manager) 2015.
• Barlas, N., Burcu Öztaşçı., Investigation of the genotoxic, histological and biochemical effects of butylparaben (Butyl 4-hydroxybenzoate) in pubertal male rats. H. U. Scientific Research Unit FHD-2015-6025 Project (Project Manager) 2015-1016.
• Barlas, N., Özdemir, E., Investigation of Antiandrogenic Effects of Propyl Paraben in Immature Male Rats, H. Ü. Scientific Research Unit, FHD-2017-13477 Project (Project Manager) 2017-1017,
• Barlas, N; Eda Nur İNKAYA; Nilüfer COŞKUN Investigation of the Combined Effect of Methyl Paraben and Propyl Paraben on Pituitary Adrenal Axis in Male Rats. H. U. Scientific Research Unit, Project No: FHD-2018-17085, 25.12.2019.
• Barlas, N; Nilüfer COŞKUN; Eda Nur İNKAYA Investigation of the Protective Effects of Fluoretin Against Bisphenol A-Induced Polycystic Ovary Syndrome in Rats, H. Ü. Scientific Research Unit, FHD-2019-17619

Publications

• Taslan C, Yaşar S, Tanyolaç MB, Turgut K, Sireli UT, Atak Ç, Haliloğlu K, Benlioğlu K, Taşkın KM, Barlas N, Yıldız G, 2020, CRISPR-Of-Things: Applications and Challenges of the Most Popular Gene Editing Tool in the Fields of Health, Agriculture and Environment, International Journal of Innovative Approaches in Science Research.
• Duygu Aydemir, Burcu Öztaşcı, Nurhayat Barlas, Nuriye Nuray Ulusu, 2021, Influence of the butylparaben administration on the oxidative stress metabolism of liver, kidney and spleen, Turkish Journal of Biochemistry, vol:46 (2021), iss:1. DOI: https://doi.org/10.1515/tjb-2020-0048.
• Nurhayat Barlas, Emre Göktekin, Gözde Karabulut, 2020, Influence of in utero di-n-hexyl phthalate and di-cyclohexyl phthalate exposure on the endocrine glands and T3, T4, TSH hormone levels of male and female rats: Postnatal outcomes, Toxicology and Industrial Health Vol. 36(6) 399–416, © DOI: 10.1177/0748233720931698.
• Duygu Aydemir, Burcu Öztaşcı, Nurhayat Barlas, Nuriye Nuray Ulusu, 2019. Butylparaben effects on antioxidant enzyme activity and histopathological changes in rat tissues, Archives of Industrial Hygiene and Toxicology, 70: 315-324. DOI: 10.2478/aiht-2019-70-3342.
• Nurhayat Barlas, Aslı Okan Oflamaz, 2019, Assessing the Potential Impact on the Liver, Kidney, Spleen and Some Endocrine Glands of Myricetin in Male Rats at Prepubertal Period, Hacettepe J. Biol. & Chem., 47 (3), 317-326.
• Duygu Aydemir, Gözde Karabulut, Muslum Gök, Nurhayat Barlas, Nuray N Ulusu, 2019, Data the DEHP induced changes on the trace element and mineral levels in the brain and testis tissues of rats, Data in Brief, 26, 104526. doi. org/10.1016/j.dib.2019.104526
• Fatma Telli Karakoç and Nurhayat Barlas, 2019, Determination of the healthiness of aquaculture fish by enzymes and histopathological methods. Marine Pollution Bulletin, 149, 110535. https://doi.org/10.1016/j.marpolbul.2019.110535.
• Nurhayat Barlas, Nuray N Nation, 2019, Endocrine Disruptors. Endocrine, Metabolic Diseases and in vitro Diagnostics. Biomarkers from Diagnosis to Treatment, Dokuz Eylul University Press. Editors: Hilal Koçar, Aysun Pabuççuoğlu, Nilgün Yener Publication No: 09.8888.5200.000/DR.018.004.938, ISBN: 978-975-444-513-1.
• Gözde Karabulut, Nurhayat Barlas, 2018, A dose–response study following in vivo exposure to di (2-ethylhexyl)-phthalate (DEHP): Genotoxic, histologic, immunohistochemical, morphometric and hormonal effects on reproductive systems in pre-pubertal male rats , Toxicology Research DOI: 10.1039/c8tx00045j. 7, 859 – 873. Q4
• Duygu Aydemir, Gözde Karabulut, Gülsu Şimsek, Muslum Gök, Nurhayat Barlas, Nuray Ulusu, 2018, Impact of the Di(2-ethylhexyl) phthalate administration on trace element and mineral levels in relation of kidney and liver damage in rats. Biological Trace Element Research. 186:474–488 https://doi.org/10.1007/s12011-018-1331-0.Q3,
• Ecem Özdemir, Nurhayat Barlas and Mehmet Alper Çetinkaya, 2018, Assessing the antiandrogenic properties of propyl paraben using the Hershberger bioassay. DOI:10.1039/c7tx00319f, Toxicology Research, 2018, 7, 235 – 243.Q4
• Emre Göktekin, Nurhayat Barlas, 2017, Biochemical and histopathological effects of in utero di-n-hexyl phthalate and di-cyclohexyl phthalate exposure on the thyroid gland and T3, T4, TSH hormone levels of male rats: at adulthood. Erciyes Medical Journal 39 (4) 176-182, DOİ:10.5152/etd.2017.17069
• Müfide Aydogan Ahbab; Celal Guven; Evrim Arzu Koçkaya; Nurhayat Barlas, 2017, Comparative developmental toxicity evaluation of Di-n-hexyl phthalate and Dicyclohexyl phthalate in rats. Toxicology and Industrial Health. WOS:000410998600004 Vol. 33(9) 696–716. DOI: 10.1177/074823371711868. Q4
• Müfide Aydoğan Ahbab, Nurhayat Barlas*, Gözde Karabulut, 2017, Toxicity studies of bisphenol A and octylphenol: hormonal, histopathologic and immunohistochemical effects on the reproductive system of prepubertal male rats, Toxicology and Industrial Health Volume 33, Issue 2, 1 February 2017 , WOS:000397442200004 Pages 133-146, DOI: 10.1177/0748233715603847.Q4
• Müfide Aydoğan Ahbab, Nurhayat Barlas., 2015, Influence of in utero Di-n-hexyl phthalate and Dicyclohexyl phthalate on fetal testicular development in rats. Toxicology Letters., 233, 125-137, doi.org/10.1016/j.toxlet.2015.01.015,
• Aslı Okan, Nurhayat Barlas, Gözde Karabulut, 2015, Investigation of effects of myricetin on thyroid-gonadal axis of male rats at prepubertal period, Environmental Toxicology and Pharmacology 40, 268-279. //dx.doi.org/doi: 10.1016/j.etap.2015.04.015.
• Nurhayat Barlas, Gözde Karabulut, 2015, Hematological and histopathological effects of apigenin, phloretin and myricetin based on uterotrophic assay in immature Wistar female albino rats, Human Experimental Toxicology Vol. 34(7) 755–768 DOI: 10.1177/0960327114557903.

Links