Laboratuvarımızda çeşitli sentez yöntemleri ile biyouyumlu, biyobozunur mikro-nanopartiküller sentezlenmektedir. Bu mikro-nanopartiküllerin, nanoteknolojik güdümlü ilaçlar, nanopartiküllere ilaç yüklemesi ve kontrollü salım, biyopolimerik ve seramik malzemeden nanokompozit tasarlanması, nanopartiküllerle antibiyotik giderimi, adsorpsiyon, biyosorpsiyon, desorpsiyon, su/toprak biyoremediyasyonu gibi alanlarda uygulamaları araştırılmaktadır.
• Ultrasonikatör
• Liyofilizatör
• HPLC
• UV-VIS Spektrofotometre
• Mekanik Karıştırıcı
• Dijital Isıtıcılı Manyetik Karıştırıcı
• Çalkalayıcı
• Ultrasonik Homojenizatör
• Otoklav
• Santrifüj
• Masaüstü Soğutmalı Santrifüj
• Santrifüjlü Öğütücü
• Peristaltik Pompa
• Peristaltik Pompa
• Ölçüm Cihazı (pH/ORP/Sıcaklık/Kons./TDS/Tuz/DO/O2)
• Hassas Terazi
• Ultra Saf Su Sistemi
• Prof. Dr. Yeşim Sağ Açıkel
• Ezgi Türkeş (Doktora Tez Öğrencisi)
• Merve Öztekin (Doktora Tez Öğrencisi)
• Görkem Polat (Doktora Tez Öğrencisi)
• Ayşe Ekin Uzunhasanoğlu (Doktora Tez Öğrencisi)
• Ayşe Burcu Nazlı (Doktora Tez Öğrencisi)
• Damla Gürel (Yüksek Lisans Tez Öğrencisi)
1. “Meme Kanseri İçin Hedeflenebilir İlaç Salım Sistemi Olarak İkili İlaç Yüklü Albümin Bazlı Nanopartiküllerin Geliştirilmesi” başlıklı Doktora Tez Projesi (Hacettepe Üniversitesi Bilimsel Araştırma Projeleri Koordinasyon Birimi (BAP) Destekli)
Tamamlanan Projeler (Son 5 Yıl)
• “Kitosan ve halloysit bazlı nanopartiküller kullanılarak adsorpsiyon yoluyla sulu ortamlardan antibiyotik giderimi”, Hacettepe Üniversitesi, Bilimsel Araştırmalar Birimi, Kapsamlı Araştırma Projesi, Proje No: 1363, 03.04.2014 -22.09.2017.
• “Halloysit-aljinat nanojellerin ve halloysit-kitosan nanopartiküllerin karakterizasyonu, fizikokimyasal ve termal özelliklerinin belirlenmesi”, Hacettepe Üniversitesi, Bilimsel Araştırmalar Birimi, Hızlı Destek Projesi, Proje No: FHD-2015-6641, 13.07.2015-24.11.2017.
A. Makaleler
• Turkes, E., Acikel, Y. S. (2020). Synthesis and characterization of magnetic halloysite-chitosan nanocomposites: use in the removal of methylene blue in wastewaters. International Journal of Environmental Science and Technology, 17(3), 1281-1294.
• Oztekin, M., Acikel, Y. S. (2020). Investigation of adsorption of metronidazole on Chitosan - Halloysite nanocomposites and controlled release. Indian Journal of Chemical Technology, 27(2), 101-115.
• Nazli, A. B., Acikel, Y. S. (2019). Loading of cancer drug resveratrol to pH-Sensitive, smart, alginate-chitosan hydrogels and investigation of controlled release kinetics. Journal of Drug Delivery Science and Technology, 53, 16.
• Polat, G., Acikel, Y. S. (2019). Synthesis and Characterization of Magnetic Halloysite-Alginate Beads for the Removal of Lead(II) Ions from Aqueous Solutions. Journal of Polymers and the Environment, 27(9), 1971-1987.
• Acikel, Y. S., Goze, B. (2017). Removal of Methyl Red, a cationic dye, Acid Blue 113, an anionic dye, from wastewaters using chitin and chitosan: influence of copper ions. Desalination and Water Treatment, 73, 289-300.
