Laboratory infrastructure is planned for preclinical studies in vaccine development. It is used jointly by the Vaccine Institute and the Faculty of Pharmacy. The Faculty of Medicine also supports the studies. Currently, studies on the development of peptide-based COVID-19 vaccine and recombinant tuberculosis vaccine are conducted.
oint facilities of Faculty of Pharmacy and Vaccine Institute
• Assoc. Dr. Sezer OKAY
• Dr. Lecturer Semra AYDIN
• Dr. Lecturer Gamze VARAN, Ph.D
Research and Development Studies on Peptide Based Vaccine Against COVID-19
• Varan, G. Varan, C., Öztürk, SC, Benito, JM, Esendağlı, G., Bilensoy, E. Therapeutic efficacy and biodistribution of paclitaxel-bound amphiphilic cyclodextrin nanoparticles: Analyses in 3D tumor culture and tumor-bearing in animals vivo, Nanomaterials, 11 (2): 1-18 (2021)
• Çelebier M., Ercan A., Oncul S., Varan G., Kocak E., Bilensoy E. Polycationic Cyclodextrin Nanoparticles Induced Cell Death on Hepatocellular Carcinoma Cells: An Evaluation at The Molecular Level, International Journal of Pharmaceutics, 598: 120379 (2021)
• Varan G., Akkın S., Demirtürk N., Benito J., Bilensoy E. Erlotinib Entrapped to Cyclodextrin Nanoparticles Shows Improved Antitumoral Efficacy in 3D Spheroid Tumors of the Lung and Liver. Journal of Drug Targeting (2020)
• Ercan A., Çelebier M., Varan G., Öncül S., Nenni M, Kaplan, O., Bilensoy E. Global Omics Strategies to Investigate the Effect of Cyclodextrin Nanoparticles on MCF-7 Breast Cancer Cells, European Journal of Pharmaceutical Sciences, 123: 377-386 (2018)
Varan G., Patrulea V., Borchard G., Bilensoy E. Cellular Interaction and Tumoral Penetration Properties of Cyclodextrin Nanoparticles on 3D Breast Tumor Model, Nanomaterials, 8 (2): 67 (2018)
• Erdoğar N., Varan G., Bilensoy E. Amphiphilic Cyclodextrin Derivatives for Targeted Drug Delivery to Tumors, Current Topics in Medicinal Chemistry, 17: 1-8 (2017)
• Varan G., Varan C., Erdoğar N., Bilensoy E. Amphiphilic Cyclodextrin Nanoparticles, International Journal of Pharmaceutics, 531-2: 457-469 (2017)
Varan G., Benito J.M., Mellet C.O., Bilensoy E. Development of Polycationic Amphiphilic Cyclodextrin Nanoparticles for Anticancer Drug Delivery, Beilstein Journal of Nanotechnology, 8, 1457--1468 (2017)
Varan G., Öncül S., Ercan A., Benito JM, Mellet CO, Bilensoy E. Anticancer and Apoptotic Effects of Anionic and Polycationic Cyclodextrin Nanoparticles for Tumor Targeted Drug Delivery, Journal of Pharmaceutical Science, 105 (10), 3172- 82 (2016)
• Kılıç N, Derici MK, Büyük İ, Aydın SS, Aras S, Cansaran-Duman D. Evaluation of in vitro Anticancer Activity of Vulpinic Acid and its Apoptotic Potential Using Gene Expression and Protein Analysis. Indian J of Pharmaceutical Education and Research. 2017; 51 (2S): S46-S53
Soydam Aydın, S., Büyük, İ, Gökçe E., Büyük BP, Kandemir İ., Cansaran-Duman D., Aras, S. Effects of lead (Pb) and cadmium (Cd) elements on lipid peroxidation, catalase enzyme activity and catalase gene expression profile in Lycopersicum esculentum L. "Ankara University, Faculty of Agriculture Journal of Agricultural Sciences. 2016- 22 (4).
• Okay, S. (2016). In silico characterization of the citrate synthase family in Mycobacterium tuberculosis. Turkish Journal of Biochemistry 41 (2): 118-126. DOI: 10.1515 / tjb-2016-0019.
• Kurt Kızıldoğan, A., Abanoz, B., Okay, S. * (2017). Global transcriptome analysis of Halolamina sp. to decipher the salt tolerance in extremely halophilic archaea. Gene 601: 56-64. DOI: 10.1016 / j.gene.2016.11.042.
• Abanoz, B., Okay, S., Kurt-Kızıldoğan, A. (2017). Highly active and stable protease production by an extreme halophilic archaeon Haloarcula sp. TG1 isolated from Lake Tuz, Turkey. Turkish Journal of Biochemistry. 42 (3): 307-315. DOI: 10.1515 / tjb-2016-0191
• Merzoug, A., Chikhi, A., Bensegueni, A., Boucherit, H., Okay S. (2017). Virtual screening approach of bacterial peptide deformylase inhibitors results in new antibiotics. Molecular Informatics. 36: 1700087. DOI: 10.1002 / minf.201700087
• Okay, S. *, Sezgin, M. (2018). Transgenic plants for the production of immunogenic proteins. AIMS Bioengineering. 5 (3): 151--161. DOI: 10.3934 / bioeng.2018.3.151
• Okay, S. *, Çetin, R., Karabulut, F., Doğan, C., Sürücüoğlu, S., Kurt Kızıldoğan, A. (2019). Immune responses elicited by the recombinant Erp, HspR, LppX, MmaA4, and OmpA proteins from Mycobacterium tuberculosis in mice. Acta Microbiologica et Immunologica Hungarica. 66 (2): 219–234. DOI: 10.1556 / 030.65.2018.048
• Rahman, A., Siddiqui, S.A., Oke-Altuntas, F., Okay, S., Gül, F., Demirtas, I. (2019). Phenolic profile, essential oil composition and bioactivity of Lasia spinosa (L.) Thwaites. Brazilian Archives of Biology and Technology. 62: e19170757. DOI: 10.1590 / 1678-4324-2019170757
• Okay, S., (2020). Single-molecule characterization of drug delivery systems. ASSAY and Drug Development Technologies. 18 (1): 56-63. DOI: 10.1089 / adt.2018.903
• Okay, S., Yildirim, V., Büttner, K., Becher, D., Özcengiz, G. (2020). Dynamic proteomic analysis of Phanerochaete chrysosporium under copper stress. Ecotoxicology and Environmental Safety 198: 110694. DOI: 10.1016 / j.ecoenv.2020.110694
• Okay, S. *, Alshehri, W. A. (2020). Overexpression of chitinase A gene from Serratia marcescens in Bacillus subtilis and characterization of enhanced chitinolytic activity. Brazilian Archives of Biology and Technology. 63: e20200061. DOI: 10.1590 / 1678-4324-2020200061
• Regular, Ö. F., Okay, S. (2020). Promoter engineering for the recombinant protein production in prokaryotic systems. AIMS Bioengineering. 7 (2): 62--81. DOI: 10.3934 / bioeng.2020007
• Okay, S. *, Özcan, Ö. Ö., Karahan, M. (2020). Nanoparticle-based delivery platforms for mRNA vaccine development. AIMS Biophysics. 7 (4): 323--338. DOI: 10.3934 / biophy.2020023
• Öztürk, S., Okay, S., Yıldırım, A. (2020). Synthesis, anticorrosion, antibacterial, and antifungal activity of new amphiphilic compounds possessing quinazolin-4 (3H) -one scaffold. Russian Chemical Bulletin. 69 (11): 2205-2214.