• Raeiatbin, P., Acikel, Y. S. (2017). Removal of tetracycline by magnetic chitosan nanoparticles from medical wastewaters. Desalination and Water Treatment, 73, 380-388.
• Turkes, E., Acikel, Y.S. (2017). Chromium(VI) removal by a novel magnetic halloysite-chitosan nanocomposite from aqueous solutions. International Journal of Food and Biosystems Engineering, 5(1), 7-14.
• Polat, G., Acikel, Y.S. (2017). Synthesis of magnetic halloysite nanotube-alginate hybrid beads: Use in the removal of methylene blue from aqueous media. International Journal of Food and Biosystems Engineering, 5(1), 15-22.
• Goze, B., Evirgen, O. A., Acikel, Y. S. (2016). Investigation of antagonistic and synergistic interactions on simultaneous adsorption of crystal violet and Cu(II) using chitin and chitosan. Desalination and Water Treatment, 57(9), 4059-4072.
B. Uluslararası Kitapta Bölüm:
• M. Öztekin, Y.S. Açıkel, "Investigation of Metranidazole Adsorption Equilibrium and Kinetics on Chitosan Nanoparticles”, in Current Academic Studies in Engineering Sciences, Edited by: Prof. Dr. Serdar Salman, Prof. Dr. Rıdvan Karapınar, Doç. Dr. Duygu Kavak, Dr. Ali Kılıçer, Vol: II, (2018), p. 913-930, IVPE, Cetinje, Montenegro.
C. Uluslararası Kongrelerde Sunulan Tebliğler:
• G. Topal Canbaz, Ü. Açıkel, Y. Sağ Açıkel, “Phenol Removal from Aqueous Environment with ZnO Nanoparticles Produced from Onion Peel Wastes by Green Synthesis”, 5th Eurasia waste Management Symposium, İstanbul, October, 26-27, 2020, Proceedings Book, Full Paper, p. 95-98, ISBN: 978-625-409-001-1.
• G. Topal Canbaz, Ü. Açıkel, Y. Sağ Açıkel, “Green Synthesis of ZnO Nanoparticles from Onion Peel Wastes”, 5th Eurasia waste Management Symposium, İstanbul, October, 26-27, 2020, Proceedings Book, Full Paper, p. 117-121, ISBN: 978-625-409-001-1.
• Ü. Açıkel, Z.S. Keskin, G. Topal Canbaz, Y. Sağ Açıkel, "Synthesis of Copper Nanoparticles from Waste Onion Peels”, (oral presentation), The 5th International Symposium on Pharmaceutical and Biomedical Sciences, Cappadocia, Nevşehir, April 26-28, 2019, ISPBS-5 Proceedings Book, Abstracts & Full Papers, p. 107-112.
• Ü. Açıkel, G. Topal Canbaz, Y. Sağ Açıkel, “Green Synthesis of Silver Nanoparticles Using pomegranate Waste”, (oral presentation), The 5th International Symposium on Pharmaceutical and Biomedical Sciences, Cappadocia, Nevşehir, April 26-28, 2019, ISPBS-5 Proceedings Book, Abstracts & Full Papers, p. 113-118.
• Y. Sağ Açıkel, Ö.C. Aşkar, “Controlled Delivery of Ciprofloxacin from Halloysite Nanotubes”, (oral presentation), The 5th International Symposium on Pharmaceutical and Biomedical Sciences, Cappadocia, Nevşehir, April 26-28, 2019, ISPBS-5 Proceedings Book, Abstracts & Full Papers, p. 119-123.
• Y. Sağ Açıkel, M. Öztekin, P. Raeiatbin, “Sustained and Controlled Antibiotic Release from Chitosan and Magnetic Chitosan Nanoparticles”, (oral presentation), The 5th International Symposium on Pharmaceutical and Biomedical Sciences, Cappadocia, Nevşehir, April 26-28, 2019, ISPBS-5 Proceedings Book, Abstracts & Full Papers, p.124-128.
• M. Öztekin, Y. Sağ Açıkel, "Investigation of Metranidazole Adsorption Equilibrium and Kinetics on Chitosan Nanoparticles”, (oral presentation), 5th. International Multidisciplinary Studies Symposium (ISMS), Crowne Plaza Hotel-Ankara, 16-17 Kasım 2018.
• SAĞ AÇIKEL Yeşim (Prof. Dr.), Parinaz Raeiatbin (Yük. Müh.), “Tetracycline Loading to Magnetic Chitosan-Iron Oxide Nanocomposites and Controlled Release", oral presentation, International Eurasian Conference on Biological and Chemical Sciences (EurasianBioChem 2018), Crowne Plaza Hotel, Ankara, Türkiye, 26-27 Nisan, 2018, Abstract Book, p 217.
• TOPAL CANBAZ Gamze (Yük. Müh.), Ünsal Açıkel (Prof. Dr.), Yeşim Sağ Açıkel (Prof. Dr.), “Biosynthesis of Silver Nanoparticles by Persea Americana", oral presentation, International Eurasian Conference on Biological and Chemical Sciences (EurasianBioChem 2018), Crowne Plaza Hotel, Ankara, Türkiye, 26-27 Nisan, 2018, Abstract Book, p. 512.
• SAĞ AÇIKEL Yeşim (Prof. Dr.), Parinaz Raeiatbin (Yük. Müh.), “Tetracycline Removal by Magnetic Halloysite Nanotubes from Medical Wastewaters", poster presentation, International Eurasian Conference on Biological and Chemical Sciences (EurasianBioChem 2018), Crowne Plaza Hotel, Ankara, Türkiye, 26-27 Nisan, 2018, Abstract Book, p 906.
• POLAT, Görkem (Yük. Müh.), Yeşim Sağ Açıkel (Prof. Dr.), “Investigation of Adsorption Kinetics and Equilibrium of Methylene Blue on Magnetic Halloysite Nanotubes-Alginate Hydrogel Beads", poster presentation, International Eurasian Conference on Biological and Chemical Sciences (EurasianBioChem 2018), Crowne Plaza Hotel, Ankara, Türkiye, 26-27 Nisan, 2018, Abstract Book, p 1382.
• TÜRKEŞ, Ezgi (Yük. Müh.), Yeşim Sağ Açıkel (Prof. Dr.), “Investigation of Adsorption Kinetics and Equilibrium of Cr (VI) Ions on Magnetic Halloysite-Chitosan Nanocomposites", poster presentation, International Eurasian Conference on Biological and Chemical Sciences (EurasianBioChem 2018), Crowne Plaza Hotel, Ankara, Türkiye, 26-27 Nisan, 2018, Abstract Book, p 1388.
• ÖZTEKİN, Merve (Yük. Müh.), Yeşim Sağ Açıkel (Prof. Dr.), “Investigation of Metronidazole Loading and Release on / from Chitosan Nanoparticles”, poster presentation, International Eurasian Conference on Biological and Chemical Sciences (EurasianBioChem 2018), Crowne Plaza Hotel, Ankara, Türkiye, 26-27 Nisan, 2018, Abstract Book, p 1389.
• TOPAL CANBAZ Gamze (Yük. Müh.), Ünsal Açıkel (Prof. Dr.), Yeşim Sağ Açıkel (Prof. Dr.), “Equilibrium and Thermodynamic Studies for Adsorption of Cu(II) on Activated Sludge", poster presentation, International Eurasian Conference on Biological and Chemical Sciences (EurasianBioChem 2018), Crowne Plaza Hotel, Ankara, Türkiye, 26-27 Nisan, 2018, Abstract Book, p 1390.
• TÜRKEŞ, Ezgi (Yük. Müh.), Yeşim Sağ Açıkel (Prof. Dr.), “Chromium(VI) removal by a novel magnetic halloysite-chitosan nanocomposite from aqueous solutions”, 3rd International Conference of Food and Biosystems Engineering, Rhodes Island, Greece, 1-4 June, 2017, Proceedings of 3rd. I.C. FABE 2017, 202-209.
• POLAT, Görkem. (Yük. Müh.), Yeşim Sağ Açıkel (Prof. Dr.), “Synthesis of magnetic halloysite nanotube-alginate hybrid beads: Use in the removal of methylene blue from aqueous media”, 3rd International Conference of Food and Biosystems Engineering, Rhodes Island, Greece, 1-4 June, 2017, Proceedings of 3rd. I.C. FABE 2017, 210-217.
• AÇIKEL, Yeşim Sağ (Prof. Dr.), Başak Göze (Yük. Müh.), “Removal of methyl red, a cationic dye, acid blue 113, an anionic dye, from wastewaters using chitin and chitosan: influence of copper ions”, Desalination for the Environment: Clean Water and Energy, Rome, Italy, 22-26 May 2016, Abstracts, European Desalination Society, 2016, 81-82, Ps 2.
• RAEIATBİN, Perinaz (Yük. Müh.), AÇIKEL, Yeşim Sağ Açıkel (Prof. Dr.), “ Removal of tetracycline by magnetic chitosan nanoparticles from medical wastewaters”, Desalination for the Environment: Clean Water and Energy, Rome, Italy, 22-26 May 2016, Abstracts, European Desalination Society, 2016, 82-83, Ps 2.
• GÖZE, Başak (Yük. Müh.), Yeşim Sağ Açıkel (Prof. Dr.), “Investigation of Biosorption Kinetics and Equilibrium of Zinc by Chitin and Chitosan”, 16th International Symposium on Environmental Issues and Waste Management in Energy and Mineral Production, Istanbul, 5-7 October, 2016, Proceedings of SWEMP 2016-6, AGRO ARGE Danışmanlık San. Ve Tic. A.Ş. Istanbul, Türkiye, p.7.
D. Ulusal Kongrelerde Sunulan Tebliğler:
• A.B. Nazlı, Y. Sağ Açıkel, “Resveratrolün Çapraz Yüklü Kitosan Nanopartiküllerden Kontrollü Salımının İncelenmesi” (sözlü sunum), 13. Ulusal Kimya Mühendisliği Kongresi, Van Yüzüncü Yıl Üniversitesi, 3-6 Eylül 2018, Özet Kitabı, 5843, S12.
• G. Polat, Y. Sağ, Açıkel, “Fe3O4-Halloysit-Aljinat Hidrojel Kürelerin Sentezi, Karakterizasyonu ve Metilen Mavisi Gideriminde Kullanılması” (sözlü sunum), 13. Ulusal Kimya Mühendisliği Kongresi, Van Yüzüncü Yıl Üniversitesi, 3-6 Eylül 2018, Özet Kitabı, 5851, S68.
• E. Türkeş, Y. Sağ Açıkel, “Halloysit-Fe3O4-Kitosan Nanokompozitlerin Sentezi,Karakterizasyonu ve Ağır Metal Gideriminde Kullanılması” (sözlü sunum), 13. Ulusal Kimya Mühendisliği Kongresi, Van Yüzüncü Yıl Üniversitesi, 3-6 Eylül 2018, Özet Kitabı, 5852, S56.
• M. Öztekin, Y. Sağ Açıkel, “Kitosan Nanopartiküller Kullanılarak Adsorpsiyon Yoluyla Sulu Ortamlardan Antibiyotik Giderimi” (sözlü sunum), 13. Ulusal Kimya Mühendisliği Kongresi, Van Yüzüncü Yıl Üniversitesi, 3-6 Eylül 2018, Özet Kitabı, 5842, S96.
• RAEIATBİN, Perinaz (Yük. Müh.), AÇIKEL, Yeşim Sağ Açıkel (Prof. Dr.), “Tetrasiklin yüklenmiş manyetik halloysit nanopartiküllerin nano ilaç taşıyıcılar olarak kullanılması”, 12. Ulusal Kimya Mühendisliği Kongresi, İzmir, 23-26 Ağustos, 2016.
• ÖZTEKİN, Merve (Yük. Müh.), AÇIKEL, Yeşim Sağ Açıkel (Prof. Dr.), “Kitosan nanopartiküllerine metranidazole yüklenmesi ve adsorpsiyonunun incelenmesi”, 12. Ulusal Kimya Mühendisliği Kongresi, İzmir, 23-26 Ağustos, 2016.
• AŞKAR Özge Can (Yük. Müh.), AÇIKEL, Yeşim Sağ Açıkel (Prof. Dr.), “Halloysit nanotüplere ciprofloxacin yüklenmesi, adsorpsiyonu ve karakterizasyonunun incelenmesi, 12. Ulusal Kimya Mühendisliği Kongresi, İzmir, 23-26 Ağustos, 2016.